姓名：高伟 性别：男 职称：教授 招生院所：中医药学院 招生类型：科学学位(博) 科学学位(硕) 招生专业：天然药物学(博) 中药学(硕) 研究方向名称：中药资源与分子生药学研究 电子信箱：weigao@ccmu.edu.cn


社会任职
1. 世界中联中药鉴定专业委员会理事
2. 中国植物学会药用植物及植物药专业委员会副秘书长
3. 中华中医药学会中药鉴定学分会委员
4. 中华中医药学会中药资源学分会常务委员
5. 中国中药杂志编委
6. 药学学报（中英文刊）青年编委
7. 中国中西医结合学会分子生药学分会秘书长
8. 首都医科大学学报编委
9. 中华中医药学会青年委员会主任委员
个人简历
1. 200508-200807:中国中医科学院中药研究所 博士研究生学习
2. 200808-201012:首都医科大学中医药学院 讲师
3. 201101-201512:首都医科大学中医药学院 副教授
4. 201309-201409:美国冷泉港实验室（Cold Spring Harbor Laboratory） 访问
5. 201601-:首都医科大学中医药学院\药学院 教授
重要学术论文
1. Jie Gao, Baowei Ma, Yun Lu, Yifeng Zhang, Yuru Tong, Siyuan Guo, Wei Gao* and Luqi Huang*.Investigating the catalytic activity of glycosyltransferase on quercetin from Tripterygium wilfordii . American Chemical Society Omega. 2020,5(3):1414-1421.SCI
2. Lichan Tu, Ping Su, Zhongren Zhang, Linhui Gao, Jiadian Wang, Tianyuan Hu, Jiawei Zhou, Yifeng Zhang, Yujun Zhao, Yuan Liu, Yadi Song, Yuru Tong, Yun Lu, Jian Yang, Cao Xu, Meirong Jia, Reuben J. Peters,Luqi Huang*, Wei Gao*.Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis. Nat Commun.. 2020,11(1): 971. doi: 10.1038/s41467-020-14776-1..SCI
3. Yuan Liu, Jiawei Zhou, Tianyuan Hu, Yun Lu, Linhui Gao, Lichan Tu, Jie Gao, Luqi Huang, Wei Gao* .Identification and functional characterization of squalene epoxidases and oxidosqualene cyclases from Tripterygium wilfordii . Plant Cell Reports. 2020,39(3):409-418.SCI
4. Yan Yin#, Yanpeng Li,# Dan Jiang, Xianan Zhang, Wei Gao*, Chunsheng Liu* .De novo biosynthesis of liquiritin in Saccharomyces cerevisiae. Acta Pharmaceutica Sinica B . 2020,10（4）:711-721.SCI
5. Tianyuan Hu, Jiawei Zhou, YuruTong, Ping Su, Xinlin Li, Yuan Liu, Nan Liu, Xiaoyi Wu, Yifeng Zhang, Jiadian Wang, Linhui Gao, Lichan Tu, Yun Lu, Zhouqian Jiang, Yongjin J. Zhou, Wei Gao*, Luqi Huang.Engineering chimeric diterpene synthases and isoprenoid biosynthetic pathways enables high-level production of miltiradiene in yeast. Metabolic Engineering. 2020,3:https://doi.org/10.1016/j.ymben.2020.03.011.SCI
6. Yun Lu, Baowei Ma, Jie Gao, Lichan Tu, Tianyuan Hu, Jiawei Zhou, Yuan Liu, Yuhe Tu, Zhaoshou Lin, Luqi Huang, Wei Gao* .Isolation and characterization of a glycosyltransferase with specific catalytic activity towards flavonoids from Tripterygium wilfordii . Journal of Asian natural products research. 2019,1:1-10.SCI
7. Ping Su#, Linhui Gao#, Yuru Tong, Hongyu Guan, Shuang Liu, Yifeng Zhang, Yujun Zhao, Jiandian Wang, Tianyuan Hu, Lichan Tu, Jiawei Zhou, Baowei Ma, Luqi Huang*, Wei Gao*.Analysis of the role of geranylgeranyl diphosphate synthase 8 from Tripterygium wilfordii in diterpenoids biosynthesis . Plant Science. 2019,285:184-192.SCI
8. Ping Su, Linhui Gao, Shuang Liu, Hongyu Guan, Jian Wang, Yifeng Zhang, Yujun Zhao, Tianyuan Hu, Lichan Tu, Jiawei Zhou, Baowei Ma, Xihong Liu, Luqi Huang*, Wei Gao*. .Probing the function of protein farnesyltransferase in Tripterygium wilfordii. Plant Cell Reports . 2019,38(2):211-220.SCI
