姓名：赵明 性别：女 职称：教授 招生院所：药学院 招生类型：科学学位(博) 科学学位(硕) 招生专业：药物化学(博) 药物化学(硕) 研究方向名称：甾体多肽及其缀合物研究 电子信箱：maozhao@126.com


社会任职
1. 北京市药学会理事
2. 承担美国JMC、BMC和欧洲JMC等刊物的审评工作
3. 生物医用材料北京实验室副主任
4. 北京市药学会药物化学专委会
5. 教育部高等学校药学类专业教学指导委员会
6. 全国药学专业学位研究生教育指导委员会专家库专家
个人简历
重要学术论文
1. Guanyu Li, Yi Ren, Xiaoyi Zhang, Shurui Zhao, Yaonan Wang, Jianhui Wu, Shiqi Peng*, Ming Zhao*.13-[CH2CO-Cys-(Bzl)-OBzl]-Berberine: Exploring The Correlation Of Anti-Tumor Efficacy With ROS And Apoptosis Protein. OncoTargets and Therapy. 2019,12:10651—10662 .SCI
2. Jianhui Wu,Yue Cui,Xiaoyi Zhang,Lin Gui,Yaonan Wang,Shiqi Peng,Ming Zhao,*.BCESA: a nano-scaled intercalator capable of targeting tumor tissue and releasing antitumoral β-carboline-3-carboxylic acid. International Journal of Nanomedicine. 2019,14:3027–3041.SCI
3. Shurui Zhao，Ze Li，Fei Huang，Jianhui Wu，Lin Gui，Xiaoyi Zhang，Yaonan Wang，Xiaozhen Wang，Shiqi Peng，Ming Zhao*.Nano-scaled MTCA-KKV: for targeting thrombus,releasing pharmacophores, inhibiting thrombosisand dissolving blood clots in vivo. International Journal of Nanomedicine. 2019,14:4817–4831.SCI
4. Wenchao Liu Yujia Mao Xiaoyi Zhang Yaonan Wang Jianhui Wu Shurui Zhao Shiqi Peng Ming Zhao*.RGDV-modified gemcitabine: a nano-medicine capable of prolonging half-life, overcoming resistance and eliminating bone marrow toxicity of gemcitabine. International Journal of Nanomedicine. 2019,14:7263–7279.SCI
5. Juan Feng, Meng Zhou, Xuanzi Lin, An Lu, Xiaoyi Zhang, and Ming Zhao*.Base-Mediated [3 + 4]-Cycloaddition of Anthranils with Azaoxyallyl Cations: A New Approach to Multisubstituted Benzodiazepines.. Org. Lett. 2019,21:6245−6248.SCI
6. Shuangling Chen , Zidong Peng, Yuji Wang , Jianhui Wu, Ran An , Rongrong Miao , Ming Zhao * , Shiqi Peng*.Development and activity evaluation of Arg-Gly-Asp-containing antithrombotic conjugate. Journal of Molecular Structure. 2019,1198:126816-126824.SCI
7. Yaonan Wang, Haiyan Chen, Xiaoyi Zhang, Jianhui Wu,Qiqi Feng, Shiqi Peng,, Ming Zhao.*.Dimethyl 2,2′-[2,2′-(ethane-1,1-diyl)bis(1H-indole-3,2-diyl)]-diacetate: a small molecule capable of nano-scale assembly, inhibiting venous thrombosis and inducing no bleeding side effect. International Journal of Nanomedicine. 2018,13 :1–10.SCI
8. Ze Li, Fei Huang, Jianhui Wu, Lin Gui, Xiaoyi Zhang, Yaonan Wang, Shurui Zhao, Xiaozhen Wang, Shiqi Peng*, and Ming Zhao*.Heptapeptide based modification leading to enhancing the action of MTCA on activated platelets, P-selectin, GPIIb/IIIa.. Future Medicinal Chemistry. 2018,10 (16) :1957-1970.SCI
9. Haiyan Chen，Wenjing Wang，Xiaoyi Zhang，Shan Liu，Yaonan Wang，Haimei Zhu，Jianhui Wu，Yuji Wang，Ming Zhao *， Shiqi Peng *.Discovery of DEBIC to correlate P-selectin inhibition and DNA intercalation incancer therapy and complicated thrombosis. Oncotarget. 2018,9(63):32119-32133.
