姓名：唐北沙 性别：男 职称：教授 招生院所：脑重大疾病研究院 招生类型：科学学位(硕) 招生专业：神经病学(硕) 研究方向名称：神经退行性疾病与遗传病的临床和基础研究 电子信箱：tbsapple@163.com


社会任职
1. 中国医学遗传学国家重点实验室学术委员会委员
2. 神经退行性疾病湖南省重点实验室主任
3. 中南大学神经退行性疾病研究中心主任
4. 中国药理学会药物基因组学专业委员会常委
5. 中华医学会神经病学分会帕金森病及运动障碍学组委员
6. 卫生部脑卒中筛查与防治工程基地医院专家委员会副主任委员
7. 湖南省医学会理事会常务理事
8. 湖南省医师协会理事会常务理事
9. 湖南省脑卒中质量控制委员会主任委员
个人简历
1. 197803-198212:湖南医学院（现中南大学湘雅医学院） 学习
2. 198212-198807:湖南医科大学（现中南大学湘雅医院）神经内科 住院医师
3. 198808-199307:湘雅医院（现中南大学湘雅医院）神经内科 主治医师
4. 199308-199807:湘雅医院（现中南大学湘雅医院）神经内科 副教授/科副主任
5. 199808-200107:湘雅医院（现中南大学湘雅医院）神经内科 教授/科副主任
6. 200108-:中南大学湘雅医院 教授/副院长
重要学术论文
1. Liu Z, Tang B*.Novel Parkinson's disease risk loci identified through a meta-analysis of genome-wide association studies. Mov Disord.. 2018,33(1):74.SCI
2. Xiao-Meng Yin, Jing-Han Lin, Li Cao, Tong-Mei Zhang, Sheng Zeng, Kai-Lin Zhang, Wo-Tu Tian, Zheng-Mao Hu, Nan Li, Jun-Ling Wang, Ji-Feng Guo Ruo-Xi Wang, Kun Xia, Zhuo-Hua Zhang, Fei Yin, Jing Peng, Wei-Ping Liao, Yong-Hong Yi, Jing-Yu Liu, Zhi-Xian Yang, Zhong Chen, Xiao Mao, Xin-Xiang Yan, Hong J.Familial paroxysmal kinesigenic dyskinesia is associated with mutations in the KCNA1 gene. Human Molecular Genetics,. 2017,27(4):757-8.SCI
3. Che XQ, Sun ZF, Mao X, Xia K, Yan XX, Jiang H, Shen L, Li N, Tang BS*.Mutation screening of the PRRT2 gene for benign epilepsy with centrotemporal spikes in Chinese mainland population.. Int J Neurosci. 2017,Jan;127(1)::10-13.SCI
4. Wei Y, Yang N, Xu Q, Sun Q, Guo J, Li K, Liu Z, Yan X, Zhu X, Tang B*.The rs** polymorphism is associated with SNCA methylation in the Chinese Han population.. J Neurol Sci. 2016,Aug 15;367::11-4.SCI
5. Shu L, Sun Q, Zhang Y, Xu Q, Guo J, Yan X, Tang B*.The Association between C9orf72 Repeats and Risk of Alzheimer's Disease and Amyotrophic Lateral Sclerosis: A Meta-Analysis.. Parkinsons Dis. 2016,2016::**.SCI
6. Yang N, Wei Y, Wang T, Guo J, Sun Q, Hu Y, Yan X, Zhu X, Tang B, Xu Q*.Genome-wide analysis of DNA methylation during antagonism of DMOG to MnCl2-induced cytotoxicity in the mouse substantia nigra.. Sci Rep. 2016,Jul 6;6::28933.SCI
7. Sun Z, Jia D, Shi Y, Hou X, Yang X, Guo J, Li N, Wang J, Sun Q, Zhang H, Lei L, Shen L, Yan X, Xia K, Jiang H, Tang B*.Prediction of orthostatic hypotension in multiple system atrophy and Parkinson disease.. Sci Rep. 2016, Feb 12;6::21649.SCI
8. Liu Z, Guo J, Wang Y, Li K, Kang J, Wei Y, Sun Q, Xu Q, Xu C, Yan X, Tang B*.Lack of association between IL-10 and IL-18 gene promoter polymorphisms and Parkinson's disease with cognitive impairment in a Chinese population.. Sci Rep. 2016,Feb 2;6::19021.SCI
9. Duan R, Shi Y, Yu L, Zhang G, Li J, Lin Y, Guo J, Wang J, Shen L, Jiang H, Wang G, Tang B*.UBA5 Mutations Cause a New Form of Autosomal Recessive Cerebellar Ataxia.. PLoS One. 2016,Feb 12;11(2)::e**.SCI
