姓名：申阿东 性别：女 职称：研究员、教授 招生院所：附属儿童医院 招生类型：科学学位(博) 科学学位(硕) 招生专业：儿内科学(博) 儿内科学(硕) 研究方向名称：儿童呼吸感染性疾病诊断及免疫机制研究，儿童结核病耐药、诊疗及发病机制研究 电子信箱：shenad16@hotmail.com


社会任职
1. 中国防痨协会结核病基础医学专业分会委员
2. 中国防痨协会结核病转化医学专业分会委员
3. 中国微生物学会人兽共患病病原学专业委员会委员
4. 中国微生物学会人兽共患病病原学专业委员会儿童病原学组组长
5. 首届中国研究型医院学会儿科学专业委员会常务委员
6. 中华医学会儿科分会呼吸学组精准医学协作组组长
7. 中国医师协会呼吸医师分会儿科呼吸工作委员会副主任委员
8. 中国防痨协会儿童与学校结核病防控专业委员会副主任委员
9. 中华医学会结核病学分会儿童结核病专业委员会主任委员
10. 中国医药生物技术协会生物诊断技术分会第三届委员会 常委
11. 中国医药生物技术协会生物诊断技术分会特殊病原学组 副组长
12. 中国医药生物技术协会生物诊断技术分会第三届委员会 常务委员
个人简历
1. 197909-198207:山东滨州医学院医疗系 学生
2. 198909-199206:首都医科大学附属北京儿童医院 研究生学习
3. 199207-:首都医科大学附属北京儿童医院 研究实习员、助理研究员、副研究员、研究员
重要学术论文
1. M. Wang, F. Liu, Q. Li, Q. Yin, A. Shen.Quality assessment of guidelines for the management of Mycobacterium tuberculosis infection in children. International Journal of Tuberculosis and Lung Disease. 2020,24(3):287-294.SCI
2. Li Jieqiong#, Sun Lin#, Wu Xirong, Guo Yan, Jiao Weiwei, Xiao Jing, Xu Baoping* and A-Dong Shen*.Early Diagnosis of Mycoplasma pneumoniae in Children: Simultaneous Amplification and Testing (SAT) Is the Key.. Frontiers in Pediatrics. 2019,7:441.SCI
3. Sun L#, Zhang L#, Wang T, Jiao W, Li Q, Yin Q, Li J, Qi H, Xu F, Shen C, Xiao J, Liu S, Mokrousov I*, Huang H*, Shen A*.Mutations of Mycobacterium tuberculosis induced by anti-tuberculosis treatment result in metabolism changes and elevation of ethambutol resistance. Infect Genet Evol. 2019,72:151-158.SCI
4. Jiao WW, Wang Y, Wang GR, Wang YC, Xiao J, Sun L, Li JQ, Wen SA, Zhang TT, Ma Q, Huang HR*, Shen AD*.Development and clinical validation of multiple cross displacement amplification combined with nanoparticles-based biosensor for detection of Mycobacterium tuberculosis: preliminary results.. Front Microbiol. 2019,10:2135.SCI
5. Yacui Wang, Yi Wang, shuting Quan, Jiao Weiwei, Jieqiong Li, Sun Lin, Yonghong Wang, xue Qi, xingyun Wang, A-Dong Shen*.Establishment and Application of a Multiple Cross Displacement Amplification Coupled With Nanoparticle-Based Lateral Flow Biosensor Assay for Detection of Mycoplasma pneumoniae.. Frontiers in Cellular and Infection Microbiology. 2019,9:325.SCI
6. Qi H#, Kou C#, Qi YJ#, Tang BH, Wu YE, Jin F, Luo XJ, Shen YH, Guo YJ, Qi X, Wang YC, Dong Q, Chen XK, Shi HY, Zheng Y, Zhao W*, Shen AD*.Population pharmacokinetics and dosing optimization of latamoxef in neonates and young infants. Int J Antimicrob Agents. 2019,53(3):347-351.SCI
