1、招生信息2、教育背景3、工作经历4、教授课程5、专利与奖励6、出版信息7、科研活动8、合作情况9、指导学生
基本信息
许执恒 男 博导 遗传与发育生物学研究所
电子邮件：zhxu@genetics.ac.cn
通信地址：北京市朝阳区北辰西路1号院-2
邮政编码：100101


研究领域利用本课题组在信号转导领域的优势，结合不同的模式动物，进行神经和肿瘤生物学研究，争取在阐明不同的重要疾病发生的分子机制方面有所突破。目前，我们的研究重点是JNK，NF？B和AKT信号通路, 这些信号通路与肿瘤、神经发育及神经退行性疾病均密切相关。 有关研究将为疾病的预防和治疗提供理论依据，同时为个体正常发育的分子机理提供新见解。


招生信息

招生专业 神经生物学
细胞生物学
神经生物学

招生方向 信号转导与脑发育
肿瘤发生的分子机制
神经疾病研究
教育背景 2005-12--今 中科院遗传发育所 “百人计划”


学历1989年获上海第二军医大学医学学士系学位，1999年获美国新泽西Rutgers大学博士学位。

学位-- 博士

工作经历1999-2005在美国哥伦比亚大学神经生物学和精神病中心做博士后及高级研究助理。先后获得美国NIH的 Ruth L. Kirschstein National Research Service Award (2002-03)及Rutgers大学Bush Fellowship (1997-1999)和Waksman Fellowship (1993-1997)，2005年中国科学院“百人计划”入选者，2007年国家杰出青年科学基金获得者。



教授课程
出版信息1. Li P… Xu Z*, and Zhu Z*. Epigenetic silencing of microRNA-149 in cancer associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment Cell Research (accepted)

2. Zhang F. Xu D,. Sun YM., Xu Z*. Epigenetic regulation of Atrophin1 by lysine-specific demethylase is required for cortical progenitor maintenance. Nat. Commun, 5:5815. doi: 10.1038/ncomms6815

3. Xu D. Zhang F, Wang Y, Sun Y, Xu Z*. (2014) Microcephaly Associated Protein WDR62 Regulates Neurogenesis through JNK1 in the developmental cortex. Cell Reports 6(1):104-16

4. Yu J, Zhang F, Zhang Y, Fan M and Xu Z* (2014) TAK1 is activated by TGF-β signaling and controls axonal growth during brain development. JMCB 6(4):349-51.

5. Yao M, Wang Y, Zhang P, Chen H, Xu Z, Jiao J, Yuan Z. (2014) BMP2-SMAD Signaling Represses the Proliferation of Embryonic Neural Stem Cells through YAP. J Neuroscience 34(36):12039-48

6. Zhu Y, Wang C, Yu M, and Xu Z*. (2013) ULK1 and JNK are Involved in Mitophagy Incurred by LRRK2 G2019S Expression. Protein Cell 4(9): 711-21.

7. Shi W, Chen Y, Gan G, Ren J, Wang Q, Xu Z, Xie X, and Zhang Y. (2013) Brain tumor regulates neuromuscular synapse growth and endocytosis in Drosophila by suppressing Mad expression. J Neuroscience 24;33(30):12352-63.

8. Xiong Y, Zhao K, Wu J, Xu Z, Jin S, Zhang YQ. (2013) HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. PNAS 19;110(12):4604-9.

9. Yang T., Sun YM…Xu Z* (2012) POSH Localizes Activated Rac1 to Control the Formation of Cytoplasmic Dilation of the Leading Process and Neuronal Migration. Cell Reports 2(3):640-51 (Article).

10. Wilhelm M, Kukekov NV, Schmit TL, Biagas KV, Sproul AA, Gire S, Maes ME, Xu Z, Greene LA.（2012）Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein. J Biol Chem. 287(3):2247-56.

11. J Niu, M Yu and Z Xu*. (2012) Leucine-Rich Repeat Kinase 2 (LRRK2) Disturbs Mitochondrial Dynamics via Dynamin-Like Protein (DLP1). J NeuroChem 122(3):650-8.