9. Yifeng Zhang, Yujun Zhao, Jiadian Wang, Tianyuan Hu, Yuru Tong, Jiawei Zhou, Jie Gao, Luqi Huang, Wei Gao*.The expression of TwDXS in the MEP pathway specifically affects the accumulation of triptolide. Physiologia Plantarum. 2019,12:DOI: 10.1111/ppl.13051.SCI
10. Song Yadi, Chen Shang, Wang Xiujuan*, Zhang Rui, Tu Lichan, Hu Tianyuan, Liu Xihong, Zhang Yifeng, Huang Luqi, Gao Wei*. A novel strategy to enhance terpenoids production using cambial meristematic cells of Tripterygium wilfordii Hook. f.. Plant methods . 2019,15(1):129.SCI
11. Baowei Ma, Xihong Liu, Yun Lu, Xiaochi Ma, Xiaoyi Wu, Xing Wang, Meirong Jia, Ping Su, Yuru Tong, Hongyu Guan, Zhouqian Jiang, Jie Gao, Luqi Huang, Wei Gao*.A specific UDP-glucosyltransferase catalyzes the formation of triptophenolide glucoside from Tripterygium wilfordii Hook. f.. Phytochemistry. 2019,166:112062.SCI
12. Yifeng Zhang, Ping Su, Xiaoyi Wu, Jiawei Zhou, Yujun Zhao, Tianyuan Hu, Yuru Tong, Luqi Huang*, Wei Gao*.The gibberellin 13-oxidase that specifically converts gibberellin A9 to A20 in Tripterygium wilfordii is a 2-oxoglutarate-dependent dioxygenase. Planta. 2019,250(5):1613-1620.SCI
13. Zhouqian Jiang, Wei Gao*, Luqi Huang.Tanshinones, Critical Pharmacological Components in Salvia miltiorrhiza. Frontiers in Pharmacology. 2019,10:202.SCI
14. Jiawei Zhou, Tianyuan Hu, Linhui Gao, Ping Su, Yifeng Zhang, Yujun Zhao, Shang Chen, Lichan Tu, Yadi Song, Xing Wang, Luqi Huang, Wei Gao* .Friedelane-type triterpene cyclase in celastrol biosynthesis from Tripterygium wilfordii and its application for triterpenes biosynthesis in yeast. New Phytologist. 2019,223(2):722-735.SCI
15. Xinlin Li#, Yuxing Xu#,Yuan Li, Rui Zhang, Tianyuan Hu, Ping Su, Man Zhou, Ting Tang, Ying Zeng, Yanlong Yang*, Wei Gao*.Rapid discovery and functional characterization of diterpene synthases from basidiomycete fungi by genome mining.. Fungal genetics and biology. 2019,128:36-42.SCI
16. Xihong Liu, Peiyuan Zhao, Xiujuan Wang*, Lei Wang,Yingjun Zhu, Wei Gao* .Triptolide induces glioma cell autophagy and apoptosis via upregulating the ROS/JNK and downregulating the Akt/mTOR signaling pathways . Frontiers in Oncology. 2019,9:387.SCI
17. Xihong Liu, Peiyuan Zhao, Xiujuan Wang*, Lei Wang, Yingjun Zhu, Yadi Song, Wei Gao*.Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells. Journal of Experimental & Clinical Cancer Research . 2019,38:184.SCI
18. Yuru Tong#, Yifeng Zhang#,Yujun Zhao, Tianyuan Hu, Jiadian Wang, Luqi Huang*, Wei Gao* .Differential expression of the TwHMGS gene and its effect on triptolide biosynthesis in Tripterygium wilfordii. Chinese Journal of Natural Medicines. 2019,17(8):575-584.SCI
19. Yuan Li, Xinlin Li, Chang-jiang-sheng Lai, Ruishan Wang, Liping Kang, Ting Ma, Zhenhua Zhao, Wei Gao*, Luqi Huang*.Functional characterization of three flavonoid glycosyltransferases from Andrographis paniculata. Royal Society Open Science . 2019,6(6):190150.SCI
20. Jian Wang, Hui-Xin Lin, Ping Su, Tong Chen, Juan Guo, Wei Gao*, Lu-Qi Huang*..Molecular cloning and functional characterization of multiple Geranylgeranyl pyrophosphate synthases (ApGGPPS) from Andrographis paniculate. . Plant Cell Reports. 2019,38(1):117-128.SCI
