姓名：钟久昌 性别：男 职称：研究员、教授 招生院所：附属朝阳医院 招生类型：科学学位(博) 科学学位(硕) 招生专业：内科学（心血管病）(博) 内科学（心血管病）(硕) 研究方向名称：高血压心血管重构与靶器官损害机制 电子信箱：jiuchangzhong@aliyun.com


社会任职
1. 国家心血管病中心高血压专家委员会常务委员
2. 中华医学会心血管病学分会高血压病学组全国委员
3. 美国心脏协会高血压研究委员会/ 国际心脏协会中国转化医学委员会委员
4. 中国高血压联盟理事
5. 中国中药协会微循环用药委员会全国副主任委员
6. 国际心脏协会中国分会青年委员
7. 中俄医学研究中心代谢疾病研究所学术委员会常务委员
8. 中国医促会血管疾病高血压分会常务委员
9. 中国医师协会心血管分会高血压专业委员会全国委员
10. 教育部博士学位中心专家库成员、上海市优秀博士学位论文奖、北京市与上海市科技进步奖评审专家库成员
11. 国家重大研究计划、国家自然科学基金项目评审专家
12. 中国医师协会高血压专业血管风险评估工作委员会委员
13. 中国病理生理学会心血管专业青年工作委员会委员
14. 《中华高血压杂志》编委
15. 《中华心脏与心律电子杂志》编委
16. 《上海医学》编委
17. 《中国分子心脏病杂志》编委
18. Hypertension、Pharmacol Res、Am J Physiol Heart Circ Physiol、Br. J Pharmacol、PLoS ONE、CEPP、Life Sciences、Biochimie、World J Cardiol、Lipid and Cardiovasc Res评审专家或编委
19. 中国药理学会表观遗传药理学专业委员会常务委员
20. 中国病理生理学会生物活性小分子专业委员会委员
21. 北京市医师协会高血压专业委员会委员
22. 北京高血压防治协会第五届理事会常务理事兼副秘书长
23. 中国中药协会心血管药物研究专业委员会委员
24. 中国老年保健医学研究会老年晕厥分会第一届委员
25. 北京市高血压重点实验室执行主任、首都医科大学附属北京朝阳医院心脏中心副主任、高血压学科主任
26. 欧洲心脏病杂志中文版编委
27. 中国病理生理学会生物活性小分子多肽委员会委员
28. 中华医学会心血管病学分会基础研究学组全国委员
个人简历
1. 200811-201009:加拿大Alberta大学心脏中心 博士后研究员
2. 201009-201711:上海交通大学医学院附属瑞金医院、上海市高血压研究所 教授、博士生导师、研究员、研究室主任、博士后合作导师
3. 201711-:首都医科大学附属北京朝阳医院 心脏中心行政副主任、高血压学科主任、北京市高血压重点实验室执行主任、教授、博导、博士后合作导师
重要学术论文
1. 宋佳玮 刘颖 王娟 钟久昌*.生长分化因子15 与血管疾病研究进展. 中国分子心脏病杂志.. 2020,20（1）:3264-3267.核心期刊
2. Song JJ, Ma Z, Wang J, Chen LX, Zhong JC*..Gender Differences in Hypertension. J Cardiovasc Transl Res. 2020,13 (1):47-54.SCI
3. Li S, Gao Y, Liu Y, Li J, Yang X, Hu R, Liu J, Zhang Y, Zuo K, Li K, Yin X, Chen M, Zhong J*, Yang X*..Myofibroblast-Derived Exosomes Contribute to Development of a Susceptible Substrate for Atrial Fibrillation. Cardiology. 2020,145(1-2):1-8.SCI
4. 钟久昌*.血管紧张素转换酶2：新型冠状病毒肺炎炎症风暴的“导火索”和“灭火器”. 中华高血压杂志. 2020,28（3）:208-212.核心期刊
5. Miao R, Gong J, Zhang C, Wang Y, Guo X, Li J, Yang S, Kuang T, Zhong J*, Feng H*..Hsa_circ_** is involved in the development of chronic thromboembolic pulmonary hypertension. Journal of Thrombosis and Thrombolysis. 2020,50（3）:386-394.SCI
6. Ma Z, Song JJ, Martin S, Yang XC*, Zhong JC*.The Elabela-APJ Axis: A Promising Therapeutic Target for Heart Failure. Heart Failure Reviews. 2020,26(1):1-10.SCI
7. Gheblawi M, Wang K, Viveiros A, Nguyen O, Zhong J, Turner AJ, Raizada MK, Grant MB, Oudit GY*..Angiotensin Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin- Angiotensin System-- Celebrating the 20th Anniversary of the Discovery of ACE2. . Circulation Research. 2020,126(9):1-15.SCI
8. Yang M, Song JJ, Liu XY, Zhao L, Wang J, Zuo K, Ma Z, Fang C, Li J, Cai J, Yang XC, Zhong GZ*, Zhong JC*.Inhibition of miRNA-122-5p counterregulates against angiotensin II-mediated loss of autophagy and promotion of apoptosis in rat cardiofibroblasts by modulation of the APLN-AMPK-mTOR signaling. Artificial Cells, Nanomedicine, and Biotechnolog. 2020,48(2):1-9.SCI
