姓名：薛明 性别：男 职称：研究员、教授 招生院所：基础医学院 招生类型：科学学位(博) 科学学位(硕) 招生专业：药理学(博) 药理学(硕) 研究方向名称：物质代谢与低氧组学 电子信箱：xuem@ccmu.edu.cn


社会任职
1. 中国药理学会常务理事
2. 北京药理学会副理事长
3. 中国微纳米技术学会理事
4. 中国药理学会药物代谢\网络药理\药源性疾病专委会委员
5. 中国药理学会分析药理\肾脏药理专委会常务委员
6. 北京生理科学会理事，北京药学会理事
7. Austin Journal of Pharmacology & Therapeutics，Asian Journal of Pharmacodynamics and Pharmacokinetics，中国药理学通报，中国药理通讯，神经药理学报，首都医科大学学报，国际药学研究杂志编委
8. 国家自然科学基金委员会化学与医学科学部项目评议专家，国家科技专家库与国家科学技术奖励评审专家库成员
9. 北京市自然科学基金委员会项目评议专家，北京市科学技术奖励评审专家库成员
个人简历
1. 198109-198506:甘肃农业大学动物医学系 本科，学士学位
2. 198507-199905:中国农业科学院兰州牧药研究所 研究实习员，助理研究员，副研究员
3. 199109-199407:中国农业科学院 硕士研究生，硕士学位
4. 199509-199812:中国科学院大学兰州化学物理研究所 博士研究生，博士学位
5. 199906-200106:军事科学院军事医学研究院药物毒物研究所 博士后
6. 200107-200312:首都医科大学基础医学院药理教研室 副研究员，研究员，室主任，硕士生导师
7. 200401-201012:首都医科大学药学院药理学系 教授，学系主任，硕士生导师，博士生导师
8. 201101-:首都医科大学基础医学院药理学系 教授，学系主任，博士生导师
重要学术论文
1. Pingxiang Xu#, Ying Liu#, Liyun Wang#, Yi Wu, Xuelin Zhou, Junhai Xiao, Jianquan Zheng, Ming Xue*.Phencynonate S-isomer as a eutomer is a novel central anticholinergic drug for anti-motion sickness. Scientific Reports. 2019,9:2000.SCI
2. Yi Ma, Yi Wu, Zhengchao Xia, Jingyi Li, Xiaorong Li, Pingxiang Xu, Xuelin Zhou*, Ming Xue* .Anti-hypoxic molecular mechanisms of Rhodiola crenulata extract in zebrafish as revealed by metabonomics. Frontiers in Pharmacology. 2019,10:1356.SCI
3. Zhengchao Xia, Xuelin Zhou, Jingyi Li, Lei Li, Yi Ma, Yi Wu, Zhong Huang, Xiaorong Li, Pingxiang Xu, Ming Xue*. .Multiple-omics techniques reveal the role of glycerophospholipid metabolic pathway in the response of Saccharomyces cerevisiae against hypoxic stress. Frontiers in Microbiology. 2019,10:1398.SCI
4. Jin-Feng Yao, Hong Yang, Yan-Zhi Zhao, Ming Xue*.Metabolism of peptide drugs and strategies to improve their metabolic stability. Current Drug Metabolism. 2018,19:892-901.SCI
5. Haiting Cheng, Can Cui, Shousi Lu, Binbin Xia, Xiaorong Li, Pinxiang Xu, Ming Xue*.Identification and analysis of hub genes and networks related to hypoxia preconditioning in mice. Oncotarget. 2018, 9 :11889-11904.SCI
6. Beikang Ge, Liang Zhao, Xiaorong Li, Pingxiang Xu, Ming Xue*.Glucuronidation is the dominating in vivo metabolism pathway of herbacetin: Elucidation of herbacetin pharmacokinetics after intravenous and oral administration in rats. Journal of Functional Foods. 2018,40:659–669.SCI
7. Te Qi, Bei-kang Ge, Liang Zhao, Yi Ma, Xiao-rong Li, Ping-xiang Xu and Ming Xue*. Cytosolic b-glucosidase inhibition and renal blood flow suppression are leading causes for the enhanced systemic exposure of salidroside in hypoxic rats. RSC Advances. 2018,8:8469–8483.SCI
8. Lu Bai, Ying Han, Pingxiang Xu, Binbin Xia, Yuming Zhao, Xiaorong Li and Ming Xue*.Plasma pharmacokinetics and brain distribution kinetics of lapachol in rats using LC-MS and microdialysis techniques. RSC Advances. 2017,7:53355-53361.SCI
9. Wenwen Gong, Pingxiang Xu, Shanshan Guo, Xiaorong Li, Zengliang Jin, Yuming Zhao, Ming Fan*, Ming Xue*.Effect of hypoxia on the pharmacokinetics and metabolism of zaleplon as a probe of CYP3A1/2 activity. RSC Advances. 2017,7:25414–25421.SCI
10. Yi Qin , Weizhe Xu , Lanjian Mo, Xiaorong Li , Beikang Ge, Jie Xiong , Lifang Gao, Pinxiang Xu, Ming Xue*.Comparison of Pharmacokinetics and tissue distribution kinetics of roxithromycin and expression of CYP 3a1 between pregnant mice and foetuses. Basic & Clinical Pharmacology & Toxicology. 2017,120:146–151.SCI
