姓名：杨金奎 性别：男 职称：主任医师、教授 招生院所：附属同仁医院 招生类型：科学与专业学位(博) 科学与专业学位(硕) 招生专业：内科学（内分泌与代谢病）(博) 内科学（内分泌与代谢病）(硕) 研究方向名称：糖尿病发病机理研究 电子信箱：jinkui.yang@foxmail.com


社会任职
1. 北京市糖尿病研究所所长
2. 北京市糖尿病防治办公室主任
3. 中国糖尿病杂志编委
4. 中国医师协会内分泌分会常委
5. 中国医师协会全科医师分会副会长
6. 中华医学会北京分会糖尿病专业委员会副主委
7. 中华预防医学会糖尿病预防与控制专业委员会副主委
个人简历
1. 199309-199607:南京医科大学 博士研究生
2. 200008-200106:香港中文大学 高级访问-港府资助
3. 200202-200208:哈佛大学 Joslin Diabetes Center 访问
重要学术论文
1. Jing-Yi Liu, Yi-Chen Zhang, Li-Ni Song, Lin Zhang, Fang-Yuan Yang,Xiao-Rong Zhu, Zhi-.Nifuroxazide ameliorates lipid and glucose metabolism in palmitate-induced HepG2 cells. RSC Advances. 2019,9:39394-39404.SCI
2. Q.-Y. Zuo#，X. Cao#，B.-Y. Liu， D. Yan，Z. Xin，X.-H. Niu， C. Li，W. Deng，Z.-Y. Dong，J.-K. Yang*.Clinical and genetic analysis of idiopathic normophosphatemic. Journal of Endocrinological. 2019,10.1007:1-11.SCI
3. Xi Cao#, Xin-Meng Lu#, Xiu Tuo, Jing-Yi Liu, Yi-Chen Zhang, Li-Ni Song, Zhi-Qiang Cheng, Jin-Kui Yang*,Zhong Xin*.Angiotensin-converting enzyme 2 regulates endoplasmic reticulum stress and mitochondrial function to preserve skeletal muscle lipid metabolism. Lipids in Health and Disease. 2019,10.1186:1-8.SCI
4. Zhu Xiao-Rong#,Zhang Hui-Rong#, Li Mei, Zhou Zhen, Liu Wei, Lu Jing, Yang Guang-Ran, Zhou Jian-Bo, Yang Jin-Kui*.Risk of silent myocardial ischemia detected by single photon emission computed tomography (SPECT) among asymptomatic Chinese patients with type 2 diabetes. Medicine. 2019,98:20:1-5.SCI
5. Cheng C, Lu J, Cao X, Yang FY, Liu JY, Song LN, Shen H, Liu C, Zhu XR, Zhou JB & YangJK*.Identification of Rfx6 target genes involved in pancreas development and insulin translation by ChIP-seq. Biochemical and biophysical research communications. 2019,508(2):556.SCI
6. Zhao MM, Krebs J, Cao X, Cui J, Chen DN, Li Y, Hua L, Mann J, Yang JK*.Helicobacter pylori infection as a risk factor for serum bilirubin change and less favourable lipid profiles: a hospital-based health examination survey. BMC Infect Dis. 2019,9(1):157.SCI
7. Li S, Wang YY, Cui J, Chen DN, Li Y, Xin Z, Xie RR, Cao X, Lu J, Yang FY @ Yang JK*.Are low levels of serum bicarbonate associated with risk of progressing to impaired fasting glucose/diabetes? A single-centre prospective cohort study in Beijing, China. BMJ open. 2018,8(7):e019145.SCI
8. Shi TT, Yang FY, Liu C, Cao X, Lu J, Zhang XL, Yuan MX, Chen C, Yang JK*.Angiotensin-converting enzyme 2 regulates mitochondrial function in pancreatic β-cells. Biochem Biophys Res Commun. 2018,495(1):860-866.SCI
9. Xin Z, Hua L, Shi TT, Tuo X, Yang FY, Li Y, Cao X, Yang JK*.A genome-wide DNA methylation analysis in peripheral blood from patients identifies risk loci associated with Graves' orbitopathy. J Endocrinol Invest. 2018,41(6):719-727.SCI
10. Yang JK*, Lu J, Yuan SS, Asan, Cao X, Qiu HY, Shi TT, Yang FY, Li Q, Liu CP et al.Hyper- to Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion. Cell reports . 2018,25(13):3800.SCI
11. Zhu XR, Zhang YP, Bai L, Zhang XL, Zhou JB, Yang JK*..Prediction of risk of diabetic retinopathy for all-cause mortality, stroke and heart failure: Evidence from epidemiological observational studies.. Medicine. 2017,96(3):e5894.SCI
12. Xin Z, Hua L, Wang XH, Zhao D, Yu CG, Ma YH, Zhao L, Cao X, Yang JK*.Reanalysis and External Validation of a Decision Tree Model for Detecting Unrecognized Diabetes in Rural Chinese Individuals. Int J Endocrinol. 2017,2017:**.SCI
