基本信息
吴仁安, 男，博士，

研究员，博士生导师

中科院“百人计划”

纳米生物效应研究组，组长

中国科学院大连化学物理研究所
大连市中山路457号，116023
辽宁，中国
E-mail: wurenan@dicp.ac.cn



科研/招生方向主要研究方向：
1） 基于纳米结构先进材料的生物分析方法和医学检测技术研究
2） 多功能纳米材料的肿瘤靶向与药物输运技术研究；
3） 基于系统生物学的纳米生物效应研究；
4） 整体分离材料的制备与高效分离分析研究。

个人简介 2002年在中国科学院大连化学物理研究所获理学博士学位。 2002-2006年分别在德国马普学会马格德堡复杂系统动力学研究所和美国北卡罗莱纳大学教堂山分校-公共卫生学院从事微纳米孔道结构材料的电渗流和小分子代谢环境毒理研究工作。2007年获中国科学院大连化学物理研究所“百人计划”资助，2008年获中国科学院“百人计划”入选资格称号, 2009 年获中国科学院“百人计划”择优支持。
现主持863项目、中国科学院重要方向性项目、中国科学院“百人计划”择优支持项目、自然科学基金面上项目各1项。已在ACS Nano, FASEB J., Toxicol. Sci., Anal. Chem., J. Proteome Res., J. Phys. Chem. C, J. Am. Soc. Mass Spectrom., Electrophoresis, J. Chromatogr. A/B等期刊上发表论文60余篇, SCI他引600 多次。申请专利9项、授权1项。整体分离材料研究论文单篇SCI他引>50次的有88次、76次、 62和52次等。2008应邀完成整体分离材料评论性文章1篇(J. Chromatogr. A.), 并成为J. Chromatogr. A. 2010 年度50篇被引最多的论文之一(现已被引88次)。申请专利9项、授权1项。研究工作曾获中国分析测试协会优秀成果一等奖。
论文/专著
Ren’an Wu, Hanfa Zou. Monolithic Columns in Microscale Separations: Monolithic Chromatography and its Modern Applications, ISBN 978-1-906799-03-8, 215-264, 2010.



Ruibin Li, Hanfa Zou, Hua Xiao and Renan Wu. Carbon Nanotubes Methods and Protocols: Chapter 13, Carbon nanotubes as intracellular carriers for multidrug resistant cells studies by capillary electrophoresis laser induced fluorescence.


Liang Zhao, Ren’an Wu*, Hanfa Zou. Selective Capture of Phosphopeptides by Zirconium Phosphonate-Magnetic Nanoparticles. Nanoproteomics Methods and Protocols, 2011, ISSN 1064-3745, 215-222