12. J Cui, M Yu, Z Xu* (2011). Expression of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibits the Processing of uMtCK to Induce Cell Death in cell culture model system. Biosci Rep 31(5):429-437.

13. Y Sun, T Fei, T Yang, F Zhang, Y Chen, Z Xu* (2010) The suppression of CRMP2 expression by BMP-SMAD gradient signaling controls multiple stages of neuronal development. J Biol Chem. 285(50): 39039–39050.

14. Ren J., Wang Y., Liang Y....and Xu Z* (2010) Methylation of ribosomal protein s10 by protein arginine methyltransferase 5 regulates ribosome biogenesis J Biol Chem. 285(17):12695-705.

15. C Wang, Y Tao, Y Wang, Z Xu* Regulation of the Protein Stability of POSH and MLK Family. Protein Cell 1(9): 871–878.

16. Y Sun, Z Xu* (2010) Regulation of Neural Stem Cell by Bone Morphogenic Protein (BMP) Signaling During Brain Development. Frontiers in Biology 5(5):380-385.

17. B Lu; Y Zhai, C Wu; X Pang, Z Xu, F Sun (2010) Expression, purification and preliminary biochemical studies of the N-terminal domain of leucine-rich repeat kinase 2. BBA-Proteins and Proteomics 804(9):1780-4.

18. M Zhang, Y Zhang and Z Xu* (2010) POSH is Involved in Egr-Bsk (TNF-JNK) Signaling and Embryogenesis in Drosophila. J Genetics and Genomics 37(9):605-19.

19. Shen Q, Qin F, Gao Z, Cui J, Xu Z, and Yang C, （2009） Adenine Nucleotide Translocator Cooperates with Core Cell Death Machinery to Promote Apoptosis in Caenorhabditis elegans. Mol Cell Biol, 29(14): 3881–3893.

20. Jin S, Pan L, Liu Z, Wang Q, Xu Z, and Zhang Y (2009) Drosophila Tubulin-specific chaperone E functions at neuromuscular synapses and is required for microtubule network formation. Development 136(9):1571-81.

21. Sproul A , Xu Z and Greene L (2009) Cbl Negatively Regulates JNK Activation and Cell Death. Cell Research 19(8):950-61.

22. Liu S, Yu M, He Y, Xiao L,…, and Xu Z* (2008) Melittin prevents liver cancer cell metastasis through inhibition of the Rac1-dependent pathway. Hepatology 47(6) 1964-73.

23. Qiao HX, Hao CJ, Li Y, He X, Chen RS, Cui J, Xu Z*, Li W*.（2008） JNK activation mediates the apoptosis of xCT-deficient Cells. BBRC 370(4):584-8.

24. Sun Y, Yang T, Xu Z* (2007) The JNK Pathway and Neuronal Migration. J Genetics and Genomics 34(11): 957-965.

25. Wilhelm M, Kukekov NV, Xu Z, Greene LA (2007) Identification of POSH2, a novel homologue of the c-Jun N-terminal kinase scaffold protein POSH. Dev Neurosci. 29(4-5):355-62.

26. Wang L, Zhang Y, Li H, Xu Z, Santella RM, Weinstein IB. (2007) Hint1 Inhibits Growth and Activator Protein-1 Activity in Human Colon Cancer Cells. Cancer Res. 67(10):4700-4708.

27. Cui J, Zhang M, Zhang YQ, Xu Z* (2007) JNK pathway: diseases and therapeutic potential. Acta Pharmacol Sin. 28(5):601-8.

28. Welhelm M, Xu Z., and Greene L （2007）Proapoptotic Nix activates the JNK pathway by interacting with POSH and mediates death in a Parkinson disease model. J Biol Chem. 282(2):1288-95.

29. Xu Z.*, Sproul A., Wang WY, and Greene L. (2006) SIAH1 Interacts with the Scaffold Protein POSH to Promote JNK Activation and Apoptosis. J Biol Chem. 281(1):303-12.
(* Corresponding author)

30. Kukekov, N*.,Xu Z.*, and Greene(2006) Direct interaction of the molecular scaffolds POSH and JIP is required for apoptotic activation of JNKs. J Biol Chem. 281(22):15517-24.
(* Equal contribution)

31. Tang G, Xu Z, Goldman JE. (2006) Synergistic effects of the SAPK/JNK & the proteasome pathways on GFAP accumulation in Alexander disease. J Biol Chem. 281(50):38634-43.