13. Cao X, Xin Z, Li S, Qi Y, Yuan M, Zhu X, Yang JK*.The Status of Maculopathy in Diabetes and Prediabetes Patients in a Population-Based Study Detected by Optical Coherence Tomography: The 2011 Health Examination Survey in Beijing. Biomed Res Int. 2017,2017:**.SCI
14. Yang H, Xin Z, Feng JP, Yang JK*.Waist-to-height ratio is better than body mass index and waist circumference as a screening criterion for metabolic syndrome in Han Chinese adults. Medicine. 2017,96(39):e8192.SCI
15. Li Q, Lu J, Cao X, Shi TT, Feng JP, Yang JK*..An Increase in Normal SUA Level Within the Normal Range Predicts Risk of Metabolic Syndrome, Especially in Women: A Cross-Sectional Study.. Horm Metab Res. 2017,10:155.SCI
16. Gao L, Xin Z, Yuan MX, Cao X, Feng JP, Shi J, Zhu XR, Yang JK*..High Prevalence of Diabetic Retinopathy in Diabetic Patients Concomitant with Metabolic Syndrome.. PLoS One. 2016,11（1）:e**..SCI
17. Cao X, Yang F, Shi T, Yuan M, Xin Z, Xie R, Li S, Li H, Yang JK*..Angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis activates Akt signaling to ameliorate hepatic steatosis.. Sci Rep.. 2016,6:21592.SCI
18. Li Q, Cao X, Qiu HY, Lu J, Gao R, Liu C, Yuan MX, Yang GR, Yang JK*..A three-step programmed method for the identification of causative gene mutations of maturity onset diabetes of the young (MODY).. Gene. 2016,588（2）:141-148.SCI
19. Zhang F, Liu C, Wang L, Cao X, Wang YY, Yang JK*..Antioxidant effect of angiotensin (1??7) in the protection of pancreatic β cell function.. Mol Med Rep. 2016,14（3）:1963-1969.SCI
20. Yang GR, Zhao XL, Jin F, Shi LH, Yang JK*.Pharmacokinetics and pharmacodynamics of a polyethylene glycol (PEG)-conjugated GLP-receptor agonist once weekly in Chinese patients with type 2 diabetes. . Journal of clinical pharmacology. 2015,55:152-158.SCI
21. Chen YW, Wang YY, Zhao D, Yu CG, Xin Z, Cao X, Shi J, Yang GR, Yuan MX, Yang JK*.High prevalence of lower extremity peripheral artery disease in type 2 diabetes patients with proliferative diabetic retinopathy. PloS one. 2015,10:e**.SCI
22. Zhou JB, Yang JK*, Zhang BH, Lu J..Interaction of Wnt pathway related variants with type 2 diabetes in a Chinese Han population.. PeerJ. 2015,3:e1304..SCI
23. Cao X, Yang FY, Xin Z, Xie RR, Yang JK*.The ACE2/Ang-(1-7)/Mas axis can inhibit hepatic insulin resistance.. Molecular and cellular endocrinology. 2014,393:30-38.SCI
24. Li HX, Zhang F, Zhao D, Xin Z, Guo SQ, Wang SM, Zhang JJ, Wang J, Li Y, Yang GR, Yang JK*.Neck circumference as a measure of neck fat and abdominal visceral fat in Chinese adults. . BMC public health . 2014,14:311.SCI
25. Wang S, Lin S, Cao X, Zheng Y, Wang J, Lu N, Yang J*.Urinary albumin excretion rate: a risk factor for retinal hard exudates in macular region in type 2 diabetic patients.. Chinese medical journal. 2014,127:2293.SCI
26. Wang JY, Gao YB, Zhang N, Zou DW, Wang P, Zhu ZY, Li JY, Zhou SN, Wang SC, Wang YY, Yang JK*.miR-21 overexpression enhances TGF-beta1-induced epithelial-to-mesenchymal transition by target smad7 and aggravates renal damage in diabetic nephropathy. . Molecular and cellular endocrinology. 2014,392:163-172.SCI
27. Yang JK*, Wang L.Nateglinide in combination with metformin in Chinese patients with type 2 diabetes mellitus: a post-marketing surveillance study. Clin Drug Invest. 2013,33(3):185-191.SCI
28. Xin Z, Liu C, Niu WY, Feng JP, Zhao L, Ma YH, Hua L, Yang JK*.Identifying obesity indicators which best correlate with type 2 diabetes in a Chinese population. BMC Public Health. 2012,12:732.SCI
29. Yang Y, Zhu XR, Xu QG, Metcalfe H, Wang ZC, Yang JK*.Magnetic resonance imaging retinal oximetry: a quantitative physiological biomarker for early diabetic retinopathy?. Diabet Med. 2012,29（4）:501-505.SCI