代表性论文：

1. Liang Zhao, Hongqiang Qin, Ren’an Wu*, Hanfa Zou*. Recent advances of mesoporous materials in sample preparation. Journal of Chromatography A, 2012, 1228, 193-204.
2. Hongqiang Qin, Fangjun Wang, Peiyuan Wang, Liang Zhao, Jun Zhu, Qihua Yang, Ren’an Wu, Mingliang Ye, Hanfa Zou. Phosphoric acid functionalized mesoporous organo-silica (EPO) as the adsorbent for in situ enrichment and isotope labeling of endogenous phosphopeptides. Chemical Communications, 2012, 48, 961–963.
3. Hongqiang Qin, Peng Gao, Fangjun Wang, Liang Zhao, Jun Zhu, Aiqin Wang, Tao Zhang, Ren’an Wu*, Hanfa Zou*. Highly Efficient Extraction of Serum Peptides by Ordered Mesoporous Carbon. Angewandte Chemie International Edition, 2011, 50, 12218 –12221.
4. Liang Zhao, Ren’an Wu*, Hanfa Zou. Selective Capture of Phosphopeptides by Zirconium Phosphonate-Magnetic Nanoparticles. Nanoproteomics Methods and Protocols, 2011, ISSN 1064-3745, 215-222
5. Hongqiang Qin, Liang Zhao, Ruibin Li, Ren’an Wu*, Hanfa Zou*. Size-selective enrichment of N-linked glycans using highly ordered mesoporous carbon material and detection by MALDI-TOF-MS. Analytical Chemistry, 2011, 83, 7721–7728.
6. Qianhao Min, Xiaoxia Zhang, Ren’an Wu, Hanfa Zou and Jun-Jie Zhu. Novel magnetic mesoporous silica packed S-shaped microfluidic reactor for online proteolysis of low-MW proteome, Chemical Communications, 2011, 47, 10725–10727.
7. Minghuo Wu, Ren’an Wu*, Zhenbin Zhang, Hanfa Zou*. Preparation and application of organic-silica hybrid monolithic capillary columns. Electrophoresis, 2011, 32, 105–115.
8. Ruibin Li, Ren’an Wu*, Liang Zhao, Zhengyan Hu, Shujing Guo, Xiulian Pan, Hanfa Zou*. Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells. Carbon, 2011, 49, 1797-1805.
9. Zhenbin Zhang, Minghuo Wu, Ren’an Wu*, Jing Dong, Junjie Ou, Hanfa Zou*. Preparation of Perphenylcarbamoylated β-Cyclodextrin-silica Hybrid Monolithic Column with “One-Pot” Approach for Enantioseparation by Capillary Liquid Chromatography. Analytical Chemistry, 2011, 83, 3616–3622.
10. Sun, S., Ma, H., Han, G., Wu, R., Zou, H., Liu, Y. Efficient enrichment and identification of phosphopeptides by cerium oxide using on-plate matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis. Rapid Commun Mass Spectrom, 2011, 25 (13), 1862-1868.
11. Qianhao Min1, Ren’an Wu1, Liang Zhao, Hongqiang Qin, Mingliang Ye, Jun-Jie Zhu*, Hanfa Zou*. Size-selective proteolysis on mesoporous silica-based trypsin nanoreactor for low-MW proteome analysis. Chemical Communications, 2010, 46, 6144–6146.
12. Minghuo Wu, Ren’an Wu*, Ruibing Li, Hongqiang Qin, Jing Dong, Zhenbin Zhang, Hanfa Zou*. Polyhedral Oligomeric Silsesquioxane as a Cross-linker for Preparation of Inorganic-Organic Hybrid Monolithic Columns. Anal. Chem., 2010, 82, 5447–5454.
13. Minghuo Wu, Yingzhuang Chen, Ren’an Wu*, Ruibing Lia, Hanfa Zou*, Bo Chen, Shouzhuo Yao. The synthesis of chloropropyl-functionalized silica hybrid monolithic column with modification of N,N-dimethyl-N-dodecyl- amine for capillary electrochromatography separation. Journal of Chromatography A, 2010, 1217, 4389–4394.
14. Zhenbin Zhang, Ren’an Wu*, Minghuo Wu, Hanfa Zou*. Recent Progress of Chiral Monolithic Stationary Phases in Capillary Electrochromatography and Capillary Liquid Chromatography. Electrophoresis, 2010, 31, 1457–1466.
15. Ruibin Li, Ren’an Wu*, Liang Zhao, Minghuo Wu, Ling Yang, Hanfa Zou*. P-glycoprotein Antibody Functionalized Carbon Nanotube Overcomes the Multidrug Resistance of Human Leukemia Cells. ACS Nano, 2010, 4, 1399–1408.
16. Zhiyuan Yu, Ren’an Wu*, Minghuo Wu, Liang Zhao, Ruibin Li, Hanfa Zou*. Preparation of polyamine-functionalized copper specific adsorbents for the selective adsorption of copper. Colloids and Surfaces B-Biointerfaces, 2010, 78, 222–228.
17. Yu Zhang, Chen Chen, Hongqiang Qin, Ren’an Wu, Hanfa Zou*. The Synthesis of Ti-Hexagonal Mesoporous Silica for Selective Capture of Phosphopeptides. Chem. Comm. 2010, 12, 2271–2273.
18. Minghuo Wu, Ren’an Wu*, Fangjun Wang, Lianbing Ren, Jing Dong, Zhen Liu, Hanfa Zou*. “One-Pot” Process for Fabrication of Organic-Silica Hybrid Monolithic Capillary Columns Using Organic Monomer and Alkoxysilane. Anal. Chem., 2009, 81, 3529–3536.
19. Ruibin Li, Ren’an Wu, Minghuo Wu, Hanfa Zou*, Hong Ma, Ling Yang*, X. Chris Le. MEKC-LIF analysis of rhodamine123 delivered by carbon nanotubes in K562 cells. Electrophoresis, 2009, 30, 1906–1912.
20. Peiyuan Wang, Liang Zhao, Ren’an Wu*, Hua Zhong, Hanfa Zou, Jie Yang, Qihua Yang*. Phosphonic Acid Functionalized Periodic Mesoporous Organosilicas and Their Potential Applications in Selective Enrichment of Phosphopeptides. Journal of Physical Chemistry C, 2009, 113(4): 1359-1366.
21. Xiaoli Dong, Ren’an Wu*, Jing Dong, Minghuo Wu, Yan Zhu, Hanfa Zou*. Recent progress of polar stationary phases in capillary electrochromatography and capillary liquid chromatography. Electrophoresis, 2009, 30(1):141-54.
22. Xiaoli Dong, Ren’an Wu*, Jing Dong, Minghuo Wu, Yan Zhu, Hanfa Zou*. The covalently bonded cellulose tris(3,5-dimethylphenylcarbamate) on a silica monolithic capillary column for enantioseparation in capillary electrochromatography, Journal of Chromatography B, 2008, 875, 317-322.
23. Xiaoli Dong, Ren’an Wu*, Jing Dong, Minghuo Wu, Yan Zhu, Hanfa Zou*. A mesoporous silica nanoparticles immobilized open-tubular capillary column with a coating of cellulose tris(3,5-dimethylphenyl-carbamate) for enantioseparation in CEC. Electrophoresis, 2008, 29, 3933-3940.
24. Liang Zhao, Ren’an Wu*, Guanghui Han, Houjiang Zhou, Lianbing Ren, Ruijun Tian, Hanfa Zou*. Highly selective enrichment of phosphopeptide on zirconium phosphonate-modified magnetic Fe3O4 nanoparticles. Journal of the American Society for Mass Spectrometry, 2008, 19, 1176–1186.
25. Xiaoli Dong, Ren’an Wu*, Jing Dong, Minghuo Wu, Yan Zhu, Hanfa Zou*. Polyacrylamide-based monolithic capillary column with coating of cellulose tris(3,5-dimethylphenyl-carbamate) for enantiomer separation in capillary electrochromatography.. Electrophoresis, 2008, 29(4):919-27. 26. Ren’an Wu, Lianghai Hu, Fangjun Wang, Mingliang Ye, Hanfa Zou*. Recent development of monolithic stationary phases with emphasis on microscale chromatographic separation. Journal of Chromatography A, 2008, 1184(1-2):369-92.

