姓名：张伟 性别：男 职称：副主任医师、副教授 招生院所：附属天坛医院 招生类型：科学与专业学位(硕) 招生专业：外科学（神外）(硕) 研究方向名称：脑胶质瘤的临床与基础研究 电子信箱：zhangwei_vincent@126.com


社会任职
1. 中国医师协会脑胶质瘤专业委员会第一届青年委员会委员
2. 中国医疗保健国际交流促进会中老年医疗保健分会青年委员会委员
3. 中国医师协会脑胶质瘤专业委员会第一届基础研究与转化专业委员会委员
4. 中国抗癌协会第一届脑胶质瘤专业委员会委员
5. 中国抗癌协会青年理事会理事
6. 中国医师协会科普分会神经外科科普专委会委员
7. 中国抗癌协会脑胶质瘤专业委员会国际学术交流与合作学组秘书长
8. 北京抗癌协会第一届青年理事会理事
9. 中国医师协会脑胶质瘤专业委员会第二届基础与转化学组委员
10. 中国医师协会脑胶质瘤专业委员会第二届青年委员会副主任委员
11. 北京医学会第八届神经外科学分会神经外科转化医学学组委员
个人简历
1. 199909-200407:东南大学医学院 大学本科
2. 200409-200707:首都医科大学北京市神经外科研究所 硕士
3. 200809-201107:首都医科大学附属北京天坛医院神经外科 博士
4. 201108-201311:首都医科大学附属北京天坛医院神经外科 住院医师
5. 201312-201511:首都医科大学附属北京天坛医院神经外科 主治医师
6. 201512-:首都医科大学附属北京天坛医院神经外科 副主任医师
7. 201603-:首都医科大学附属北京天坛医院神经外科 副教授
8. 201704-201804:美国MD安德森癌症中心 神经肿瘤科 博士后
9. 201901-:首都医科大学附属北京天坛医院神经外科 肿瘤五病区副主任
重要学术论文
1. Li G#, Zhai Y, Wang Z, Wang Z, Huang R, Jiang H, Li R, Feng Y, Chang Y, Jiang T*, Zhang W*.Postoperative standard chemoradiotherapy benefits primary glioblastoma patients of all ages. Cancer Med. 2020,9(6):1955-1965.SCI
2. Wang Z#, Zhong L#, Li G, Huang R, Wang Q, Wang Z, Zhang C, Chen B, Jiang T*, Zhang W*.Pre-treatment neutrophils count as a prognostic marker to predict chemotherapeutic response and survival outcomes in glioma: a single-center analysis of 288 cases. Am J Transl Res. 2020,12(1):90-104.SCI
3. Zhai Y#, Li G, Jiang T, Zhang W*.CAR-armed cell therapy for gliomas. Am J Cancer Res. 2019,9(12):2554-2566.SCI
4. Li GZ#, Zhang KN#, Wang Z, Hu HM, Wang ZL, Huang RY, Jiang HY, Zhai Y, Feng YM, Chang YH, Li RP, Wu F, Zeng F, Jiang T*, Zhang W*.Siglecs, Novel Immunotherapy Targets, Potentially Enhance The Effectiveness of Existing Immune Checkpoint Inhibitors in Glioma Immunotherapy. Onco Targets Ther. 2019,12:10263-10273.SCI
5. Hu H#, Mu Q#, Bao Z#, Chen Y#, Liu Y#, Chen J, Wang K, Wang Z, Nam Y, Jiang B, Sa JK, Cho HJ, Her NG, Zhang C, Zhao Z, Zhang Y, Zeng F, Wu F, Kang X, Liu Y, Qian Z, Wang Z, Huang R, Wang Q, Zhang W, Qiu X, Li W, Nam DH, Fan X*, Wang J*, Jiang T*.Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor. Cell. 2018,175(6):1665-1678.SCI
6. Wang Z#, Wang Z#, Zhang C, Liu X, Li G, Liu S, Sun L, Liang J, Hu H, Liu Y, Zhang W, Jiang T*..Genetic and clinical characterization of B7-H3 (CD276) expression and epigenetic regulation in diffuse brain glioma. cancer science. 2018,109(9):2697-2705.SCI
7. Wang Z#, Yang P#, You G, Zhang W, Bao ZS, Jiang T*, Zhang CB*.Predicting the likelihood of postoperative seizure status based on mRNA sequencing in low-grade gliomas. Future Oncol. 2018,14(6):545-552.SCI
8. Wang Z#, Liu X#, Wang Z, Bao Z, Zhang W, Zhang C, Jiang T*.Identification of a Good-Prognosis IDH-Mutant-Like Population of Patients with Diffuse Gliomas. Curr Mol Med. 2018,17(7):518-526.SCI
9. Guanzhang Li#, Yiming Li, Xing Liu#, Zheng Wang, Chuanbao Zhang, Fan Wu, Haoyu Jiang, Wenlong Zhang, Zhaoshi Bao, Yongzhi Wang, Jinquan Cai, Liang Zhao, Ulf D. Kahlert, Tao Jiang, Wei Zhang*.ALDH1A3 induces mesenchymal differentiation and serves as a predictor for survival in glioblastoma. Cell Death Dis. 2018,9(12):1190.SCI