11. Weizhe Xu#, Yan Zhao#, Yi Qin, Beikang Ge, Wenwen Gong, Yingting Wu, Xiaorong Li, Yuming Zhao, Pingxiang Xu, Ming Xue*.Enhancement of exposure and reduction of elimination for paeoniflorin and albiflorin via co-administration with total peony glucosidesand hypoxic pharmacokinetics comparison. Molecules. 2016,21:874–887.SCI
12. Huanli Xu, Qunying Chen, Hong Wang, Pingxiang Xu, Ru Yuan, Xiaorong Li, Lu Bai, Ming Xue*.Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase I. Journal of Experimental & Clinical Cancer Research. 2016,35:178-187.SCI
13. Zeng-liang Jin, Nana Gao, Weizhe Xu , Pingxiang Xu, Shuaiqi Li, Yuan-yuan Zheng, Ming Xue*.Receptor and transporter binding and activity profiles of albiflorin extracted from Radix paeoniae Alba. Scientific Reports. 2016,6:33793.SCI
14. Shousi Lu, Shanshan Guo, Pingxiang Xu, Xiaorong, Li, Yuming Zhao, Wei Gu*, Ming Xue*.hydrothermal synthesis of nitrogen-doped carbon dots with real-time live-cell imaging and blood–brain barrier penetration capabilities. International Journal of Nanomedicine. 2016,11:6325–6336.SCI
15. Shanshan Guo, Shousi Lu, Pingxiang Xu, Yi Ma, Liang Zhao, Yuming Zhao, Wei Gu*, Ming Xue*.Biomimetic synthesis of needle-like fluorescent calcium phosphate/carbon dot hybrid composites for cell labeling and copper ion detection. Dalton Transactions. 2016,45:7665-7671.SCI
16. Can Cui#, Tao Zhou#, Jingyi Li, Hong Wang, Xiaorong Li, Jie Xiong, Pingxiang Xu, Ming Xue*.Proteomic analysis of the mouse brain after repetitive exposure to hypoxia. Chemico-Biological Interactions. 2015,236:57-66.SCI
17. Tao Zhou, Mingming Wang, Haiting Cheng, Can Cui, Su Su, Pingxiang Xu, Ming Xue*.UPLC-HRMS based metabolomics reveals the sphingolipids with long fatty chains and olefinic bonds up-regulated in metabolic pathway for hypoxia preconditioning. Chemico-Biological Interactions. 2015,242:145-152.SCI
18. Yuming Zhao, Pingxiang Xu, Shengquan Hu, Libo Du Zhiqing Xu, Huan Zhang, Wei Cui, Shinghung Mak , Daping Xu, Jianggang Shen, Yifan Han, Yang Liu*, Ming Xue*.TanshinoneIIA, a multiple target neuroprotectant, promotes caveolae dependent neuronal differentiation. European Journal of Pharmacology. 2015,765:437-446.SCI
19. Su Su, Yanan Wang, Lu Bai, Binbin Xia, Xiaorong Li, Yu Tang, Pingxiang Xu, Ming Xue*.Structural elucidation of in vivo metabolites of isobavachalcone in rat by LC–ESI-MSn and LC–NMR. Journal of Pharmaceutical and Biomedical Analysis. 2015,104:38-46.SCI
20. Wenwen Gong, Shuhong Liu, Pinxiang Xu, Ming Fan*, Ming Xue*.Simultaneous quantification of diazepam and dexamethasone in plasma by high-performance liquid chromatography with tandem mass spectrometry and its application to the pharmacokinetic comparison between the normoxic and hypoxic rats. Molecules. 2015,20:6901-6912.SCI
21. Binbin Xia, Lu Bai, Xiaorong Li, Jie Xiong, Pinxiang Xu, Ming Xue*.Structural analysis of metabolites of asiatic acid and its analogue madecassic acid in zebrafish using LC/IT-MSn. Molecules. 2015,20:3001-3019.SCI
22. Jin-Feng Yao#, Ning Zhou#, Lu Bai, Ping-Xiang Xu, Ke-Liang Liu, Ming Xue∗.Simultaneous determination of five novel luteinizinghormone-releasing hormone antagonists by LC–MS and pharmacokinetics in rats following cassette dosing. Journal of Chromatography B. 2014,962:94-101.SCI