10. Haiyan Chen, An Lu, Xiaoyi Zhang, Lin Gui, Yaonan Wang, Jianhui Wu, Hua Feng, Shiqi Peng* and Ming Zhao*.Design and development of ICCA as dual inhibitor of GPIIb/IIIa and P-selectin receptors. Drug Design, Development and Therapy. 2018,12:2097–2110..SCI
11. Haimei Zhu, Yuji Wang, Ce Song, Qiqi Feng, Jianhui Wu, Shurui Zhao, Lin Gui, Xiaoyi Zhang, Ming Zhao* and Shiqi Peng*.Docking of THPDTPI: to explore P-selectin been a common target of anti-tumor, anti-thrombotic and anti-inflammatory agent. Oncotarget. 2018,9 (1):268-281.
12. Jianhui Wu, a§ Haimei Zhu, a§ Guodong Yang,a Jianhong He, *c Yuji Wang, Shurui Zhao, Xiaoyi Zhang, Lin Gui, Ming Zhao*,&Shiqi Peng*.Design and synthesis of nano-scaled IQCA-TAVV as a delivery capable of anti- platelet activation, targeting arterial thrombus and releasing IQCA.. International Journal of Nanomedicine. 2018,13 :1139-1158 .SCI
13. Jianhui Wu, § Haimei Zhu, § Guodong Yang, Yuji Wang, Yaonan Wang, Shurui Zhao, Ming Zhao* & Shiqi Peng*.IQCA-TAVV: To get insight of the association between P-selectin, GPIIb/IIIa, IL-2, IL-6 and IL-8 into deep venous thrombosis. Oncotarget. 2017,8（53）:91391-91401.SCI
14. Haiping Ma, Ming Zhao*, Yuji Wang, Haimei Zhu, Yaonan Wang, Shurui Zhao, Jianhui Wu, Shiqi Peng*.Cholyl-L-Lysine-carboxyl butyryl adriamycin produgs targeting chemically induced liver injury.. J. Mater. Chem. B. 2017,5:470-478 .SCI
15. Yuji Wang, Xinyi Xu, Ce Song, Jianhui Wu, Xi Hu, Haimei Zhu, Xiaoyi Zhang,Yaonan Wang, Lin Gui, Ming Zhao*, and Shiqi Peng*.ATIQCTPC targeting MMP-9: a key step to slowing primary tumor growth and inhibiting metastasis of lewis lung carcinoma in vivo. Oncotarget. 2017,8,38:63881-63889 .SCI
16. Xiaozhen Wang , Yuji Wanga, Jianhui Wu, Lin Gui , Xiaoyi Zhang , Meiqing Zheng , Yaonan Wang, Shurui Zhao , Ze Li , Ming Zhao*, Shiqi Peng*.Docking based design of diastereoisomeric MTCA as GPIIb/IIIa receptor inhibitor.. Bioorganic & Medicinal Chemistry Letters. 2017,27:5114–5118.SCI
17. Xi Hu, Ming Zhao*, Yuji Wang, Yaonan Wang, Shurui Zhao, Jianhui Wu, Xiangmin Li and Shiqi Peng*.Tetrahydro-b-carboline-3-carboxyl-thymopentin: a nano-conjugate for releasing pharmacophores to treat tumor and complications. J. Mater. Chem. B. 2016,4:1384-1397.SCI
18. Xu Wenyun, Zhao Ming*, Wang Yuji, Zhu haimei, Wang Yaonan, Zhao Shurui, Wu Jianhui, Peng Shiqi*.Design, synthesis, and in vivo evaluations of benzyl Nω-nitro-Nα-(9H-pyrido[3,4-b]indole-3-carbonyl)-L-argininate as an apoptosis inducer capable of decreasing the serum concentration of P-selectin. Medchemcomm. 2016,7:1730-1737.SCI
19. Ning Song,Ming Zhao*,Yuji Wang,Xi Hu,Jianhui Wu,Xueyun Jiang,Shan Li,Chunying Cui,Shiqi Peng*. Nanomedical strategy to prolong survival period, heighten cure rate, and lower systemic toxicity of s180 mice treated with mtx/mit. Drug Design Development & Therapy. 2016,10: 2701-2711.SCI
