姓名：陈瑞 性别：男 职称：教授 招生院所：公共卫生学院 招生类型：科学学位(博) 科学学位(硕) 招生专业：卫生毒理学(博) 卫生毒理学(硕) 研究方向名称：卫生毒理学 电子信箱：ruichen@ccmu.edu.cn


社会任职
1. 中国环境诱变剂学会第七届理事会理事
2. 中国环境诱变剂学会生物标志物专业委员会常务委员
3. 中国毒理学会工业毒理学专业委员会常务委员
4. 中国毒理学会生化与分子毒理专业委员会常务委员
5. 中国毒理学会纳米毒理学专业委员会委员
6. 中国毒理学会呼吸毒理专业委员会副主任委员
7. 中华预防医学会卫生毒理分会副主任委员
8. Toxicology Research Editor
9. 环境与职业医学杂志编委
个人简历
1. 199709-200207:南京医科大学 学习
2. 200209-200707:南京医科大学 学习
3. 200710-200801:美国纽约大学Nelson环境研究中心 任职
4. 200801-201109:美国得克萨斯大学西南医学中心 任职
5. 201109-201406:美国得克萨斯大学西南医学中心 任职
6. 201406-201812:东南大学 任职
7. 201812-:首都医科大学 任职
重要学术论文
1. Li Xiaobo#, Zhang Yanshu#, Li Bin, Yang Hongbao, Cui Jian, Li Xiaoyan,Zhang Xinwei,Sun Hao,Meng Qingtao, Wu Shenshen, Li Shuang, Wang Jianbo,Aschner Michael*, Chen Rui*.Activation of NLRP3 in microglia exacerbates diesel exhaust particles-induced impairment in learningand memory in mice. ENVIRONMENT INTERNATIONAL . 2020,136:UNSP 105487.SCI
2. Kassim Said Abasse, Tang Weiyan, Abbas Muhammad, Wu Shenzhen, Meng Qingdao, Zhang Chengcheng,Li Xiaobo,Chen Rui*.Clinicopathologic and epidemiological characteristics of prognostic factors in post-surgical survival ofcolorectal cancer patients in Jiangsu Province, China. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE . 2020,62:UNSP 101565.SCI
3. Kassim Said Abasse, Abbas Muhammad, Tang Weiyan, Wu Shenzhen,Meng Qingdao, Zhang Chengcheng,Naeem Shagufta, Li Xiaobo, Chen Rui*.Retrospective study on melanosis coli as risk factor of colorectal neoplasm: a 3-year colonoscopic findingin Zhuhai Hospital, China. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE. 2020,35(2):213-222.SCI
4. Yang Hongbao,Li Xiaobo,Meng Qingtao,Sun Hao,Wu Shenshen,Hu Weiwei,Liu Guilai, Li Xianjing, Yang Yong*, Chen Rui*.CircPTK2 (hsa_circ_**) as a novel therapeutic target for metastatic colorectal cancer. MOLECULAR CANCER. 2020,1(19):13.SCI
5. Li Yang#,Duan Junchao#,Chai Xiangyuan,Yang Man,Wang Ji, Chen Rui*, Sun Zhiwei*.Microarray-assisted size-effect study of amorphous silica nanoparticles on human bronchial epithelialcells. NANOSCALE. 2020,11:22907-22923.SCI
6. Zhang Xinwei#,Zhang Yanshu#, Meng Qingtao, Sun Hao, Wu Shenshen, Xu Jie, Yun Jun, Yang Xi, Li Bin, Zhu Hao, Xue Ling, Li Xiaobo, Chen Rui*.MicroRNA-382-5p is involved in pulmonary inflammation induced by fine particulate matter exposure. Environmental pollution. 2020,262:114278.SCI
7. Wu Shenshen, Sun Hao, Wang Yajie, Yang Xi,Meng Qingtao, Yang Hongbao, Zhu Haitao, Tang Weiyan, Li Xiaobo, Aschner Michael, Chen Rui*.MALAT1 rs664589 Polymorphism Inhibits Binding to miR-194-5p, Contributing to Colorectal Cancer Risk,Growth, and Metastasis. Cancer Research. 2019,79(20):5432-5441.SCI
8. Kassim Said Abasse#,Yang Xi#,Abbas Muhammad,Wu Shenshen,Baig Mirza Muhammad Faran Ashraf,Meng QingTao,Zhang Chengcheng,Li Xiaobo,Chen Rui*.Pri-miR-34b/c rs** Polymorphism is Associated with Decreased Risk and Better Prognosis forColorectal Cancer Patients. ARCHIVES OF MEDICAL RESEARCH. 2019,50(2):55-62.SCI
