姓名：吴建平 性别：男 职称：研究员、教授 招生院所：附属天坛医院 招生类型：科学学位(博) 科学学位(硕) 招生专业：神经病学(博) 神经病学(硕) 研究方向名称：癫痫、脑血管疾病与离子通道 电子信箱：biojpwu@ccmu.edu.cn


社会任职
个人简历
1. 198609-199707:武汉同济医科大学 学习
2. 199708-199908:南京医科大学 讲师
3. 199909-200306:佐治亚州立大学 博士后
4. 200307-200909:伯明翰阿拉巴马大学 研究员助理（Research Associate)
5. 200910-201203:圣路易斯华盛顿大学麻醉系 资深研究员（Sr. Scientist)
6. 201203-201912:弗吉尼亚理工大学凯瑞琳医学研究所 资深研究员、助理教授
7. 201901-209912:首都医科大学附属天坛医院 教授、研究员
重要学术论文
1. Yang H, Shan W, Zhu F, Wu J, Wang Q*. Ketone Bodies in Neurological Diseases: Focus on Neuroprotection and Underlying Mechanisms. Front Neurol. 2019,10:585.SCI
2. Fan JJ, Shan W, Wu J, Wang Q*. Research progress of vagus nerve stimulation in the treatment of epilepsy. CNS Neurosci The. 2019,25(11):1222-1228.SCI
3. Yang T, Zang DW, Shan W, Guo AC, Wu J, Wang YJ, Wang Q*. Synthesis and Evaluations of Novel Apocynin Derivatives as Anti-Glioma Agents. Front Pharmacol. 2019,10:951.SCI
4. Zhu F, Shan W, Xu Q, Guo A, Wu J, Wang Q*. Ketone Bodies Inhibit the Opening of Acid-Sensing Ion Channels (ASICs) in Rat Hippocampal Excitatory Neurons in vitro. Front Neurol. 2019,10:155.SCI
5. Martinez-Espinosa PL#, Wu J#, Yang C, Gonzalez-Perez V, Zhou H, Liang H, Xia XM, Lingle CJ*.Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons. Elife. 2015,10.7554/eLife.10013.:1-27.SCI
6. Thornell IM#, Wu J, Liu X, Bevensee MO*.PIP2 hydrolysis stimulates electrogenic Na/bicarbonate cotransporter NBCe1-B and -C variants expressed in Xenopus laevis oocytes. J Physiol. 2013,590(Pt 23):5993-6011.SCI
7. Wang W, Wu J, Bernard K, Li G, Wang G, Bevensee MO, Kirk KL.ATP-independent CFTR channel gating and allosteric modulation by phosphorylation. Proc Natl Acad Sci U S A. 2010, 23;107(8):3888-93.SCI
8. Wu J, McNicholas CM, Bevensee MO*.PIP2 modulation electrogenic Na/bicarbonate cotransporter (NBCe1). Proc Natl Acad Sci USA. 2009,106(33):14150-5.SCI
9. Wu J, Hablitz JJ*.Cooperative activation of D1 and D2 dopamine receptors enhances a hyperpolarization-activated inward current in layer I interneurons. J Neurosci. 2005,25(27):6322-8.SCI
10. Wang R#, Rojas A#, Wu J#,Piao H, Adams CY, Xu H, Shi Y, Wang Y, Jiang C*.Determinant role of membrane helices in KATP channel gating. J Membr Biol. 2005 Mar;204(1):1-10.. 2005,204(1):1-10.SCI
11. Wu J, Xu H, Shen W and Jiang C*.Expression and co-expression of CO2- sensitive Kir Channels in brainstem neuron of rats. J Membr Biol . 2004,197(3):179-91.SCI
12. Wu J, Piao H, Rojas A, Wang R, Wang Y, Cui N, Shi Y, Chen F and Jiang C.Critical membrane helical domains and amino acid residues in gating Kir6.2 channels by intracellular ATP. J Cell Physiol. 2004,198(1):73-81.SCI
13. Li L, Rojas A, Wu J and Jiang C.Disruption of glucose sensing and insulin secretion by ribozyme Kir6.2-gene targeting in insulin-secreting cells. Endocrinology. 2004,145(9):4408-14.SCI
14. Li L, Wu J and Jiang C.Differential expression of Kir6.1 and SUR2B mRNA in Vasculatures of various tissues in rats. J Membr Biol. 2003,196(1):61-69.SCI
15. Mao J, Wu J, Fuxue Chen, Xueren Wang, Chun Jiang. .Inhibition of G-protein Coupled Inward Rectifying K+ Channels by Intracellular Acidosis. J Biol Chem. 2003,278(9):7091-8.SCI
16. Cui N#,Wu J#,Xu H#, Wang R, Rojas A, Piao H, Mao J, Abdulkadir L, Li L, Jiang C .Threonine residue (Thr71) plays a critical role in the gating of Kir6.2 channel by intracellular ATP and pH. J Membr Biol. 2003,192(2):111-22.SCI
17. Wang X, Wu J, Li L, Chen F, Wang R, Jiang C.Hypercapnic acidosis activates KATP channels in vascular smooth muscles. Circ Res. 2003,92(11):1225-32.SCI
18. Wu J, Cui, N, Piao, H, Wang, Y, Xu, H, Mao J, Jiang, C..Allosteric modulation of the mouse Kir6.2 channel by intracellular H+ and ATP. J Physiol. 2002,543(2):495-504.SCI
19. Mao J, Li L, McManus M, Wu J, Cui N, Jiang C.Molecular Determinants for Activation of G-protein Coupled Inward Rectifier K+ (GIRK) Channels by Extracellular Acidosis. J Biol Chem. 2002,277(48):4666-77.SCI
20. Wu J, Xu H., Yang Z, Wang Y, Mao J and Jiang C.Proton activate homomeric Kir6.2 channels by selective suppression of the long and intermediate closures. J Membr Biol. 2002,190(2):105-16.SCI
21. Xu H, Wu J, Cu, N, Abdulkadir L, Wang R, Mao J, Giwa LR, Chanchevalap S, Jiang C..Distinct histidine residues control the acid-induced activation and inhibition of the cloned KATP channel. J Biol Chem. 2001,276(42):38690-6.SCI
22. Piao H, Cui N, Xu H, Mao J, Rojas, A, Wang R, Abdulkadir L., Li L, Wu J, Jiang C..Requirement of multiple protein domains and residues for gating KATP channels by intracellular pH. J Biol Chem. 2001,276(39):36673-80.SCI
23. Xu H, Cui, N, Yang, Z, Wu J, Giwa LR, Abdulkadir L, Sharma P and Jiang C.Direct activation of KATP channels by intracellular acidosis. J Biol Chm. 2001,276(16):12898-902.SCI
24. Qu Z, Yang Z, Cui N, Chanchevalap S, Zhu G, Liu C, Xu H, Shen W, Wu J, Li Y, Jiang C. Kir gating by proton-mediated interactions of N- and C-terminal domains. J Biol Chem. 2000,275(41):31573-80.
主编或副主编的著作/译著
重要奖项
1. 美国精神分裂症和抑郁症研究联盟青年奖 NARSAD Young Investigator Award 200503