姓名：郝峻巍 性别：男 职称：主任医师、教授 招生院所：附属宣武医院 招生类型：科学与专业学位(博) 科学与专业学位(硕) 招生专业：神经病学(博) 神经病学(硕) 研究方向名称：免疫炎症与神经系统疾病 电子信箱：haojunwei@vip.163.com


社会任职
1. 中华医学会神经病学分会第五和六届委员会青年委员会委员
2. 中国神经科学学会第七届理事会理事
个人简历
重要学术论文
1. Li Q# , Cao Y , Dang C , Han B , Han R , Ma H , Hao J* , Wang L*..Inhibition of Double-Strand DNA-sensing cGAS Ameliorates Brain Injury After Ischemic Stroke. EMBO Mol Med. 2020,12（4）:e11002.SCI
2. Han B#, Jiang W# , Liu H #, Wang J, Zheng K , Cui P , Feng Y, Dang C, Bu Y ,Wang Q, Ju Z*, Hao J* .Upregulation of Neuronal PGC-1α Ameliorates Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion. Theranostics . 2020,10(6):2832-2848.SCI
3. Meng H#, Zhao H#, Cao X#, Hao J, Zhang H, Liu Y, Zhu MS, Fan L, Weng L, Qian L, Wang X, Xu Y*.Double-negative T cells remarkably promote neuroinflammation after ischemic stroke. Proc Natl Acad Sci U S A. 2019,116 (12):5558-5563.SCI
4. Xue Z#, Zhang Z#, Liu H, Li W, Guo X, Zhang Z, Liu Y, Jia L, Li Y, Ren Y, Yang H, Zhang L, Zhang Q, Da Y, Hao J, Yao Z, Zhang R*.lincRNA-Cox2 regulates NLRP3 inflammasome and autophagy mediated neuroinflammation. Cell Death Differ. 2019,26(1):130-145.SCI
5. Li H#, Chen L, Ma X, Cui P, Lang W, Hao J*.Shared Gene Expression Between Multiple Sclerosis and Ischemic Stroke. Front Genet.. 2019,9:598.SCI
6. Lang W#, Wang J, Ma X, Zhang N, Li H, Cui P, Hao J *.Identification of Shared Genes Between Ischemic Stroke and Parkinson's Disease Using Genome-Wide Association Studies. Front Neurol. 2019,10:297.SCI
7. Dang C#, Han B, Li Q, Han R, Hao J*..Up-regulation of PGC-1αin neurons protects against experimental autoimmune encephalomyelitis.. The FASEB Journal . 2019,33(12):14811-24..SCI
8. Zhang F＃, Yan C, Wei C, Yao Y, Ma X, Gong Z, Liu S, Zang D, Chen J, Shi FD, Hao J*.Vinpocetine Inhibits NF-κB-Dependent Inflammation in Acute Ischemic Stroke Patients. Transl ational Stroke Research. 2018,9(2):174-184.SCI
9. Li D＃, Lang W, Zhou C, Wu C, Zhang F, Liu Q, Yang S*, Hao J*.Upregulation of MicroglialZEB1Ameliorates Brain Damage afterAcute Ischemic Stroke. Cell Reports. 2018,22:3574-86.SCI
10. Cui P,# Ma X, Li H, Lang W, Hao J*. Shared Biological Pathways Between Alzheimer's Disease and Ischemic Stroke. Front Neurosci.. 2018,12:605.SCI
11. Zhang F＃, Liu G,Li D, Wei C, Hao J* .DDIT4 and Associated lncDDIT4 Modulate Th17 Differentiation through the DDIT4/TSC/mTOR Pathway . The Journal of Immunology. 2018,200(5):1618-1626.SCI
12. Li M＃, Li Z, Yao Y, Jin W, Kris W, Liu Q, Shi FD, Hao J*.Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity . Proc Natl Acad Sci U S A. 2017,114(3):E396-E405.SCI
13. Liu R＃,Ma X＃,Chen L,Yang Y, Zeng Y,Gao Y,Jiang W,Zhang F ,Li D,Han B,Han R,Qiu R，Huang W. Wang Y* and Hao J*.MicroRNA-15b Suppresses Th17 Differentiation and Is Associated with Pathogenesis of Multiple Sclerosis Targeting O-GlcNAc Transferase . The Journal of Immunology . 2017,198(7):2626-2639.SCI
14. Han B＃, Li X＃, Hao J*.The cholinergic anti-inflammatory pathway: An innovative treatment strategy for neurological diseases . Neuroscience and Biobehavioral Reviews. 2017,77:358-368.SCI