9. Li Xiaobo, Cui Jian, Yang Hongbao, Sun Hao, Lu Runze,Gao Na, Meng Qingtao, Wu, Shenshen, Wu Jiong, Aschner Michael, Chen Rui*.Colonic Injuries Induced by Inhalational Exposure to Particulate-Matter Air Pollution. Advanced Science. 2019,6(18):**.SCI
10. Li Xiaobo, Sun Hao, Li Bin, Zhang Xinwei, Cui Jian,Yun Jun, Yang Yiping, Zhang Li'e,Meng Qingtao,Wu Shenshen, Duan Junchao, Yang Hongbao, Wu Jiong,Sun Zhiwei,Zou Yunfeng, Chen Rui*.Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure. Advanced Science. 2019,6(18):**.SCI
11. Xu Jie#, Meng Qingtao#,Li Xiaobo, Yang Hongbao, Xu Jin, Gao Na, Sun Hao, Wu Shenshen, Familiari Giuseppe, Relucenti Michela, Zhu Haitao, Wu Jiong, Chen Rui*.Long Noncoding RNA MIR17HG Promotes Colorectal Cancer Progression via miR-17-5p. Cancer Research. 2019,79(19):4882-4895.SCI
12. Yun Jun#, Yang Hongbao#, Li Xiaobo, Sun Hao, Xu Jie, Meng Qingtao, Wu Shenshen, Zhang Xinwei, Yang Xi, Li Bin, Chen Rui*.Up-regulation of miR-297 mediates aluminum oxide nanoparticle-induced lung inflammation throughactivation of Notch pathway. Environmental pollution. 2019,259:113839.SCI
13. Cui Jian#,Fu You#,Lu Runze Bi Yuan,Zhang Li,Zhang Chengcheng,Aschner Michael,Liao Xiaobo*,Chen Rui*.Metabolomics analysis explores the rescue to neurobehavioral disorder induced by maternal PM2.5 exposure in mice. Ecotoxicology and Environmental Safety. 2018,(169):687-695.SCI
14. Meng Qingtao#,Wu Shenshen#,Wang Yajie, Xu Jin, Sun Hao,Lu Runze,Gao Na,Yang Hongbao,Li Xiaobo,Tang Boping,Aschner Michael,Chen Rui*.MPO Promoter Polymorphism rs** Enhances Malignant Phenotypes of Colorectal Cancer by Altering the Binding Affinity of AP-2 alpha. Cancer Research. 2018,78(10):2760-2769.SCI
15. Fu You#,Lu Runze#,Cui Jian,Sun Hao,Yang Hongbao,Meng Qingtao,Wu Shenshen,Aschner Michael,Li Xiaobo*，chen Rui*.Inhibition of ATP citrate lyase (ACLY) protects airway epithelia from PM2.5-induced epithelial-mesenchymal transition. Ecotoxicology and Environmental Safety. 2018,1(15):309~316.SCI
16. Wu Shenshen,Meng Qingtao,Zhang Chengcheng,Sun Hao,Lu Runze,Gao Na,Yang Hongbao,Li Xiaobo,Aschner Michael,Chen Rui*.DR4 mediates the progression, invasion, metastasis and survival of colorectal cancer through the Sp1/NF1 switch axis on genomic locus. International Journal of Cancer. 2018,143(2):289-297.SCI
17. Wang Qiang#,Chen Qi#,Zhu Liwen,Chen Minjuan,Xu Wenxia,Panday S,Wang Zhangding,Li Aiping,Roe Oluf Dimitri,Chen Rui,Wang Shouyu,Zhang Ruiwen,Zhou Jianwei*.JWA regulates TRAIL-induced apoptosis via MARCH8-mediated DR4 ubiquitination in cisplatin-resistant gastric cancer cells. Oncogenesis. 2017,6(7):0-e353.SCI
18. Mao Zhilei,Yao Mengmeng,Xu Bo,Ji Xiaoli,Jiang Hua,Han Xiumei,Tang Qiusha,Zhou Zuomin,Chen Rui,Li Xiaobo,Xia Yankai*.Cytoskeletons of Two Reproductive Germ Cell Lines Response Differently to Titanium Dioxide Nanoparticles Mediating Vary Reproductive Toxicity. Journal of Biomedical Nanotechnology. 2017,13(4):409~416.SCI
