姓名：李冬果 性别：女 职称：副教授 招生院所：生物医学工程学院 招生类型：科学学位(硕) 招生专业：生物医学工程(硕) 研究方向名称：复杂疾病的生物信息学分析 电子信箱：ldg213@ccmu.edu.cn


社会任职
1. 中国细胞生物学会功能基因组信息学和系统生物学分会理事
个人简历
1. 199109-199507:吉林大学数学系 学习
2. 199508-:首都医科大学 任职
3. 199909-200306:首都医科大学 硕士研究生学习
4. 200809-201106:首都医科大学 博士研究生学习
5. 201208-201312:中国医学科学院基础研究所北京协和医学院基础所 进修学习
重要学术论文
1. Jianghuai Ji,Lei Zhao,Xiaoxiao Zhao,Qianpeng Li,Yi An,DongguoLi.Genome‑wide DNA methylation regulation analysis of long non‑coding RNAs in glioblastoma. International Journal of Molecular Medicine. 2020,3:10.3896.SCI
2. Qianpeng Li,Qiuhong Yu,Jianghuai Ji,Peng Wang, Dongguo Li*.Comparison and analysis of lncRNA-mediated ceRNA regulation in different molecular subtypes of glioblastoma. Molecular Omics. 2019,12: OI: 10.1039/c9mo00126c.SCI
3. 李乾鹏，嵇江淮，安奕，李莉，赵磊，李冬果*.胶质母细胞瘤中内源竞争RNA网络介导的长链非编码RNAs功能研究. 生物医学工程研究. 2018,37（4）:518-522.核心期刊
4. 余静芸，李乾鹏，李冬果*.基于表达谱数据的乳腺癌疾病力学-药物靶点识别研究. 北京生物医学工程. 北京生物医学工程. 2017,36(6):558-563.核心期刊
5. Cuiying Liu a, Xiang Li a, Jiantao Feng a, Fulong Liao a,b,∗, Dongguo Li c,∗ and Dong Han a.Substrate stiffness modulates mRNA expression profiling in breast cancer cells. Clinical Hemorheology and Microcirculation. 2016,63 :399–410.SCI
6. Cuiying Liu, Xiang Li, Wenda Hua, Jianjun Li, Xinxiao Han, Qing Ha, Jiantao Feng, Fulong Liao, Dongguo Li*, .Porous matrix stiffness modulates response to targeted therapy in breast carcinoma carcinoma . Small. 2016,12(34) :4675-81 .SCI
7. Cuiying Liu 1,2,3,†, Lei Zhao 4,†, Song Han 2, Junfa Li 2,* and Dongguo Li 1,2,*.Identification and Functional Analysis of MicroRNAs in Mice following Focal Cerebral Ischemia Injury. International Journal of Molecular Sciences. 2015,16:24302-24318.SCI
8. Dongguo Li, Hong Xia, Zhenya Li, Lin Hua*, Lin Li*.Identification of novel breast cancer subtype-specific biomarkers by integrating genomics analysis of DNA copy number aberrations and miRNA-mRNA dual expression profiling. BioMed Research International. 2015,1:1-18.SCI
9. Desi Shang , Chunquan Li, Qianlan Yao, Haixiu Yang, Yanjun Xu, Junwei Han,Jing Li, Fei Su , Yunpeng Zhang, Chunlong Zhang, Dongguo Li*,Xia Li* .Prioritizing candidate disease metabolites based on global functional relationships between metabolites in the context of metabolic pathways. PloS one . 2014,9(8): e104934.SCI
10. Yansong WANG2,#, Wei WANG3,#, Dongguo LI1,4,#, Mi LI2, Peipei WANG1, Jian WEN2, MinLIANG2, Bo SU2, Yanling YIN 1, *.IGF-1 Alleviates NMDA-Induced Excitotoxicity in Cultured Hippocampal Neurons Against Autophagy via the NR2B/PI3K-AKT-mTOR Pathway. Journal of Cellular Physiology. 2014,229(11):1618-1629.SCI
11. Sujuan Feng, Dongguo Li, Yun Li, Xuan Yang, Song Han, Junfa Li *.Insight into hypoxic preconditioning and ischemic injury through determination of nPKCe-interacting proteins in mouse brain. Neurochemistry International . 2013,63:69-79.SCI
12. 李冬果，华琳，李林*.复杂疾病风险基因模块识别及其调控机制研究. 中国优生与遗传杂志. 2013,21（10）:3-5.核心期刊
13. 李冬果 刘翠英＊ 李俊发＊.蛋白激酶c γ在疾病中作用相关研究进展. 数理医药学杂志. 2013,26（3）:336-338.核心期刊
14. 李冬果 韩松 刘翠英 李俊发.低氧预适应和大脑中动脉阻塞小鼠脑内差异microRNAs鉴定. 北京生物医学工程. 2013,32（5）:456-462.核心期刊
15. 韩松，李俊发，李冬果*.基于KEGG 通路富集分析的缺血/低氧预适应鼠脑内PKC 亚型特异性信号通路研究. 中国优生与遗传杂志. 2013,21（8）:13-16.核心期刊
16. Xue Xiao, Dongguo Li, Lei Gao, Xia Li*,Qianghu Wang,Shaojun Zhang,Zhicheng Liu.Screening for Cancer Associated MiRNAs through Co-gene, Co-function and Co-pathway Analysis. Computers in Biology and Medicine. 2012,42(5）:624-30.SCI
17. 李冬果，韩松，刘翠英，李俊发.蛋白激酶c β在常见肿瘤发病中研究进展. 医学信息. 2012,25（6）:378-379.核心期刊
18. Cuiying Liu, Zhifeng Peng, Nan Zhang, Li Yu, Song Han, Dongguo Li, Junfa Li*.Identification of differentially expressed microRNA and their PKC-isoform specific gene network prediction during hypoxic pre-conditioning and focal cerebral ischemia of mice. Journal of Neurochemistry. 2012, 120(5) :830-841.SCI
19. Lin Hua#, Dongguo Li#, Hui Lin, Lin Li, Xia Li*,Zhi-cheng Liu.The correlation of gene expression and co-regulated gene patterns in characteristic KEGG pathways. Journal of Theoretical Biology. 2010,266(2): 242–249.SCI
主编或副主编的著作/译著
1. 《医用生物信息学理论与实践》,副主编,科学出版社,2019.4
2. 《医学统计学方法及SPSS实现》,主编,科学出版社,201608
3. 《线性代数》,主编,科学出版社,201501
重要奖项