姓名：陆宇 性别：女 职称：研究员、教授 招生院所：胸科医院 招生类型：科学学位(博) 科学学位(硕) 招生专业：药理学(博) 药理学(硕) 研究方向名称：抗结核药物的药理学研究 电子信箱：luyu4876@ccmu.edu.cn


社会任职
1. 中国防痨协会学术工作委员会委员
2. 中国防痨杂志编委
3. 中国药理学会化疗药理专业委员会青委会主任委员
4. 中国防痨协会标准化专业委员会常委
5. 中国药学会抗生素专业委员会委员
个人简历
重要学术论文
1. 张叶，李媛媛，徐建，陈曦，王彬，付雷，陆宇*.吡法齐明抗耐药结核分枝杆菌作用机制的初步研究. 中国防痨杂志. 2019,41(11):1160-1166.核心期刊
2. 张叶，朱慧，付雷，王彬，郭少晨，陈曦，刘忠泉，黄海洪，Tianjian Yang，陆宇*.Identifying regimens containing a new drug candidate TBI-166 against Mycobacterium tuberculosis in vitro and in vivo. Antimicrob Agents Chemother. 2019,63（7）:02496-18.SCI
3. 徐建，王彬，付雷，朱慧，郭少晨，黄海洪, 尹大力, 张叶，陆宇*.In vitro and in vivo activities of the riminophenazine TBI-166 against Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2019,63(5）: 02155-18.SCI
4. Apeng Wang, Hongjian Wang, Yunhe Geng, Lei Fu, Jian Gu, Bin Wang, Kai Lv,Zeyu Tao , Chao Ma, Mingliang Liu*，陆宇*.Design, synthesis and antimycobacterial activity of less lipophilic Q203 derivatives containing alkaline fused ring moieties. Bioorganic & Medicinal Chemistry . 2019,27(5):813-821.SCI
5. Hongjian Wang, Kai Lv,XiaoningLi, BoWang, ApengWang, ZeyuTao, YunheGeng, Bin Wang, MenghaoHuang, Huiyuan Guo，Mingliang Liu，陆宇*.Design, synthesis and antimycobacterial activity of novel nitrobenzamide derivatives. Chinese Chemical Letters. 2019,30(2):413-416.SCI
6. Apeng Wang, Kai Lv，LinhuLi， HongtaoLiu，ZeyuTao，Bin Wang，ChaoMa， XicanMa， BingHan， AoyuWang，Mingliang Liu，陆宇*.Design, synthesis and biological activity of N-(2-phenoxy)ethylimidazo[1,2-a]pyridine-3-carboxamides as new antitubercular agents. European Journal of Medicinal Chemistry. 2019,178:715-725.SCI
7. Dongfeng Zhang，Yun Lin, Xi Chen， Wenting Zhao, Dongni Chen, Meng Gao, Qinglin Wang，Bin Wang，Haihong Huang, Yongjun Lu, 陆宇*.Docking- and pharmacophore-based virtual screening for the identification of novel Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitor with a thiobarbiturate scaffold. Bioorganic Chemistry. 2019,85:229-239.SCI
8. 张叶，陆宇*.亚胺吩嗪类药物抗结核作用研究进展. 中华结核和呼吸杂志. 2019,42(2):118-121.核心期刊
9. Apeng Wang, Kai Lv，Zeyu Tao, Jian Gu, Lei Fu, Baojie Wan, Scott G. Franzblau, Chao Ma, Xican Ma, Bing Han, Aoyu Wang, Shijie Xu， Mingliang Liu，陆宇*.Identification of benzothiazinones containing an oxime functional moiety as new anti-tuberculosis agents. European Journal of Medicinal Chemistry . 2019,181:【未填写起止页码】.SCI