20. Qiqi Feng, Ming Zhao*,Taiping Gan, Haimei Zhu, Yaonan Wang, Shurui Zhao, Yuji Wang, Jianhui Wu and Shiqi Peng*..DHDMIQK(KAP): a novel nano-delivery system of dihydroxyl-tetrahydro-isoquinoline-3-carboxylic acid and KPAK towards the thrombus.. Journal of Materials Chemistry B. 2016,4:5991-6003..SCI
21. Lv Xiaojie, Zhao Ming*, Wang Yuji, Hu Xi, Wu Jianhui, Jiang Xueyue, Li Shan, Cui Chunying, Peng Shiqi*.Loading cisplatin onto 6-mercaptopurine covalently modified MSNS: a nanomedicine strategy to improve the outcome of cisplatin therapy.. Drug Design, Development and Therapy. 2016,10:3933-3946.SCI
22. Jianhui Wu, Ming Zhao*, Yuji Wang, Yaonan Wang, Haimei Zhu, Shurui Zhao, Shiqi Peng*.A novel lead of P-selectin inhibitor: Discovery, synthesis, bioassays and action mechanism.. Bioorg Med Chem Lett. 2016,26:4631 - 4636.SCI
23. xueyun jiang，ming zhao*，haimei zhu，shurui zhao，yuanbo song，shiqi，peng*.RGD(F/S/V)-Dex: towards the development of novel, effective, and safe glucocorticoids. Drug Design, Development and Therapy. 2016,10:1059-1076.SSCI
24. Zhigang Zhao, Xingang Li, Shusen Sun,Shenghui Mei,Ning Ma,Zhongrong Miao,Ming Zhao* , Shiqi Peng*.Impact of genetic polymorphisms related to clopidogrel or acetylsalicylic acid pharmacology on clinical outcome in Chinese patients with symptomatic extracranial or intracranial stenosis.. European Journal of Clinical Pharmacology.. 2016,72:1195-1204.SCI
25. Haimei Zhu, Yuanbo Song, Yuji Wang, Ming Zhao, Yi Ren, Yaonan Wang, Shurui Zhao, Jianhui Wu and Shiqi Peng.Design, synthesis and evaluation of a novel π–π stacking nano-intercalator as an anti-tumor agent. MedChemComm. 2016,7:247-257.SCI
26. Yinghuan Li, Lei Gao, Xi Tan, Feiyang Li, Ming Zhao, Shiqi Peng.Lipid rafts-mediated endocytosis and physiology-based cell membrane traffic models of doxorubicin liposomes. .Biochimica Biophysica Acta. 2016,1858 (8) :1801-1811.SCI
27. Taiping Gan, Yuji Wang, Ming Zhao*,Jianhui Wu, Jian Yang, and Shiqi Peng* .5-(Bis(3-(2-hydroxyethyl)-1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHIMHA): Showing a strategy of designing drug to block lung metastasis of tumors. Drug Design, Development and Therapy. 2016,10:711-721.SCI
28. Yuji Wang, Jingcheng Tang, Haimei Zhu, Xueyun Jiang,Jiawang Liu,Wenyun Xu,HaipingMa,Qiqi Feng,Jianhui Wu,Ming Zhao*, Shiqi Peng*.Aqueous extract of Rabdosia rubescens leaves: forming nanoparticles, targeting P-selectin, and inhibiting thrombosis. International Journal of Nanomedicine. 2015,2015:10:1-14.SCI
29. Feng Wang, Shan Li, Yuji Wang, Haimei Zhu , Xiaoyi Zhang , Ming Zhao *, Jianhui Wu and Shiqi Peng *.Enantiomeric diketopiperazines: getting insight into the impact of the configuration on the conformation, nanoimage, u-PA inhibition and anti-metastatic activity. Med. Chem. Commun.. 2015,2015,6:956-962 .SCI
