姓名：周德山 性别：男 职称：教授 招生院所：基础医学院 招生类型：科学学位(博) 科学学位(硕) 招生专业：人体解剖与组织胚胎学(博) 人体解剖与组织胚胎学(硕) 研究方向名称：胃肠微细结构与胃肠肿瘤 电子信箱：zhouds08@ccmu.edu.cn


社会任职
1. 中国解剖学会副理事长、兼任秘书长
2. 中国解剖学会组胚专业委员会主任委员
3. 北京解剖学会理事长
个人简历
1. 197801-198212:中国医科大学 临床医学 毕业 本科生
2. 198301-198512:第三军医大学硕士研究生 毕业 硕士研究生
3. 198601-198712:第三军医大学、组织学与胚胎学教研室 助教
4. 198801-199303:日本爱媛大学医学部解剖组胚学系 博士研究生
5. 199304-199803:日本早稻田大学，生命科学院生物系 博士后研究员
6. 199804-200010:日本产业技术综合研究所细胞分子研究室 博士后研究员
7. 200011-200712: 第三军医大学组织胚胎学教研室 教授、博导、主任
8. 200801-:首都医科大学人体解剖组胚学系 教授、博导、主任
重要学术论文
1. Sun T, Wang Y, Hu S, Sun H, Yang S, Wu B, Ji F, Zhou D*.. Lipopolysaccharide induces the early enhancement of mice colonic mucosal paracellular permeability mainly mediated by mast cells. . Histol Histopathol. 2019,34(2)::191-200.SCI
2. Li G#, Yang S#, Shen P, Wu B, Sun T, Sun H, Ji F*, Zhou D*. .SCF/c-KIT signaling promotes mucus secretion of colonic goblet cells and development of mucinous colorectal adenocarcinoma.. Am J Cancer Res. . 2018,8(6)::1064-1073..SCI
3. Shen P, Yang S, Sun H, Li G, Wu B, Ji F, Sun T, Zhou D*. .SCF/c-KIT signaling increased mucin2 production by maintaining Atoh1 expression in mucinous colorectal adenocarcinoma. Int J Mol Sci. . 2018,19(5).: pii: E1541. .SCI
4. Sun T, Li D, Hu S, Huang L, Sun H, Yang S, Wu B, Ji F, Zhou D*..Aging-dependent decrease in the numbers of enteric neurons, interstitial cells of Cajal and expression of connexin43 in various regions of gastrointestinal tract. Aging (Albany NY). 2018,10(12)::3851-3865.SCI
5. Wu B, Yang S, Sun H, Sun T, Ji F, Wang Y, Xu L, Zhou D*. . Keap1 inhibits metastatic properties of NSCLC cells by stabilizing architectures of F-actin and focal adhesions.. Mol Cancer Res. . 2018,16(3): :508-516..SCI
6. Dong F, Yang S, Sun H, Yan J, Guo X, Li D, Zhou D*..Persistent mechanical stretch-induced calcium overload and MAPK signal activation contributed to SCF reduction in colonic smooth muscle in vivo and in vitro.. J Recept Signal Transduct Res. 2017,37:: 141-148..SCI
7. Deng J#, Yang S#, Yuan Q, Chen Y, Li D, Sun H, Tan X, Zhang F*, Zhou D*.Acupuncture ameliorates postoperative ileus via IL-6–miR-19a–KIT axis to protect interstitial cells of Cajal.. Am J Chinese Med.. 2017,45(4)::737-755.SCI
8. Du J, Xu Z, Liu Q, Yang Y, Qian H, Hu M, Fan Y, Li Q, Yao W, Li H, Qian G, He B, Zhou D*, Mao C*, Wang G*.ATG101 single-stranded antisense RNA-loaded triangular DNA nanoparticles control human pulmonary endothelial growth via regulation of cell macroautophagy.. ACS Appl Mater Interfaces.. 2017,9(49):42544-42555.SCI
9. Yang S, Wu B, Sun H, Sun T, Han K, Li D, Ji F, Zhang G*, Zhou D*.Impaired insulin/IGF-1 is responsible for diabetic gastroparesis by damaging myenteric cholinergic neurons and interstitial cells of Cajal.. Biosci Rep.. 2017,35(5): pii:BSR**.SCI
10. Yang S, Dong F, Li D, Sun H, Wu B, Sun T, Wang Y, Shen P, Ji F*, Zhou D*.Persistent distention of colon damages interstitial cells of Cajal through Ca2+-ERK-AP-1-miR-34c-SCF deregulation.. J Cell Mol Med.. 2017,21(9):1881-1892.SCI
