姓名：施福东 性别：男 职称：主任医师、教授 招生院所：附属天坛医院 招生类型：科学与专业学位(博) 科学与专业学位(硕) 招生专业：神经病学(博) 神经病学(硕) 研究方向名称：神经免疫与炎症 电子信箱：fshi66@ncrcnd.org.cn


社会任职
1. 美国免疫学协会委员
2. 美国神经病学协会委员
3. 中华医学会神经病学分会委员会常务委员
4. 天津神经病学分会主任委员
5. 泛亚多发性硬化治疗和研究（PACTRIMS）核心决策委员会委员及学术委员会主席
6. 美国心脏病学学会委员
7. 天津市卒中学会理事长
8. 中国神经免疫联盟主席
9. 中华医学会神经病学分会神经免疫组组长
10. Science子刊Science Translational Medicine编委
个人简历
1. 1984-1989:哈尔滨医科大学和北京协和医院 临床医学学士学位
2. 1989-1995:哈尔滨医科大学第二医院内科/神经内科 住院医师、硕士研究生、主治医师
3. 1995-1998:瑞典Karolinska 学院神经病学系（Karolinska Institute） 神经病学博士学位
4. 1999-2003:美国圣地亚哥Scripps 研究所（The Scripps Research Institute） 博士后
5. 2003-2008:美国Arizona 州St. Joseph’s 医院Barrow神经病学研究所（Barrow Neurological Institute） 助理教授,神经内科住院医师培训
6. 2010-:美国Barrow神经病学研究所（Barrow Neurological Institute） 神经病学副教授 (with tenure, 永久)
7. 2014-:天津医科大学总医院 副院长
8. 2018-:北京天坛医院，国家神经系统疾病临床研究中心，京津神经免疫中心 基础与转化医学中心执行主任，中心主任
重要学术论文
1. Zhang C, Zhang M, Qiu W, Ma H, Zhang X, Prof Zhu Z, Yang CS, Jia D, Zhang TX, Yuan M, Feng Y, Yang L, Lu W, Yu C, Bennett J, Shi FD*.Tocilizumab versus azathioprine in highly relapsing neuromyelitis optica spectrum disorder (TANGO): a multicenter, randomised, head-to-head comparison trial . Lancet Neurol . 2020,0:0.SCI
2. Shi K, Tian DC, Li ZG, Ducruet AF, Lawton MT, Shi FD*..Global brain inflammation in stroke. The Lancet. Neurology. 2019,18（11）:1058-1066.SCI
3. Shi K, Zhang J, Dong JF, Shi FD*.Dissemination of brain inflammation in traumatic brain injury. Cellular & molecular immunology. 2019,16(6):523-530.SCI
4. Zhao H, Feng Y, Wei C, Li Y, Ma H, Wang X, Cui Z, Jin WN, Shi FD*..Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway. Neuroscience. 2019,416:198-206.SCI
5. Liu Q, Shi FD*.Enhancing natural killer cells is beneficial in multiple sclerosis - No. Multiple sclerosis . 2019,25(4):512-513.SCI
6. Yang CS, Zhang QX, Deng Y, Zhou BJ, Zhang LJ, Li LM, Qi Y, Wang J, Yang L, Shi FD*.Increased serum IL-36β and IL-36γ levels in patients with neuromyelitis optica spectrum disorders: association with disease activity. BMC neurology. 2019,19(1):1471-2377.SCI
7. Yao Y, Miao W, Liu Z, Han W, Shi K, Shen Y, Li H, Liu Q, Fu Y, Huang D, Shi FD*.Dimethyl Fumarate and Monomethyl Fumarate Promote Post-Ischemic Recovery in Mice. Translational stroke research. 2018,7(6):535-547.SCI
8. Tian DC, Shi K, Zhu Z, Yao J, Yang X, Su L, Zhang S, Zhang M, Gonzales RJ, Liu Q, Huang D, Waters MF, Sheth KN, Ducruet AF, Fu Y, Lou M, Shi FD*. .Fingolimod enhances the efficacy of delayed alteplase administration in acute ischemic stroke by promoting anterograde reperfusion and retrograde collateral flow. Ann Neurol. 2018,84（5）:717-728.SCI
9. Yang CS, Zhang QX, Chang SH, Zhang LJ, Li LM, Qi Y, Wang J, Sun ZH, Zhangning N, Yang L, Shi FD*.Neuromyelitis optica spectrum disorders with and without connective tissue disorders. BMC neurology. 2018,18(1):177.SCI
10. Jin WN, Ducruet AF, Liu Q, Shi SX, Waters M, Zou M, Sheth KN, Gonzales R, Shi FD*.Activation of JAK/STAT3 restores NK-cell function and improves immune defense after brain ischemia. FASEB J. 2018,32(5):2757-2767.SCI
