姓名：黄家强 性别：男 职称：教授 招生院所：胸科医院 招生类型：科学学位(博) 科学学位(硕) 招生专业：免疫学(博) 免疫学(硕) 研究方向名称：肿瘤与免疫表观遗传调控 电子信箱：hjq65@hotmail.com


社会任职
个人简历
1. 199910-200209: NCI-Frederick，NIH Visiting Fellow
2. 200209-200411: SAIC Basic program，NCI-Frederick，NIH Scientist
3. 200412-200704:Department of Dermatology, Johns Hopkins University School of Medicine Faculty Member, Research Associate
4. 200704-201110:QIAGEN-Frederick Genome Center Senior Scientist
5. 201111-:北京交通大学 教授
6. 201304-:Cancer and Inflammation Program（CIP），NCI-Frederick，NIH Research collaborator
7. 201810-:首都医科大学附属胸科医院 教授，研究员，肿瘤研究中心执行主任
重要学术论文
1. Zhang M, Gao JL, Chen K, Yoshimura T, Liang W, Gong W, Li X, Huang J, McDermott DH, Murphy PM, Wang X, Wang JM*.A Critical Role of Formyl Peptide Receptors in Host Defense against Escherichia coli. . J Immunol. 2020,【未填写卷（期）】:【未填写起止页码】.SCI
2. Lin S, Zhang Y, Hu Y, Yang B, Cui J, Huang J, Wang JM, Xing R*, Lu Y*. .Epigenetic downregulation of MUC17 by H. pylori infection facilitates NF-κB-mediated expression of CEACAM1-3S in human gastric cancer. Gastric Cancer.. Gastric Cancer. 2019,22(5):941-954.SCI
3. Lin S, Wang X, Pan Y, Tian R, Lin B, Jiang GS, Chen K, He YQ, Zhang L, Zhai W, Jin P, Yang L, Li G, Wu Y, Hu J, Gong W, Chang Z, Sheng JQ, Lu Y, Wang JM, Huang J*..Transcription Factor Myeloid Zinc-Finger 1 Suppresses Human Gastric Carcinogenesis by Interacting with Metallothionein 2A. Clin Cancer Res. . 2019,25-3:1050-1062.SCI
4. Yoshimura T, McLean MH, Dzutsev AK, Yao X, Chen K, Huang J, Gong W, Zhou J, Xiang Y, H Badger J, O'hUigin C, Thovarai V, Tessarollo L, Durum SK, Trinchieri G, Bian XW, Wang JM*. .The Antimicrobial Peptide CRAMP Is Essential for Colon Homeostasis by Maintaining Microbiota Balance. J Immunol. . 2018,200-6:2174-2185.SCI
5. Wang XF，Chen K, Yu Y，Xiang Y， Kim JH，Gong W，Huang J，Shi S， LiQ，Zhou M，Sayers T, Tewary P, Gao B, and Wang JM*. .5.Wang XF，Chen K, Yu Y，Xiang Y， Kim JH，Gong W，Huang J，Shi S， LiQ，Zhou M，Sayers T, Tewary P, Gao B, and Wang JM. Oncotarget. 2017,8-65:109068-109078.
6. Lin S, Lin B, Wang X, Pan Y, Xu Q, He JS, Gong W, Xing R, He Y, Guo L, Lu Y, Wang JM, Huang J*. .Silencing of ATP4B of H+, K+-ATPase Beta by Intragenic Epigenetic Alteration in Human Gastric Cancer cells. . Oncology Research. . 2017,25:317-329.SCI
7. Jiao YY, Fu YH, Yan YF, Hua Y, Ma Y, Zhang XJ, Song JD, Peng XL, Huang J, Hong，T, He JS. .A single intranasal administration of virus-like particle vaccine induces an efficient protection for mice against human respiratory syncytial virus. Antiviral Res.. 2017,144:57-69..SCI
8. Lin B#,, Zhou X#, Lin S, Wang X, Zhang M, Cao B, Dong Y, Yang S, Wang JM, Guo M*, Huang, J*. .Epigenetic silencing of PRSS3 provides growth and metastasis advantage for human hepatocellular carcinoma.. J Molecular Medicine (Berl).. 2017,95:1237-1249.SCI
9. Xiang Y, Yao X, Chen K, Wang X, Zhou J, Gong W, Yoshimura T, Huang J, Wang R, Wu Y, Shi G, Bian X, Wang J*. .The G-protein coupled chemoattractant receptor FPR2 promotes malignant phenotype of human colon cancer cells. . Am J Cancer Res. . 2016,6（11）:2599-2610.SCI
10. Xing R, Li L, Chen L, Gao Z, Wang H, Li W, Cui J, Tian G, Liang Q, Yu J, Sung JJ, Luo G, Gao H, Xu X, Yang H, Wang J, Zhang X, Wang JM, Huang J, Yu Y, Wang J, Lu Y*. .Copy number variations of HLA-I and activation of NKp30 pathway determine the sensitivity of gastric cancer cells to the cytotoxicity of natural killer cells.. Oncogene. 2016,35(20）:2584-91.SCI
11. Pan Y#, Lin S#, Xing R, Zhu M, Lin B, Cui J, Li W, Gao J, Shen L, Zhao Y, Guo M, Wang JM, Huang J*, Lu Y:*.Epigenetic upregulation of metallothionein 2a by diallyl trisulfide enhances chemosensitivity of human gastric cancer cells to docetaxel through attenuating nf-kappab activation. . Antioxidants Redox Signal. . 2016,24（15）:839-854.SCI