21. Li Yuan, Lin Hui-Xin, Wang Jian, Yang Jian, Lai Chang-Jiang-Sheng, Wang Xing, Ma Bao-Wei, Tang Jin-Fu, Li Yong, Li Xin-Lin, Guo Juan, Gao Wei*, Huang Lu-Qi*.Glucosyltransferase Capable of Catalyzing the Last Step in Neoandrographolide Biosynthesis. Organic letters. 2018,20(19):5999-6002.SCI
22. Ping Su, Hongyu Guan, Yujun Zhao, Yuru Tong, Meimei Xu, Yifeng Zhang, Tianyuan Hu, Jian Yang, Qiqing Cheng, Linhui Gao, Yujia Liu, Jiawei Zhou, Reuben J. Peters, Luqi Huang*, and Wei Gao*.Identification and functional characterization of diterpene synthases for triptolide biosynthesis from Tripterygium wilfordii.. Plant Journal. 2018,93(1):50-65.SCI
23. Yun Lu, Jiawei Zhou, Tianyuan Hu, Yifeng Zhang, Ping Su, Jiadian Wang, Wei Gao*, Luqi Huang.A multifunctional oxidosqualene cyclase from Tripterygium regelii that produces both α- and β-amyrin. RSC Advances. 2018,8(42):23516-23521.SCI
24. Yu-ru Tong, Ping Su, Hong-yu Guan, Tian-yuan Hu, Jin-long Chen, Yi-feng Zhang, Yu-jun Zhao, Lin-hui Gao, Xia-nan Zhang, Lu-qi Huang*, Wei Gao*.Eudesmane-type sesquiterpene diols directly synthesized by a sesquiterpene cyclase in Tripterygium wilfordii. Biochemical Journal. 2018,475 (17):2713-2725.SCI
25. Zhou Jia-wei, Zhang Yong, Hu Tianyuan, Su Ping, Zhang Yifeng, Liu Yujia, Huang Luqi, Gao Wei*.Functional characterization of squalene epoxidase genes in the medicinal plant Tripterygium wilfordii. International Journal of Biological Macromolecules. 2018,120(Pt A):203-212.SCI
26. Wang Jiadian, Zhao Yujun, Zhang Yifeng, Su Ping, Hu Tianyuan, Lu Yun, Zhang Rui, Zhou Jiawei, Ma Baowei, Gao Wei*, Huang Luqi*.Overexpression and RNAi-mediated downregulation of TwIDI regulates triptolide and celastrol accumulation in Tripterygium wilfordii. Gene. 2018,679:195-201.SCI
27. Yujun Zhao, Yifeng Zhang, Ping Su, Jian Yang, Luqi Huang* and Wei Gao*.Genetic Transformation System for Woody Plant Tripterygium wilfordii and Its Application to Product Natural Celastrol. Frontiers in Plant Science. 2018,8:2221.SCI
28. Yifeng Zhang, Yujun Zhao, Jiadian Wang, Tianyuan Hu, Yuru Tong, Jiawei Zhou, Yadi Song, Wei Gao*, Luqi Huang*.Overexpression and RNA interference of TwDXR regulate the accumulation of terpenoid active ingredients in Tripterygium wilfordii. Biotechnology Letters. 2018,40(2):419-425.SCI
29. Yifeng Zhang,Yujun Zhao,Jiadian Wang,Tianyuan Hu,Yuru Tong,Jiawei Zhou,Yadi Song,Wei Gao*,Luqi Huang*..Overexpression and RNA interference of TwDXR regulate the accumulation of terpenoid active ingredients in Tripterygium wilfordii.. Biotechnology Letters. 2018,40（2）:419-425.SCI
30. Ping Su#, Tianyuan Hu#, Yujia Liu, Yuru Tong, Hongyu Guan, Yifeng Zhang, Jiawei Zhou, Luqi Huang*, Wei Gao*.Functional characterization of NES and GES responsible for the biosynthesis of (E)-nerolidol and (E,E)-geranyllinalool in Tripterygium wilfordii.. Scientific reports. 2017,7:40851.SCI
