姓名：胡文立 性别：男 职称：主任医师、教授 招生院所：附属朝阳医院 招生类型：科学与专业学位(博) 科学与专业学位(硕) 招生专业：神经病学(博) 神经病学(硕) 研究方向名称：缺血性脑血管病 神经危重症 脑小血管病和认知障碍 电子信箱：huwenli@sina.com


社会任职
1. 北京神经科学学会 理事
2. 世界卒中协会 委员
3. 北京医师协会神经内科专科分会 常务理事
4. 中国医药协会脑病药物研究专业委员会副主任委员
5. 北京脑血管防治协会 副秘书长
6. 北京市医疗事故鉴定委员会 委员
7. 中华中医药学会络病委员会 委员
8. 中华医学会北京神经病学专业委员会常委
9. 北京医学会血栓和止血学会副主任委员
10. 中华老年医学会神经内科分会委员
11. 北京神经内科学会副会长
12. 中国医师科普分会神经专业主任委员
13. 中华医学会北京神经病学分会神经重症专业组组长
14. 北京神经内科学会神经重症专业委员会主任委员
15. 中华医学会老年神经病学组及抗衰老学会委员
16. 中国研究型医院学会介入神经病学专业委员会常委
17. 中国医药协会脑病药物研究专业委员会副主任委员
18. 中国医疗保健国际交流促进会神经病学分会委员
19. 中国卒中学会质量管理与促进分会委员
20. 中国卒中学会血管性认知障碍分会常委
21. 中国老年保健医学研究会抗衰老研究分会副主任委员
22. 中华医学会神经病学分会 委员
个人简历
重要学术论文
1. Li X#, Yuan J#, Han J*, Hu W*..Serum levels of Homocysteine, Vitamin B12 and Folate in Patients with Multiple Sclerosis an Updated Meta-Analysis. International Journal of Medical Sciences. 2020,17(6):751-761.SCI
2. Li Y, Li M, Yang L, Qin W, Yang S, Yuan J, Jiang T, Hu W*..The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study. Clinical Interventions in Aging. 2019,14:871-878.SCI
3. Yuan J#, Jia Z#, Qin W, Hu W*..Paraneoplastic neuromyelitis optica spectrum disorder associated with breast cancer. Clinical Interventions in Aging. 2019,14:1039-1044.SCI
4. Du X, Gu H, Hao F, Gao L, Wang J, Sun C, Zhang H, Ma P, Zhang X, Hu W*..Utility of brain CT for predicting delayed encephalopathy after acute carbon monoxide poisoning. Experimental and Therapeutic Medicine. 2019,17（4）:2682-2688.SCI
5. Li X#, Yuan J#, Liu L, Hu W*..Antibody-LGI 1 autoimmune encephalitis manifesting as rapidly progressive dementia and hyponatremia: a case report and literature review. BMC Neurol. 2019,19(1) :19.SCI
6. Yuan JL#, Wang WX#, Hu WL*..Clinical features of syphilitic myelitis with longitudinally extensive myelopathy on spinal magnetic resonance imaging. World Journal of Clinical Cases. 2019,7(11):1282-1290.SCI
7. Li XT#, Yuan JL#, Hu WL*..Vertebrobasilar artery dissection manifesting as Millard-Gubler syndrome in a young ischemic stroke patient: A case report. World J Clin Cases. 2019,7(1）:73-78.SCI
8. Li Y, Li M, Zuo L, Shi Q, Qin W, Yang L, Jiang T, Hu W*.. Compromised Blood-Brain Barrier Integrity Is Associated With Total Magnetic Resonance Imaging Burden of Cerebral Small Vessel Disease . Front Neurol. . 2018,6（9）:221 .SCI
9. Yang S, Yuan J, Qin W, Yang L, Fan H, Li Y, Hu W*..Twenty-four-hour ambulatory blood pressure variability is associated with total magnetic resonance imaging burden of cerebral small-vessel disease.. Clin Interv Aging. 2018,10（13）:1419-1427.SCI
10. Yang L, Qin W, Hu W*..Intracerebral hemorrhage in a patient with tuberous sclerosis complex.. Arch Med Sci. 2018,14(4):945-949.SCI
11. Yuan J#, Feng L#, Hu W*, Zhang Y*.. Use of Multimodal Magnetic Resonance Imaging Techniques to Explore Cognitive Impairment in Leukoaraiosis . Med Sci Monit. 2018,9（24）:8910-8915.SCI