30. Liu C, Lv XH, Li HX, Cao X, Zhang F, Wang L, Yu M, Yang JK*.Angiotensin-(1-7) suppresses oxidative stress and improves glucose uptake via Mas receptor in adipocytes. Acta Diabetol. 2012,49(4):291-299.SCI
31. Xin Z, Yuan MX, Li HX, Hua L, Feng JP, Shi J, Zhu XR, Cao X, Yang JK*.Evaluation for fasting and 2-hour glucose and HbA1c for diagnosing diabetes based on prevalence of retinopathy in a Chinese population. PLoS One. 2012,7(7):e40610.SCI
32. Zhou JB, Liu C, Niu WY, Xin Z, Yu M, Feng JP, Yang JK*.Contributions of renin-angiotensin system-related gene interactions to obesity in a Chinese population. PLoS One. 2012,7(8):e42881.SCI
33. Yang JK*, Zhou JB, Xin Z, Zhao L, Yu M, Feng JP, Yang H, Ma YH.Interactions among related genes of renin-angiotensin system associated with type 2 diabetes. Diabetes Care. 2010,33(10:2271-2273.SCI
34. Yang JK*, Liu W, Shi J, Li YB.An association between subclinical hypothyroidism and sight-threatening diabetic retinopathy in type 2 diabetic patients. Diabetes Care. 2010,33(5):1018-1020.SCI
35. Yang GR, Yang JK*, Zhang L, An YH, Lu JK.Association between subclinical hypothyroidism and proliferative diabetic retinopathy in type 2 diabetic patients: a case-control study. Tohoku J Exp Med. 2010,222(4):303-310.SCI
36. Zhou JB, Yang JK*, Zhao L, Xin Z. Variants in KCNQ1, AP3S1, MAN2A1, and ALDH7A1 and the risk of type 2 diabetes in the Chinese Northern Han population: a case-control study and meta-analysis. Med Sci Monit. 2010,16(6):BR179-183.SCI
37. Yang JK*, Lin SS, Ji XJ, Guo LM.Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes. Acta Diabetologica. 2010,47(3):193-199.SCI
38. Zhou JB, Yang JK*, Lu JK, An YH.Angiotensin-converting enzyme gene polymorphism is associated with type 2 diabetes: a meta-analysis. Mol Biol Rep. 2010,37(1):67-73.SCI
39. Ding YL, Wang YH, Huang W, Liu G, Ross C, Hayden MR, Yang JK*.Glucose intolerance and decreased early insulin response in mice with severe hypertriglyceridemia. Exp Biol Med. 2010,235(1):40-46.SCI
40. Xin Z, Yuan J, Hua L, Ma YH, Zhao L, Lu Y, Yang JK*.A simple tool detected diabetes and prediabetes in rural Chinese. J Clin Epidemiol. 2010,63(9):1030-1035.SCI
41. Zhang XL, Yang JK*, Yu M, Xue GF.Improved, low-cost methods for pancreatic islet purification in rats. Transplant Proc. 2009,41(10):4297-4301.SCI
42. Ma YH, Zhao L, Xian XD, Yang D, Huang W, Wang YH, Mueller O, Chang E, Konigshofer Y, Van-Cleve M, Liu G, Yang JK*.A case-control study on the relationship between HDL2b and non-alcoholic fatty liver disease in Chinese type 2 diabetic patients. Clin Chem Lab Med. 2009,47(9):1067-1072.SCI
43. Zhao L, Ma YH, Xu JX, Li SB, Yang JK*.High prevalence of impaired fasting glucose in Chinese children and adolescents with prehypertension/hypertension. Acta Paediatr. 2009,98(10):1641-1645.SCI
44. Zhou JB, Yang JK*.Meta-analysis of association of ACE2 G8790A polymorphism with Chinese Han essential hypertension. J Renin Angiotensin Aldosterone Syst. 2009,10:31-34.SCI
45. Niu MJ, Yang JK*.Loss of angiotensin-converting enzyme 2 leads to impaired glucose homeostasis in mice. Endocrine. 2008,34:56-61.SCI
主编或副主编的著作/译著
1. 《健康大百科（中青年篇）》,主编,人民卫生出版社,201112
重要奖项
1. 糖尿病发病机制和诊疗关键技术的研究与应用 中华医学科技奖 二等奖 201912
2. 糖尿病微血管病变早期诊断新方法的应用研究 北京市科技进步奖 三等奖 201902
3. 糖尿病视网膜病变与肾病早期诊断新方法的应用研究 华夏医学科技奖 二等奖 201810
4. 糖尿病性视网膜病变流行病学、发病机理及早期干预研究 北京市科技进步奖 三等奖 201512
5. 中国北方人群及成人2型糖尿病高危因素调查研究 省部级（不包括北京市级奖项） 三等 201311