姓名：杜杰 性别：男 职称：教授 招生院所：附属安贞医院 招生类型：科学学位(博) 科学学位(硕) 招生专业：内科学（心血管病）(博) 内科学（心血管病）(硕) 研究方向名称：心血管病因学和病理生理学 电子信箱：jiedubj@126.com


社会任职
1. 中国国家自然科学基金委员会二审专家
2. 多项科研项目基金评审专家：American Heart Association，Lipid and Atherosclerosis Study Section，Regular Member等
3. 多种国际心血管学术期刊审稿人：Circulation，Circulation Research，Atherosclerosis Thrombus Vascular Biology等
4. 担任Arteriosclerosis, Thrombosis, and Vascular Biology 副主编，Cardiovascular Toxicology副主编，Cardiovascular Research副主编，Cardiovascular Drugs and Therapy编委，Frontiers in Vascular Physiology编委
5. Cardiovascular Drugs and Therapy编委，《中华分子心脏病学》副主编，《中国动脉硬化杂志》 、 《临床心血管病杂志》 、 《心肺血管疾病杂志》 、 《中华高血压杂志》和《转化医学杂志》编委
个人简历
1. 198109-198507:北京大学 大学学习
2. 198509-198907:中国农科院生物技术研究中心 硕士、博士学习
3. 1989-1992:美国德克萨斯州A&M大学 博士后研究助理
4. 1992-1995:Emory大学医学院心脏病科 博士后
5. 1995-1998:Emory大学医学院心脏病科 医学讲师
6. 1998-2001:Emory大学医学院肾脏病科 Assistant Professor
7. 2001-2002:堪萨斯大学医学中心心血管科 Associate Professor
8. 2002-2005:美国德克萨斯州大学加尔维斯敦分校 Associate Professor
9. 2005-2008:Baylor College of Medicine Associate Professor
重要学术论文
1. Qiao B#, Nie J-J#, Shao Y, Li Y, Zhang C, Hao W, Li S, Chen D, Yu B, Li H*, Xu F-J*, Du J*..Functional Nanocomplexes with Vascular Endothelial Growth Factor A/C Isoforms Improve Collateral Circulation and Cardiac Function. Small.. 2020,16(4):e**.SCI
2. Qiu S, Liu T, Piao C, Wang Y, Wang K, Zhou Y, Cai L, Zheng S, Lan F*, Du J*.AMPKα2 knockout enhances tumour inflammation through exacerbated liver injury and energy deprivationassociated AMPKα1 activation. J Cell Mol Med. 2019,23(3):1687-1697.SCI
3. Xu C, Zhang Y, Xu K, Nie JJ, Yu B, Li S, Cheng G, Li Y*, Du J*, Xu FJ*.Multifunctional cationic nanosystems for nucleic acid therapy of thoracic aortic dissection. Nat Commun. 2019,10(1):3184.SCI
4. Zhang X, Xu C, Gao S, Li P, Kong Y, Li T, Li Y*, Xu FJ*, Du J*. .CRISPR/Cas9 Delivery Mediated with Hydroxyl-Rich Nanosystems for Gene Editing in Aorta.. Adv Sci (Weinh). 2019,6(12):**.SCI
5. Zhang J, Qu C, Li T, Cui W, Wang X, Du J*..Phagocytosis mediated by scavenger receptor class BI promotes macrophage transition during skeletal muscle regeneration. J Biol Chem. 2019,294(43):15672-15685.SCI
6. You H, Jiang W, Jiao M, Wang X, Jia L, You S, Li Y, Wen H, Jiang H, Yuan H, Huang J, Qiao B, Yang Y, Jin M*, Wang Y*, Du J*..Association of Soluble ST2 Serum Levels With Outcomes in Pediatric Dilated Cardiomyopathy.. Can J Cardiol. 2019,35(6):727-735.SCI
7. Zhi Y, Xu C, Sui D, Du J*, Xu FJ*, Li Y*. .Effective Delivery of Hypertrophic miRNA Inhibitor by Cholesterol-Containing Nanocarriers for Preventing Pressure Overload Induced Cardiac Hypertrophy. Adv Sci (Weinh). 2019,6(11):**.SCI
8. Li Y*, Chen B, Yang X, Zhang C, Jiao Y, Li P, Liu Y, Li Z, Qiao B, Bond Lau W, Ma XL*, Du J*..S100a8/a9 Signaling Causes Mitochondrial Dysfunction and Cardiomyocyte Death in Response to Ischemic/Reperfusion Injury.. Circulation. 2019,140(9):751-764.SCI
9. Liu C, Zhang C, Jia L, Chen B, Liu L, Sun J, Zhang W, You B, Li YL, Li ping, Du J*..Interleukin 3 stimulates matrix metalloproteinase 12 production from macrophages promoting thoracic aortic aneurysm/dissection.. Clin Sci (Lond). 2018,132(6):655-668.SCI
10. Nie J, Qiao B, Duan S, Xu C, Chen B, Hao W, Yu B, Li Y*, Du J*, Xu F*..Unlockable nanocomplexs with self-acctlerating nucleic acid release for effective staged gene therapy of cardiovascular disease. Adv Mater. 2018,30(31):570-581.SCI