9. 赵蕾，郑美丽，杨梅，钟久昌*，杨新春*..3T3-L1前体脂肪细胞诱导分化方法优化的初步探讨. . 首都医科大学学报. 2019,40（4）:17-22.核心期刊
10. 左琨，杨新春，钟久昌*.急性缺血性脑卒中损伤机制及其治疗药物研究进展. 药学进展. 2019,43（8）:576-583.核心期刊
11. 张茜，王宇星，钟久昌*.培养性讲课教学法在心血管内科住院医师规范化培训中的应用. 中国病案. 2019,20（4）:75-77.核心期刊
12. He L, Zhou Q, Huang Z, Xu J, Zhou H, Lv D, Lu L, Huang S, Tang M, Zhong J, Chen JX, Luo X, Li L, Chen L*..PINK1/Parkin-mediated mitophagy promotes apelin-13-induced vascular smooth muscle cell proliferation by AMPKα and exacerbates atherosclerotic lesions.. J Cell Physiol. 2019,234(6):8668-8682.SCI
13. Zuo K, Li K, Liu M, Li J, Liu X, Liu X, Zhong J, Yang X*. .Correlation of left atrial wall thickness and atrial remodeling in atrial fibrillation: Study based on low-dose-ibutilide-facilitated catheter ablation. Medicine (Baltimore). 2019,98(15):e15170.SCI
14. Chi H, Feng H, Shang X, Jiao J, Sun L, Jiang W, Meng X, Fan Y, Lin X*, Zhong J*, Yang X*..Circulating connective tissue growth factor is associated with diastolic dysfunction in patients with diastolic heart failure.. Cardiology. 2019,143(3-4):77-84.SCI
15. Chi HJ, Feng HJ, Chen XJ, Zhao XT, Zhang EX, Fan YF, Meng XC, Zhong JC, Wu SL, Cai J*. .The association between orthostatic blood pressure changes and subclinical target organ damage in subjects over 60 years old. J Geriatr Cardiol. 2019,16(5):387-394.SCI
16. Zuo K, Li J, Xu Q, Hu C, Gao Y, Chen M, Hu R, Liu Y, Chi H, Yin Q, Cao Y, Wang P, Qin Y, Liu X, Zhong J, Cai J, Li K, Yang X*.Dysbiotic gut microbes may contribute to hypertension by limiting vitamin D production.. Clin Cardiol. 2019,42(8):710-719.SCI
17. Zuo K, Li J, Li K, Hu C, Gao Y, Chen M, Hu R, Liu Y, Chi H, Wang H, Qin Y, Liu X, Li S, Cai J, Zhong J*, Yang X*..Disordered gut microbiota and alterations in metabolic patterns are associated with atrial fibrillation.. GigaScience. 2019,8(6):pii: giz058.SCI
18. Wang J, Wei L, Yang X*, Zhong J*..Roles of growth differentiation factor 15 in atherosclerosis and coronary artery disease.. J Am Heart Assoc. 2019,8(17):e012826.SCI
19. Tang M, Huang Z, Luo X, Liu M, Wang L, Qi Z, Huang S, Zhong J, Chen JX, Li L, Wu D, Chen L*..Ferritinophagy activation and sideroflexin1-dependent mitochondria iron overload is involved in apelin-13-induced cardiomyocytes hypertrophy.. Free Radic Biol Med. 2019,134:445-457.SCI
20. Wang J, Zhang DP, Liu HB, Zhong JC*, Yang XC*..Should atrial fibrillation patients with hypertension as an additional risk factor of the CHA2DS2-VASc score receive oral anticoagulation?. J Geriatr Cardiol. 2018,15（3）:229-234.SCI