7. Lin Sun, Xue Qi, Fang Liu, Xirong Wu, Qingqin Yin, Yan Guo, Baoping Xu, Anxia Jiao, Yajie Guo, Weiwei Jiao, Chen Shen, Jing Xiao, Adong Shen*.A Test for more accurate diagnosis of pulmonary Tuberculosis.. Pediatrics. 2019,144(5):e**.SCI
8. Wang Y, Sun L, Li JQ, Wang ZM, Jiao WW, Xiao J, Shen C, Xu F, Qi H, Wang YH, Guo YJ, Shen AD*..Detection of Nucleic Acids and Prevention of Carryover Contamination Using Cross-Priming Amplification Combined with Nanoparticles-Based Biosensor and Antarctic Thermal Sensitive Uracil-DNA-Glycosylase.. J Biomed Nanotechnol. 2019,15（5）:878-892.SCI
9. Zheng Y#, Liu SP#, Xu BP, Shi ZR, Wang K, Yang JB, Huang X, Tang BH, Chen XK, Shi HY, Zhou Y, Wu YE, Qi H, Jacqz-Aigrain E, Shen AD*, Zhao W*.Population Pharmacokinetics and Dosing Optimization of Azithromycin in Children with Community-Acquired Pneumonia . Antimicrob Agents Chemother. 2018,62(9):pii:AAC.00686-18.SCI
10. Yingjia Li#, Haijing Tang#, Hui Qi, Chen Shen, Lin Sun, Jieqiong Li, Fang Xu, Weiwei Jiao, Xu Yang, Adong Shen*.rs** of the IL6 gene is associated with increased risk for antituberculosis drug-induced hepatotoxicity in Chinese Han children. Tuberculosis. 2018,111:71-77.SCI
11. Sun L, Zhang L, Wang T, Jiao W, Li Q, Yin Q, Li J, Qi H, Xu F, Shen C, Xiao J, Liu S, Mokrousov I, Huang H, Shen A*.Mutations of Mycobacterium tuberculosis Induced by Anti-Tuberculosis Treatment Result in Metabolism Changes and Elevation of Ethambutol Resistance. Infect Genet Evol. 2018,S1567-1348(18):30759-30767.SCI
12. Shu-Ping Liu#, Yi Zheng, Xi-Rong Wu, Bao-Ping Xu, Xiu-Yun Liu, Guo-Shuang Feng, Lin Sun, Chen Shen, Jie-qiong Li, Bo-Hao Tang, Evelyne Jacqz-Aigrain, Wei Zhao*, A-Dong Shen* .Early Target Attainment of Azithromycin Therapy in Children with Lower Respiratory Tract Infections. Journal of Antimicrobial Chemotherapy. 2018,73(10):2846-2850.SCI
13. Wang T, Dong F, Li QJ, Yin QQ, Song WQ, Mokrousov I, Jiao WW*, Shen AD*.Clinical and Drug Resistance Characteristics of New Pediatric Tuberculosis Cases in Northern China . Microb Drug Resist . 2018,24(9):1397-1403.SCI