11. Wang Y, Tan X, Gao H, Yuan H, Hu R, Jia L, Zhu J, Sun L, Zhang H, Huang L, Zhao D, Gao P* and Du J*.Magnitude of Soluble ST2 as a Novel Biomarker for Acute Aortic Dissection. Circulation. 2018,137（3）:259-269.SCI
12. Ke Xu, Chen Xu, Yanzhenzi Zhang, Feiran Qi, Bingran Yu, Ping Li, Lixin Jia, Yulin Li, Fu-jian Xu*, Jie Du*. Identification of type IV collagen exposure as a molecular imaging target for early detection of thoracic aortic dissection. Theranostics. 2018,8(2):437-449.SCI
13. Lei Wang, Yun-Long Zhang, Qiu-Yue Lin, Yu Liu, Xu-Min Guan, Xiao-Lei Ma, Hua-Jun Cao, Ying Liu, Jie Bai, Yun-Long Xia, Jie Du*, and Hui-Hua Li*.CXCL1-CXCR2 axis mediates angiotensin II-induced cardiac hypertrophy and remodelling through regulation of monocyte infiltration. Eur Heart J. 2018,39（20）:1–14 .SCI
14. Zhang C, Wang C, Li Y, Miwa T, Liu C, Cui W, Song WC, Du J* .Complement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking. Nat Commun. 2017,8(1):2078.SCI
15. Jia L, Zhang W, Ma Y, Chen B, Liu Y, Piao C, Wang Y, Yang M, Liu T, Zhang J, Li T, Nie S* and Du J*.Haplodeficiency of Ataxia Telangiectasia Mutated Accelerates Heart Failure After Myocardial Infarction. J Am Heart Assoc. 2017,6(7) :01.SCI
16. Li YL, Li ZY, Zhang CC, Li P, Wu YN, Wang CX, Bond Lau W, Ma XL*, Du J* .Cardiac fibroblast-specific activating transcription factor 3 protects against heart failure by suppressing map2k3-p38 signaling. Circulation. 2017,135(21):2041- 2057.SCI
17. Wang C, Zhang C, Liu L, A X, Chen B, Li Y, Du J*.Macrophage-Derived mir-155-Containing Exosomes Suppress Fibroblast Proliferation and Promote Fibroblast Inflammation during Cardiac Injury. Mol Ther. 2017,25(1):192-204.SCI
18. Cai L, Xu S, Piao C, Qiu S, Li H, Du J*.Adiponectin induces CXCL1 secretion from cancer cells and promotes tumor angiogenesis by inducing stromal fibroblast senescence. Mol Carcinog. 2016,55(11):1796-1806.SCI
19. Li RQ, Wu Y, Zhi Y, Yang X, Li Y*, Xua FJ*, Du J*.PGMA-Based Star-Like Polycations with Plentiful Hydroxyl Groups Act as Highly Efficient miRNA Delivery Nanovectors for Effective Applications in Heart Diseases. Adv Mater. 2016,28(33):7204-12.SCI
20. Piao C, Zhu Y, Zhang C, Xi X, Liu X, Zheng S, Li X, Guo J, Jia L, Nakanishi T, Cai T, Gu H*, Du J*.Identification of multiple ACVRL1 mutations in patients with pulmonary arterial hypertension by targeted exome capture. Clin Sci (Lond). 2016,130(17):1559-69.SCI
21. Kan X, Wu Y, Ma Y, Zhang C, Li P, Wu L, Zhang S, Li Y, Du J*.Deficiency of IL-12p35 improves cardiac repair after myocardial infarction by promoting angiogenesis. Cardiovasc Res. 2016,109(2):249-59.SCI
22. Li TT, Li XY, Jia LX, Zhang J, Zhang WM, Li YL, Qi YF, Du J*.Whole Transcriptome Analysis of Hypertension Induced Cardiac Injury Using Deep Sequencing. Cell Physiol Biochem. 2016,38(2):670-82.SCI
23. Zhang WM, Liu Y, Li TT, Piao CM, Liu O, Liu JL, Qi YF, Jia LX, Du J*.Sustained activation of ADP/P2ry12 signaling induces SMC senescence contributing to thoracic aortic aneurysm/dissection. J Mol Cell Cardiol. 2016,99:76-86.SCI
24. Peng X, Xiao Z, Zhang J, Li Y, Dong Y, Du J*.Il-17a produced by both gammadelta t and th17 cells promotes renal fibrosis via rantes-mediated leukocyte infiltration after renal obstruction. The Journal of pathology. 2015,235(1):79-89.SCI