15. Liu G＃, Zhang F＃, Hu Y, Jiang Y, Gong Z, Liu S, Chen X, Jiang Q*, Hao J* .Genetic Variants and Multiple Sclerosis Risk Gene SLC9A9 Expression in Distinct Human Brain Regions . Molecular Neurobiology. 2017,54(9):6820-6826.SCI
16. Zhang F＃, Liu G, Gao C, Hao J*.Linc-MAF-4 regulates Th1/Th2 Differentiation and is associated with the Pathogenesis of MS by Targeting MAF . The FASEB Journal. 2017,31:519-525.SCI
17. Jiang W＃, Li D, Han R, Zhang C, Jin WN, Wood K, Liu Q, Shi FD, Hao J*.Acetylcholine-producing NK cells attenuate CNS inflammation via modulation of infiltrating monocytes/macrophages. Proc Natl Acad Sci U S A. 2017,114(30):E6202-11.SCI
18. Liu H＃, Wan C＃, Ding Y, Han R, He Y, Xiao J, Hao J*.PR-957, a selective inhibitor of immunoproteasome subunit low-MW polypeptide 7, attenuates experimental autoimmune neuritis by suppressing Th17 cell differentiation and regulating cytokine production. The FASEB Journal. 2017,31(4):1756-1766.SCI
19. Han R＃, Luo J＃,Shi Y＃, Yao Y,Hao J* .PD-L1(Programmed Death Ligand 1) Protects Against Experimental Intracerebral Hemorrhage-Induced Brain Injury. Stroke. 2017,48:2255-62.SCI
20. Ma X#, Li H#, He Y, Hao J*.The emerging link between O-GlcNAcylation and neurological disorders. Cell Mol Life Sci. 2017,74(20):3667-3686.SCI
21. Han B#, Zhang C, Liu S, Xia Y, Sun H, Gong Z, Simard AR, Liu Q, Hao J*.Non-neuronal cholinergic activity is potentiated in myasthenia gravis. BMC Neurol. 2017,17(1):28.SCI
22. Jiang Q#, Jin S#, Jiang Y, Liao M, Feng R, Zhang L, Liu G*, Hao J*.Alzheimer's Disease Variants with the Genome-Wide Significance are Significantly Enriched in Immune Pathways and Active in Immune Cells. Mol Neurobiol. 2017,54(1):594-600.SCI
23. Liu B, Ni J, Shi M, Bai L, Zhan C, Lu H, Wu Y, Tu J, Ning X, Hao J*, Wang J*.Carotid Intima-media Thickness and its Association with Conventional Risk Factors in Low-income Adults: A Population-based Cross-Sectional Study in China. Sci Rep. 2017,7:41500.SCI
24. Liu G#, Zhang F#, Jiang Y, Hu Y, Gong Z, Liu S, Chen X, Jiang Q*, Hao J*.Integrating genome-wide association studies and gene expression data highlights dysregulated multiple sclerosis risk pathways. . Mult Scler. 2017,23(2):205-212.SCI
25. Xu J#, Zhang F, Gao C, Ma X, Peng X, Kong D, Hao J*.Microarray Analysis of lncRNA and mRNA Expression Profiles in Patients with Neuromyelitis Optica. Mol Neurobiol. 2017,54(3):2201-2208.SCI
26. Liu G,# Zhang F#, Hu Y, Jiang Y, Gong Z, Liu S, Chen X, Jiang Q*, Hao J*.Multiple sclerosis risk pathways differ in Caucasian and Chinese populations. J Neuroimmunol. 2017,307:63-68.SCI
27. Zhang Y#, Han B#, He Y, Li D, Ma X, Liu Q, Hao J*. MicroRNA-132 attenuates neurobehavioral and neuropathological changes associated with intracerebral hemorrhage in mice. Neurochem Int. 2017,107:148-155.SCI
28. Li X#, Xiao J#, Ding Y, Xu J, Li C, He Y, Zhai H, Xie B, Hao J*.Clinical and electrophysiological features of post-traumatic Guillain-Barré syndrome. BMC Neurol. 2017,17(1):142.SCI
