姓名：兰峰 性别：男 职称：教授 招生院所：附属安贞医院 招生类型：科学学位(博) 科学学位(硕) 招生专业：病理学与病理生理学(博) 病理学与病理生理学(硕) 研究方向名称：基于干细胞的心血管转化医学研究 电子信箱：fenglan@ccmu.edu.cn


社会任职
1. 北京生理学会心血管病学专业委员会 再生医学组 副组长
2. 北京市干细胞临床研究专家委员会委员
个人简历
1. 200409-200906:北京大学 博士研究生
2. 200907-201405:斯坦福大学医学院 博士后
3. 201405-:首都医科大学附属安贞医院 教授
重要学术论文
1. Qiu S, Liu T, Piao C, Wang Y, Wang K, Zhou Y, Cai L, Zheng S, Lan F*, Du J*. .AMPKα2 knockout enhances tumour inflammation through exacerbated liver injury and energy deprivation-associated AMPKα1 activation. . J Cell Mol Med. 2019,23(3):1687-1697.SCI
2. Ren W, Liu Y, Wang X, Piao C, Ma Y, Qiu S, Jia L, Chen B, Wang Y, Jiang W, Zheng S, Liu C, Dai N, Lan F, Zhang H, Song WC, Du J*.The Complement C3a-C3aR Axis Promotes Development of Thoracic Aortic Dissection via Regulation of MMP2 Expression. The Journal of Immunology. 2018,200（5）:1829-1838.SCI
3. Li J, Guan X, Liu O, Wang X, Liu Y, Li H, Lan F, Gong M, Zhang H..Changes in coagulation factor XII and its function during aortic arch surgery for acute aortic dissection-a prospective observational study. J Thorac Dis. 2018,10(7):4006-4016.SCI
4. Ke B, Zeng Y, Zhao Z, Han F, Liu T, Wang J, Khalique A, Lu WJ, Chong J, Lan F*, He H*. .Uric acid: a potent molecular contributor to pluripotent stem cell cardiac differentiation via mesoderm specification. Cell Death and Differentiation. 2018,7(23):1-17.SCI
5. Jiang Q, Li K, Lu WJ, Li S, Chen X, Liu XJ, Yuan J, Ding Q, Lan F*, Cai SQ*. .Identification of small-molecule ion channel modulators in C. elegans channelopathy models. . Nature Communication. 2018,9(1):3941-3952.SCI
6. Ren W, Liu Y, Wang X, Jia L, Piao C, Lan F, Du J.β-Aminopropionitrile monofumarate induces thoracic aortic dissection in C57BL/6 mice. Scientific Reports. 2016,N:N.SCI
7. Zhou P, Wu F, Zhou T, Cai X, Zhang S, Zhang X, Li Q, Li Y, Zheng Y, Wang M, Lan F, Pan G, Pei D, Wei S.Simple and versatile synthetic polydopamine-based surface supports reprogramming of human somatic cells and long-term self-renewal of human pluripotent stem cells under defined conditions. Biomaterials. 2016,87:1-17.SCI
8. Yu Y, Sun S, Wang S, Zhang Q, Li M, Lan F, Li S, Liu C.Liensinine- and Neferine-Induced Cardiotoxicity in Primary Neonatal Rat Cardiomyocytes and Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Int J Mol Sci.. 2016,17（2）:N.SCI
9. Guan XL, Wang XL, Liu YY, Lan F, Gong M, Li HY, Liu O, Jiang WJ, Liu YM, Zhu JM, Sun LZ, Zhang HJ..Changes in the Hemostatic System of Patients With Acute Aortic Dissection Undergoing Aortic Arch Surgery.. Ann Thorac Surg.. 2016,101（3）:945-951.SCI
10. 3.Zhou S, Liu Y, Feng R, Wang C, Jiang S, Zhang X, Lan F* and Yang Li*.Survivin improves reprogramming efficiency of human neural progenitors by single molecule OCT4. Stem Cells Int. 2016,N:N.SCI
11. Liang P, Sallam K, Wu H, Li Y, Itzhaki I, Garg P, Zhang Y, Vermglinchan V, Lan F, Gu M, Gong T, Zhuge Y, He C, Ebert AD, Sanchez-Freire V, Churko J, Hu S, Sharma A, Lam CK, Scheinman MM, Bers DM, Wu JC.Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell–Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome. Journal of the American College of Cardiology. 2016,68(19):2086-2096.SCI
12. Li H, Jiang W, Ren W, Guo D, Guo J, Wang X, Liu Y, Lan F, Du J, Zhang H.Downregulation of the Yes-Associated Protein Is Associated with Extracellular Matrix Disorders in Ascending Aortic Aneurysms. Stem Cells Int. 2016,N:N.SCI
13. Hu W#, Lu H, Wang S, Yin W, Liu X, Dong L, Chiu R, Shen L, Lu W, Lan F*.Suppression of Nestin Reveals a Critical Role for p38-EGFR Pathway in Neural Progenitor Cell Proliferation. oncotarget. 2016,7(52):87052-87063.SCI
14. Jiang W, Lan F*, Zhang H*.Human Induced Pluripotent Stem Cell Models of Inherited Cardiovascular Diseases. Curr Stem Cell Res Ther. 2016,11(7):533-547.SCI