14. Qi H#, Zhang YB#, Sun L#, Chen C#, Xu B, Xu F, Liu JW, Liu JC, Chen C, Jiao WW, Shen C, Xiao J, Li JQ, Guo YJ, Wang YH, Li QJ, Yin QQ, Li YJ, Wang T, Wang XY, Gu ML, Yu J, Shen AD* .Discovery of Susceptibility Loci Associated with Tuberculosis in Han Chinese . Human Molecualr Genetics. . 2017,26(23):4752-4763.SCI
15. Li QJ#, Jiao WW#, Yin QQ, Li YJ, Li JQ, Xu F, Sun L, Xiao J, Qi H, Wang T, Mokrousov I, Huang HR, Shen AD.Positive epistasis of major low-cost drug resistance mutations rpoB531-TTG and katG315-ACC depends on the phylogenetic background of Mycobacterium tuberculosis strains . Int J Antimicrob Agents. 2017,49(6):757-762.SCI
16. Li J, Sun L, Xu F, Qi H, Shen C, Jiao W, Xiao J, Li Q, Xu B, Shen A* .Screening and identification of APOC1 as a novel potential biomarker for differentiate of mycoplasma pneumoniae in children . Front Microbiol . 2016,7:1961.SCI
17. Li QJ, Jiao WW, Yin QQ, Xu F, Li JQ, Sun L, Xiao J, Li YJ, Mokrousov I, Huang HR, Shen AD*.Compensatory Mutations of Rifampin Resistance Are Associated with Transmission of Multidrug-Resistant Mycobacterium tuberculosis Beijing Genotype Strains in China. Antimicrob Agents Chemother. 2016,60(5):2807-2812.SCI
18. Yin QQ, Jiao WW, Li QJ, Xu F, Li JQ, Sun L, Li YJ, Huang HR*, Shen AD*.Prevalence and molecular characteristics of drug-resistant Mycobacterium tuberculosis in Beijing, China: 2006 versus 2012. BMC Microbiol. 2016,16(1):85.SCI
19. Xie Z, Wang X, Sun L, Liu J, Guo Y, Xu B, Zhao L*, Shen A* .Appraisal of clinical practice guidelines on community-acquired pneumonia inchildren with AGREE II instrument. BMC Pediatr. 2016,16:119.SCI
20. Shen C, Li YJ, Yin QQ, Jiao WW, Li QJ, Xiao J, Sun L, Xu F, Li JQ, Qi H, Shen AD*.Identification of differentially expressed transcripts targeted by the knockdown of endogenous IFITM3. Mol Med Rep. 2016,14(5):4367-4373.SCI
21. Qing-qin Yin#, Hai-can Liu#, Wei-wei Jiao#, Qin-jing Li, Rui Han, Jian-ling Tian, Zhi-guang Liu, Xiu-qin Zhao, Ying-jia Li, Kang-lin Wan*, A-dong Shen* & Igor Mokrousov*.Evolutionary History and Ongoing Transmission of Phylogenetic Sublineages of Mycobacterium tuberculosis Beijing Genotype in China. Scientific Reports. 2016,6:34353.SCI
22. Li J, Qi H, Sun L, Shen C, Jiao W, Xu F, Xiao J, Shen A*.Rs** of SFTPA 1 gene is associated with pediatric tuberculosis in Han Chinese population. Infect Genet Evol. 2016,41:16-20.SCI