10. Yan W, Zhao C, Sun L, Tang B*.Association between polymorphism of COMT gene (Val158Met) with Alzheimer's disease: An updated analysis.. J Neurol Sci. 2016,Feb 15;361::250-5.SCI
11. Li K, Tang BS, Liu ZH, Kang JF, Zhang Y, Shen L, Li N, Yan XX, Xia K, Guo JF. .LRRK2 A419V variant is a risk factor for Parkinson's disease in Asian population. Neurobiol Aging. Neurobiol Aging. 2015,Oct;36(10)::2908 e11-5..SCI
12. Liu Z, Guo J, Li K, Qin L, Kang J, Shu L, Zhang Y, Wei Y, Yang N, Luo Y, Sun Q, Xu Q, Yan X, Tang B. .Mutation analysis of CHCHD2 gene in Chinese familial Parkinson's disease. . Neurobiol Aging. 2015,Nov;36(11)::3117 e7-8..SCI
13. Jiao B, Tang B, Liu X, Yan X, Zhou L, Yang Y, Wang J, Xia K, Shen L*.Identification of C9orf72 repeat expansions in patients with amyotrophic lateral sclerosis and frontotemporal dementia in mainland China. Neurobiol Aging. 2014,35(4):919-922.SCI
14. Sun ZF, Zhang YH, Guo JF, Sun QY, Mei JP, Zhou HL, Guan LP, Tian JY, Hu ZM, Li JD, Xia K, Yan XX, and Tang BS*.Genetic diagnosis of two dopa-responsive dystonia families by exome sequencing.. PLoS One. 2014,9(9):e106388.SCI
15. Wang X, Guo J, Fei E, Mu Y, He S, Che X, Tan J, Xia K, Zhang Z, Wang G*, Tang B*.BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation.. PLoS One. 2014,9(1):e86276.SCI
16. Ai SX, Xu Q, Hu YC, Song CY, Guo JF, Shen L, Wang CR, Yu RL, Yan XX, Tang BS*.Hypomethylation of SNCA in blood of patients with sporadic Parkinson's disease.. J Neurol Sci.. 2014,337(1-2):123-128.SCI
17. He M, Tang BS, Li N, Mao X, Li J, Zhang JG, Xiao JJ, Wang J, Jiang H, Shen L, Guo JF, Xia K, and Wang JL*.Using a combination of whole-exome sequencing and homozygosity mapping to identify a novel mutation of SCARB2.. Clin Genet. 2014,10.1111:cge.12338.SCI
18. Wang JL, Mao X, Hu ZM, Li JD, Li N, Guo JF, Jiang H, Shen L, Li J, Shi YT, Xia K, Liu JY, Liao WP, Tang BS*.Mutation analysis of PRRT2 in two Chinese BFIS families and nomenclature of PRRT2 related paroxysmal diseases.. Neurosci Lett. 2013,552:40-45.SCI
19. Guan WJ, Wang JL, Liu YT, Ma YT, Zhou Y, Jiang H, Shen L, Guo JF, Xia K, Li JD*, Tang BS*.Spinocerebellar ataxia type 35 (SCA35)-associated transglutaminase 6 mutants sensitize cells to apoptosis.. Biochem Biophys Res Commun.. 2013,430(2):780-786.SCI
20. Shi Y, Wang J, Li JD, Ren H, Guan W, He M, Yan W, Zhou Y, Hu Z, Zhang J, Xiao J, Su Z, Dai M, Wang J, Jiang H, Guo J, Zhou Y, Zhang F, Li N, Du J, Xu Q, Hu Y, Pan Q, Shen L, Wang G, Xia K, Zhang Z, Tang B*.Identification of Chip as a novel causative gene for Autosomal Recessive Cerebellar Ataxia.. Plos One. 2013,8(12):e81884.SCI
21. Tian JY, Guo JF, Wang L, Sun QY, Yao LY, Luo LZ, Shi CH, Hu YC, Yan XX, Tang BS*.Mutation analysis of LRRK2, SCNA, UCHL1, HtrA2 and GIGYF2 genes in Chinese patients with autosomal dorminant Parkinson's disease.. Neurosci Lett. 2012,516(2):207-211.SCI