10. Li G#, Wang Z#, Zhang C, Liu X, Yang F, Sun L, Liang J, Hu H, Liu Y, You G, Bao Z, Zhang W, Wang Z, Jiang T*..MEGF10, a Glioma Survival-Associated Molecular Signature, Predicts IDH Mutation Status. disease markers. 2018,2018:**.SCI
11. Shi Y#, Guryanova OA#, Zhou W#, Liu C, Huang Z, Fang X, Wang X, Chen C, Wu Q, He Z, Wang W, Zhang W, Jiang T, Liu Q, Chen Y, Wang W, Wu J, Kim L, Gimple RC, Feng H, Kung HF, Yu JS, Rich JN, Ping YF, Bian XW*, Bao S*.Ibrutinib inactivates BMX-STAT3 in glioma stem cells to impair malignant growth and radioresistance. Sci Transl Med. 2018,10(443):pii: eaah6816.SCI
12. Li G* ,Wang Z*,Zhang C*,Liu X* Cai J,Wang Z,Hu H,Wu F,Bao Z,Liu Y,Zhao L,Liang T,Yang F,Huang R,Zhang W*,Jiang T*.Molecular and clinical characterization of TIM-3 in glioma through 1,024 samples.. Oncoimmunology . 2017,6(8):e**.SCI
13. Yang P#, Zhang C#, Cai J, You G, Wang Y, Qiu X, Li S, Wu C, Yao K, Li W, Peng X, Zhang W*, Jiang T*.Radiation combined with temozolomide contraindicated for young adults diagnosed with anaplastic glioma. Oncotarget. 2016,7(48):80091-80100.SCI
14. Wang Z#, Zhang CB#, Liu X, Wang ZL, Sun LH, Li GZ, Liang JS, Hu HM, Liu YW, Zhang W*, Jiang T*. Molecular and clinical characterization of PD-L1 expression at transcriptional level via 976 samples of brain glioma. Oncoimmunology. 2016,5(11):e**.SCI
15. Yang P#, Zhang C#, Cai J, You G, Wang Y, Qiu X, Li S, Wu C, Yao K, Li W, Peng X, Zhang W*, Jiang T*..Radiation combined with temozolomide contraindicated for young adults diagnosed with anaplastic glioma. Oncotarget. 2016,7(48):80091-80100.SCI
16. Chen B#, Wang Z#, Liu Y, You G, Wang J, Wang J, Jiang Z, Zhang W*.Intracranial benign fibrous histiocytoma mimicking parasagittal meningioma: report of two cases and review of literature. Int J Clin Exp Pathol. 2015,8(9):11708-11714.SCI
17. Zhang W, Liu Y, Hu H, Huang H, Bao Z, Yang P, Wang Y, You G1, Yan W, Jiang T*, Wang J*, Zhang W*.ALDH1A3: A Marker of Mesenchymal Phenotype in Gliomas Associated with Cell Invasion. PLoS One. 2015,10(11):e**.SCI
18. Cai J#, Zhang W#, Yang P#, Wang Y, Li M, Zhang C, Wang Z, Hu H, Liu Y, Li Q1, Wen J, Sun B, Wang X, Jiang T*, Jiang C*.Identification of a 6-cytokine prognostic signature in patients with primary glioblastoma harboring M2 microglia/macrophage phenotype relevance. PLOS ONE. 2015,10(5):e**.SCI
19. Yang P#, Zhang W#, Wang Y, Peng X, Chen B, Qiu X, Li G, Li S, Wu C, Yao K, Li W, Yan W, Li J, You Y, Chen CC*, Jiang T*..IDH mutation and MGMT promoter methylation in glioblastoma: Results of a prospective registry. Oncotarget. 2015,6(38):40896-906.SCI
20. Cai J#, Yang P#, Zhang C#, Zhang W#, Liu Y, Bao Z, Liu X, Du W, Wang H, Jiang T*, Jiang C*..ATRX mRNA expression combined with IDH1/2 mutational status and Ki-67 expression refines the molecular classification of astrocytic tumors: evidence from the whole transcriptome sequencing of 169 samples. Oncotarget. 2014,5(9):2551-61.SCI