11. Wang Y, Sun T, Sun H, Yang S, Li D, Zhou D*. .SCF/C-Kit/JNK/AP-1 signaling pathway promotes Claudin-3 expression in colonic epithelium and colorectal carcinoma. Int J Mol Sci. . 2017,18(4). :pii: E765.SCI
12. Xiao J, Yang S, Shen P, Wang Y, Sun H, Ji F, Zhou D*.. Phosphorylation of ETV4 at Ser73 by ERK kinase could block ETV4 ubiquitination degradation in colorectal cancer. . Biochem Biophys Res Commun. . 2017,pii: S0006-291X(17):30641-1..SCI
13. Yang S, Wu B, Sun H, Ji F, Sun T, Zhao Y, Zhou D*.Interrupted E2F1-miR-34c-SCF negative feedback loop by hyper-methylation promotes colorectal cancer cell proliferation. Biosci Rep. . 2016,36(1): :e00293..SCI
14. Yan J, Guo D, Yang S, Sun H, Wu B, Zhou D*..Inhibition of miR-222-3p activity promoted osteogenic differentiation of hBMSCs by regulating Smad5-RUNX2 signal axis. . Biochem Biophys Res Commun. 2016, 470(3):: 498-503.SCI
15. Zou W, Yang S, Zhang T, Sun H, Wang Y, Xue H, Zhou D*. .Hypoxia enhances glucocorticoid‑induced apoptosis and cell cycle arrest via the PI3K/Akt signaling pathway in osteoblastic cells. J Bone Miner Metab. 2015, 33: 615-624.
16. Yang S, Lu W, Zhou D*, Tang Y*.Enriched environment increases myelinated fiber volume and length in brain white matter of 18-month female rats.. Neurosci lett.. 2015, 593: 66-71.SCI
17. Yang S, Li W, Sun H, Wu B, Ji F, Sun T, Chang H, Shen P, Wang Y, Zhou D*..Resveratrol elicits anti-colorectal cancer effect by activating miR-34c-KITLG in vitro and in vivo.. BMC Cancer. 2015,15（1）:969-.SCI
18. Tan J, Yang S, Shen P, Sun H, Xiao J, Wang Y, Wu B, Ji F, Yan J, Xue H, Zhou D*..C-kit signaling promotes proliferation and invasion of colorectal mucinous adenocarcinoma in a murine model.. Oncotarget. 2015,6(29):: 27037-27048.SCI
19. Yang S, Li W, Dong F, Wu B, Sun H, Tan J, Zou W, Zhou D*.KITLG is a novel target of miR-34c that is associated with the inhibition of growth and invasion in colorectal cancer cells. J Cell Mol Med. 2014,18(10):: 2092-2102..SCI
20. Li X, Xue H, Kang Q, Sun H, Yang S, Zhang G, Zhou D*.Alterations of the interstitial cells of Cajal and the microstructure of the gastrointestinal tract in KIT distal kinase mutant mice. Cell Tissue Res. . 2014,355(1):49-58.SCI
21. Xue H, Zhang Z, Li X, Sun H, Kang Q, Wu B, Wang Y, Zou W, Zhou D*.Localization and vasopressin regulation of the Na+-K+-2Cl- cotransporter in the distal colonic epithelium. World J Gastroenterology. 2014,20(16):4692-4701.SCI
22. Wu B, Liu L, Gao H, Sun H, Xue H, Li X, Zhang G, Zhou D*.Distribution of interstitial cells of Cajal in Meriones unguiculatus and alterations in the development of incomplete intestinal obstruction. Histol Histopathol.. 2013,28(12):1567-1575.SCI
23. Yang S, Sun H, Yan J, Xue H, Wu B, Dong F, Li W, Ji F, Zhou D*.Conditioned medium from human amniotic epithelial cells may induce the differentiation of human umbilical cord blood mesenchymal stem cells into dopaminergic neuron-like cells. J Neurosci Res.. 2013,91(7):978-986.SCI