23. Li J#, Sun L#, Xu F, Qi H, Shen C, Jiao W, Xiao J, Li Q, Xu B, Shen A* .Screening and identification of APOC1 as a novel potential biomarker for differentiate of mycoplasma pneumoniae in children. Front Microbiol. 2016,7:1961.SCI
24. Sun L#, Li JQ#, Ren N, Qi H, Dong F, Xiao J, Xu F, Jiao WW, Shen C, Song WQ*, Shen AD*.Utility of Novel Plasma Metabolic Markers in the Diagnosis of Pediatric Tuberculosis: A Classification and Regression Tree Analysis Approach. J Proteome Res. 2016,15(9):3118-3125.SCI
25. Shen C, Shen AD*.Identification of a novel transcript of human MD2 gene. Gene. 2016,590(1) :123-127.SCI
26. Jiao WW, Liu ZG, Han R, Zhao XQ, Dong F, Dong HY, Huang HR, Li QJ, Lin N, Song WQ, Wan KL, Shen AD*.Prevalence of drug resistant Mycobacterium tuberculosis among children in China. Tuberculosis. 2015,95(3):315-320.SCI
27. 申晨, 张晨光, 申阿东*.IFITM3真核表达载体的构建和细胞内定位研究. 标记免疫分析与临床. 2012,19(1):39-43.核心期刊
28. Lin Sun,# Jing Xiao#, Qing Miao, Wei-xing Feng, Xi-rong Wu, Qing-qin Yin, Wei-wei Jiao, Chen Shen,Fang Liu, Dan Shen, and A-dong Shen*.Interferon gamma release assay in diagnosis of active and latent tuberculosis infection in children：a meta-analysis. FEMS Immunol Med Microbiol. 2011,63(2):165-173.SCI
29. 尹青琴, 申阿东*.不同国家y干扰素释放试验临床应用指南. 国际呼吸杂志. 2011,31(21):1663.核心期刊
30. 刘芳,苗青(共同第一), 申阿东.汉族儿童Ⅱ相药物代谢酶基因GSTM1和GSTT1的多态性分布. 中国循证儿科杂志. 2011, 6(3):219.核心期刊
31. 孙琳，肖婧，李惠民，焦伟伟，赵顺英，冯卫星，吴喜荣，苗青，焦安夏，郭雅洁，江载芳，申阿东*.结核菌素皮试和全血γ干扰素测定诊断儿童结核病的准确性研究. 中国循证儿科杂志. 2010,5（2）:176-181.核心期刊
32. 肖婧, 申丹, 刘永革, 张新根, 孙琳, 吴喜蓉, 焦伟伟, 冯卫星, 苗青, 顾艺, 刘芳, 张桂荣, 申阿东*.以流式细胞术建立中国汉族健康儿童外周血淋巴细胞亚群相对计数的正常参考值. 中国循证儿科杂志. 2010,5(4):245-250.核心期刊
33. Xiao J, Sun L, Yan HM, Jiao WW, Miao Q, Feng WX, Wu XR, Gu Y, Jiao AX, Guo YJ, Peng XX, Shen AD*.Metaanalysis of P2X7 gene polymorphisms and tuberculosis susceptibility. FEMS Immunol Med Microbiol. 2010,60:165-170.SCI
34. 吴喜蓉, 申阿东*.SLC11A1基因作用机制及其与结核病易感性的研究. 国际儿科学杂志. 2010,37(5):499-502.核心期刊
35. 冯卫星, 申阿东*.结核病宿主遗传相关基因研究进展. 中国当代儿科杂志. 2010,41(10):911-915.核心期刊
36. 孙琳, 申阿东*.干扰素γ释放试验在结核感染和活动性结核病诊断中的应用. 中国循证儿科杂志. 2010,5(6):469-476.核心期刊
37. 顾艺，肖婧，孙琳，焦伟伟，冯卫星，吴喜荣，申阿东*.P2X7基因多态性与结核病易感性的关联研究——Meta分析. 标记免疫分析与临床. 2010,17（2）:98-101.核心期刊
38. 焦伟伟, 李兆娜, 孙琳, 赵顺英, 李惠民, 焦安夏, 郭雅洁, 江载芳, 申阿东*.维生素D受体基因多态性与中国汉族儿童结核病易感性的研究. 中国实用儿科杂志. 2009,24(4):264-266.核心期刊