31. Ping Su, Hongyu Guan, Yifeng Zhang, Xing Wang, Linhui Gao, Yujun Zhao, Tianyuan Hu, Jiawei Zhou, Baowei Ma, Lichan Tu, Yuru Tong, Luqi Huang* , Wei Gao*..Probing the single key amino acid responsible for the novel catalytic function of ent-kaurene oxidase supported by NADPH-cytochrome P450 reductases in Tripterygium wilfordii.. Frontiers in Plant Science. 2017,8:1756.SCI
32. Hongyu Guan#, YujunZhao#, PingSu, YuruTong, YujiaLiu, Tianyuan Hu, YifengZhang, XiananZhang, JiaLi, XiaoyiWu, Luqi Huang*, WeiGao*..Molecular cloning and functional identification of sterol C24-methyl transferase gene from Tripterygium wilfordii .. Acta Pharmaceutica Sinica B. 2017,7(5):603-609.SCI
33. Baowei Ma, Tianyuan Hu, Pei Li, Qingjun Yuan, Zhaoshou Lin, Yuhe Tu, Jia Li, Xianan Zhang, Xiaoyi Wu, Xiujuan Wang, Luqi Huang, Wei Gao*.Phylogeographic and phylogenetic analysis for Tripterygium species delimitation.. Ecology and Evolution. 2017,7(20):8612-8623.SCI
34. Hong-Yu Guan, Ping Su, Yu-Jun Zhao, Xia-Nan Zhang*, Zhu-Bo Dai, Juan Guo,Yu-Ru Tong, Yu-Jia Liu, Tian-Yuan Hu, Yan Yin, Lin-Hui Gao, Wei Gao & Lu-QiHuang*.Cloning and functional analysis of two sterol-C24-methyltransferase 1 (SMT1) genes from Paris polyphylla. Journal of Asian Natural Products Research. 2017,2:1-10.SCI
35. Ping Su#, Tianyuan Hu#, Yujia Liu, Yuru Tong, Hongyu Guan, Yifeng Zhang, Jiawei Zhou, Luqi Huang*, Wei Gao*.Functional characterization of NES and GES responsible for the biosynthesis of (E)-nerolidol and (E,E)-geranyllinalool in Tripterygium wilfordii. Scientific reports. 2017,7:40851.SCI
36. Qiqing Cheng，Yuru Tong，Zihao Wang，Ping Su，Wei Gao*，Luqi Huang*.Molecular cloning and functional identification of a cDNA encoding 4-hydroxy-3-methylbut-2-enyl diphosphate reductase from Tripterygium wilfordii. Acta Pharmaceutica Sinica B. 2017,2(7):208-214.SCI
37. Qiqing Cheng#，Yuru Tong，Zihao Wang，Ping Su，Wei Gao*，Luqi Huang*.Molecular cloning and functional identification of a cDNA encoding 4-hydroxy-3-methylbut-2-enyl diphosphate reductase from Tripterygium wilfordii.. Acta Pharmaceutica Sinica B. 2017,7(2):208-214.SCI
38. Yujun Zhao, Yifeng Zhang, Ping Su, Jian Yang, Luqi Huang* , Wei Gao*.Genetic transformation system for woody plant Tripterygium wilfordii and its application to product natural celastrol.. Frontiers in Plant Science. 2017,8:2221.SCI
39. Guojie Xu, Wei Cai, Wei Gao*,Chunsheng Liu*.A novel glucuronosyltransferase has an unprecedented ability to catalyse continuous two-step glucuronosylation of glycyrrhetinic acid to yield glycyrrhizin. New Phytologist . 2016,212（1）:123-135.SCI
40. Ping Su#, Yuru Tong#,Qiqing Cheng, Yating Hu, Meng Zhang, Jian Yang,Zhongqiu Teng, Wei Gao*,Luqi Huang*.Functional characterization of entcopalyl diphosphate synthase, kaurene synthase and kaurene oxidase in the Salvia miltiorrhiza gibberellin biosynthetic pathway. Scientific reports. 2016,6:23057.SCI