10. 陈曦，刘忠泉，王彬， 朱慧， 付雷， 李媛媛，陆宇*.14种抗结核药物的巨噬细胞内活性的比较研究. 中国防痨杂志. 2019,41(9):993-998.核心期刊
11. Apeng Wang， Kai Lv，Zeyu Tao,Lei Fu, Hongtao Liu, Bin Wang, Chao Ma, Hongjian Wang, Xican Ma, Bing Han, Aoyu Wang, Kai Zhang，Mingliang Liu，陆宇*.hERG optimizations of IMB1603, discovery of alternative benzothiazinones as new antitubercular agents. European Journal of Medicinal Chemistry. 2019,179:208-217.SCI
12. Hongjian Wang, Apeng Wang，Jian Gu, Lei Fu, Kai Lv, Chao Ma, Zeyu Tao, Bin Wang, Huiyuan GuoMingliang Liu，陆宇*.Synthesis and antitubercular evaluation of reduced lipophilic imidazo [1,2-a]pyridine-3-carboxamide derivatives. European Journal of Medicinal Chemistry . 2019,165:11-17.SCI
13. 赵皎洁，陆宇*.抗结核药物药代动力学/药效学的研究及进展. 中国防痨杂志. 2019,41(6):700-704.核心期刊
14. 王彬，付雷，徐建，郭少晨，朱慧，陆宇*.圣露丸的抗结核作用初步实验研究. 中国防痨杂志. 2018,40（1）:80-83.核心期刊
15. Apeng Wang ，, Yang Yang , Yangsheng Jun , Bin Wang, Kai Lv , Mingliang Liu, Huiyuan Guo ，Yu Lu*.Synthesis, evaluation and CoMFA/CoMSIA study of nitrofuranyl methyl N-heterocycles as novel antitubercular agents. Bioorganic & Medicinal Chemistry. 2018,2018（26）:2073-2084.SCI
16. Kai Lv , 1, Zeyu Tao , Qian Liu , Lu Yang a, Bin Wang, Shuo Wu , Apeng Wang,Menghao Huang , Mingliang Liu *, Yu Lu *.Design, synthesis and antitubercular evaluation of benzothiazinones containing a piperidine moiety. European Journal of Medicinal Chemistry . 2018,2018（151）:1-8.SCI
17. Li L, Jin Y, Wang B, Yang Z, Liu M, Guo H, Zhang J, Lu Y*..A structure-based strategy toward the development of novel candidates for antimycobacterial activity: Synthesis, biological evaluation, and docking study.. Chem Biol Drug Des.. 2018,91(3):769-780.SCI
18. Wang A, Li W, Wang B, Lv K, Wang H, Liu M, Guo H, Lu Y*..Synthesis and evaluation of nitrofuranyl methyl N-heterocycles derivatives as novel antitubercular agents.. Future Med Chem. 2018,10(17):2059-2068.SCI
19. Li L, Lv K, Yang Y, Sun J, Tao Z, Wang A, Wang B, Wang H, Geng Y, Liu M, Guo H, Lu Y*..Identification of N-Benzyl 3,5-Dinitrobenzamides Derived from PBTZ169 as Antitubercular Agents.. ACS Med Chem Lett. 2018,9(7):741-745.SCI
20. Zhu H#, Guo SC#, Liu ZQ, Wang B, Fu L, Chu NH, Lu Y*..Therapeutic drug monitoring of cycloserine and linezolid during anti-tuberculosis treatment in Beijing, China. INT J TUBERC LUNG DIS. 2018,22(8):931-936.SCI