15. Chao MP#, Gentles AJ, Chatterjee S, Lan F, Reinisch A, Corces MR, Xavy S, Shen J, Haag D, Chanda S, Sinha R, Morganti RM, Nishimura T, Ameen M, Wu H, Wernig M, Wu JC*, Majeti R*.Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease. cell stem cell. 2016,20(3):329-344.SCI
16. Huang C, Guo D, Lan F, Zhang H, Luo J.Noninvasive measurement of regional pulse wave velocity in human ascending aorta with ultrasound imaging: an in-vivo feasibility study. Journal of Hypertension. 2016,34(10):2026-2037.SCI
17. Gong M, Ma WG, Guan XL, Wang LF, Li JC, Lan F, Sun LZ, Zhang HJ.Moderate hypothermic circulatory arrest in total arch repair for acute type A aortic dissection: clinical safety and efficacy. Journal of thoracic disease. 2016,8(5):925.SCI
18. Liu O, Xie W, Qin Y, Jia L, Zhang J, Xin Y, Guan X, Li H, Gong M, Liu Y, Wang X, Li J, Lan F, Zhang H.MMP-2 gene polymorphisms are associated with type A aortic dissection and aortic diameters in patients. Medicine (Baltimore). 2016,95(42):N.SCI
19. Liang P, Sallam K, Wu H, Li Y, Itzhaki I, Garg P, Zhang Y, Vermglinchan V, Lan F, Gu M, Gong T, Zhuge Y, He C, Ebert AD, Sanchez-Freire V, Churko J, Hu S, Sharma A, Lam CK, Scheinman MM, Bers DM, Wu JC.Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell–Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome. Journal of the American College of Cardiology. 2016,68(19):2086-2096.SCI
20. Guan X, Li J, Gong M, Lan F, Zhang H.The hemostatic disturbance in patients with acute aortic dissection: A prospective observational study. Medicine. 2016,95(36):N.SCI
21. Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang Y, Bers DM, Wu JC.Epigenetic regulation of phosphodiesterases 2A and 3A underlies compromised β-adrenergic signaling in an iPSC model of dilated cardiomyopathy. Cell Stem Cell. 2015,17(1):89-100.SCI
22. Sanchez-Freire V#, Lee AS, Hu S, Abilez OJ, Liang P, Lan F, Huber BC, Ong SG, Hong WX, Huang M, Wu JC*.Effect of human donor cell source on differentiation and function of cardiac induced pluripotent stem cells.. Journal of the American College of Cardiology. 2014,64（5）:436-448.SCI
23. Wang Y#, Liang P#, Lan F# (Co-first author), Wu H#, Lisowski L, Gu M, Hu S, Kay M, Urnov F, Shinnawi R, Gold J, Gepstein L, Wu J*.Genome Editing of Isogenic Human Induced Pluripotent Stem Cells Recapitulates Long QT Phenotype. Journal of the American College of Cardiology. 2014,64（5）:451-459.SCI
24. Ebert AD, Kodo K, Liang P, Wu H, Huber BC, Riegler J, Churko J, Lee J, de Almeida P, Lan F, Diecke S, Burridge PW, Gold JD, Mochly-Rosen D, Wu JC*.Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system. Science Translational Medicine. 2014,6:255.SCI
25. Liang P#, Lan F# (Co-first author) , Lee AS#, Gong T, Sanchez-Freire V, Wang Y, Nguyen PK , Bers DM, Robbins RC, Wu JC*.Drug Screening Using a Library of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveals Disease Specific Patterns of Cardiotoxicity . Circulation. 2013,127:1677-1691.SCI
26. Lan F#, Lee AS#, Liang P#, Sanchez-Freire V, Nguyen PK , Wang L, Han L, Yen M, Wang Y, Sun N, Abilez OJ, Navarrete EG, Wheeler M, Lewis R, Yamaguchi Y, Ashley EA, Bers DM, Robbins RC, Longaker MT, Wu JC*.Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells. . Cell Stem Cell. 2013,12:101-113.SCI
27. Hu S#, Wilson K., Ghosh Z, Han L, Wang Y, Lan F, Ransohoff KJ, and Wu JC*.MicroRNA-302 Increases Reprogramming Efficiency via Repression of NR2F2.. Stem Cells. 2013,31(2):259-268.SCI
28. Wang Y#, Zhang WY, Hu S, Lan F, Lee AS, Huber B, Lisowski L, Liang P, Huang M, de Almeida PE, Won JH, Sun N, Robbins RC, Kay MA, Urnov FD, Wu JC*.Genome editing of human embryonic stem cells and induced pluripotent stem cells with zinc finger nuclease for cellular imaging.. Circulation Research. 2012,126:S20-28.SCI