21. Liu Y#, Hu H#, Wang K, Zhang C, Wang Y, Yao K, Yang P, Han L, Kang C, Zhang W*, Jiang T*..Multidimensional analysis of gene expression reveals TGFB1I1-induced EMT contributes to malignant progression of astrocytomas. Oncotarget. 2014,5(24):12593-606.SCI
22. Feng Y#, Wang Z#, Bao Z, Yan W, You G, Wang Y, Hu H, Zhang W*, Zhang Q*, Jiang T*..SOCS3 Promoter Hypermethylation Is a Favorable Prognosticator and a Novel Indicator for G-CIMP-Positive GBM Patients. PLoS One. 2014,9(3):e91829.SCI
23. Bao Z#, Zhang C#, Yan W, Liu Y, Li M, Zhang W*, Jiang T*..BMP4, a strong better prognosis predictor, has a subtype preference and cell development association in gliomas. J Transl Med. 2013,11:100.SCI
24. Liu Y#, Tang K#, Yan W, Wang Y, You G, Kang C, Jiang T*, Zhang W*..Identifying Ki-67 specific miRNA-mRNA interactions in malignant astrocytomas. Neurosci Lett. 2013,546:36-41.SCI
25. Zhang W#, Yan W#, You G, Bao Z, Wang Y, Liu Y, You Y, Jiang T*..Genome-wide DNA methylation profiling identifies ALDH1A3 promoter methylation as a prognostic predictor in G-CIMP- primary glioblastoma. Cancer Lett. 2013,328(1):120-5.SCI
26. Wang Z#, Bao Z#, Yan W, You G, Wang Y, Li X*, Zhang W*..Isocitrate dehydrogenase 1 (IDH1) mutation-specific microRNA signature predicts favorable prognosis in glioblastoma patients with IDH1 wild type. J Exp Clin Cancer Res. 2013,32(1):59.SCI
27. Bao ZS#, Zhang CB#, Wang HJ, Yan W, Liu YW, Li MY, Zhang W*..Whole-genome mRNA expression profiling identifies functional and prognostic signatures in patients with mesenchymal glioblastoma multiforme. CNS Neurosci Ther. 2013,19（9）:714-720.SCI
28. Wang H#, Feng Y#, Bao Z#, Jiang C, Yan W, Wang Y, Zhang C, Liu Y, Zhang Q, Zhang W*, Jiang C*.Epigenetic silencing of KAZALD1 confers a better prognosis and is associated with malignant transformation/progression in glioma. ONCOLOGY REPORTS. 2013,30(5):2089-96.SCI
29. Yan W#, Zhang W#, You G#, Zhang J, Han L, Bao Z, Wang Y, Liu Y, Jiang C, Kang C, You Y, Jiang T*..Molecular classification of gliomas based on whole genome gene expression: a systematic report of 225 samples from the Chinese Glioma Cooperative Group. Neuro Oncol. 2012,14(12):1432-40.SCI
30. Yan W#, Zhang W#, You G, Bao Z, Wang Y, Liu Y, Kang C, You Y, Wang L*, Jiang T*..Correlation of IDH1 mutation with clinicopathologic factors and prognosis in primary glioblastoma: a report of 118 patients from China. PLoS One. 2012,7(1):e30339.SCI
31. Zhang W#, Zhang J#, Hoadley K, Kushwaha D, Ramakrishnan V, Li S, Kang C, You Y, Jiang C, Song SW*, Jiang T*, Chen CC*..miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression. Neuro Oncol. 2012,14(6):712-9.SCI
主编或副主编的著作/译著
重要奖项
1. 脑胶质瘤诊疗关键技术创新与推广应用 国家科技进步奖 二等奖 201712
2. 脑胶质瘤精准诊疗新技术的临床应用与机理研究 江苏省科学技术奖 二等奖 201702
3. 脑胶质瘤诊疗技术创新研究与临床应用 中国抗癌学会科技奖 二等奖 201409
4. 脑胶质瘤诊疗技术创新的基础研究与临床应用 教育部科学技术进步奖 一等奖 201301