30. Shuangling Chen, Yuji Wang, Shan Li, Yaonan Wang, Ming Zhao*, Haimei Zhu, Jianhui Wu, Shiqi Peng*.Poly-α,β-aspartyl-Arg-Gly-Asp-Phe: A novel polymeric nanomedicine.. MedChemComm. 2015,2015, 6, :182-186..SCI
31. Shan Li, Yuji Wang, Feng Wang, Yaonan Wang, Xiaoyi Zhang, Ming Zhao*， Qiqi Feng, Jianhui Wu, Shurui Zhao, Wei Wu, Shiqi Peng*.Small molecule PZL318: forming fluorescent nanoparticles capable of tracing their interactions with cancer cells and activated platelets, slowing tumor growth and inhibiting thrombosis. International Journal of Nanomedicine . 2015,2015:10:5273–5292.SCI
32. Xueyun Jiang, Yuji Wang, Haimei Zhu, Yaonan Wang, Ming Zhao*, Shurui Zhao, Jianhui Wu, Shan Li, Shiqi Peng*.Modifying tetramethyl-nitrophenyl-imidazoline with amino acids: Design, synthesis and 3D-QSAR for improving inflammatory pain therapy.. Drug Des Dev Ther. 2015,2015, 9, :2329-2342.SCI
33. Shan Li, Yuji Wang, Ming Zhao*, Jianhui Wu, Shiqi Peng*. BPIC: A novel anti-tumor lead capable of inhibiting inflammation and scavenging free radicals. Bioorg Med Chem Lett. 2015,2015, 25:1146-1150.SCI
34. Nan Xie, Ke Feng, Bin Chen,b Ming Zhao*, Li-Ping Zhang, Chen-Ho Tung, Li-Zhu Wu, Shiqi Peng*.A modular designed copolymer with antithrombotic activity and imaging capability. ChemComm. 2014,50:9535-9542.SCI
35. Wenhua Zhao, Yuji Wang, Weijia Hao, Ming Zhao*, Shiqi Peng*.In vitro inhibition of fatty acid synthase by 1,2,3,4,6-penta-O-galloyl-β-D-glucose plays a vital role in anti-tumour activity. BBRC. 2014,445:346-351.SCI
36. Nan Xie, Ke Feng, Bin Chen, Ming Zhao, Shiqi Peng*, Liping Zhang, Chenho Tung, Lizhu Wu.Water-soluble copolymeric materials: switchable NIR two-photon fluorescence imaging agents for living cancer cells. J. Mater. Chem. B. 2014,2:502-510.SCI
37. Haimei Zhu#, Yuji Wang, Ming Zhao*, Jianhui Wu, Xiaoyi Zhang, Guodong Yang, Shiqi Peng*.Energy minimized crystal structures of P-selectins based on molecular dynamics simulation: Leading to two average structures capable of designing anti-thrombotic agents.. MedChemComm. 2013,4:1066 - 1072.SCI
38. Haimei Zhu*, Yuji Wang, Yaonan Wang, Shurui Zhao, Ming Zhao*, Lin Gui, Wenyun Xu, Xiangyun Amy Chen, Yanming Wang, Shiqi Peng*.Folded conformation, cyclic pentamer, nano-structure and PAD4 binding mode of YW3-56. J Phys Chem C. 2013,117:10070-10078.SCI
39. Wenjing Wang#, Chenjie Fang, Xiaozhu Wang, Yuxi Chen, Wei Feng, Chunhua Yan, Ming Zhao*, Shiqi Peng*.Modifying mesoporous silica nano-particle to avoid the metabolic deactivation of 6-mercaptopurine and methotrexate in combinatorial chemotherapy. Nanoscale . 2013,5:6249 - 6253.SCI
40. Shaoming Jin,#Yaonan Wang#, Haimei Zhu, Yuji Wang, Shurui Zhao, Ming Zhao,* Jiawang Liu,Jianhui Wu, Wen Gao, and Shiqi Peng*.Nanosized Aspirin-Arg-Gly-Asp-Val: elivery of Aspirin to Thrombus bythe Target Carrier Arg-Gly-Asp-Val etrapeptide. Acsnano. 2013,【未填写卷（期）】:NO. XX ’ 000–000 ’ XXXX.SCI