申请专利吴仁安, 邹汉法, 叶明亮. 一种非电荷型电色谱柱其制备及应用, 申请号:**.4, 公开号:CN**. 邹汉法, 于志远，吴仁安. 一种用于胆红素吸附的单分散聚苯乙烯－二乙烯基苯微球的制备方法, 申请号:**3.x. 邹汉法，李瑞宾，吴仁安. 一种肿瘤靶向碳纳米管药物载体及其制备, 申请号: **5.9. 邹汉法, 赵樑, 吴仁安，周厚江. 一种磷酸酯锆纳米磁珠及其制备和应用, 申请号: **0.6. 邹汉法, 于志远，吴仁安. 用于血液净化的聚苯乙烯－二乙烯苯微球的制备, 申请号: **2.0. 邹汉法，于志远，吴仁安. 用于治疗威尔森氏症的铜离子鳌合吸附介质的制备方法, 申请号: **2.3. 邹汉法，吴明火，吴仁安. 有机－无机杂化多孔整体材料的一锅法制备. 申请号: **3.4. 邹汉法，赵樑，吴仁安. 一种有序短孔道磁性介孔材料. 申请号: **5.7. 邹汉法，张宇，陈晨，徐杰，吴仁安. 一种基于金属杂化介孔材料的磷酸化肽富集方法. 申请号: **7.2.
科研项目中国科学院“百人计划”择优支持项目，项目负责人，200万.863计划(2008AA02Z211)，免疫吸附血液净化材料制备技术与规模化生产，项目首席，300万. 国家自然科学基金，面上项目(**)，基于介孔材料的生物样品预分离富集方法研究, 课题负责人，33万.中国科学院知识创新工程重要方向项目(KSCX2-YW-G-049)，免疫吸附血液净化材料的研究, 150 万，项目负责人. 973项目(2007CB914103)，多维、多模式、阵列式的蛋白质高效分离新技术的研究，主要学术骨干. 国家自然科学基金，重点项目(**)，蛋白质组和肽组学分析新技术和新方法的研究, 主要学术骨干.
学生培养现指导学生
刘胜菊 硕士研究生 分析化学
徐桂菊 博士研究生 分析化学

共同指导学生

吴明火 硕博连读　分析化学, 2010毕业，加拿大UBC， 博后
李瑞宾 硕博连读　分析化学, 2011毕业，美国UCLA， 博后
赵 樑 硕博连读　分析化学, 2012毕业，德国马普慕尼黑生物所，博后
秦洪强 硕博连读　分析化学
张振宾 硕博连读　分析化学
胡争艳 硕博连读　分析化学
张　轶 硕博连读　分析化学

指导博士后

Artaches Kazarian，Australia (2011)