21. Wang A, Huang G, Wang B, Lv K, Wang H, Tao Z, Liu M, Guo H, Lu Y*..Design, synthesis and antimycobacterial activity of 3,5-dinitrobenzamide derivatives containing fused ring moieties.. Bioorg Med Chem Lett. 2018,28(17):2945-2948.SCI
22. Zhang Y, Zhu H, Yang X, Guo S, Liang Q, Lu Y*, Chen X*.Serum vitamin D level and vitamin D receptor genotypes may be associated with tuberculosis clinical characteristics: A case-control study. Medicine (Baltimore). 2018,(97)30:e11732.SCI
23. 陆宇.治疗药物监测与药物基因组学在优化抗结核治疗中的作用. 临床药物治疗杂志. 2018,16(4):23-28.核心期刊
24. 郭少晨,朱慧,郭超,王彬,刘忠泉,徐建,付雷,陈效友,陆宇*.909例结核病患者一线抗结核药物血药浓度监测结果分析. 中国防痨杂志. 2018,40(7):744-749.核心期刊
25. Peng Li, Bin Wang ,Xinwei Zhang ,Sarah M. Batt , Gurdyal S. Besra,Tingting Zhang,, Chen Ma,Dongfeng Zhang, Ziyun Lin, Gang Li,Haihong Huang*, Yu Lu*.Identification of Novel benzothiopyranone compounds against Mycobacterium tuberculosis through scaffold morphing from benzonthiazinones. Eur J Med Chem. 2018,160:157-170.SCI
26. 冉飞勇,付雷,王彬,郭少晨,陆宇*,陈效友*.维生素D在豚鼠结核感染中的辅助治疗作用评价. 中国防痨杂志. 2018,40(5):512-518.核心期刊
27. Jian Xu, Ju-xian Wang, Jin-ming Zhou, Chang-liang Xu, Bin Huang, Yun Xing, Bin Wang, Rui Luo, Yu-cheng Wang, Xue-fu You, Yu Lu * and Li-yan Yu .A novel protein kinase inhibitor IMB-YH-8 with anti-tuberculosis activity. Scientific RepoRts . 2017, Jul 11;7(1):5093:s41598-017-04108-7..SCI
28. Hongyi Zhao, Yu Lu#, Li Sheng, Zishuo Yuan, Bin Wang, Weiping Wang, Yan Li, Chen Ma, Xiaoliang Wang, Dongfeng Zhang, and Haihong Huang.Discovery of Fluorine-Containing Benzoxazinyl-oxazolidinones for the Treatment of Multidrug Resistant Tuberculosis . ACS Medicinal Chemistry Letters. 2017,8(5):533-537.SCI
29. Kai Lv , Linhu Li , Bo Wang, Mingliang Liu, Bin Wang, Weiyi Shen, Huiyuan Guo,Yu Lu *.Design, synthesis and antimycobacterial activity of novel imidazo[1,2-a]pyridine-3-carboxamide derivatives. European Journal of Medicinal Chemistry . 2017,2017:137:117-125.
30. Xu J, Wang B, Hu M, Huo F, Guo S, Jing W, Nuermberger E, Lu Y*.Primary clofazimine and bedaquiline resistance among isolates from patients with multidrug-resistant tuberculosis. Antimicrob. Agents Chemother. 2017, AAC.2017.3.20:AAC.00239-17.SCI
31. Rui Zhang，Kai Lv, Bin Wang,Linhu Li,Bo Wang,Mingliang Liu,* Huiyuan Guo,Apeng Wang，Yu Lu*.Design, synthesis and antitubercular evaluation of benzothiazinones containing an oximido or amino nitrogen heterocycle moiety. RSC Advances. 2017,2017,7:1480-1483.SCI