24. Li X#, Yang S#, Lv X, Sun H, Weng J, Liang Y, Zhou D*.The mechanism of Mesna in protection from Cisplatin-induced ovarian damage in female rats.. J Gynecol Oncol.. 2013,24(4):177-185.SCI
25. Yang S, Xue D, Wu B, Sun H, Li X, Dong F, Li W, Ji F, Zhou D*.Pleiotrophin is involved in the amniotic epithelial cell-induced differentiation of human umbilical cord blood-derived mesenchymal stem cells into dopaminergic-like neurons.. Neurosci lett.. 2013,539:86-91.SCI
26. Yan J, Yang S, Sun H, Guo D, Wu B, Ji F, Zhou D*.Effects of releasing rhGDF-5 from PLGA microsphere for repair of the rat degenerated intervertebral disc.. J Biomaterials Appl.. 2013,29(1):72-80.SCI
27. Guo D, Wu B, Yan J, Li X, Sun H, Zhou D*.A possible gene silencing mechanism: Hypermethylation of the Keap1 promoter abrogates binding of the transcription factor Sp1 in lung cancer cells.. Biochem Bioph Res Co.. 2012,428(1):80-85.SCI
28. Yang S, Xiong C, Sun H, Li X, Zhang G, Wu B, Zhou DS*.Distribution of HCN2-positive cells in the myenteric plexus of mice gastrointestinal tract.. J Anat.. 2012,221(4):303-310.SCI
29. Jiang Z, Chai J, Chuang HH, Li S, Wang T, Cheng Y, Chen W, Zhou D*.Artesunate induces G0/G1 cell cycle arrest and iron-mediated mitochondrial apoptosis in A431 human epidermoid carcinoma cells.. Anti-cancer Drug. 2012,23(6):606-613.SCI
30. Liu Y, Chan F, Sun H, Yan J, Fan D, Zhao D, An J, Zhou DS*.Resveratrol protects human keratinocytes HaCaT cells from UVA-induced oxidative stress damage by downregulating Keap1 expression.. Eur J Pharmacol.. 2011,650:130-137.SCI
31. Chan FX, Liu Y, Sun, HM, Li, XS, Shang HW, Fan, DY, An J, Zhou DS*.Distribution and possible role of PDGF-AA and PDGFR-α in the gastrointestinal tract of adult guinea pigs . Virchows Arch.. 2010,457(3):381-388.SCI
32. Mei F, Yu B, Ma H, Zhang HJ，Zhou DS*.Interstitial cells of Cajal could regenerate and restore their normal distribution after disrupted by intestinal transection and anastomosis in the adult guinea pigs.. Virchows Arch.. 2006,449(3):348-357 .SCI
33. Zhou DS*，Komuro T.Ultrastructure of the zinc iodide-osmic acid stained cells in guinea pig small intestine.. J Anat. 1995,187: 481-485.SCI
34. Zhou DS*， Komuro T .Interstitial cells associated with the deep muscular plexus of the guinea-pig small intestine, with special reference to the interstitial cells of Cajal. Cell Tissue Res.. 1992,268:205-216.SCI
35. Zhou DS，Komuro T .The cellular network of interstitial cells associated with the deep muscular plexus of the guinea pig small intestine. Anat Embryol. 1992,186 (6): 519-527.SCI
主编或副主编的著作/译著
1. 《组织化学与细胞化学技术（第三版）》,主编,人民卫生出版社,202012
2. 《医学组织学图谱与实习指导（中英对照）》,主编,清华大学出版社,201909
3. 《组织学与胚胎学（第四版）》,副主编,北京大学医学出版社,201806
4. 《组织学与胚胎学（第3版）》,副主编,高等教育出版社,201801
5. 《组织学与胚胎学（第6版）》,副主编,人民卫生出版社,201511
6. 《组织学与胚胎学要点速记》,主编,北京大学医学出版社,201501
7. 《组织化学与细胞化学技术（第2版）》,副主编,人民卫生出版社,201412
8. 《组织学与胚胎学（第3版）》,副主编,北京大学医学出版社,201312
9. 《组织学与胚胎学（第2版）》,副主编,高等教育出版社,201307
10. 《Textbook of Histology and Embryology》,副主编,北京大学医学出版社,201101
重要奖项
1. 首都医科大学教育教学奖（第二届） 首都医科大学教育教学奖 2018
2. 首都医科大学我最喜爱的教师 首都医科大学我最喜爱的教师 201512
3. 军队科技进步奖 二等奖 200901