12. Chen K, Xiang Y, Huang J, Gong W, Yoshimura T, Jiang Q, Tessarollo L, Le Y, Wang JM*. .The formylpeptide receptor 2 (Fpr2) and its endogenous ligand cathelin-related antimicrobial peptide (CRAMP) promote dendritic cell maturation. . J Biol Chem. . 2014,289 (25):17553-63..SCI
13. Guo L, Bai H, Zou D, Hong T, Liu J, Huang J, He P, Zhou Q, He J *. .The role ofmicroRNA-133b and its target gene FSCN1 in gastric cancer. . J Exp Clin Cancer Res. . 2014,33(1):99.SCI
14. Pan Y#, Huang J#, Xing R, Yin X, Cui J, Li W, Yu J, Lu Y*. .Metallothionein 2A inhibits NF-kappaB pathway activation and predicts clinical outcome segregated with TNM stage in gastric cancer patients following radical resection. . J Transl Med. . 2013,11（173）:1-14.SCI
15. Kibe R, Zhang S, Guo D, Marrero L, Tsien F, Rodriguez P, Khan S, Zieske A, Huang J, Li W, Durum SK, Iwakuma T, Cui Y*. .IL-7Rapha deficiency in p53(null) mice exacerbates thymocyte telomere erosion and lymphomagenesis. Cell Death Differ. . Cell Death Differ. . 2012,19:1139-51..SCI
16. Hamano, R., Huang, J., Toshimura, T., Howard, O.M. Z., Oppenheim, J.J., Chen，X*. .TNF induces co-stimulatory TNF receptor superfamily member TNFR2, 4-1BB andOX40 on CD4+FoxP3+ regulatory T cells. . Eur. J. Immunol. . 2011,41:2010-20.SCI
17. Tao Y, Xi S, Shan J, Maunakea A, Che A, Briones V, Lee EY, Geiman T, Huang J, Stephens R, Leighty RM, Zhao K, Muegge K*. .Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences. Proc Natl Acad Sci U S A. . 2011,108:5626-31.SCI
18. Huang, J., Chen, K., Huang, J., Gong, W., Dunlop, N.M., Howard, O.M., Bian, X., Gao, Y., Wang, J.M*.. Regulation of the leukocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation.. Carcinogenesis. . 2009,30: 348-55. .SCI
19. Zhu, G., Augustine, M.M., Azuma, T., Luo, L., Yao, S., Anand, S., Rietz, A.C., Huang, J., Xu, H., Flies, A.S., Flies, S.J., Tamada, K., Colonna, M., van Deursen, J.M., Chen, L.*. B7-H4-deficient mice display augmented neutrophil-mediated innate immunity.. Blood. 2009,113: 1759-67. .SCI
20. Jiang, Q., Huang, J., Li, W.Q., Muegge, M., and Durum, S.K. * .Role of the Intracellular Domain of IL-7 Receptor in T Cell Development.. J. Immunol. . 2007,178: 178: 228-234. .SCI
21. Wang, L.H. &, Yang, X.Y., Zhang, X., An, P., Kim, H., Huang, J., Clarke, R., Osborne, C.K., Inman, J.K., Appella, E., and Farrar, L.W.* .Disruption of estrogen receptor zinc finger domains and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer. . Cancer Cell. 2006,10:487-499.SCI
22. Huang, J., Fan, T., Yan, Q., Zhu, H., Fox, S., Issaq, H.J., Best, L., Gangi, L., Munroe, D. and Muegge, K*..Lsh, an epigenetic guardian of repetitive elements. . Nucleic Acids Research . 2004,32:5019-5018..SCI
23. Wang, L.H., Yang, X.Y., Zhang, X., Huang, J., Mihalic, K., Zhu, H., Xiao, W., Muegge, K., Farrar, L.W*..Transcriptional inactivation of STAT3 by PPAR gamma suppresses IL-6-responsive multiple myeloma cells. . Immunity. 2004,20:205-18.SCI
24. Yan Q#, Huang J#,Fan T, Zhu H, Muegge K*..Lsh, a modulator of CpG methylation, is crucial for normal histone methylation. . EMBO J. . 2003,22:5154-62..SCI
25. Fan, T. Yan, Q., Huang, J., Austin, S., Cho, E., Ferris, D., Muegge, K*..Lsh deficient murine embryonic fibroblasts show reduced proliferation with signs of abnormal mitosis.. Cancer Research. 2003,63:4677-4683.SCI
26. Khaled AR, Li WQ, Huang J, Fry TJ, Khaled AS, Mackall CL, Muegge K, Young HA, Durum SK*..Bax deficiency partially corrects interleukin-7 receptor alpha deficiency. . Immunity. . 2002,17:561-73. .SCI
27. Huang J, Durum SK, Muegge K*..Cutting edge: histone acetylation and recombination at the TCR gamma locus follows IL-7 induction. J Immunol. . 2001,167:6073-7.SCI
28. Huang, J. and Muegge, K*..Control of chromatin accessibility for V(D)J recombination by interleukin 7. . Journal of Leukocyte Biology . 2001,69:907-11.SCI
主编或副主编的著作/译著
重要奖项