32. 胡明豪，徐建，王彬，付雷，陆宇*.结核分枝杆菌对PA-824耐药的体外诱导及稳定性研究. 中国抗生素杂志. 2017,42（2）:144-148.核心期刊
33. 胡明豪，王彬，付雷，徐建，陆宇*.体外诱导获取对利奈唑胺耐药的MTB菌株及其稳定性研究. 中国防痨杂志. 2017,39（4）:397-401.核心期刊
34. Zhao H, Lu Y#, Sheng L1, Yuan Z, Wang B, Wang W, Li Y, Ma C, Wang X, Zhang* , Huang H*.Discovery of Fluorine-Containing Benzoxazinyl-oxazolidinones for the Treatment of Multidrug Resistant Tuberculosis. ACS Med Chem Lett.. 2017,8（5）:533-537.SCI
35. 张叶，郭少晨，朱慧，郭超，陆宇*，陈效友*.UPLC-MS/MS法测定人血浆中25羟基维生素D的浓度及其应用 . 中国药房. 2016,27（14）:1907-1910.核心期刊
36. Wu Z, Lu Y#, Li L, Zhao R, Wang B, Lv K, Liu M, You X*..Identification of N (2-Phenoxyethyl)imidazo[1,2 a]pyridine-3-carboxamides as New Antituberculosis Agents. ACS Medicinal Chemistry Letters . 2016,7（12）:1130-1133.SCI
37. 胡明豪，陆宇*.硝基咪唑类抗结核新药研究进展. 中国防痨杂志. 2016,38（11）:990-994.核心期刊
38. Linhu Li, Zhuorong Li , Mingliang Liu *, Weiyi Shen, Bin Wang， Huiyuan Guo， Yu Lu*.Design, Synthesis and Antimycobacterial Activity of Novel Imidazo[1,2-a]pyridine Amide-Cinnamamide Hybrids. Molecules. 2016,21, 49:doi:10.3390/molecules**.SCI
39. Ju Huang , Minghua Wang, Bin Wang, Zhaoyang Wua, Mingliang Liu，Lianshun Feng，Jun Zhang, Xiaoning Li，Yang Yang,Yu Lu*.Synthesis, antimycobacterial and antibacterial activity of 1-(6-amino-3,5-difluoropyridin-2-yl)fluoroquinolone derivatives containing an oxime functional moiety. Bioorg. Med. Chem. Lett. 2016,26（2016）:2262-2267.SCI
40. 左小淑，王彬，徐建，付雷，陆宇*.结核分枝杆菌对氯法齐明耐药的体外诱导实验研究. 中国防痨杂志. 2015,37（6）:632-636.核心期刊
41. Ju Huang，Hongtao Liu ，Mingliang Liu , Rui Zhang, Linhu Li, Bin Wang, Minghua Wang,Chunlan Wang, Yu Lu*.Synthesis, antimycobacterial and antibacterial activity of l-[(1R,2S)-2-fluorocyclopropyl]naphthyridone derivatives containing an oxime-functionalized pyrrolidine moiety. Bioorg. Med. Chem. Lett. 2015,25:5058-5063.SCI
42. Tingting Zhang,Weiyi Shen,Mingliang Liu*, Rui Zhang,Minghua Wang,Linhu Li, Bin Wang, Huiyuan Guo，Yu Lu *.Synthesis, antimycobacterial and antibacterial activity of fluoroquinolone derivatives containing an 3-alkoxyimino-4- (cyclopropylanimo)methylpyrrolidine moiety. European Journal of Medicinal Chemistry. 2015,104:73-85.SCI
43. Hui Zhu, Shao-Chen Guo, Lan-Hu Hao, Cheng-Cheng Liu, Bin Wang, Lei Fu, Ming-Ting Chen, Lin Zhou, Jun-Ying Chi, Wen Yang, Wen-Juan Nie, Yu Lu*.Relative bioavailability of rifampicin in four Chinese fixed-dose combinations compared with rifampicin in free combinations. Chin Med J. 2015,128(4):433-437.SCI