41. Yuji Wang#, Jianhui Wu, Guifeng Kang, Ming Zhao,* Lin Gui, Ning Li, Li Peng, Xiaoyi Zhang, Li Li and Shiqi Peng*.Novel nano-materials, RGD-tetrapeptide-modified 17b-amino-11a-hydroxyandrost-1,4-diene-3-one: synthesis, self-assembly based nano-images and in vivo anti-osteoporosis evaluation. J. Mater. Chem. 2012,22:4652–4659.SCI
42. Li Li#, Ming Zhao,* Wenhao Li, Yuji Wang, Zhuge Zhang, Ran An and Shiqi Peng*.Self-complexation and complexation-controlled target cancer therapy. Med. Chem. Commun. 2012,3:1059 - 1061.SCI
43. Gui Lin#, Zhao Ming*, Wang Yuji, Wang Yinye, Qin Yang, Li Li, Shiqi Peng*.Synthesis, nano-features, ex vivo anti-platelet aggregation and in vivo antithrombotic activities of poly-α,β-DL-aspartyl-L-arginine. Med. Chem. Commun. 2012,3:102-108..SCI
44. uji Wang#,Guifeng Kang,Jiawang Liu,Ming Zhao,*Jianhui Wu, Xiaoyi Zhang,Ye Li, Xiaobo Zhong, Yifan Yang and Shiqi Peng*.Novel potassium N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxylhex-1-yl]-L-amino acid dichloroplatinates(II) with high anti-tumor activity and low side reaction. Metallomics. 2012,4:441–447.SCI
45. Li Li#, Ming Zhao*, Wenhao Li, Yuji Wang, Chunna Liu,Zhuge Zhang, Songchun Su, Shiqi Peng*.1 pH-Dependent nanostructure based on isoquinoline-cyclodextrin conjugate for thrombosis therapy. Nanomedicine: Nanotechnology, Biology, and Medicine. 2012,8（7）:1216–1222.SCI
46. anxia Xu, Yuji Wang, Ming Zhao*, Baoguang Hou, Li Peng, Meiqing Zheng, Jianhui Wu, Shiqi Peng*.Lead detoxification activities and ADMET hepatotoxicities of a class of novel 5-(1-carbonyl-L-amino-acid)-2,2-dimethyl-[1,3]dithiolane-4-carboxylic acids. Bioorganic & Medicinal Chemistry Letters . 2011,21:1754–1757.SCI
47. Hong Wang, Le Peng, Ming Zhao, Jiawang Liu, Xiaoyi Zhang, Yuji Wang,Jianhui Wu, Li Li, Shiqi Peng..2-Substituted (S)-2-(3,3-dimethyl-1-oxo-10,10a-dihydroimidazo[1,5-b]isoquino-. Bioorganic & Medicinal Chemistry. 2011,9(2):871-882 .SCI
48. Yuji Wang, Xueyun Jiang, Jiawang Liu, Ming Zhao,*Guifeng Kang, Jianhui Wu, Li Peng and Shiqi Peng*.HPLC-MS aided PC12 cell systems: to quantitatively monitor the conversion of nitronyl nitroxide in biological systems with and without NO.. Mol. BioSyst.. 2011,7:1678–1683 .SCI
49. Yanxia Xu, Yuji Wang, Ling Wang, Ming Zhao,* Xiaoyi Zhang, Xiaomin Hu, Baoguang Hou, Li Peng,Meiqing Zheng, Jianhui Wu, and Shiqi Peng*.Lead Detoxification Activities of a Class of Novel DMSA_Amino Acid Conjugates. Chem. Res. Toxicol. 2011,24:979–984.SCI
50. Liu Liu, Lei Wei, Yifan Yang, Ming Zhao,* Xiaoyi Zhang, Meiqing Zheng, Yuji Wang and Shiqi Peng*.A class of novel AA-Trp-Trp-OBzl: synthesis, in vitro anti-proliferation, in vivo anti-tumor action, and intercalation mechanism. Med. Chem. Commun.. 2011,2011（2）:126-131.SCI