29. Lan F#, Liu J#, Narsinh KH, Hu S, Han L, Lee AS, Karow M, Nguyen PK, Nag D, Calos MP, Robbins RC, Wu JC*.Safe genetic modification of cardiac stem cells using a site-specific integration technique. Circulation. 2012,126:S20-28.SCI
30. Liu J#, Narsinh KH#, Lan F# (Co-first author), Wang L, Nguyen PK, Hu S, Lee A, Han L, Gong Y, Huang M, Nag D, Rosenberg J, Chouldechova A, Robbins RC, Wu JC*..Early stem cell engraftment predicts late cardiac functional recovery: Preclinical insights from molecular imaging. Circulation: Cardiovascular Imaging. 2012,5:481-490.SCI
31. Nguyen PK#, Lan F, Wang Y, Wu JC*.Imaging: Guiding the clinical translation of cardiac stem cell therapy. Circulation Research. 2011,109:962-979.SCI
32. Karow M#, Chavez CL, Farruggio AP, Geisinger JM, Keravala A, Jung WE, Lan F, Wu JC, Chen-Tsai Y, Calos MP*..Site-specific recombinase strategy to create induced pluripotent stem cells efficiently with plasmid DNA. Stem Cells. 2011,29:1686-1704.SCI
33. Lu WJ#, Lee NP, Kaul SC, Lan F, Poon RT, Wadhwa R, Luk JM*.Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy. Cell Death Differentiation. 2011,18:1046-1056.SCI
34. Hu S#, Huang M, Nguyen PK, Gong Y, Li Z, Jia F, Lan F, Liu J, Nag D, Robbins RC, Wu JC*.Novel microrna prosurvival cocktail for improving engraftment and function of cardiac progenitor cell transplantation. Circulation. 2011,124:S27-34.SCI
35. Lee AS#, Xu D#, Plews JR, Nguyen PK, Nag D, Lyons JK, Han L, Hu S, Lan F, Liu J, Huang M, Narsinh KH, Long CT, de Almeida PE, Levi B, Kooreman N, Bangs C, Pacharinsak C, Ikeno F, Yeung AC, Gambhir SS, Robbins RC, Longaker MT, Wu JC*..Preclinical derivation and imaging of autologously transplanted canine induced pluripotent stem cells.. The Journal of Biological Chemistry. 2011,286:32697-32704.SCI
36. Pearl JI#, Lee AS, Leveson-Gower DB, Sun N, Ghosh Z, Lan F, Ransohoff J, Negrin RS, Davis MM, Wu JC*. .Short-term immunosuppression promotes engraftment of embryonic and induced pluripotent stem cells. Cell Stem Cell. 2011,8:309-317.SCI
37. Lu WJ#, Lan F# (Co-first author), He Q#, Lee A, Tang CZ, Dong L, Lan B, Ma X, Wu JC, Shen L*.Inducible expression of stem cell associated intermediate filament nestin reveals an important role in glioblastoma carcinogenesis.. International Journal of Cancer. 2011,128:343-351.SCI
38. Lu WJ#, Lee NP, Kaul SC, Lan F, Poon RT, Wadhwa R, Luk JM*.Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin.. International Journal of Cancer. 2011,129(8):1696-1704.SCI
39. Dong L#, Qi N, Ge RM, Cao CL, Lan F, Shen L*.Overexpression of cd133 promotes the phosphorylation of erk in u87mg human glioblastoma cells.. Neuroscience letters. 2010,484(3):210-214.SCI
40. Li Y#, Zhao H#, Lan F# (Co-first author), Lee A, Chen L, Lin C, Yao Y, Li L*.Generation of human-induced pluripotent stem cells from gut mesentery-derived cells by ectopic expression of oct4/sox2/nanog. Cellular Reprogramming. 2010,12(3):237-247.SCI
41. Lan F#, Ma X, Liu Y, Shen L*.Adenovirus-mediated ctla4ig gene transfer improves the survival of grafted human hepatic progenitors in mouse liver. Transplantation proceedings. 2009,41(5):1862-1864.SCI
42. Lan F#, Xu J#, Zhang X, Wong VW, Li X, Lu A, Lu W, Shen L, Li L*..Hepatocyte growth factor promotes proliferation and migration in immortalized progenitor cells. Neuroreport. 2008,19:765-769.SCI
43. He Q#, Liu Z, Jia B, Li X, Shi J, Zhang J, Lan F, Yang Z, Liu Y, Shen L, Wang F*..In vivo gamma imaging of the secondary tumors of transplanted human fetal striatum neural stem cells-derived primary tumor cells.. Neuroreport. 2008,19:1009-1014.SCI
主编或副主编的著作/译著
重要奖项
1. 国家自然科学基金优秀青年基金 国家级 201409