29. Yang L, Kong Y, Ren H, Li M, Wei CJ, Shi E, Jin WN, Hao J, Vandenbark AA, Offner H*.Upregulation of CD74 and its potential association with disease severity in subjects with ischemic stroke. Neurochem Int. 2017,107:148-155.SCI
30. He Y#, Ma X#, Li D, Hao J*.Thiamet G mediates neuroprotection in experimental stroke by modulating microglia/macrophage polarization and inhibiting NF-κB p65 signaling. J Cereb Blood Flow Metab. 2017,37(8):2938-2951.SCI
31. Shi K, Wang Z, Liu Y, Gong Y, Fu Y, Li S, Wood K, Hao J, Zhang GX, Shi FD, Yan Y*. .CFHR1-Modified Neural Stem Cells Ameliorated Brain Injury in a Mouse Model of Neuromyelitis Optica Spectrum Disorders. J Immunol. 2016,197(9):3471-3480.SCI
32. Chen L, Zhang Y, Li D, Zhang N, Liu R, Han B, Wei C, Liu H, Xu X, Hao J*.Everolimus (RAD001) ameliorates vascular cognitive impairment by regulating microglial function via the mTORC1 signaling pathway. J Neuroimmunol. 2016,299:164-171.SCI
33. Zhong Q#, Zhou K#, Liang QL#, Lin S, Wang YC, Xiong XY, Meng ZY, Zhao T, Zhu WY, Yang YR, Liao MF, Gong QW, Liu L, Xiong A, Hao J, Wang J, Yang QW*.Interleukin-23 Secreted by Activated Macrophages Drives γδT Cell Production of Interleukin-17 to Aggravate Secondary Injury After Intracerebral Hemorrhage. J Am Heart Assoc. 2016,5(10):【未填写起止页码】.SCI
34. Xu J#, Gao C#, Zhang F, Ma X, Peng X, Zhang R, Kong D, Simard AR, Hao J*.Differentially expressed lncRNAs and mRNAs identified by microarray analysis in GBS patients vs healthy controls. Sci Rep. 2016,6:21819.SCI
35. Zhang F, Gao C, Ma X, Peng X, Zhang R, Kong D, Simard AR, Hao J*.Expression Profile of Long Noncoding RNAs in Peripheral Blood Mononuclear Cells from Multiple Sclerosis Patients. CNS Neurosci Ther. 2016,22(4):298-305..SCI
36. Han R#, Gao J#, Zhai H, Xiao J, Ding Y, Hao J*..RAD001 (everolimus) attenuates experimental autoimmune neuritis by inhibiting the mTOR pathway, elevating Akt activity and polarizing M2 macrophages. Exp Neurol. 2016,280:106-14.SCI
37. Han R, Xiao J, Zhai H, Hao J*.Dimethyl fumarate attenuates experimental autoimmune neuritis through the nuclear factor erythroid-derived 2-related factor 2/hemoxygenase-1 pathway by altering the balance of M1/M2 macrophages. J Neuroinflammation. 2016,13(1）:97.SCI
38. Zhang C, Xia Y, Jiang W, Wang C, Han B, Hao J*.Determination of non-neuronal acetylcholine in human peripheral blood mononuclear cells by use of hydrophilic interaction ultra-performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016,1022:265-273.SCI
39. Sun N, Shen Y, Han W, Shi K, Wood K, Fu Y, Hao J, Liu Q, Sheth KN, Huang D, Shi FD*.Selective Sphingosine-1-Phosphate Receptor 1 Modulation Attenuates Experimental Intracerebral Hemorrhage. Stroke. 2016,47(7):1899-906.SCI
40. Wang P#, He Y#, Li D, Han R, Liu G, Kong D, Hao J*.Class I PI3K inhibitor ZSTK474 mediates a shift in microglial/macrophage phenotype and inhibits inflammatory response in mice with cerebral ischemia/reperfusion injury. J Neuroinflammation. 2016,13(1):192.SCI