41. YuJia Liu, YuJun Zhao, Ping Su, Meng Zhang, YuRu Tong, TianYuan Hu, LuQi Huang*, Wei Gao*.The MVA pathway genes expressions and accumulation of celastrol in Tripterygium wilfordii suspension cells in response to methyl jasmonate treatment. Journal of Asian Natural Products Research. 2016,14(4):1-10.SCI
42. Yu-ru Tong, Meng Zhang, Ping Su, Yu-jun Zhao, Xiu-juan Wang, Xia-nan Zhang, Wei Gao*Lu-Qi Huang*.Cloning and functional characterization of an isopentenyl diphosphate isomerase gene from tripterygium wilfordii. Biotechnology & Applied Biochemistry. 2015,63（6）:863-869.SCI
43. Meng Zhang, Ping Su, Yong-Jin Zhou, Xiu-Juan Wang*, Yu-Jun Zhao, Yu-Jia Liu, Yu-Ru Tong, Tian-Yuan Hu, Lu-Qi Huang*, Wei Gao*.Identification of geranylgeranyl diphosphate synthase genes from Tripterygium wilfordii. Plant Cell Rep. 2015,34(12):2179-2188.SCI
44. Yuru Tong, Ping Su, Yujun Zhao, Meng Zhang, Yujia Liu, Xiujuan Wang, Xiannan Zhang, Wei Gao*, Luqi Huang * .Molecular cloning and characterization of DXS and DXR genes in terpenoid biosynthetic pathway from Tripterygium wilfordii. International Journal of Molecular Sciences. 2015,16(10):25516-25535.SCI
45. Ping Su,Qiqing Cheng,Xiujuan Wang,Xiaoqing Cheng,Meng Zhang,Yuru Tong,Fei Li,Wei Gao*,Luqi Huang*..Characterization of 8 terpenoids from tissue cultures of the Chinese herbal plant, Tripterygium wilfordii, by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Biomedical chromatography. 2014,28（9）:1183–1192.SCI
46. Wei Gao,Hai-Xi Sun#,Hongbin Xiao#,Guanghong Cui#,Matthew L Hillwig,Alana Jackson,Xiao Wang,Ye Shen,Nan Zhao,Liangxiao Zhang,Xiu-Jie Wang,Reuben J Peters,Luqi Huang*.Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza. BMC Genomics . 2014,15:73.SCI
47. Yu-Jun Zhao, Qi-Qing Cheng, Ping Su, Xin Chen, Xiu-Juan Wang, Wei Gao*, Lu-Qi Huang*.Research progress relating to the role of cytochrome P450 in the biosynthesis of terpenoids in medicinal plants. Applied Microbiology and Biotechnology. 2014,98:2371–2383.SCI
48. Qiqing Cheng,Ping Su,Yating Hu,Yunfei He, Wei Gao*,Luqi Huang*.RNA interference mediated repression of SmCPS copalyldiphosphate synthase expression in hairy roots of Salvia miltiorrhiza causes a decrease of tanshinones and sheds light on the functional role of SmCPS. Biotechnol Letters. 2014,36(2):363-369.SCI
49. Yongjin J. Zhou#, Wei Gao#, Qixian Rong, Guojie Jin, Huiying Chu, Wujun Liu, Wei Yang, Zhiwei Zhu, Guohui Li, Guofeng Zhu, Luqi Huang*, and Zongbao K. Zhao*.（共同第1作者）.Modular Pathway Engineering of Diterpenoid Synthases and the Mevalonic Acid Pathway for Miltiradiene Production. Journal of the American Chemical Society. 2012,134(6):3234−3241.SCI
主编或副主编的著作/译著
1. 《分子生药学》,副主编,中国中医药出版社,201708
重要奖项
1. “”科技创新领军人才 国家级 201902
2. - 科技部中青年科技创新领军人才 国家级 201810
3. 中华中医药学会中青年创新人才 - 201711
4. 第二届中国药学会以岭生物医药青年奖 - 201709
5. “奖励计划”青年 国家级 201704
6. 中国药学会-赛诺菲青年生物药物奖 201612
7. 丹参酮生物合成途径解析及其合成生物学研究 中国药学会科学技术奖 一等奖 201511
8. 北京市百千万人才工程 市级人选 2014
9. 北京市“高创计划” 领军人才 2014
10. 国家“” 中组部青年拔尖人才 2014
11. 道地药材的道地性形成机理研究及应用 中华医学会科学技术奖 二等奖 201112
12. 丹参酮类化合物生物合成相关酶基因克隆及功能研究 全国优秀博士学位论文 201010
13. 中药抗氧化活性新的评价方法研究 中国中西医结合学会科学技术奖 二等奖 200812