51. Wenjing Wang, Ming Zhao,* Yuji Wang, Jiawang Liu, Jianhui Wu, Guifeng Kang and Shiqi Peng*.{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1Hindol-3-yl}-acetic acid methyl ester (MIAM): Its anti-cancer efficacy andintercalation mechanism identified via multi-model system. Molecular BioSystems.. 2011,7:766-772.SCI
52. Ning Li, Guifeng Kang, Lin Gui, *Ming Zhao, Wenjing Wang, Jianwei Zhang, Yan-Feng Yue, *Shiqi Peng..Novel Cu(II)-RGD-octapeptides: Synthesis, coordination mode, in vitro anti- platelet aggregation/in vivo anti-thrombotic evaluation and correlation of sequence with nano-structure. Nanomed-Nanotechnol. 2011,7(4):403–409.SCI
53. Ming Zhao, Yuji Wang, Caixia Huo, Jiawang Liu, Chunyu Li, Xiaoyi Zhang, Li Peng, and Shiqi Peng*.Lead Detoxification Activity and ADMET Hepatotoxicity of N-(r-LArabino-furanos-1-yl)-L-cysteine. Chem. Res. Toxicol 23（7） . 2010,23（7）:xxx-xxx.SCI
54. Lin Gui, Ming Zhao*,Yinye Wang, Yang Qin, Jiangyuan Liu, Shiqi Peng*.Synthesis, nanofeatures, in vitro thrombus lysis activity and in vivo thrombolytic activity of poly-α, β-aspartyl-L-alanine. Nanomedicine . 2010,5:703–714 .SCI
55. Jianhui Wu, Chunyu Li, Ming Zhao *, Wenjing Wang, Yuji Wang, Shiqi Peng *,.A class of novel carboline intercalators: Their synthesis, in vitro anti-proliferation, in vivo anti-tumor action, and 3D QSAR analysis. Bioorganic & Medicinal Chemistry . 2010,18:6220–6229 .SCI
56. Guifeng Kang, Ming Zhao, Xiaoyi Zhang, Li Peng, Chunbo Li, Wei Mao, Weidong Ye, Shiqi Peng..A class of novel conjugates of substituted purine and Gly-AA-OBzl: Synthesis and evaluation of orally analgesic activity . Bioorganic & Medicinal Chemistry Letters, . 2010,20（20）:6157-6160.SCI
57. Jianhui Wu, Ming Zhao & Shiqi Peng.Quinazolin-4(3H)-ones capable ofupregulating the expression of endogenous apolipoprotein A-1. Expert Opin. Ther. Patents. 201,213(:431-435.SCI
58. Jianhui Wu, Ming Zhao*, Keduo Qian, Kuo-Hsiung Lee, Susan Morris-Natschke, Shiqi Peng*.Novel N-(3-carboxyl-9-benzylcarboline-1-yl) ethylamino acids: Synthesis, antitumor evaluation, intercalating determination, 3D QSAR analysis and docking investigation. Eur. J. Med. Chem. 2009,44:4153–4161.SCI
59. Fei Huang, Ming Zhao*, Xiaoyi Zhang, Chao Wang, Keduo Qian, Jen-Yun Kuo, Susan Morris- Natschke, Kuo-Hsiung Lee, Shiqi Peng*.Synthesis, DNA Intercalation and 3D QSAR Analysis of cis-2,4,5-Trisubstituted-1,3-dithiolanes as a Novel Class of Antitumor Agents. Bioorg. Med. Chem. 2009,17:6085–6095.SCI
60. Ming Zhao, Jiangyuan Liu, Xiaoyi Zhang, Li Peng, Chunyu Li, Shiqi Peng*.3D QSAR of novel estrogen-RGD peptide conjugates: Getting insight into structural dependence of anti-osteo- porosis activity and side effect of estrogen in ERT. Bioorg. Med. Chem. 2009,17:3680-3689..SCI