19. Li xiaobo#,Yang hongbao#,Sun Hao,Lu Runze,Zhang Chengcheng,Gao Na,Meng Qingtao,Wu Shenshen,Wang Susanna,Aschner Michael,Wu Jiong,Tang boping,Gu Aihua,Kay Steve A*, Chen Rui*.Taurine ameliorates particulate matter-induced emphysema by switching on mitochondrial NADH dehydrogenase genes. Proceedings of the National Academy of Sciences of the United States of America. 2017,114(45):9655-9664.SCI
20. Li Xiaobo,Yang Hongbao,Wu Shenshen,Meng Qingtao,Sun Hao,Lu Runze,Cui Jian,Zheng Yuxin,Chen Wen,Zhang Rong,Aschner Michael,Chen Rui*.Suppression of PTPN6 exacerbates aluminum oxide nanoparticle-induced COPD-like. Particle and Fibre Toxicology. 2017,14(1):0~53.SCI
21. Wu Shenshen#,Wang Shizhi#,Fu You#,Tang Weiyan,Jin Hua,Meng Qingtao,Zhang Chengcheng,Cui Mengjing,Cao Xiaoli,Li Xiaobo,Zhang Zhengdong,Chen Rui*.A novel mechanism of rs763110 polymorphism contributing to cervical cancer risk by affecting the binding affinity of C/EBPbeta and OCT1 complex to chromatin.. International Journal of Cancer. 2017,140(4):756~763.SCI
22. Zhang Chengcheng#,Meng Qingtao#,Zhang Xin,Wu Shenshen,Wang Shizhi,Chen Rui*,Li Xiaobo*.Role of astrocyte activation in fine particulate matter-enhancement of existing ischemic stroke in Sprague-Dawley male rats. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES. 2016,79(9-10):393-401.SCI
23. Chen Y, Huang Y, Zhu L, Chen M, Huang Y, Zhang J, He S, Li A, Chen R*, Zhou J*.SOX2 inhibits metastasis in gastric cancer. J Cancer Res Clin Oncol. 2016,142(6):1221-1230.SCI
24. Li X, Ding Z, Zhang C, Zhang X, Meng Q, Wu S, Wang S, Yin L, Pu Y, Chen R*.MicroRNA-1228 inhibit apoptosis in A549 cells exposed to fine particulate matter. Environmental Science and Pollution Research. 2016,23(10):10103~10113.SCI
25. Wang S, Wu S, Meng Q, Li X, Zhang J, Chen R*, Wang M*.FAS rs** and rs** polymorphisms jointly contributed to risk of colorectal cancer by affecting SP1/STAT1 complex recruitment to chromatin. Scientific reports. 2016,6:19229.SCI
26. Li Xiaobo,Zhang Chengcheng,Bian Qian,Gao Na,Zhang Xin,Meng Qingtao,Wu Shenshen,Wang Shizhi,Xia Yankai,Chen Rui*.Integrative functional transcriptomic analyses implicate specific molecular pathways in pulmonary toxicity from exposure to aluminum oxide nanoparticles. Nanotoxicology. 2016,10(7):957~969.SCI
27. Li Xiaobo,Zhang Chengcheng,Zhang,Xin,Wang Shizhi,Meng Qingtao,Wu Shenshen,Yang Hongbao,Xia Yankai,Chen,Rui*.An acetyl-L-carnitine switch on mitochondrial dysfunction and rescue in the metabolomics study on aluminum oxide nanoparticles. Particle and Fibre Toxicology. 2016,13:0-4.SCI
28. Wang S, Wu S, Zhu H, Ding B, Cai Y, Ni J, Wu Q, Meng Q, Zhang X, Zhang C, Li X, Wang M, Chen R*, Jin H*, Zhang Z*.PSCA rs** polymorphism contributes to the decreased risk for cervical cancer in a Chinese population. Scientific reports. 2016,6:23465.SCI
29. Huang Y, Chen R*, Zhou J*. E2F1 and NF-κB: Key Mediators of Inflammation-associated Cancers and Potential Therapeutic Targets. Curr Cancer Drug Targets. 2016,16(9):765-772.SCI