21. Chen YY, Zhang P, Zhou XM, Liu D, Zhong JC, Yu HM*.Relationship between genetic variants of ACE2 gene and circulating levels of ACE2 and its metabolites. J Clin Pharm Ther. 2018,43(1):189-195.SCI
22. 钟久昌*.肿瘤心脏病学科的过去、现在与将来——机遇和挑战. 药学进展. 2018,42(7):481-482.核心期刊
23. Zhou X, Li J, Guo J, Geng B, Ji W, Zhao Q, Li J, Liu X, Liu J, Guo Z, Cai W, Ma Y, Ren D, Miao J, Chen S, Zhang Z, Chen J, Zhong J, Liu W, Zou M, Li Y, Cai J*..Gut-dependent microbial translocation induces inflammation and cardiovascular events after ST-elevation myocardial infarction.. Microbiome. 2018,6(1):66-78.SCI
24. 杨梅，钟光珍，钟久昌*.SIRT信号与心血管疾病. 中国分子心脏病学杂志. 2018,18（6）:2699-2702.核心期刊
25. 程玉文, 钟久昌*.沉默信息调节因子6与心血管疾病研究进展. 上海医学. 2018,41(10):596-601.核心期刊
26. 张艳, 程玉文，钟久昌*.ACE2/Apelin 信号在血管自噬调控和高血压发病中的作用. . 上海交通大学学报（医学版）. 2017,37 (9):1192-1196.核心期刊
27. 程玉文，张振洲, 余俊贤，钟久昌*.ACE2/Apelin信号在心血管系统中的调控作用及相关靶向治疗药物. 药学进展. 2017,41 (7):483-489.核心期刊
28. 钟久昌*.血管紧张素转换酶2/apelin信号与高血压靶器官损害. 中华高血压杂志. 2017,25（10）:913-916.核心期刊
29. Zhang ZZ, Wang W, Jin HY, Chen X, Cheng YW, Xu YL, Song B, Penninger JM, Oudit GY, Zhong JC* .Apelin is a negative regulator of angiotensin II-mediated adverse myocardial remodeling and dysfunction.. Hypertension. 2017,70（6）:1165-1175.SCI
30. Zhang ZZ, Cheng YW, Jin HY, Chang Q, Shang QH, Xu YL, Chen LX, Xu R, Song B, Zhong JC* .The Sirtuin 6 Prevents Angiotensin II-Mediated Myocardial Fibrosis and Injury by Targeting AMPK-ACE2 Signaling. . Oncotarget . 2017,8(42):72302-72314 .SCI
31. Shi J, Bei Y, Kong X, Liu X, Lei Z, Xu T, Wang H, Xuan Q, Chen P, Xu J, Che L, Liu H, Zhong J, Sluijter JP, Li X, Rosenzweig A, Xiao J. .miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury.. Theranostics. 2017,7(3):664-676.SCI
32. Zhong JC, Zhang ZZ, Wang W, McKinnie SMK, Vederas JC, Oudit GY. .Targeting the Apelin pathway as a novel therapeutic approach for cardiovascular diseases. . Biochim Biophys Acta-Mol Bas Dis . 2017,1863(8):1942-1950 .SCI
33. Patel VB#, Zhong JC, Grant MB, Oudit GY* .Role of the ACE2/Angiotensin 1-7 axis of the renin-angiotensin system in heart failure. Circulation Research . 2016,118(8):1313-1326 .SCI
34. Tao L, Bei Y, Chen P, Lei Z, Fu S, Zhang H, Xu J, Che L, Chen X, Sluijter JP, Das S, Cretoiu D, Xu B, Zhong J, Xiao J, Li X*.Crucial Role of miR-433 in Regulating Cardiac Fibrosis. . Theranostics . 2016,6(12):2068-2083.SCI
35. Wang H, Bei Y, Huang P, Zhou Q, Shi J, Sun Q, Zhong J, Li X, Kong X, Xiao J*.Inhibition of miR-155 Protects Against LPS-induced Cardiac Dysfunction and Apoptosis in Mice.. Mol Ther Nucleic Acids. 2016,5(10):e374 .SCI
36. Chen LJ, Xu YL, Song B, Yu HM, Oudit GY, Xu R, Zhang ZZ, Jin HY, Chang Q, Zhu DL, Zhong JC* .Angiotensin-converting enzyme 2 ameliorates renal fibrosis by blocking the activation of mTOR/ERK signaling in apolipoprotein e-deficient mice.. Peptides . 2016,79(1):49-57 .SCI