23. Weiwei Guan#,Wei Gu#,ling Ye, Chenyang Guo, Su Su, Pingxiang Xu, Ming Xue*.Microwave-assisted polyol synthesis of carbon nitride dots from folic acid for cell imaging. International Journal of Nanomedicine. 2014,9:5071-5078.SCI
24. Yuya Yang, Lu Bai, Chenyang Guo, Xiaorong Li, Lina Sun, Pinxiang Xu, Ming Xue*.Transportation of active flavonoids, based on cytotoxicity and lipophilicity: an evaluation using blood–brain barrier cell and Caco-2 cell models. Toxicology in Vitro. 2014,28:388-396.SCI
25. Lu Bai, Ying Han, Jinfeng Yao, Xiaorong Li, Yuhang Li, Pinxiang Xu, Ming Xue*.Structural elucidation of the metabolites of lapachol in rats by liquid chromatography–tandem mass spectrometry. Journal of Chromatography B. 2014,944:128-135.SCI
26. Ying Liu, Yun Wang, Yuhang Li, PingxiangXu, He Liu, Keliang Liu, Jianquan Zheng*,Ming Xue*.Thiencynonate S-isomer as the novel eutomer of muscarinic receptor antagonist: a comparison of pharmacodynamics, pharmacokinetics and brain distribution kinetics. Austin Journal of Pharmacology and Therapeutics. 2014,2(11):2-7.
27. Huanli Xu, Jinmei Yu, Yan Sun, Xiaona Xu, Li Li, Ming Xue, Guanhua Du∗.Scutellaria barbata D. Don extract synergizes the antitumor effects of low dose5-fluorouracil through induction of apoptosis and metabolism. Phytomedicine. 2013,20:897-903.SCI
28. Haiting Cheng, Xiaoli Li, Xiaorong Li, Yuhang Li, Lijuan Wang, Ming Xue*.Simultaneous quantification of selected compounds from Salvia herbs by HPLC method and their application. Food Chemistry. 2012,130:1031-1035.SCI
29. Meizi Wang#, Wu Liu#, Qingjun Lu, Huiyang Zeng, Sumeng Liu, Yankun Yue, Haiting Cheng, Ying Liu, Ming Xue*.Pharmacokinetic comparison of ketorolac after intracameral, intravitreal, and suprachoroidal administration in rabbits. RETINA. 2012,32:2158-2164.SCI
30. Haixue Dai, Xiaorong Li, Xiaoli Li, Lu Bai, Yuhang Li, Ming Xue*.Coexisted components of Salvia enhance intestinal absorption of cryptotanshinone via inhibition of the intestinal P-gp. Phytomedicine. 2012,19:1256-1262.SCI
31. Jin-feng Yao, Ning Zhou, Yu-Jian Lv, Ruifeng Zhang, Ke-Liang Liu, Ming Xue*.Metabolic stability of long-acting luteinizing hormone-releasing hormone antagonists. Amino Acids. 2012,43:1557- 1566.SCI
32. Xiaorong Li, Lijuan Wang, Yuhang Li, Lu Bai, Ming Xue*.Acute and subacute toxicological evaluation of scutellarin in rodents. Regulatory Toxicology and Pharmacology. 2011,60:106-111.SCI
33. Xiaorong Li, Lijuan Wang, Yuhang Li, Yeung Ho, Dongxu Yang, Yi Chen, Xiaomin Hu, Ming Xue*.Polysorbates as novel lipid-modulating candidates for reducing serum total cholesterol and low-density lipoprotein levels in hyperlipidemic C57BL/6J mice and rats. Europen Journal of Pharmacology. 2011,660:468-475.SCI
34. Mingming Wang, Haixue Dai, Xiaorong Li, Yuhang Li, Lijuan Wang, Ming Xue*.Structural elucidation of metabolites of tanshinone I and its analogue dihydrotanshinone I in rats by HPLC-ESI-MSn. Journal of Chromatography B. 2010,878:915-924.SCI
35. Chunyan Gao, Xiaorong Li, Yuhang Li, Lijuan Wang and Ming Xue*.Pharmacokinetic interaction between puerarin and edaravone and effect of bomeol on the brain distribution kinetics of puerarin in rats. Journal of Pharmacy and Pharmacology. 2010,62:360-367.SCI
36. Xiaorong Li, Yongjiang Luo, Lijuan Wang, Yuhang Li, Yanbin Shi, Yin Cui, Ming Xue*.Acute and subacute toxicity of ethanol extracts from Salvia przewalskii Maxim in rodents. Journal of Ethnopharmacology. 2010,131:110-115.SCI