44. 陆宇.实验技术人员在研究生培养中的作用探讨. 基础医学教育. 2015,17（1）:81-83.核心期刊
45. 杨雯，王彬，郝兰虎，陈效友，陆宇*.滚环扩增技术直接检测痰标本中结核分枝杆菌利福平敏感性的初步研究. 中国抗生素杂志. 2014,39（11）: 849-855.核心期刊
46. 郭少晨，朱慧，徐建，郝兰虎，王彬，付雷，陈明亭，周林，池俊英， 陆宇*.两种国产抗结核固定剂量复合剂中利福平的药代动力学和生物等效性. 中国防痨杂志. 2014,36（12）:1075-1079.核心期刊
47. Dongfeng Zhang, Yang Liu, Chunlin Zhang, Hao Zhang, Bin Wang, Jian Xu, Lei Fu, Dali Yin, Christopher B. Cooper, Zhenkun Ma*, Yu Lu,* and Haihong Huang *.Synthesis and Biological Evaluation of Novel 2-Methoxypyridylamino-Substituted Riminophenazine Derivatives as Antituberculosis Agents. Molecules. 2014,19:4380-4394.SCI
48. Hongmin Liu, Ju Huang, Jiayang Wang, Minghua Wang, Mingliang Liu, *Bin Wang, Huiyuan Guo, Yu Lu*.Synthesis, antimycobacterial and antibacterial evaluation of l-[(1R,2S)-2-fluorocyclopropyl]fluoroquinolone derivatives containing an oxime functional moiety. European Journal of Medicinal Chemistry. 2014,86(2014):628-638.SCI
49. Lanhu Hao, Shaochen Guo, Chengcheng Liu, Hui Zhu, Bin Wang, Lei Fu, Mingting Chen, Lin Zhou, Junying Chi, Wen Yang, Wenjuan Nie, Yu Lu*.Comparative bioavailability of rifampicin and isoniazid from fixed dose combinations with separate formulation. International Journal of Tuberculosis and Lung Disease. 2014,18(12):1505-1512.SCI
50. 朱慧，王彬，付雷，刘诚诚，陆宇*.吡嗪酰胺每日一次与三次给药在小鼠体内的药代动力学比较及其对异烟肼-利福平的影响. 中国防痨杂志. 2013,35（12）:983-988.核心期刊
51. 刘诚诚，金海霞，徐建，李华，朱慧，付雷，王彬，陆宇*.结核病患者N-乙酰基转移酶2基因型与异烟肼血药浓度关系的研究. 中国防痨杂志. 2013,35（3）: 179-183.核心期刊
52. Zengquan Wei, Jian Wang, Mingliang Liu,*, Sujie Li, Lanying Sun , Huiyuan Guo, Bin Wang ,Yu Lu* .Synthesis, in Vitro Antimycobacterial and Antibacterial Evaluation of IMB-070593 Derivatives Containing a Substituted Benzyloxime Moiety. Molecules . 2013,18:3872-3893.SCI
53. 刘诚诚，金海霞，徐建，李华，朱慧，付雷，王彬，陆宇*.结核病患者N-乙酰基转移酶2基因型与异烟肼血药浓度关系的研究. 中国防痨杂志. 2013,35（3）:179-182.核心期刊
54. Jian Xu, Haixia Jin, Hui Zhu, Meiqin Zheng, Bin Wang, Chengcheng Liu, Mingting Chen, Lin Zhou, Weijie Zhao, Lei Fu, Yu Lu*.Oral Bioavailability of Rifampicin, Isoniazid, Ethambutol,and Pyrazinamide in a 4-Drug Fixed-Dose Combination Compared With the Separate Formulations in Healthy Chinese Male Volunteers. Clinical Therapeutic. 2013,35（2）:161-167.SCI