37. Xu R, Zhang ZZ, Chen LJ, Yu HM, Guo SJ, Xu YL,Song B, Chen DR, Zhu DL, Zhong JC*.Ascending aortic adventitial remodeling and fibrosis are ameliorated with Apelin-13 in rats after TAC via suppression of the miRNA-122 and LGR4-β-catenin signaling.. Peptides . 2016,86(1):85-94 .SCI
38. Liu D, Chen Y, Zhang P, Zhong J, Jin L, Zhang C, Lin S, Wu S, Yu H*..Association between circulating levels of ACE2-Ang-(1-7)-MAS axis and ACE2 gene polymorphisms in hypertensive patients.. Medicine (Baltimore).. 2016,95(24):e3876..SCI
39. 张振洲, 宋蓓, 钟久昌*.ACE2/Apelin与动脉粥样硬化. 上海交通大学学报（医学版）. 2016,36(6):917-920.核心期刊
40. Chen YY#, Liu D#, Zhang P, Zhong JC, Zhang CJ, Wu SL, Zhang YQ, Liu GZ, He M, Jin LJ*, Yu HM*..Impact of ACE2 gene polymorphism on antihypertensive efficacy of ACE inhibitors. . J Hum Hypertens. 2016,30(12):766-771.SCI
41. 张振洲，徐冉，常青，徐颖乐，金海燕，陈来江，宋蓓，钟久昌*.重组血管紧张素转换酶2 对ApoE 基因缺陷小鼠肾脏caspase 信号及细胞凋亡的影响. 上海交通大学学报（医学版）. 2016,36 (8):93-98.核心期刊
42. Jin HY, Chen LJ, Zhang ZZ, Xu YL, Song B, Xu R, Oudit GY, Gao PJ, Zhu DL, Zhong JC* .Deletion of angiotensin-converting enzyme 2 exacerbates renal inflammation and injury in apolipoprotein E-deficient mice through modulation of the nephrin and TNF-alpha-TNFRSF1A signaling.. J Transl Med . 2015,13(1):255-271 .SCI
43. Chen LJ#, Xu R#, Yu HM, Chang Q, Zhong JC*..The ACE2/Apelin Signaling, MicroRNAs, and Hypertension.. Int J Hypertens. 2015,2015:896861.SCI
44. Sun J, Yang W, Zhu Y, Liu X, Wei X, Wang B, Zhong JC*, Fu Y*. .The Relationship Between Nocturnal Blood Pressure and Hemorrhagic Stroke in Chinese Hypertensive Patients.. J Clin Hypertens (Greenwich) . 2014,16(9):652-657 .SCI
45. Li Y, Jiang H, Ruan C, Zhong JC, Gao P, Zhu D, Niu W, Guo S* .Transient receptor potential melastatin 7 interacting with macrophages promotes vascular adventitial remodeling in the transverse aortic constriction rats. . Hypertens Res . 2014,37(1):35-42 .SCI
46. Patel VB, Zhong JC, Fan D, Basu R, Morton JS, Parajuli N, McMurtry MS, Davidge ST, Kassiri Z, Oudit GY* .Angiotensin converting enzyme 2 is a critical determinant of angiotensin II-induced loss of vascular smooth muscle cells and adverse vascular remodeling. . Hypertension. 2014,64(1):157-164.SCI
47. Chen J, Ren J, Wu J, Cai M, Liu W, Zou J, Li X, Li P, Nie H, Zhong J, Xu C, Zhou T..Effects of rapamycin on DC-SIGN expression and biological functions in DC.. Front Biosci (Landmark Ed). . 2014,19(1):557-565..SCI
48. Zhang Z#, Chen L#, Zhong J*, Gao P, Oudit GY..ACE2/Ang-(1-7) signaling and vascular remodeling.. Sci China Life Sci.. 2014,57(8):802-828 .SCI