61. Ming Zhao, Caixia Huo, Yuji Wang, Chongyu Li, Xiaoyi Zhang, Li Peng, Shiqi Peng*.Stereoselective synthesis of Novel N-(α-L-arabinose-1-yl)-L-amino Acids.. Tetrahedron: Asymmetry. 2009,20:247-258.SCI
62. Mei Yang, Guohui Cui, Ming Zhao*, ChaoWang, LiliWang,Hu Liu, Shiqi Peng*.The effect of complexation of Cu(II) with P6A peptide and itsanalogs on their thrombolytic activities. International Journal of Pharmaceutics. 2008,362:81-87.SCI
63. Xue Ren, Guohui Cui, Ming Zhao, Chao Wang, Shiqi Peng*.Coordination of Thrombolytic Pro-Ala-Lys peptides with Cu (II): Leading to nano-scale self-assembly, increase of thrombolytic activity and additional vasodilation. The Journal of Physical Chemistry . 2008,112:8174-8180.SCI
64. Yang Jian, Zhiyu Tang, Yinye Wang,, Shiqi Peng*.Polyaspartoyl L-arginine protects endothelial cells against injury. European Journal of Pharmacology . 2008,599:96-101.SCI
65. Meiqing Zheng , Xiaoyi Zhang , Ming Zhao ,*, Heng Wei Chang *, Wei Wang ， Yuji Wang , Shiqi Peng*.(3S)-N-(L-Aminoacyl)-1,2,3,4-tetrahydroisoquinolines, a class of novelantithrombotic agents: Synthesis, bioassay, 3D QSAR, and ADME analysis. Bioorganic & Medicinal Chemistry . 2008,16: 9574–9587.SCI
66. Lanrong Bi, Ming Zhao, Keli Gu, Chao Wang, Jingfang Juc, Shiqi Peng*.Toward the develop- ment of chemoprevention agents (III): Synthesis and anti-inflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes. Bioorg. Med. Chem. 2008,16:1764-1774.SCI
67. Ming Zhao, Zheng Li, Li Peng, Yu-Rong Tang, Chao Wang, Ziding Zhang, Shiqi Peng*.A new class of analgesic agents toward prostacyclin receptor inhibition: synthesisbiological studies and QSAR analysis of 1-hydroxyl-2-substitutedphenyl-4,4,5,5-tetramethylimidazolines. Eur. J. Med. Chem. 2008,43:1048-1058.SCI
68. Li Li, Guohui Cui, Ming Zhao,* Yuji Wang, Hong Wang, Wei Li, and Shiqi Peng*.Assembly of _-Cyclodextrin with 3S-Tetrahydro-_-carboline-3-carboxylic Acid and. J. Phys. Chem. 2008,112:12139–12147.SCI
69. Jiawang Liu, Guohui Cui, Ming Zhao*, Chunying Cui, Jingfang Ju, Shiqi Peng*.Design, synthesis, MES-SA/Dx5 cell assay and SAR of 2,2-dimethyl-3-[1’-substi-tutedacetyloxybenzyl]-4- oxoimidazo[3’,5’:2,3]tetrahydro-β-carbolines. Bioorg. Med. Chem. 2007,15:7773-7778. .SCI
70. Guofeng Wu, Lanrong Bi, Ming Zhao*, Chao Wang, Michèle Baudy-Floc’h , Jingfang Ju, Shiqi Peng*.Toward breast cancer resistance protein (BCRP) inhibitors: Design, synthesis of a series of new simplified fumitremorgin C analogues. Tetrahedron. 2007,63:5510-5528.SCI
71. Jiawang Liu, Guofeng Wu, Guohui Cui, Wei-Xuan Wang, Ming Zhao*, Chao Wang, Ziding Zhang, Shiqi Peng*.A new class of anti-thrombosis hexahydropyrazino[1’,2’:1,6]- pyrido[3,4-b]indole-1,4-dions: Design, synthesis, logK determination and QSAR analysis. Bioorg. Med. Chem. 2007,15:5672-5693.