39. 李兆娜, 刘梅, 吕冰, 赵秀芹, 刘志广, 焦伟伟, 孙琳, 贾文祥, 申阿东*, 万康林*.不同串联重复序列位点组合用于中国结核分枝杆菌基因分型的能力比较分析. 中华预防医学杂志. 2009,43(3):215-222.核心期刊
40. Jing Jin, Lin Sun, Weiwei Jiao, Shunying Zhao, Huimin Li, Xiaolei Guan, Anxia Jiao, Zaifang Jiang, Adong Shen*.SLC11A1 (formerly NRAMP1) gene polymorphisms associated with Chinese pediatric tuberculosis. Clin Infect Dis. 2009,48(6):733-738.SCI
41. 金婧, 孙琳, 焦伟伟, 赵顺英, 李惠民, 关晓蕾, 焦安夏, 迟巍, 江载芳, 申阿东*.NRAMP1基因多态性与中国汉族儿童结核病易感性研究. 中国当代儿科杂志. 2009,11(4):283-287.核心期刊
42. 焦伟伟, 孙琳, 李兆娜, 顾艺, 孙桂芝, 申阿东*. 等位基因特异多重PCR快速检测结核分枝杆菌异烟肼耐药性研究. 标记免疫分析与临床. 2009,16(1):34-37.核心期刊
43. 孙琳, 焦伟伟, 赵顺英, 李兆娜, 胡英惠, 冯雪莉, 李惠民, 迟巍, 江沁波, 江载芳, 申阿东*.ELISPOT检测技术在儿童结核病诊断中的应用. 标记免疫分析与临床. 2008,15(6):349-353.核心期刊
44. 李墨，焦伟伟，孙桂芝，Igor Mokrousov,郭雅洁，申阿东*.三种基因分型法在北京地区基因型结核分枝杆菌中的应用研究. 中国人兽共患病学报. 2008,24(6):505-509.核心期刊
45. 孙琳, 申阿东*.全血IFN-γ测定试验在结核病诊断中的新进展. 中华检验医学杂志. 2008,31(9):1070-1072.核心期刊
46. 焦伟伟, 申阿东*..结核分枝杆菌基因分型方法研究进展. 国际儿科学杂志. 2008,35(1):6-8.核心期刊
47. 李兆娜, 申阿东*.IL-12在结核病发展过程中的作用. 中国人兽共患病杂志. 2008,24(3):272-275.核心期刊
48. 孙琳, 肖婧, 焦伟伟, 李兆娜, 赵顺英, 李惠民, 焦安夏, 郭雅洁, 江载芳, 申阿东*.P2X7基因多态性与中国汉族儿童结核病易感性的研究. 中国循证儿科杂志. 2008,3(6):438-443.核心期刊
49. Igor Mokrousov, Wei Wei Jiao, Gui Zhi Sun, Jia Wen Liu, Violeta Valcheva, Mo Li, Olga Narvskaya, A Dong Shen*.Evolution of drug resistance in different sublineages of Mycobacterium tuberculosis Beijing genotype.. Antimicrob Agents Chemother. 2006,50(8) :2820-2823.SCI
50. Igor Mokrousov#, Wei Wei Jiao#, Gui Zhi Sun, Jia Wen Liu, Violeta Valcheva, Mo Li, Olga Narvskaya, A Dong Shen*.Evolution of drug resistance in different sublineages of Mycobacterium tuberculosis Beijing genotype.. Antimicrob Agents Chemother. 2006,50(8) :2820-2823.SCI
51. I. Mokrousov, WW Jiao, GZ Sun, JW Liu, M Li, O. Narvskaya, AD Shen*.Evaluation of the rpoB macroarray assay to detect rifampin resistance in Mycobacterium tuberculosis in Beijing, China. Eur J Clin Microbiol Infect Dis. . 2006,25(11):703-710.SCI
主编或副主编的著作/译著
重要奖项
1. 《我国耐药结核病流行状况及关键防治技术的研究》 2015年中华预防医学会科学技术奖 三等奖 201501
2. 北京市“十百千”卫生人才工程专项经费资助 入选十人计划 2011
3. 北京市“十百千”卫生人才工程专项经费资助 入选 2005
4. 获北京市优秀人才培养专项 D类资助 2004
5. 中华医学奖 B组链球菌感染分子流行病学及荚膜多糖结合蛋白疫苗制备研究 二等奖 2004
6. 北京市科技进步 B组链球菌临床分离株的表型和基因型研究 三等奖 2003
7. 北京市“十百千”卫生人才工程专项经费资助 入选 2002
8. 1998年曾获第六届儿科医学奖励基金中青年医学成就个人 一等奖 1998
9. 北京市科技新星计划 1997
10. 北京市科技进步奖 B组链球菌感染和抗血清及试剂盒制备研究 三等奖 1994