12. Jun-Liang Yuan, Yan Xing , Wen-Li Hu*.The clinical features of patients concurrent with Guillain-Barre syndrome and myasthenia gravis. Neurosciences (Riyadh). 2018,23(1):66-70.SCI
13. Wang Y, Dong Q, Li SJ, Hu WL*..New clinical characteristics and risk factors of hand knob infarction.. Neurol Sci. 2018,39（5）:857-862.SCI
14. Wang W, Hu W*. .Salvianolic acid B recovers cognitive deficits and angiogenesis in a cerebral small vessel disease rat model via the STAT3/VEGF signaling pathway.. Mol Med Rep. 2018,17(2):3146-3151.SCI
15. Junliang Yuan#, Shuna Yang#, Shuangkun Wang, Wei Qin, Lei Yang, Wenli Hu*..Mild encephalitis/encephalopathy with reversible splenial lesion (MERS) in adults-a case report and literature review. BMC Neurology. 2017,17(1):103.SCI
16. Li X#, Yuan J#, Yang L, Qin W, Yang S, Li Y, Fan H, Hu W*.. The significant effects of cerebral microbleeds on cognitive dysfunction: An updated meta-analysis. PLoS One. 2017,12(9):e** .SCI
17. Ji M, Wang W, Li S, Hu W*.Implantation of bone mesenchymal stem cells overexpressing miRNA‑705 mitigated ischemic brain injury. . Mol Med Rep. 2017,16(6):8323-8328.SCI
18. Yun Wang, Heyin Mi, Hongjun Hao, Wenli Hu*. .Miller-Fisher syndrome with cognitive impairment: A case report.. Biomedical Research. 2017,28 (13):5790-5792.SCI
19. Mi HY, Li SJ, Zhao X, Li LX, Hu, WL. .Reversible posterior white matter encephalopathy complicated with cerebral hemorrhage after orthotopic liver transplantation. . BIOMEDICAL RESEARCH-INDIA. 2017,28(13):5972-5974.SCI
20. Yang S#, Yuan J#, Zhang X, Fan H, Li Y, Yin J, Hu W*.Higher ambulatory systolic blood pressure independently associated with enlarged perivascular spaces in basal ganglia. . Neurol Res. 2017,39(9):787-794.SCI
21. Jun-Liang Yuan#, Shuang-Kun Wang#, Xiao-Juan Guo, Lei-lei Teng, Hua Jiang, Hua Gu, Wen-Li Hu*..Disconnections of Cortico-Subcortical Pathways Related to Cognitive Impairment in Patients with Leukoaraiosis: A Preliminary Diffusion Tensor Imaging Study. . Eur Neurol. 2017,78(1-2):41-47.SCI
22. Li Y, Li M, Zhang X, Yang S, Fan H, Qin W, Yang L, Yuan J, Hu W*. Clinical features and the degree of cerebrovascular stenosis in different types and subtypes of cerebral watershed infarction.. BMC Neurol. 2017,17(1):166.SCI
23. Shuna Yang#, Junliang Yuan#, Wei Qin, Yue Li, Lei Yang, Wenli Hu*. .The Clinical Characteristics of Acute Cerebrovascular Accidents Resulting from Ovarian Hyperstimulation Syndrome. Eur Neurol. 2017,77:221-230.SCI
24. Junliang Yuan#, Jinsheng Dai#, William A, Li, Wenli Hu*. .Factors Associated with Benign Paroxysmal Positional Vertigo in a Chinese Case-Control Study. Med Sci Monit. 2017,23:3885-3889.SCI
25. Yue Li, Man Li, Xiaoyu Zhang, Qinglei Shi, Shuna Yang, Huimin Fan, Wei Qin, Lei Yang, Junliang Yuan, Tao Jiang, Wenli Hu*. .Higher blood–brain barrier permeability is associated with higher white matter hyperintensities burden.. J Neurol. 2017,264(7):1474-1481.SCI