30. Chen R*#, Xu M, Nagati JS, Hogg RT, Das A, Gerard RD, Garcia JA*. The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment. Plos One. 2015,10(2):e**.SCI
31. Zhang X#, Xu Y#, Zhou L, Zhang C, Meng Q, Wu S, Wang S, Ding Z, Chen X, Li X*, Chen R*.Sex-Dependent Depression-Like Behavior Induced by Respiratory Administration of Aluminum Oxide Nanoparticles. International Journal of Environmental Research and Public Health. 2015,12(12):15692-15705.SCI
32. Stuart BD, Choi J, Zaidi S, Xing C, Holohan B, Chen R, Choi M, Dharwadkar P, Torres F, Girod CE, Weissler J, Fitzgerald J, Kershaw C, Klesney-Tait J, Mageto Y, Shay JW, Ji W, Bilguvar K, Mane S, Lifton RP, Garcia CK*.Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening. Nature genetics. 2015,47(5):512-517.SCI
33. Xu Min,Nagati Jason S,Xie Jian,Li Jiwen,Walters Holly,Moon YoungAh,Gerard Robert D,Huang Chou Long,Comerford Sarah A,Hammer Robert E,Horton Jay D,Chen Rui* ,Garcia Joseph A*.An acetate switch regulates stress erythropoiesis. Nature Medicine. 2014,20(9):.SCI
34. Scheuermann TH, Li QM, Ma HW, Key J, Zhang L, Chen R, Garcia JA, Naidoo J, Longgood J, Frantz DE, Tambar UK, Gardner KH*, Bruick RK*. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat Chem Biol. 2013,9(4):271-276.SCI
35. Kocabas F, Mahmoud AI, Sosic D, Porrello ER, Chen R, Garcia JA, DeBerardinis RJ, Sadek HA*.The Hypoxic Epicardial and Subepicardial Microenvironment. J Cardiovasc Transl. 2012,5(5):654-665.SCI
36. Chen R#, Xu M#, Hogg RT, Li J, Little B, Gerard RD, Garcia JA*.The Acetylase/Deacetylase Couple CREB-binding Protein/Sirtuin 1 Controls Hypoxia-inducible Factor 2 Signaling. Journal of Biological Chemistry. 2012,287(36):30800-30811.SCI
37. Chen R#, Dioum EM, Hogg RT, Gerard RD, Garcia JA*.Hypoxia Increases Sirtuin 1 Expression in a Hypoxia-inducible Factor-dependent Manner. Journal of Biological Chemistry. 2011,286(16):13869-13878.SCI
38. Dioum EM, Chen R#, Alexander MS, Zhang Q, Hogg RT, Gerard RD, Garcia JA.Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science. 2009,324(5932) :1289-93 .SCI
39. Chen Rui, Qiu Wen,Liu Zulong,Cao Xingjiang,Zhu Ting,Li Aiping,Wei Qingyi,Zhou Jianwei*.Identification of JWA as a novel functional gene responsive to environmental oxidative stress induced by benzo[a]pyrene and hydrogen peroxide. Free Radical Biology and Medicine. 2007,42(11):1704~1714.SCI
40. He Xiaoqing,Chen Rui#,Yang Ping,Li Aiping,Zhou Jianwei,Liu,Qizhan*.Biphasic effect of arsenite on cell proliferation and apoptosis is associated with the activation of JNK and ERK1/2 in human embryo lung fibroblast cells.. Toxicology and Applied Pharmacology,. 2007,220(1):18-24.SCI
41. Chen Rui,Li Aiping,Zhu Ting,Li Chunping,Liu Qizhan,Chang Hebron C,Zhou Jianwei* .JWA - A novel environmental-responsive gene, involved in estrogen receptor-associated signal pathway in MCF-7 and MDA-MB-231 breast carcinoma cells. Journal of Toxicology and Environmental Health Part A:Current Issues,. 2005,68(6):445-456.SCI
主编或副主编的著作/译著
重要奖项
1. 中国独立学会优秀青年科技奖 中国独立学会优秀青年科技奖 一等奖 201610
2. 诺奖之星 诺奖之星 一等奖 201609