72. Ming Zhao, Zheng Li, Yihui Wu, Chao Wang, Ziding Zhang, Shiqi Peng*.Studies on LogP, Retention Time and QSAR of 2-Substitutedphenylnitronyl Nitroxides as Free Radical Scavenger. Eur. J. Med. Chem.. 2007,42:955-965.SCI
73. Ming Zhao, Zheng Li, Li Peng, Yu-Rong Tang, Chao Wang, Ziding Zhang, Shiqi Peng*.Novel 1-Oxyl-2-substitutedphenyl-4,4,5,5-tetramethylimidazolines: Synthesis, Selectively Analgesic Action and QSAR analysis. Bioorg. Med. Chem. . 2007,15:2815-2826.SCI
74. Ming Zhao, Xin Jia, Chao Wang, Qin Li, Kexiang Zhou, Lili Wang, Hu Liu and Shiqi Peng*.PAK: An Essential Motif for Forming β-Turn Structures and Exhibiting Thrombolytic Effect for P6A and Its Analogs. Biochem. Cell Biol.. 2007,85:730-740.SCI
75. Keli Gu, Lanrong Bi, Ming Zhao, Chao Wang, Cheryl Dolan, Michael C. Kao, Jeffrey B.-H. Tok and Shiqi Peng*.Stereoselective synthesis and anti-inflammatory activities of 6- and 7-membered dioxacycloalkanes. Bioorg. & Med. Chem. 2006,14:1339－1347.SCI
76. Ming Zhao, Lanrong Bi, Wei Bi, Chao Wang, Zhe Yang, Jingfang Ju and Shiqi Peng*..Synthesis of new class dipeptide analogues with improved permeability and antithrombotic activity. Bioorg. & Med. Chem. . 2006,14:4761-4774.SCI
77. Ming Zhao, Lanrong Bi, Wei Wang, Chao Wang, Michèle Baudy-Floc’h, Jingfang Ju, Shiqi Peng*..Synthesis and cytotoxic activities of β-carboline amino acid ester conjugates. Bioorg. & Med. Chem. . 2006,14:6998-7010.SCI
78. Yihui Wu, Lanrong Bi, Wei Bi, Zeng Li, Ming Zhao, Chao Wang, Jingfang Ju, Shiqi Peng*..Novel 2-Substitutednitronyl Nitroxides as Free Radical Scavengers: Synthesis, Biological Evaluation and Structure- Activity Relationship. Bioorg. & Med. Chem. 2006,14:5711-5720.SCI
79. Lanrong Bi, Yue Zhang, Ming Zhao, Chao Wang, Priscilla Chan, Jeffrey B.-H. Tok, Shiqi Peng*.Novel Synthesis and Anti-inflammatory Activities of 2,5-disubstituted-dioxacycloalkanes. Bioorg. & Med. Chem. 2005,13:5640－5646.SCI
80. Ming Zhao, Junling Liu, Chao Wang, Lili Wang, Hu Liu, Shiqi Peng.Synthesis and Biological Activity of Nitronyl Nitroxide Containing Peptides. J Med. Chem. 2005,48:4285-4292.SCI
81. Ming Zhao, Chao Wang, Yanfen Wu, Kexiang Zhou, and Shiqi Peng*.Synthesis and Thrombolytic Activity of Carboline-3-carboxylic Acid Modified Metabolites of ARPAK. Preparative Biochemistry & Biotechnology. 2004,34:55-74.SCI
82. Ming Zhao, Chao Wang, Shiqi Peng*.The composition and sequence specificity of Pro-Ala-Lys-OH for the throm- bolytic activities of P6A and related oligopeptides. Bioorg. & Med. Chem. 2004,12:2275-2286.SCI
主编或副主编的著作/译著
1. 《药物的波谱解析》,主编,高等教育出版社,201408
2. 《骨质疏松症及多用途径预防策略》,主编,高等教育出版社,201310
3. 《General Chemistry》,主编,高等教育出版社,201211
4. 《Pharmaceutical Bioassays: Methods and Applications》,副主编,John Wiley. &Sons, Inc,200912
重要奖项
1. 创新和创业型药学人才培养渐进路径与实践 北京市教育教学成果奖 二等奖 2013
2. 基于医学和生物学的药学实验教学模式 北京市教育教学成果奖 二等 2009
3. 治疗中风和骨质疏松多肽的关键技术研究 北京市科技进步奖 贰等奖 2005
4. 新型口服重金属驱排立得益片 四川省科技进步奖 叁等奖 2003
5. 基于氨基酸的寡肽活性物质研究 北京市科学技术进步奖 二等奖 2001
6. 基于氨基酸的杂环药物先导结构的研究 中国高校科技进步 贰等奖 2001