25. Jia LX, Zhang WM, Zhang HJ, Li TT, Wang YL, Qin YW, Gu H*, Du J*.Mechanical stretch-induced endoplasmic reticulum stress, apoptosis and inflammation contribute to thoracic aortic aneurysm and dissection. The Journal of pathology. 2015,236(3):373-383.SCI
26. Qiu S, Xiao Z, Piao C, Zhang J, Dong Y, Cui W, Liu X, Zhang Y, Du J*.AMPKα2 reduces renal epithelial transdifferentiation and inflammation after injury through interaction with CK2β. J Pathol. 2015,237(3):330-42.SCI
27. Wu Y, Li Y, Zhang C, A X, Wang Y, Cui W, Li H, Du J*.S100a8/a9 released by CD11b+Gr1+ neutrophils activates cardiac fibroblasts to initiate angiotensin II-Induced cardiac inflammation and injury. Hypertension. 2014,63(6):1241-1250.EI
28. Li Y, Wu Y, Zhang C, Li P, Cui W, Hao J, Ma X, Yin Z, Du J*.γδT Cell-derived interleukin-17A via an interleukin-1β-dependent mechanism mediates cardiac injury and fibrosis in hypertension. Hypertension. 2014,64(2):305-314.SCI
29. Peng X, Xiao Z, Zhang J, Li Y, Dong Y, Du J*.IL-17A produced by both γδ T and Th17 cells promotes renal fibrosis via RANTES-mediated leukocyte infiltration after renal obstruction. J Pathol. 2014,235(1):79-89.SCI
30. Yang M, Shao JH, Miao YJ, Cui W, Qi YF, Han JH, Lin X, Du J*.Tumor cell-activated CARD9 signaling contributes to metastasis-associated macrophage polarization. Cell Death Differ. 2014,21(8):1290-1302.SCI
31. Ren J, Yang M, Qi G, Zheng J, Jia L, Cheng J, Tian C, Li H, Lin X and Du J* .Proinflammatory Protein CARD9 is Essential for Infiltration of Monocytic Fibroblast Precursors and Cardiac Fibrosis Caused by Angiotensin II Infusion. American Journal Hypertension.. 2011,24（6）:701-7.SCI
32. Zhang Y, Zeng Y, Wang M, Tian C, Ma X, Chen H, Fang Q, Jia L, Du J*, and Li H*. .Cardiac-specific overxpression of E3 ligase Nrdp1 increases ischemia and reperfusion-induced cardiac injury. Basic Res Cardiol.. 2011,106（3）:371-83.SCI
33. Zhang LP Wang XH, Wang H, Du J* Mitch WE.Satellite Cell Dysfunction and Impaired IGF-1 Signaling Cause CKD-Induced Muscle Atrophy. J Am Soc Nephrol. 2010,21(3):419-427.SCI
34. Wu X, Cheng J, LiP Yang M, Qiu S, Liu P, Du J*.Mechano-Sensitive Transcriptional Factor Egr-1 Regulates Insulin-Like Growth Factor-1 Receptor Expression and Contributes to Neointima Formation in Vein Grafts. Arteriosclerosis, Thrombosis, Vasc, Biol.. 2010,30(3):471-476.SCI
35. Haudek SB, Cheng J, Du J, Wang Y, Hermosillo-Rodriguez J, Trial J, Taffet GE, Entman ML..Monocytic fibroblast precursors mediate fibrosis in angiotensin-II-induced cardiac hypertrophy.. J Mol Cell Cardiol.. 2010,49（3）:499-507.SCI
36. Qin YW, Ye P, He JQ, Sheng L, Wang LY, DU J*.Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a "Western-style diet" by increasing PPAR α and γ expression and reducing TC, MMP-9, and Cat S levels. Acta Pharmacol Sin. 2010,31（10）:1350-8.SCI
37. Wang, X, Zhang, L., Mitch, W.E., LeDoux, J.M., Hu, J., Du J*..Caspase-3 cleaves specific 19S proteasome regulatory subunits in skeletal muscle stimulating proteasome activity. J Biol Chem . 2010,285（28）:21249-57.SCI
38. Zhang LP, Du J*, Delafontaine and Mitch WE. IL-6 and serum amyloid A synergy mediates angiotensin II-induced muscle wasting. . J Am Soc Nephrol. 2009,20（3）:604-12.SCI
39. Zhang LP, Ran LM, Garcia G, Wang XN, Han SH, Du J* and Mitch WE.Chemokine CXCL16 Regulates Neutrophil and Macrophage Infiltration into Injured Muscle Promoting Muscle Regeneration. American J Pathology. 2009,175(6):2518-2527.SCI