22. Tian JY, Tang BS, Shi CH, Lv ZY, Li K, Yu RL, Shen L, Yan XX, Guo JF*.Association between PLA2G6 gene polymorphisms and Parkinson's disease in the Chinese Han population.. Parkinsonism Relat Disord. 2012,18(5):641-644.SCI
23. Zhang HN, Guo JF, He D, Lei LF, Wang YQ, Wang CY, Tan LM, Yan XX, Shen L, Tang BS*.Lower serum UA levels in Parkinson's disease patients in the Chinese population.. Neurosci Lett. 2012,514(2):152-155.SCI
24. 【未填作者】.Genetic variations of Omi/HTRA2 in Chinese patients with Parkinson's disease.. Brain Res. 2011,1385:293-297002E.SCI
25. 【未填作者】.Identification of PRRT2 as the causative gene of paroxysmal kinesigenic dyskinesias.. Brain. 2011,134(12):3493-3501.SCI
26. 【未填作者】.Glucocerebrosidase gene L444P mutation is a risk factor for Parkinson's disease in Chinese population.. Mov Disord. 2010,25(8):1005-1011.SCI
27. 【未填作者】.Novel GIGYF2 gene variants in patients with Parkinson's disease in Chinese population.. Neurosci Lett. 2010,473(2):131-135.SCI
28. 【未填作者】.Novel mutation of SCN1A in familial generalized epilepsy with febrile seizures plus.. Neurosci Lett. 2010,480(3):211-214.SCI
29. 【未填作者】.Mutation analysis of Parkin, PINK1 and DJ-1 genes in Chinese patients with sporadic early onset parkinsonism.. J Neurol. 2010,257(7):1170-1175.SCI
30. 【未填作者】.TGM6 identified as a novel causative gene of spinocerebellar ataxias using exome sequencing.. Brain. 2010,133(12):3510-3518.SCI
31. 【未填作者】.R492X mutation in PTEN-induced putative kinase 1 induced cellular mitochondrial dysfunction and oxidative stress.. Brain res. 2010,1351(10):229-237.SCI
32. 【未填作者】.A novel LRRK2 mutation in a mainland Chinese patient with familial Parkinson's disease.. Neurosci Lett. 2010,468(3):198-201.SCI
33. 【未填作者】.A novel presenilin 1 mutation (Ser169del) in a Chinese family with early-onset Alzheimer's disease.. Neurosci Lett.. 2010,468(1):34-37.SCI
34. 【未填作者】.Screening for two SNPs of LINGO1 gene in patients with essential tremor or sporadic Parkinson's disease in Chinese population.. Neurosci Lett. 2010,481(2):69-72.SCI
35. 【未填作者】.Genetic analysis of Spinocerebellar ataxia type 17 in Parkinson's disease in Mainland China.. Parkinsonism Relat Disord. 2010,16(10):700-702.SCI
36. 【未填作者】.Analysis of SCA2 and SCA3/MJD repeats in Parkinson's disease in mainland China: genetic, clinical, and positron emission tomography findings. Mov Disord. 2009,24(13):2007-2011.SCI
37. 【未填作者】.Analysis of SCA2 and SCA3/MJD repeats in Parkinson's disease in mainland China: genetic, clinical, and positron emission tomography findings.. Mov Disord. 2009,24(13):2007-2011.SCI
主编或副主编的著作/译著
重要奖项
1. 神经系统遗传病致病基因克隆与功能研究 湖南省自然科学奖 一等奖 2017
2. 帕金森病及运动障碍疾病的分子诊断与功能影像研究 中华医学科技奖 二等奖 2017
3. 帕金森病的分子病理机制 其他省级科技奖 一等奖 2013
4. 卫生部有特殊贡献中青年专家 卫生部 2007
5. 神经性高频耳聋等遗传性疾病基因的克隆和遗传性疾病家系的收集 国家自然科学奖 二等奖 2000
6. 人类神经性高频性耳聋致病基因的克隆 成就奖 一等奖 1999