基本信息
吴允昆 男 博导 中国科学院福建物质结构研究所
电子邮件： wuyk@fjirsm.ac.cn
通信地址： 杨桥西路155号
邮政编码： 350002
研究领域

生物大分子结构与功能机制研究；
基于结构的生物分子调节剂和纳米运载体研发。

招生信息

生物学071010


生物化学和分子生物学结构生物学, 生物化学和分子生物学


生物工程
教育背景2002-12--2007-06 University of Alabama at Birmingham 博士
1992-09--1996-07 武汉大学生命科学院 本科


学历武汉大学细胞生物学 本科
University of Alabama at Birmingham 博士/博士后
HHMI/UT Southwestern Medical Center 博士后
学位博士
工作经历Professor 04/2011-Present
Fujian Institute of Research on the Structure of Matter
Chinese Academy of Sciences

HHMI Research Fellow 01/2008-06/2011
Howard Hughes Medical Institute
University of Texas Southwestern Medical Center at Dallas, USA

Postdoctoral Associate 07/2007-12/2007
Department of Cell Biology, School of Medicine
University of Alabama at Birmingham, USA

Graduate Research Assistant 12/2002-06/2007
Department of Cell Biology, School of Medicine
University of Alabama at Birmingham, USA

Research Assistant
Laboratory of Internal-Oncology and Laboratory of Immunopathology
Fujian Tumor Hospital, China

专利与奖励Biophysical Society 51st Annual Meeting Student Research Achievement Awards, 2007
University of Alabama at Birmingham Graduate Scholarship, 2003-2007

发表论文


Li S, Zhao Y, Zhao Z, Wu X, Sun L, Liu Q, Wu Y. (2016) Crystal structure of GRAS domain of SCARECROW-LIKE 7 in Oryza sativa. Plant Cell. DOI: 10.1105/tpc.16.00018. (highlighted article)
Zhang L, Zeng Z, Hu C, Bellis SL, Yang W, Su Y, Zhang X, Wu Y. (2016) Controlled and targeted release of antigens by intelligent shell for improving applicability of oral vaccines. Biomaterials 77:307-9.

Zhang L, Bellis SL, Fan Y, Wu Y. (2015) Using Inositol as a Biocompatible Ligand for Efficient Transgene Expression. International Journal of Nanomedicine. 2015:10 2871-84.

Zhao Y, Ye X, Su Y, Sun L, She F, Wu Y. (2014) Crystal structure confirmation of JHP933 as a nucleotidyltransferase superfamily protein from Helicobacter pylori strain J99. PLoS One 9(8):e104609.

Zhang L, Fan Y, Wu Y. (2014) Inositol based none-viral vectors for transgene expression in human cervical carcinoma and hepatoma cell lines. Biomaterials 35(6):2039-50.

Zhang L, Hu C, Fan Y, Wu Y. (2013) Binary gene vectors based on hyperbranched poly(L-lactide-co-polyglycerol) and polyethylenimine for prolonged transgene expression via co-assembly with DNA into fiber core–shell triplexes. J. Mater. Chem. B 1(45), 6271-6282.

Wu Y, Yang Y, Ye S, Jiang Y. (2010) Structure of the Intracellular Gating Ring from the Human High-conductance Ca2+-gated K+ Channel. Nature 466(7304):393-7.

Wu Y, Sha B. (2006). Crystal structure of yeast mitochondrial outer membrane translocon member Tom70p. Nature Structural & Molecular Biology 13(7):589-93.

Li J*, Wu Y*, Qian X, Sha B. (2006). Crystal structure of yeast Sis1 peptide-binding fragment and Hsp70 Ssa1 C-terminal complex. Biochemical Journal 398(3): 353-60.
（* Equal contributions）

Wu Y, McCombs D, Nagy L, Delucas L, Sha B. (2006). Preliminary X-ray crystallographic studies of yeast mitochondrial protein Tom70p. Acta Crystallogr Sect F Struct Biol Cryst Commun. 62(Pt 3):265-7.

Wu Y, Li J, Jin Z, Fu Z, Sha B. (2005). The crystal structure of the C-terminal fragment of yeast Hsp40 Ydj1 reveals novel dimerization motif for Hsp40. Journal of Molecular Biology 346(4):1005-11.