49. Yu H, Lin S, Zhong J, He M, Jin L, Zhang Y, Liu G..A core promoter variant of angiotensinogen gene and interindividual variation in response to angiotensin-converting enzyme inhibitors.. J Renin Angiotensin Aldosterone Syst.. 2014,15(4):540-546..SCI
50. Zhang ZZ, Shang QH, Jin HY, Song B, Oudit GY, Lu L, Zhou T, Xu YL, Gao PJ, Zhu DL, Penninger JM, Zhong JC*.Cardiac Protective Effects of Irbesartan via the PPAR-gamma Signaling Pathway in Angiotensin-Converting Enzyme 2-Deficient Mice.. J Transl Med . 2013,11(1):229-239 .SCI
51. Song B, Jin H, Yu X, Zhang Z, Yu H, Ye J, Xu Y, ...Penninger JM, Zhong JC*.Angiotensin-converting enzyme 2 attenuates oxidative stress and VSMC proliferation via the JAK2/STAT3/SOCS3 and profilin-1/MAPK signaling pathways. . Regul Pept . 2013,185(1):44-51.SCI
52. Cai M, Wu J, Mao C, Ren J, Li P, Li X, Zhong JC, Xu C, Zhou T* .A Lectin-EGF antibody promotes regulatory T cells and attenuates nephrotoxic nephritis via DC-SIGN on dendritic cells.. J Transl Med . 2013,11(1):103-108 .SCI
53. Song B, Zhang ZZ, Zhong JC*, Yu XY, Oudit GY, Jin HY, Lu L, Xu YL, Kassiri Z, Shen WF, Gao PJ, Zhu DL . Loss of angiotensin-converting enzyme 2 exacerbates myocardial injury via activation of the CTGF-Fractalkine signaling pathway. . Circulation Journal . 2013,77(12):2997-3006 .SCI
54. Patel VB, Bodiga S, Fan D, Das SK, Wang Z, Wang W, Basu R, Zhong JC, Kassiri Z, Oudit GY*.Cardioprotective Effects Mediated by Angiotensin II Type 1 Receptor Blockade and Enhancing Angiotensin 1-7 in Experimental Heart Failure in Angiotensin-Converting Enzyme 2-Null Mice. . Hypertension . 2012,59(6):1195-1203 .SCI
55. Jin HY, Song B, Oudit GY, Davidge ST, Yu HM, Jiang YY, Gao PJ, Zhu DL, Ning G, Kassiri Z, Penninger JM, Zhong JC* .ACE2 Deficiency Enhances Angiotensin II-Mediated Aortic Profilin-1 Expression, Inflammation and Peroxynitrite Production. . PLoS ONE . 2012,7(6)::e3850 .SCI
56. Patel VB, Bodiga S, Basu R, Das SK, Wang W, Wang Z, Lo J, Grant MB, Zhong JC, Kassiri Z, Oudit GY*.Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axis. . Circulation Research. 2012,110(10):1322-1335 .SCI
57. Bodiga S, Zhong J, Wang W, Basu R, Lo J, Liu GC, Guo D, Holland SM, Scholey JW, Penninger JM, Kassiri Z, Oudit GY*.Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47phox NADPH oxidase subunit. . Cardiovascular Research . 2011,91(1):151-161 .SCI
58. Zhong J, Guo D, Chen CB, Wang W, Schuster M, Loibner H, Penninger JM, Scholey JW, Kassiri Z, Oudit GY*.Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2.. Hypertension. 2011,57(2):314-322.SCI
59. Zhong JC*, Ye JY, Jin HY, Yu X, Yu HM, Zhu DL, Gao PJ, Huang DY, Shuster M, Loibner H, Guo JM, Yu XY, Xiao BX, Gong ZH, Penninger JM, Oudit GY..Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression. . Regul Pept. 2011,166(1-3):90-97.SCI
