姓名：胡爱华 性别：男 职称：研究员、教授 招生院所：附属儿童医院 招生类型：科学学位(博) 科学学位(硕) 招生专业：儿内科学(博) 儿内科学(硕) 研究方向名称：心血管疾病分子病学 电子信箱：aihuacn@hotmail.com


社会任职
1. 全国卫生产业企业管理协会基因技术研究与应用专业委员会 副会长
2. 中国高血压联盟 理事
3. 北京市高血压防治协会 理事
4. 美国胸科协会 会员
5. 美国心脏学会 会员
6. 多种国际学术期刊审稿人：Circulation, Circulation Research, British Journal of Pharmacology, Clinica Chimica Acta, Clinical Cardiology 等
7. 担任国际学术期刊 Gene， Open Journal of Respiratory Diseases 副主编
个人简历
1. 199209-199706:中国医学科学院中国协和医科大学 研究生
2. 199706-199806:中国医学科学院阜外医院 主治医师
3. 199806-200306:美国国立卫生研究院心肺血研究所(NIH,NHLBI) 博士后
4. 200306-200506:美国托马斯杰佛逊大学医学院 研究助理
5. 200506-201712:美国宾夕法尼亚大学费城儿童医院 副研究员、研究员
6. 201609-:北京高血压联盟研究所 教授（兼职）
7. 201809-:首都医科大学附属北京儿童医院 研究员 教授
重要学术论文
1. Jiang X, Quan X, Yang J, Zhou X, Hu A, Zhang Y.Electrocardiographic criteria for the diagnosis of abnormal hypertensive cardiac phenotypes. J Clin Hypertens (Greenwich). 2019,21(3):372-378.SCI
2. Guo L, Tian S, Chen Y, Mao Y, Cui S, Hu A, Zhang J, Xia SL, Su Y, Du J, Block ER, Wang XL, Cui Z.CAT-1 as a novel CAM stabilizes endothelial integrity and mediates the protective actions of l-Arg via a NO-independent mechanism. J Mol Cell Cardiol. 2015,87:180-191.SCI
3. Hu A, Diener BL, Josephson MB, Grunstein MM..Constitutively active signaling by the G protein βγ-subunit mediates intrinsically increased phosphodiesterase-4 activity in human smooth muscle cells. PLoS One. 2015,10(3):e**.SCI
4. Du Q, Wu J, Wang H, Wang X, Xu L, Zhang Z, Liu J, Zhang J, Chen J, Hakonarson H, Hu A, Zhang L.Perindopril treatment promote left ventricle remodeling in patients with heart failure screened positive for autoantibodies against angiotensin II type 1 receptor. BMC Cardiovasc Disord. 2013,31:13:94.SCI
5. Hu A, Josephson MB, Diener BL, Nino G, Xu S, Paranjape C, Orange JS, Grunstein MM.Pro-asthmatic cytokines regulate unliganded and ligand-dependent glucocorticoid receptor signaling in smooth muscle. PLoS One. 2013,8(4):e60452.SCI
6. Hou D, Chen Y, Liu J, Xu L, Zhang Z, Zhang J, Wang H, Wang X, Chen J, Zhao R, Hu A, Hakonarson H, Zhang L, Shen Y..Proteomics screen to reveal molecular changes mediated by C722G missense mutation in CHRM2 gene. J Proteomics. 2013,89C:39-50.SCI
7. Gao L, Wang L, Liu Y, Zhou X, Hui R, Hu A.A family with Liddle syndrome caused by a novel missense mutation in the PY motif of the beta-subunit of the epithelial sodium channel. J Pediatr.. 2013,162(1):166-70.SCI
8. Nino G*, Hu A*,Grunstein JS, McDonough J, Kreiger PA, Josephson MB, Choi JK, Grunstein MM..G Protein βγ-subunit signaling mediates airway hyperresponsiveness and inflammation in allergic asthma. PLoS One. 2012,7(2):e32078.SCI
9. Yuan H, Yan B, Wang HH, Hua S, Hu A. Nitric oxide preserves XIAP and reduces hypoxia/reoxygenation-induced cardiomyocytes apoptosis via ERK1/2 activation.. Biochem Biophys Res Commun. 2012,421(1):134 -142.SCI
10. Josephson MB, Jiao J, Xu S, Hu A, Paranjape C, Grunstein JS, Grumbach Y, Nino G, Kreiger PA, McDonough J, Grunstein MM.IL-13-induced changes in endogenous glucocorticoid metabolism in the lung regulate the proasthmatic response. Am J Physiol Lung Cell Mol Physiol. 2012,303(5):L382-90.SCI
11. Nino G, Hu A, Grunstein JS, Grunstein MM.Mechanism of glucocorticoid protection of smooth muscle from proasthmatic effects of long-acting beta2-adrenoceptor agonist exposure.. J Allergy Clin Immunol.. 2010,125(5):1020-7.SCI
12. Nino G, Hu A, Grunstein JS, Grunstein MM.Mechanism regulating proasthmatic effects of prolonged homologous beta2-adrenergic receptor desensitization in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2009,297(4):L746-57.