26. Jun Liang Yuan, Shuang Kun Wang, Tao Jiang, Wenli Hu*. .Nitrous oxide induced subacute combined degeneration with longitudinally extensive myelopathy with inverted V-sign on spinal MRI. BMC Neurology. 2017,17(1):222.SCI
27. Mi H, Li S, Li H, Hu W*..The effects of infection on severe stroke patients in the neurological intensive care unit in China.. Int J Neurosci . 2017,128(8）:1-6..SCI
28. Yang S, Zhang X, Yuan J, Yin J, Hu W*..Serum Uric Acid is Independently Associated with Enlarged Perivascular Spaces.. Sci Rep. 2017,7(1):16435.SCI
29. Shuna Yang, Wei Qin, Lei Yang, Huimin Fan, Yue Li, Jiangmei Yin, Wenli Hu*. .The relationship between ambulatory blood pressure variability and enlarged perivascular spaces: a crosssectional study.. BMJ Open. 2017,7:e015719.SCI
30. Xu JH, Mi HY*..A randomized controlled trial of acupressure as an adjunctive therapy to sodium valproate on the prevention of chronic migraine with aura.. Medicine (Baltimore). 2017,96(27):e7477.SCI
31. Jiao J, Guo H, He Y, Wang J, Yuan J, Hu W*.Meta-analysis of the association between serum iron levels and Parkinson's disease: Evidence from 11 publications.. Brain Res, 2016;:. 2016,1646:490-3..SCI
32. Qin W, Zhang X, Yang S, Li Y, Yuan J, Yang L, Li S, Hu W*.Risk Factors for Multiple Organ Dysfunction Syndrome in Severe Stroke Patients. PLoS One. 2016,11(11):e**.SCI
33. Chen YD, Zhang J, Wang Y, Yuan JL, Hu WL*.Efficacy of Cholinesterase Inhibitors in Vascular Dementia: An Updated Meta-Analysis. Eur Neurol. 2016,,75(3-4):132-41.SCI
34. Yang L, Qin W, Zhang X, Li Y, Gu H, Hu W*.Infarct Size May Distinguish the Pathogenesis of Lacunar Infarction of the Middle Cerebral Artery Territory.. Med Sci Monit,2016, :. 2016,20;22:211-8.SCI
35. Zhang X, Ding L, Yang L, Qin W, Yuan J, Li S, Hu W*.Brain Atrophy Correlates with Severe Enlarged Perivascular Spaces in Basal Ganglia among Lacunar Stroke Patients. PLoS One.. 2016,11(2):e**.SCI
36. Zhang X, Ding L, Yang L, Qin W, Li Y, Li S, Hu W*.Relationship Between White Matter Hyperintensities Penumbra and Cavity Formation. Med Sci Monit. 2016,22:41-9.SCI
37. Ding L, Zhang X, Guo H, Yuan J, Li S, Hu W, Golden T, Wu N.The Functional Study of a Chinese Herbal Compounded Antidepressant Medicine--Jie Yu Chu Fan Capsule on Chronic Unpredictable Mild Stress Mouse Model. 2015 Jul 17;. 2015,10(7):e**.SCI
38. Zhang X, Ding L, Yuan J, Qin W, Hu W*.Spatial Relationship between Acute Lacunar Infarction and White Matter Hyperintensities. Eur Neurol . 2015,74:259-266.SCI
39. Yang L, Qin W, Xu JH, Hu WL*.Marchiafava-Bignami disease with asymmetric extracallosal lesions. Arch Med Sci. 2015,11(4):895-8.SCI
40. He Y#, Ma N, Xing C, Wang X, Xiao H, Zheng M, Han G, Chen G, Hou C, Shen B, Li Y, Jiang Z, Wang R, Hu W*..Novel IL-6-secreting γδT cells increased in patients with atherosclerotic cerebral infarction.. Mol Med Rep. . 2015,11(2):1497-503.SCI