37. Sha Liao,Jian-Kun Qie,Ming Xue,Zhen-Qing Zhang*, Ke-Liang Liu*, Jin-XiuRuan.Metabolic stability of human parathyroid hormone peptide hPTH(1-C34)in rat tissue homogenates: kinetics and product of proteolytic degradation. Amino Acids. 2010,38:1595-1605.SCI
38. Ying Liu, Yuyin Kou, Ming Xue*, Yanxia Xu, Liu He, Jinxiu Ruan, Keliang Liu.Structural elucidation of in vivo metabolites of phencynonate and its analogue thiencynonate in rats by HPLC–ESI-MSn. Talanta. 2010,82:1200-1211.SCI
39. Yun Liu, Xiaorong Li, Yuhang Li, Lijuan Wang, Ming Xue∗.Simultaneous determination of danshensu, rosmarinic acid, cryptotanshinone, tanshinone IIA, tanshinone I and dihydrotanshinone I by liquid chromatographic–mass spectrometry and the application to pharmacokinetics in rats. Journal of Pharmaceutical and Biomedical Analysis. 2010,53:698–704.SCI
40. Li Wu, Xiaorong Li, Yuhang Li, Lijuan Wang, Yu Tang, Ming Xue*.Proliferative inhibition of danxiongfang and its active ingredients on rat vascular smooth muscle cell and protective effect on the VSMC damage induced by hydrogen peroxide. Journal of Ethnopharmacology. 2009,123:197-206.SCI
41. Yuying Kou, Ying Liu, Ming Xue*, Yanxia Xu, He Liu, Jinxiu Ruan, Keliang Liu.Comparative pharmacolinetics and distribution kinetics in brain of phenynonate enantiomers in rats. International Journal of Pharmaceutics. 2008,353:88-94.SCI
42. Ying Liu, Mingming Wang, Ming Xue*, Yuhang Li, Xiaorong Li, Jinxiu Ruan, Keliang Liu.Structural elucidation of in vivo metabolites of penehyclidine in rats by the method of liquid chromatography–mass spectrometry, gas chromatography–mass spectrometry and isotope ion cluster. Journal of Chromatography B. 2008,873:41–50.SCI
43. Haixue Dai, Mingming Wang, Xiaorong Li, Lijuan Wang, Yuhang Li, Ming Xue*.Structural elucidation of in vitro and in vivo metabolites of cryptotanshinone by HPLC–DAD–ESI–MS. Journal of Pharmaceutical and Biomedical Analysis. 2008,48:885–896.SCI
44. Xiaoli Li, Xiaorong Li, Lijuan Wang, Yuhang Li, Yanxia Xu, Ming Xue*.Simultaneous determination of danshensu, ferulic acid, cryptotanshinone and tanshinone IIA in rabbit plasma by HPLC and their pharmacokinetic application in danxiongfang . Journal of Pharmaceutical and Biomedical Analysis. 2007,44:1106-1112.SCI
45. Xue Ming*,Shulan Yuan,Jinxiu Ruan,Jianzhong Qiao,Yanxia Xu,Zhenqin Zhang,Keliang Liu.Determination of penehyclidine by gas chromatographic-mass spectrometry and its application to pharmacokinetics in humans,rabbits and mice. Journal of Chromatography B. 2006,843:234-239.SCI
46. Yanxia Xu,Yuying Kou,Xue Ming*,Ying Liu,Jinxiu Ruan,Zhenqin Zhang,Keliang Liu.Determination of thiencynonate by liquid chromatographic-mass spectrometry and its application to pharmacokinetics in rats. Journal of Pharmaceutical and Biomedical Analysis. 2006,42:149-154.SCI
47. Yuying Kou, Yanxia Xu, Ming Xue*, Jinxiu Ruan, Zengqing Zhang, Keliang Liu.Liquid chromatography-tandem mass spectrometry method for the determination of phencynonate in rat blood and urine. Journal of Chromatography B. 2005,828:74-79.SCI
48. Yin Cui, Ming Xue*, Yongjiang Luo, Yanbin Shi, Zongtian Zhou, Wenjiang Xia.Pharmacokinetics and excretion of cryptotanshinone after intravenous injection in pigs. Asian Journal of Drug Metabolism and Pharmacokinetic. 2005,5(3):231-234.