13. A Hu, S Fatma, J Cao, J Grunstein, G Nino,Y Grumbach, and M Grunstein.Th2 cytokine-induced upregulation of 11 beta-hydroxysteroid dehydrogenase-1 facilitates glucocorticoid suppression of smooth muscle function. Am J Physiol Lung Cell Mol Physiol.. 2009,296(5):L790-803.SCI
14. A Hu, X Jiao, E Gao, Y Li, S Sharifi-Azad, Z Grunwald, J Sun.Tonic beta-adrenergic drive provokes proinflammatory and proapoptotic changes in aging mouse heart. Rejuvenation Research. 2008,11(1):215-226.SCI
15. L Zhang*, A Hu*, H Yuan, L Cui, G Miao, J Liu, X Liu, S Wang, Z Zhang, L Liu, R Zhao, Y Shen.A missense mutation in the CHRM2 gene is associated with familial dilated cardiomyopathy. Circ Res. 2008,102(11):1426-32.SCI
16. Y Li, N Chu, A Hu, B Gran, A Rostami and G Zhang.Inducible IL-23p19 expression in human microglia via p38 MAPK and NF-kappaB signal pathways. Exp Mol Pathol. 2008,84(1):1-8.
17. Zhou LF, Zhang MS, Hu AH, Zhu Z, Yin KS..Selective blockade of NF-kappaB by novel mutated IkappaBalpha suppresses CD3/CD28-induced activation of memory CD4+ T cells in asthma.. Allergy. 2008,63(5):509-17.SCI
18. A Hu, G Nino, J Grunstein, S Fatma, and M Grunstein.Prolonged heterologous beta2-adrenoceptor desensitization promotes smooth muscle function via PKA/ERK1/2-mediated phosphodiesterase-4 induction. Am J Physiol Lung Cell Mol Physiol.. 2008,294(6):L1055-67.SCI
19. Haviva Veler, Aihua Hu, Sumbul Fatma, Judith S. Grunstein, Christine M. DeStephan, Donald Campbell, Jordan S. Orang and Michael M. Grunstein.Superantigen Presentation by Airway Smooth Muscle to CD4+ T Lymphocytes Elicits Reciprocal Proasthmatic Changes in Airway Function.. J Immunol. 2007,178(6):3627-36.SCI
20. Li Y, Chu N, Hu A, Gran B, Rostami A, Zhang GX.Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia. Brain. 2007,130(Pt 2):490-501..SCI
21. Lin-Fu Zhou, Yi Zhu, Xue-Fan Cui, Wei-Ping Xie, Ai-Hua Hu and Kai-Sheng Yin..Arsenic trioxide, a potent inhibitor of NF-kappaB, abrogates allergen-induced airway hyperresponsiveness and inflammation. Respir Res. 2006,7:146.SCI
22. Xiaoyin Shan, Aihua Hu, Haviva Veler, Sumbul Fatma, Judith S Grunstein, Sing Chuang, and Michael M Grunstein.Regulation of Toll-like Receptor 4-Induced Pro-asthmatic Changes in Airway Smooth Muscle Function by Opposing Actions of ERK1/2 and p38 MAPK Signaling.. Am J Physiol Lung Cell Mol Physiol. 2006,291(3):L324-33.SCI
23. 26.D Li, Y Qu, L Tao, H Liu, A Hu, F Gao, Said-Azad, Zvi Grunwald, X-L Ma and J-Z Sun.Inhibition of iNOS Protects the Aging Heart Against beta-Adrenergic Receptor Stimulation-Induced Cardiac Dysfunction and Myocardial Ischemic Injury. J Surg Res. 2006,131(1):64:72.SCI
24. L Tao, E Gao, A Hu, C Coletti, Y Wang, T A Christopher, B L Lopez, W Koch and X L Ma.Thioredoxin reduces post-ischemic myocardial apoptosis by reducing oxidative/nitrative stress. Br J Pharmacol.. 2006,149(3):311-8..SCI
25. Zhang L, Zhang L, Li YH, Zhang HY, Chen ML, Gao MM, Hu AH, Yang HS, Yang HS.High-dose glucose-insulin-potassium treatment reduces myocardial apoptosis in patients with acute myocardial infarction.. Eur J Clin Invest.. 2005,35(3):164-70.SCI
26. H Liu, E Gao, Aihua Hu, L Tao, TA Christopher, BL lopez and X Ma.Role of Omi/Htr2 in apoptotic cell death after myocardial ischemia and reperfusion.. Circulation. 2005,111(1):90-6.SCI
27. H-R Liu, F Gao, L Tao, W-L Yan, E Gao, T A Christopher, B L Lopez, A Hu and X L Ma.Antiapoptotic mechanisms of benidipine in the ischemic/reperfused heart. Br J Pharmacol. Br J Pharmacol. 2004,142(4):627-34.SCI
28. L Tao, E Gao, NS. Bryan, A Hu, TA. Christopher, BL. Lopez, J Yodoi, WJ. Koch, M Feelisch and XL. Ma.Cardioprotective effects of thioredoxin in myocardial ischemia and the reperfusion role of S-nitrosation. Proc Natl Acad Sci U S A. 2004,101(31):11471-6.SCI
29. Fei Wang, Mihály Kovács, Aihua Hu, John Limouze, Estelle V. Harvey and James R. Sellers..Kinetic mechanism of non-muscle myosin IIB: functional adaptations for tension generation and maintenance. J Biol Chem. 2003,278(30):27439-48.SCI
30. Mihály Kovács, Fei Wang, Aihua Hu, Yue Zhang and James R. Sellers.Functional divergence of human cytoplasmic myosin II: kinetic characterization of the non-muscle IIA isoform.. J Biol Chem. 2003,278(40):38132-40.SCI
31. A Hu, F Wang, J Sellers.Mutations in Human Normuscle Myosin IIA Found in Patients with May-Hegglin Anomaly and Fechtner Syndrome Result in Impaired Enzymatic Function.. J Biol Chem. 2002,277(48):46512-46517.SCI
主编或副主编的著作/译著
重要奖项