40. Wang XH, Du J, Klein J, Baiely J and Mitch WE.Exercise ameliorates chronic kidney disease-induced defects in muscle protein metabolism and progenitor cell function . Kidney International. 2009,76(7):751-759.SCI
41. Wang X, Hu Z, Du J, Klein J*.Cardiac muscle protein catabolism in diabetes mellitus: activation of the ubiquitin-proteasome system by insulin deficiency. Endocrinology. 2008,149(11):5384-5390.SCI
42. Zhu Q, Youn H, Tang J, Tawfik O, Dennis K, Terranova PF, Du J, Raynal P, Thrasher JB, Li B* .Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers. Oncogene. 2008,27(33):4569-4579.SCI
43. Cheng J,Zhang J,Merched A,Zhang L,Zhang P,Troung L Boriek AM,Du J*.Mechanical stretch inhibits oxidized low density lipoprotein-induced apoptosis in vascular smooth muscle cells by up-regulating integrin alphavbeta3 and stablization of PINCH-1. J Biol Chem. 2007,282(47):34268-34275.SCI
44. Cheng JZ, Cui RW, Chen C, Du J*.Oxidized low-density lipoprotein stimulates p53-dependent activation of proapoptotic Bax leading to apoptosis of differentiated endothelial progenitor cells. Endocrinology. 2007,148(5):2085-2094.SCI
45. Hu Z, Lee IH, Wang X, Sheng H, Zhang L, Du J and Mitch WE*.PTEN expression contributes to the regulation of muscle protein degradation in diabetes. Diabetes. 2007,56(10):2449-2456.SCI
46. Cheng JZ, Du J*.Mechanical stretch simulates proliferation of venous smooth muscle cells through activation of the insulin-like growth factor-1 receptor. Arteriosclerosis, Thrombosis, Vasc. Biol. 2007,27(8):1744-1751.SCI
47. Workeneh BT, Rondon-Berrios H, Zhang L, Hu Z, Ayehu G, Ferrando A, Kopple JD, Wang H, Storer T, Fournier M, Lee SW, Du J, Mitch WE*.Development of a Diagnostic Method for Detecting Increased Muscle Protein Degradation in Patients with Catabolic Conditions. J Am Soc Nephrol. 2006,17(11):3233-3239.SCI
48. Ma Y, Zhang L, Peng T, Cheng J, Taneja S, Zhang J, Delafontaine P, Du J*.Angiotensin II stimulates transcription of insulin-like growth factor I receptor in vascular smooth muscle cells: role of nuclear factor-kappaB. Endocrinology. 2006,147(3):1256-1263.SCI
49. Wang X, Hu J, Hu Z, Du J and Mitch WE*.Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling. Endocrinology. 2006,147(9):4160-4168.SCI
50. Du J, Hu Z, Mitch WE*.Molecular mechanisms activating muscle protein degradation in chronic kidney disease and other catabolic conditions. J Clin Invest. 2005,35(3):157-163.SCI
51. Zhang L, Cheng J, Ma Y, Thomas W, Zhang J, Du J*.Dual pathways for nuclear factor kappaB activation by angiotensin II in vascular smooth muscle: phosphorylation of p65 by IkappaB kinase and ribosomal kinase. Circ Res. 2005,97(10):975-982.SCI
52. Zhang L, Ma Y, Zhang J, Cheng J and Du J* .A New Cellular Signaling for Angiotensin II Activation of NF-kB: an IkB-independent, RSK-mediated Phosphorylation of p65. Arteriosclerosis, Thrombosis, Vasc，Biol. 2005,25(6):1148-1153.SCI
53. Zhang L, Cui R, Cheng X, Du J*.Anti-apoptotic Effect of Serum and Glucocorticoid-Inducible Protein Kinase is Mediated by Activating Nuclear Transcription Factor kB. Cancer Res. 2005,65(2):457-464.SCI
54. Song Y, Li Y, Du J, Mitch WE*.Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting . J Clin Invest. 2005,115(2):451-458.SCI
主编或副主编的著作/译著
重要奖项