41. Mi H, Hu W*. Polymorphisms in the PTX1 may not be associated with ischemic stroke susceptibility. Int J Clin Exp Med. 2014,7(11):3992-9.SCI
42. Li J#, Zhang J, Li S, Guo H, Qin W, Hu WL*..Predictors of percutaneous endoscopic gastrostomy tube placement after stroke. Can J Neurol Sci.. 2014,41（1）:24-8.SCI
43. JI, M#, LI, S-J; HU, W-L*..Effects of different antihypertensive drugs on blood pressure variability in patients with ischemic stroke.. Eur Rev Med Pharmacol Sci.. 2014,18(17):2491-5.SCI
44. Li J#, Hu W*..Glucose metabolism measured by positron emission tomography is reduced in patients with white matter presumably ischemic lesions.. Med Sci Monit. . 2014,20:1525-30.SCI
45. Qin W#, Yang L, Guo H, Xiang N, Hu W*..Pro-urokinase promotes angiogenesis but does not reduce neuronal apoptosis in infarcted cerebral tissue.. Neural Regen Res.. 2014,9(5):502-3.SCI
46. HL Guo, XR Shen, Ye Xu, YD He and WL Hu*. .The effect of activin A on signal transduction pathways in PC12 cells subjected to oxygen and glucose deprivation. . Int J Mol Med.. 2014,33(1):135-41.SCI
47. Hai-ying Li, Shu-juan Li, Nan Yang, Wen-li Hu*.Evaluate the nosocomial infection risk by using APACHE II scores in neurological intensive care unit. Journal of Clinical Neuroscience. 2014,21(8):1409-12.SCI
48. HAO Yong-gang, GU Song, ZHAI Ying-hui, YUAN Jun-liang, YANG Yuan-hua and HU Wen-li*.Chorea in a Chinese adult after pulmonary endarterectomy with deep hypothermia and circulatory arrest. Chinese Medical Journal. 2013,126(19):3794-3795.SCI
49. 袁俊亮,王双坤,胡文立*. . 脑白质疏松症患者认知功能障碍的神经影像学研究进展. 中华医学杂志. 2013,93(5):394-396.核心期刊
50. L.Zhao，C.-B.Chu，J,-F.Li，Y.-T.Yang，S.-Q.NIU，W.Qin，Y.-G.Hao，Q.Dong，R.Guan，W.-L.Hu*, Y.Wang*.Glycogen synthase kinase-3 reduces acetylcholine level in striatum via disturbing cellular distribution of choline acetylatransferase in cholinergic interneurons in rats. Neuroscience. 2013,255:203-211 .SCI
51. Li J, Hu W.Bilateral hippocampal abnormalities in magnetic resonance imaging in transient global amnesia: a case report and literature review. Am J Emerg Med. 2013,31(4):755.SCI
52. Guo HL, Shen XR, Xu Y, Yuan JL, Zhao DM, Hu WL*..Emodin prevents hypoxic-ischemic neuronal injury: involvement of the activin A pathway. Neural Regen Res. 2013,8(15)::1360-1367.SCI
53. 袁俊亮 王双坤 胡文立.脑白质疏松症患者认知功能障碍的神经影像学研究进展. 中华医学杂志. 2013,93(5):394-396.核心期刊
54. Juan Zhang, Shiqin Niu, MM, Yan Wang, Wenli Hu*.Myasthenia gravis and Guillain-Barré cooccurrence syndrome. American Journal of Emergency Medicine. 2013,31(8):1264-7.SCI
55. 李淑娟，张玉杰，刘东涛，陈冬辉，王笑峰，胡文立.染色体9p21上rs**单核苷酸多态性与中国汉族脑梗死的相关性分析. 中国卒中杂志. 2012,7(2):86-90.核心期刊
56. 袁俊亮，王双坤，胡文立*.脑白质疏松症患者认知功能障碍的磁共振波谱研究. 中华医学杂志. 2012,92（5）:303-306.
57. 张晓丹，胡文立*.ABCD3-I评分预测短暂性脑缺血发作后早期卒中风险. 中国卒中杂志. 2012,7（1）:12-17.