49. Ming Xue, Jinxiu Ruan*, Shulan Yuan, Zhenqin Zhang, Jianzhong Qiao.Pharmacokinetics of penehyclidine hydrochloride raceme and its four optical isomers in rabbits. Asian Journal of Drug Metabolism and Pharmacokinetics. 2003,3(1):11-14.
50. Ming Xue*, Ying Cui, Hanqin Wang, Yongjiang Luo, Yanbin Shi, Zongtian Zhou, Wenjiang Xia.Identification and determination of phase I metabolites of cryptotanshinone in pigs. Asian Journal of Drug Metabolism and Pharmacokinetics. 2002, 2 (4):271-274.
51. Ming Xue, Yanbin Shi,Yin Cui, Zongtian Zhou, Bin Zhang, Yongjiang Luo, Wenjiang Xia, Rongcai Zhao,Hanqin Wang*.Studies on Antibacterial QSAR of Diterpene Quinones from Salvia Przewalskii Maxim. Scientia Agricultura Sinica. 2001,1:134-139.
52. Ming Xue*, Yin Cui, Hanqin Wang*, Zhenyin Hu, Bin Zhang.RP-high performance liquid chromatographic determination of cryptotanshinone and its active metabolite in pig plasma and urine. Journal of Pharmaceutical and Biomedical Analysis. 1999,21:207-213.SCI
主编或副主编的著作/译著
1. 《药理学(第2版）》,副主编,科学出版社,201708
2. 《古德曼-吉尔曼治疗学的药理学基础(第12版)》,副主译,人民卫生出版社,201612
3. 《医用药理学基础（国家级规划教材）(第7版)》,主编,世界图书出版公司,201507
4. 《Pharmacology（英文）》,副主编,高等教育出版社,201506
5. 《医学机能实验学(第2版)》,副主编,人民卫生出版社,201502
6. 《护理药理学（全国高等学校“十二五”医学规划教材）》,主编,高等教育出版社,201105
7. 《案例版-药理学（全国高等医药院校规划教材）》,副主编,科学出版社,201007
8. 《朗-戴尔药理学(第6版)》,副主译,北京大学医学出版社,201001
9. 《医学机能学实验教程》,副主编,北京大学医学出版社,200706
10. 《High-Yield药理学》,主译,中信出版社,200401
重要奖项
1. 药用鼠尾草活性成分代谢和药效作用物质基础的系统研究(2013中-3-003) 北京市科学技术奖 三等奖（第1完成人） 201401
2. 低氧预适应的基础研究与应用前景(2010-060) 中华医学奖 三等奖（第7完成人） 201012
3. 抗菌消炎新兽药消炎醌的研制应用（2006-J3-104） 甘肃省科学技术奖 三等奖（第1完成人） 200612
4. 青蒿琥酯的药物代谢及“焦虫净”的研制应用（2005-28-1） 中国农业科技成果奖 二等奖（第1完成人） 200505
5. 丹参抗菌有效成分的代谢转化与构效关系研究（2000-07-081） 中国农业科技成果奖 一等奖（第1完成人） 200005
6. 强力复合碘消毒剂的研制（1999-3-056/2） 甘肃省科学技术奖 三等奖（第2完成人） 199912