41. Xiong X, Liu L, Wang F, Yang YR, Hao J, Wang P, Zhong Q, Zhou K, Xiong A, Zhu W, Zhao T, Meng Z, Wang Y, Gong Q, Liao M, Wang J, Yang Q.Toll-Like Receptor 4/MyD88-Mediated Signaling of Hepcidin Expression Causing Brain Iron Accumulation, Oxidative Injury, and Cognitive Impairment After Intracerebral Hemorrhage. Circulation. 2016,134(14):1025-1038.SCI
42. Zhang F#, Liu G#, Bu Y, Ma X, Hao J*.Expression profile of long noncoding RNAs and mRNAs in peripheral blood mononuclear cells from myasthenia gravis patients. J Neuroimmunol. 2016,299:124-129.SCI
43. Li W#, Zhang Z#, Zhang K#, Xue Z, Li Y, Zhang Z, Zhang L, Gu C, Zhang Q, Hao J, Da Y, Yao Z, Kong Y*, Zhang R*.Arctigenin Suppress Th17 Cells and Ameliorates Experimental Autoimmune Encephalomyelitis Through AMPK and PPAR-γ/ROR-γt Signaling. Mol Neurobiol. 2016,53(8):5356-66.SCI
44. Liu G＃, Hu Y, Jin S, Zhang F, Jiang Q*, Hao J*.Cis-eQTLs regulate reduced LST1 gene and NCR3 gene expression and contribute to increased autoimmune disease risk. Proc Natl Acad Sci U S A. 2016,113(42):E6321-E6322.SCI
45. Jiang W＃, St-Pierre S, Roy P, Morley BJ, Hao J*, Simard AR*.Infiltration of CCR2+Ly6C high Proinflammatory Monocytes and Neutrophils into the Central Nervous System Is Modulated by Nicotinic Acetylcholine Receptors in a Model of Multiple Sclerosis . The Journal of Immunology. 2016,196(5):2095-108.SCI
46. Li D＃, Wang C, Yao Y, Chen L, Liu G, Zhang R, Liu Q, Shi FD, Hao J*.mTORC1 pathway disruption ameliorates brain inflammation following stroke via a shift in microglia phenotype from M1 mTORC1 pathway disruption ameliorates brain inflammation following stroke via a shift in microglia phenotype from M1 type to M2 type. FASEB Journal. 2016,30(10):3388-3399.SCI
47. Ding Y＃, Han R, Jiang W, Xiao J, Liu H, Chen X, Li X, Hao J*.Programmed Death Ligand 1 Plays a Neuroprotective Role in Experimental Autoimmune Neuritis by Controlling Peripheral Nervous System Inflammation of Rats. The Journal of Immunology. 2016,197(10):3831-3840.SCI
48. Zhang C, Xie B, Shi FD, Hao J*.Multiple intracranial arteritis and hypothyroidism secondary to Streptococcus anginosus infection. J Neurol Neurosurg Psychiatry. 2015,86(9）:1044-5.SCI
49. Fu Y, Hao J, Zhang N, Ren L, Sun N, Li YJ, Yan Y, Huang D, Yu C, Shi FD.*.Fingolimod for treatment of intracerebral hemorrhage: a two-arm proof-of-concept study. JAMA Neurology. 2014,71(9):1092-101.SCI
50. Hao J＃, Campagnolo D,Liu R, Piao W, Shi S, Hu B, Xiang R,Zhou Q, Vollmer T,Van Kaer L,La Cava A,Shi FD* .IL-2/IL-2 antibody therapy induces target organ NK cells that inhibit central nervous system inflammation. Annals of Neurology. 2011,69:721-34.SCI
51. Hao J＃, Liu R＃,Piao W＃, Zhou Q, Vollmer TL, Campagnolo DI,La Cava A,Van Kaer L, Shi FD* .Central nervous system (CNS)-resident natural killer cellssuppress Th17 responses and CNS autoimmune pathology . Journal of Experimental Medicine. 2010,207(9):1907-21.SCI
主编或副主编的著作/译著
重要奖项
1. 2016年度中国杰出神经内科医师青年医师奖 2016