58. Jun-Liang Yuan, Askiel Bruno, Tao Li, Shu-Juan Li, Xiao-Dan Zhang, Hai-Ying Li, Ke Jia, Wei Qin, Andrew CN Chen, Wen-Li Hu*.Replication and extension of the simplified modified Rankin scale in 150 Chinese stroke patients. European Neurology. 2012,67:206-210.SCI
59. 牛世芹,袁俊亮,李海英,王姝梅,李淑娟,刘芳,李向红,岳云,胡文立.脑电双频指数在大面积脑梗死昏迷患者中的临床应用. 中华老年心脑血管杂志. 2012,14(6):564-566.核心期刊
60. Wang S#, Yuan J#, Guo X, Peng P, Gu H, Niu S, Fregni F, Chen AC, Hu W.Neurochemical correlates of cognitive dysfunction in patients with leukoaraiosis: a proton magnetic resonance spectroscopy study.. Neurological Research. 2012,34(10):989-97.SCI
61. 王双坤　袁俊亮　郝咏刚　李淑娟　胡文立　郭晓娟　刘敏　顾华　张慧博　彭朋.脑白质疏松症患者执行功能障碍的 弥散张量成像研究. 中华老年医学杂志. 2012,31(3):200-204.核心期刊
62. 袁俊亮，王双坤，胡文立*.脑白质疏松症患者认知功能损害的临床特征. 中华医学杂志. 2012,92（3）:147-151.
63. You XF, Qin W, Hu WL*.Aquaporin-4 antibody positive neuromyelitis optica with syndrome of inappropriate antidiuretic hormone secretion. Neurosciences . 2011,16（1）:68-71 .SCI
64. 尤小凡, 秦伟, 胡文立*.视神经脊髓炎高危综合征血清尿酸水平与临床相关性研究. 中华神经科杂志. 2011,44(2):109-112..核心期刊
65. Xiaofan You, Wei Qin, Jing Ye, Yonggang Hao, Wenhui Zhao, Wenli Hu*.Decreased serum uric acid in patients of longitudinally extensive transverse myelitis.. Neural Regeneration Research . 2011,6 (2):150-154.SCI
66. 杨磊.应该规范进展性卒中的定义. 中华神经科杂志. 2011,44（4）:292-293.
67. Yu-dan Chen, Shu-juan Li, Feng-hui Sun, Yue-yang Liu, Wen-li Hu*..Monitoring of Medical Complications after Acute Ischemic Stroke in a Neurological Intensive Care Unit. European Neurology. 2011,66（4）:204-209 .SCI
68. Yuan JL, Wang SK, Guo XJ, Hu WL*.Acute infarct of the corpus callosum presenting as alien hand syndrome: evidence of diffusion weighted imaging and magnetic resonance angiography. BMC Neurol. 2011,11(1):142.SCI
69. Yang XC, Zhang Q, Li SJ, Wan XH, Zhong GZ, Hu WL, Li L, Yu SZ, Jin L, Wang XF.Association study between three polymorphisms and myocardial infarction and ischemic stroke in Chinese Han population. Thromb Res. 2010,126(4):292-4..SCI
70. 尤小凡, 胡文立*.水通道蛋白4与视神经脊髓炎发病机制. 中华神经科杂志. 2010,43 (4):296-298.核心期刊