11. Yang CS, Zhang LJ, Sun ZH, Yang L, Shi FD*.Acute prevertebral abscess secondary to intradiscal oxygen-ozone chemonucleolysis for treatment of a cervical disc herniation. J Int Med Res. 2018,0（0）:1-5.SCI
12. Liu Q, Jin WN, Liu Y, Shi K, Sun H, Zhang F, Zhang C, Gonzales RJ, Sheth KN, La Cava A, Shi FD*.Brain ischemia suppresses immunity in the periphery and brain via different neurogenic innervations. Immunity. 2017,46（3）:474-487.SCI
13. Fan M, Fu Y, Su L, Shen Y, Wood K, Yang L, Liu Y, Shi FD*..Comparison of brain and spinal cord magnetic resonance imaging features in neuromyelitis optica spectrum disorders patients with or without aquaporin-4 antibody. Multiple Sclerosis and Related Disorders. 2017,13（0）:58-66.SCI
14. De-cai Tian, Lei Su, Moli Fan, Jian Yang, Rui Zhang, Peng Wen, Yujuan Han, Changlu Yu, Chao Zhang, Honglei Ren, Kaibin Shi, Zilong Zhu, Yinhua Dong, Yaou Liu, Fu-Dong Shi*.Bidirectional degeneration in the visual pathway in neuromyelitis optica spectrum disorder (NMOSD). Multiple sclerosis journal. 2017,0（0）:1-9.SCI
15. Li M, Li Z, Ren H, Jin WN, Wood K, Liu Q, Sheth KN, Shi FD*.Colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhage. Journal of cerebral blood flow and metabolism. 2017,37（7）:2382-2395.SCI
16. Zhang C, Tian DC, Yang CS, Han B, Wang J, Yang L, Shi FD*.Safety and Efficacy of Bortezomib in Patients With Highly Relapsing Neuromyelitis Optica Spectrum Disorder. JAMA Neurology. 2017,74（8）:1010-1012.SCI
17. Zhang J, Shi K, Li Z, Li M, Han Y, Wang L, Zhang Z, Yu C, Zhang F, Song L, Dong JF, La Cava A, Sheth KN, Shi FD*.Organ- and cell-specific immune responses are associated with the outcomes of intracerebral hemorrhage. FASEB journal. 2017,32（1）:1-10.SCI
18. Li M, Li Z, Yao Y, Jin WN, Wood K, Liu Q, Shi FD, Hao J*.Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity. Proceedings of the National Academy of Sciences of the United States of America. 2017,114(3):E396-E405.SCI
19. Liu Q, Sanai N, Jin WN, La Cava A, Van Kaer L, Shi FD*.Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation. Nature Neuroscience. 2016,19（2）:243-252.SCI
20. Yan Y, Li Y, Fu Y, Yang L, Su L, Shi K, Li M, Liu Q, Borazanci A, Liu Y, He Y, Bennett JL, Vollmer TL, Shi FD*.Autoantibody to MOG suggests two distinct clinical subtypes of NMOSD. SCIENCE CHINA-LIFE SCIENCES. 2016,59（12）:1270-1281.SCI
21. Sun N, Shen Y, Han W, Shi K, Wood K, Fu Y, Hao J, Liu Q, Sheth KN, Huang D, Shi FD*.Selective sphingosine-1-phosphate receptor 1 modulation attenuates experimental. Stroke. 2016,47（7）:1899-1906.SCI
22. Fu Y, Yan Y, Qi Y, Yang L, Li T, Zhang N, Yu C, Su L, Zhang R, Shen Y, Lin S, Liu Q, Shao Z, Han Z, Shi FD*.Impact of Autologous Mesenchymal Stem Cell Infusion on Neuromyelitis Optica Spectrum Disorder: A Pilot, 2-Year Observational Study. CNS Neuroscience & Therapeutics. 2016,22（8）:677-685.SCI
23. Liu Y, Fu Y, Schoonheim MM, Zhang N, Fan M, Su L, Shen Y, Yan Y, Yang L, Wang Q, Zhang N, Yu C, Barkhof F, Shi FD*.Structural MRI substrates of cognitive impairment in neuromyelitis optica. Neurology. 2015,85（17）:1491-1499.SCI