60. Oudit GY, Liu GC, Zhong JC, Basu R, Chow FL, Zhou J, Loibner H, Janzek E, Schuster M, Penninger JM, Herzenberg AM, Kassiri Z, Scholey JW .Human recombinant ACE2 reduces the progression of diabetic nephropathy. . Diabetes . 2010,59(2):529-538 .SCI
61. Zhong JC, Basu R, Guo D, Chow FL, Byrns S, Shuster M, Loibner H, Wang X, Penninger JM, Kassiri Z, Oudit GY .Angiotensin converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis and cardiac dysfunction. . Circulation . 2010,122(7):717-728 .SCI
62. Kassiri Z, Zhong J, Guo D, Basu R, Wang X, Liu PP, Scholey JW, Penninger JM, Oudit GY..Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction.. Circulation Heart Failure. 2009,2(5):446-455.SCI
63. Yu H, Lin S, Jin L, Yu Y, Zhong J, Zhang Y, Liu G..Adenine/cytosine(1166) polymorphism of the angiotensin II type 1 receptor gene and the antihypertensive response to angiotensin-converting enzyme inhibitors.. Journal of Hypertension. 2009,27(11):2278-2282..SCI
64. Xiao B, Guo J, Miao Y, Jiang Z, Huan R, Zhang Y, Li D, Zhong J..Detection of miR-106a in gastric carcinoma and its clinical significance.. Clin Chim Acta. 2009,400(1-2):97-102.SCI
65. Zhong JC*, Yu XY*, Lin QX, Li XH, Huang XZ, Xiao DZ, Lin SG .Enhanced angiotensin converting enzyme 2 regulates the insulin/Akt signalling pathway by blockade of macrophage migration inhibitory factor expression.. BRITISH JOURNAL OF PHARMACOLOGY. 2008,153(1):66-74.SCI
66. Zhong JC*, Yu XY*, Huang Y, Yung LM, Lau CW, Lin SG .Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice.. Cardiovascular Research. 2007,74(3):388-395 .SCI
67. Zhong JC,Huang DY*, Liu GF, Jin HY, Yang YM, Li YF, Song XH, Du K .Effects of all-trans retinoic acid on orphan receptor APJ signaling in spontaneously hypertensive rats. . Cardiovascular Research . 2005,65(3):743-750 .SCI
68. Zhong JC, Huang DY*, Yang YM, Li YF, Liu GF, Song XH, Du K.Upregulation of angiotensin-converting enzyme 2 by all-trans retinoic acid in spontaneously hypertensive rats.. Hypertension. 2004,44(6):907-912.SCI
主编或副主编的著作/译著
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重要奖项
1. GWICC-CAAC北美中华青年奖 ACE2与高血压心肌纤维化重构研究 二等奖 201608
2. 上海市教委人才项目/上海交通大学医学院高峰高原建设计划奖 高血压心血管重构机制及其潜在治疗靶点的研究 一等奖 201601
3. 上海市科学技术委员会上海市浦江人才计划奖 ACE2基因调控高血压肾纤维化的炎症机制研究 一等奖 201409
4. 浙江省宁波市科学技术进步奖 短链非编码RNA的鉴定、功能分析及价值 二等奖 201409
5. 上海交通大学SMC“晨星青年奖励计划”奖励 ACE2基因在高血压心肌氧化应激中的保护效应研究 一等奖 201201
6. 长城青年医师奖一等奖 炎症与高血压 一等奖 201111
7. 上海交通大学医学院“新”奖 高血压心血管增殖分子机制研究 一等奖 201109
8. 加拿大AHFMR卫生与健康研究基金研究奖 The regulatory roles of angiotensin converting enzyme 2 (ACE2) in myocardial ischemic injury. 一等奖 200812