71. 杨磊，于玲，孙奉辉，李淑娟，胡文立*.伴意识障碍的缺血性脑卒中患者营养支持的研究. 中华老年心脑血管病杂志. 2010,12（11）::1014-1016.核心期刊
72. 尤小凡,叶静,胡文立*.视神经脊髓炎血清尿酸水平与临床相关性研究. 中华内科杂志. 2010,49(11）:123-124..核心期刊
73. 郝咏刚，翟英慧，尤小凡，胡文立*..血清前白蛋白降低对急性脑梗死患者住院期间死亡的预测. 中华老年心脑血管病杂. 2010,12(10):918-920.核心期刊
74. 李淑娟，王淑敏，王艳丽，张凌云，刘岳阳，胡文立*.影响脑梗死后行机械通气患者撤机的危险因素分析. 中国脑血管病杂志. 2010,7（4:）:182-186.核心期刊
75. Wen-li Hu, Shu-juan Li, Dong-tao Liu, YanWang, Shi-qin Niu, Xin-chun Yang,Qi Zhang, Shun-Zhang Yu, Li Jind, Xiao-fengWang*.Genetic variants on chromosome 9p21 and ischemic stroke in Chinese. Brain Research Bulletin. 2009,79（6）:43-45.SCI
76. Shu-juan Li, Wen-li Hu, Dong-tao Liu, Feng-hui Sun, Qi Zhang, Xin-chun Yang, Shun-Zhang Yu,Li Jin, Xiao-feng Wang.MTAP gene is associated with ischemic stroke in Chinese Hans. Journal of the Neurological Sciences. 2009,284（1/2）:103-107.SCI
77. 徐雪冬，徐依成，胡文立*.进展性缺血性卒中相关危险因素分析. 脑与神经疾病杂志. 2009,17（1）:58-61.核心期刊
78. 李淑娟，孙奉辉，刘岳阳，杨磊，胡文立*.缺血性卒中患者机械通气撤机成功的影响因素分析. 中国卒中杂志. 2009,4（12）:953-957.
79. 徐雪冬　胡文立*.CT灌注成像对颈内动脉闭塞与重度狭窄患者. 脑与神经疾病杂志. 2009,17（3）:231-234.核心期刊
80. 李淑娟，胡文立*.急性重症缺血性卒中的评价和处理. 中国卒中杂志. 2009,4（12）:947-950.
81. 孙奉辉，李淑娟，秦伟，郭素良，胡文立*.感觉刺激疗法在昏迷促醒治疗中的应用. 中国卒中杂志. 2009,4（12）:1009-1012.
82. 孙奉辉; 胡文立 *.磁共振弥散加权成像与短暂性脑缺血发作预后的相关性研究. 中国神经精神疾病杂志. 2009,35(2):36-37.核心期刊
83. 李淑娟，王艳丽，刘东涛，孙奉辉，胡文立*.血液学指标对复发脑梗死的诊疗价值. 中国脑血管病杂志. 2009,12（6）:631-635.核心期刊
84. 胡文立.干细胞治疗在脑卒中的应用. 中国实用内科杂志. 2007,27(10):737-741.核心期刊
85. 刘瑜，刘国贞，宋爱利，胡文立，钟萍萍，董小黎*.尿激酶热敏脂质体的体内溶栓实验 . 中华老年心脑血管病杂志. 2007,9（1）:57-59.
86. 胡文立，杨磊.横窦乙状窦血栓形成的诊断和处理. 中国实用内科杂志. 2007,27(21):1658--1659.核心期刊
87. 李淑娟，胡文立*，王艳丽，操斌全.血D-二聚体浓度对主动脉夹层的诊断价值. 中国急救医学. 2006,26（3）:166-168.
88. 魏雪飞，许贤豪，胡文立*. 重症肌无力患者胸腺凋亡基因Bcl-2和Fas的表达水平与临床的相关性 . 临床神经病学杂志. 2006,19（5）:321-323.
89. 魏雪飞，许贤豪，张华，胡文立*.重症肌无力患者胸腺细胞经AChR刺激后T淋巴细胞亚群Bcl-2的表达 . 中国神经免疫学和神经病学杂志 . 2006,13（1）:1-4.
90. 杨磊，郭红梅，秦伟，项宁，胡文立*，王乐丰，吴雅峰.冠脉3支病变与颈动脉狭窄程度之间的关系. 中风与神经疾病杂志 . 2006,23（5）:623.无
91. 胡文立*，刘敬忠，牛世芹，刘旻，石怀银，韦立新.Prevalence of CMV in arterial walls and leukocytes in patients with atherosclerosis. Chinese Medical Journal. 2001,114（11）:1208-1210.SCI
主编或副主编的著作/译著
重要奖项
1. 国家专利---治疗缺血性心脑血管病及周围血管病的中药组合物 ZL 02 1 03991.7 200406