32. Xu Z.*, Kukekov, N., and Greene L (2005) A stability-based self-amplifying feed forward loop mechanism for regulation of the apoptotic JNK pathway. Mol Cell Biol. 25(22):9949-59.
(* Corresponding author)

33. Xu Z.* and Greene L. (2006) Regulation of the apoptotic JNK pathway. Methods Enzymol 406:479-89. (* Corresponding author)

34. Zheng S.*, Xu Z.*¨, and Longey J. (2005) Cbl-b/Cbl regulates c-Kit receptor stability through the proteasomal pathway in mast cells. Blood 105(1):226-32. (* Equal contribution, ¨ Corresponding author).

35. Hanlon SE, Xu Z, Norris DN, Vershon AK. (2004) Analysis of the meiotic role of the mitochondrial ribosomal proteins Mrps17 and Mrpl37 in Saccharomyces cerevisiae. Yeast. 21(15):1241-52.

36. Kim K., Kim B., Xu Z, and Kim S. (2004). Mixed lineage kinase (MLK) 3-activated p38 MAP kinase mediates TGF-Beta-induced apoptosis in hepatoma cells. J Biol Chem. 279(28):29478-84.

37. Xu Z., Kukekov N., and Greene LA (2003). POSH (plenty of SH3’s) Acts as a Scaffold for a Multiprotein Complex that Mediates JNK Activation in Apoptotic Death. EMBO J 15; 22(2): 252-61.

38. Xu Z, Maroney AC, Dobrzanski P, Greene LA (2001). The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. Mol Cell Biol. 21(14): 4713-24.

39. Maroney AC, Finn JP, Connors TJ, Durkin JT, Angeles T, Gessner G, Xu Z, Meyer SL, Savage MJ, Greene LA, Scott RW, Vaught JL (2001). Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. J Biol Chem. 276(27): 25302-8.

40. Troy CM, Rabacchi SA, Xu Z, Maroney AC, Connors TJ, Shelanski ML, Greene LA (2001). beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation. J Neurochem. 77(1):157-64.

41. Xu Z., and Norris D. (1999). The SFP1 gene product of S. cerevisiae regulates G2/M transitions in the mitotic cell cycle and in response to DNA damage. Genetics 150(4): 1419-28.

科研活动

科研项目 （1） 973，参与，国家级，2012-05--2017-05
（2） 干细胞专项，参与，部委级，2012-01--2016-12


参与会议
指导学生已指导学生

任金琪 博士研究生 071009-细胞生物学

于梅 博士研究生 071009-细胞生物学

张明 博士研究生 071009-细胞生物学

崔婕 博士研究生 071009-细胞生物学

牛竞文 博士研究生 071009-细胞生物学

王春艳 博士研究生 071009-细胞生物学

鲁彬 硕士研究生 071009-细胞生物学

杨涛 博士研究生 071009-细胞生物学

池智霞 硕士研究生 071007-遗传学

孙一明 博士研究生 071009-细胞生物学

张鸿声 博士研究生 071009-细胞生物学

徐丹 博士研究生 071009-细胞生物学

张威亚 硕士研究生 071009-细胞生物学

现指导学生

刘亮 博士研究生 071009-细胞生物学

王硕 博士研究生 071006-神经生物学

袁玲 博士研究生 071009-细胞生物学

张峰 博士研究生 071009-细胞生物学

李翠 硕士研究生 071007-遗传学

刘新异 硕士研究生 071006-神经生物学

夏衍珩 博士研究生 071009-细胞生物学

范俊婉 博士研究生 071009-细胞生物学

洪帅 硕士研究生 071006-神经生物学

李光辉 硕士研究生 071006-神经生物学

祝星亮 博士研究生 071006-神经生物学

王骎 博士研究生 071006-神经生物学

王桃 硕士研究生 071006-神经生物学