24. Zhu Z, Fu Y, Tian D, Sun N, Han W, Chang G, Dong Y, Xu X, Liu Q, Huang D, Shi FD*.Combination of an immune modulator fingolimod with alteplase in acute ischemic stroke. Circulation. 2015,132（12）:1104-1112.SCI
25. Fu Y, Liu Q, Anrather J, Shi FD*.Immune interventions in stroke. Nature Reviews Neurology. 2015,11（9）:524-535.SCI
26. Song Y, Pan L, Fu Y, Sun N, Li YJ, Cai H, Su L, Shen Y, Cui L, Shi FD*.Sleep abnormality in neuromyelitis optica spectrum disorder. Neurology(R) neuroimmunology & neuroinflammation. 2015,2(3):e94.SCI
27. Zhiwei Tang,Yan Gan,Qiang Liu,Jun-Xiang Yin,Qingwei Liu,Jiong Shi,Fu-Dong Shi*.CX3CR1 deficiency suppresses proliferation and neurotoxicity of macrophage/microglia in MCAO mice. Journal of Neuroinflammation. 2014,11（0）:26.SCI
28. Zhang CJ, Zhai H, Yan Y, Hao J, Li MS, Jin WN, Su N, Vollmer TL, Shi FD*.Glatiramer acetate ameliorates experimental autoimmune neuritis. immunology and cell biology. 2014,92（2）:164-169.SCI
29. Fu Y, Zhang N, Ren L, Yan Y, Sun N, Li YJ, Han W, Xue R, Liu Q, Hao J, Yu C, Shi FD*.Impact of an immune modulator fingolimod on acute ischemic stroke. Proceedings of the national academy of sciences of the united states of america. 2014,111（51）:18315-18320.SCI
30. Sun F, Ladha SS, Yang L, Liu Q, Shi SX, Su N, Bomprezzi R, Shi FD*.IL-10 producing B cells in myasthenia gravis during rituximab therapy. Muscle and Nerve. 2014,49（4）:487-494.SCI
31. Gan Y, Liu Q, Wu W, Yin JX, Bai XF, Shen R, Wang Y, Chen J, La Cava A, Poursine-Laurent J, Yokoyama W, Shi FD*.Ischemic neurons recruit NK cells that accelerate brain infarction. Proceedings of the national academy of sciences of the united states of america. 2014,111（7）:2704-2709.SCI
32. Fu Y, Hao J, Zhang N, Ren L, Sun N, Li YJ, Yan Y, Huang D, Yu C, Shi FD*.Fingolimod for the Treatment of Intracerebral Hemorrhage: A 2-Arm Proof-of-Concept Study. JAMA Neurology. 2014,71（9）:1092-1101.SCI
33. Su N, Shi SX, Zhu X, Borazanci A, Shi FD*, Gan Y*.Interleukin-7 expression and its effect on natural killer cells in patients with multiple sclerosis. Journal of neuroimmunology. 2014,276（1-2）:180-186.SCI
34. Kong XD, Bai S, Chen X, Wei HJ, Jin WN, Li MS, Yan Y, Shi FD*.Alterations of natural killer cells in traumatic brain injury. Neuroscience Bulletin. 2014,30（6）:903-912.SCI
35. Yang CS, Yang L, Li T, Zhang DQ, Jin WN, Li MS, Su N, Zhangning N, Liu Q, Shao ZH, Yu C, Shi FD*.Responsiveness to reduced dosage of rituximab in Chinese neuromyelitis optica patients. Neurology. 2013,81（8）:710-713.SCI
36. Simard AR, Gan Y, St-Pierre S, Kousari A, Patel V, Whiteaker P, Morley BJ, Lukas RJ, Shi FD*.Differential modulation of EAE by α9*- and β2*-nicotinic acetylcholine receptors. Immunology and Cell Biology. 2013,91（3）:195-200.SCI
主编或副主编的著作/译著
重要奖项
1. 天津市科学技术奖“脑卒中的免疫学研究” 自然科学奖一等奖 201801
2. 中国卒中奖 201701
3. 中国杰出神经内科医师 201701
4. 天津市创新人才推进计划重点领域创新团队 201601
5. 中国卒中创新研究奖 201501
6. 中枢神经系统炎性脱髓鞘疾病的免疫学、诊断和治疗研究 天津市科学技术奖 科技进步公益类二等奖 201405
7. 中国侨界（创新人才）贡献奖 201401