55. Meiqin Zheng, Haixia Jin, Lei Fu, Jian Xu, Bin Wang, Weijie Zhao, Hui Zhu,Peng Li, Yu Lu* , Qi Li .A comparative study on the activities of six combination regimens against multidrugresistant Mycobacterium tuberculosis infection in BALB/c mice . Journal of Chemotherapy . 2013,25（2）:81-86.SCI
56. Shuo Wang， Xuedong Jia， Mingliang Liu， Yu Lu*, Huiyuan Guo.Synthesis, antimycobacterial and antibacterial activity of ciprofloxacin derivatives containing a N-sunstituted benzyl moiety. Bioorganic﹠Medicinal Chemistry Letters. 2012,15:5971-5975.SCI
57. 金海霞，付雷，王彬，郑梅秦，陆宇*.结核分枝杆菌利福平依赖性的初步研究. 中国防痨杂志. 2012,34(10):670-675.核心期刊
58. Jian Xu, Yu Lu*, Lei Fu, Hui Zhu, Bin Wang, Khisimuzi Mdluli ,Anna M. Upton, Haixia Jin, Meiqin Zheng, Weijie Zhao, Peng Li .In vitro and in vivo activity of clofazimine exhibits activity against Mycobacterium tuberculosis persisters. International Journal of Tuberculosis and Lung Disease. 2012,16(8):1119-1125.SCI
59. Dongfeng Zhang, Yu Lu#, Kai Liu, Binna Liu, Jingbin Wang,Gang Zhang, Hao Zhang, Yang Liu,Bin Wang, Meiqin Zheng, Lei Fu,Yanyan Hou, Ningbo Gong,Yang Lv, Chun Li,Christopher B. Cooper,Anna M. Upton, Dali Yin,Zhenkun Ma, and Haihong Huang.Identification of Less Lipophilic Riminophenazine Derivatives for the Treatment of Drug-Resistant Tuberculosis . Joural of Medicinal Chemistry . 2012,55:8409−8417 .SCI
60. 朱慧，李芃，陆宇*.LC - MS/MS 方法同时检测人血浆中异烟肼、乙胺丁醇和吡嗪酰胺的浓度. 药物分析杂志. 2012,32（6）:945-949.核心期刊
61. Yu Lu*, Meiqin Zheng, Bin Wang, Lei Fu, Weijie Zhao, Peng Li, Jian Xu, Hui Zhu, Haixia Jin， Dali Yin, Haihong Huang and Zhenkun Ma.Clofazimine Analogs with Efficacy against Drug Sensitive and Drug Resistant Experimental Tuberculosis and Reduced Potential for Tissue Discoloration. Antimicrob Agent and Chemotherapy. 2011,vol.55 (11):5185-5193.SCI
62. 郑梅琴; 付雷; 王彬; 李芃; 陆宇*.豚鼠结核病模型在抗结核新药评价中的应用. 临床肺科杂志. 2011,16(8):1205-1209.核心期刊
63. 郑梅琴; 陆宇*; 王彬; 付雷.Alamar blue法检测药物细胞内抗结核活性的研究 . 中国抗生素杂志. 2011,36（6）:468-471.核心期刊
64. 徐建 陆宇* 郑梅琴 付雷 赵伟杰 王彬 李芃.气溶胶感染小鼠急性结核病治疗模型的建立及应用. 中国防痨杂志. 2010,32(8):462-466.核心期刊
65. 陆宇 ，王彬，赵伟杰，郑梅琴，李芃，付雷，梁博文.氯法齐明与其他抗结核药物联用对结核分枝杆菌的作用. 中华结核和呼吸杂志. 2010,33（9）:675-678.核心期刊
66. 陆宇，郑梅琴，王彬，赵伟杰，付雷，李芃，梁博文，初乃惠.异烟肼对氯法齐明在小鼠体内组织分布和蓄积的影响. 中华结核和呼吸杂志. 2009,32（9）:694-697.核心期刊
67. 郑梅琴，陆宇*，付雷，赵伟杰.MTT法在抗结核新药细胞毒性快速筛选中的应用研究. 中国防痨杂志. 2009,31（9）:530-533.核心期刊
68. 陆宇，赵伟杰，郑梅琴，王彬，M. Weisspapir，H. Gao，J . Schwarz.纳米链霉素在小鼠结核病模型中的治疗作用研究. 中国防痨杂志. 2008,30（6）:502-505.核心期刊
69. 陆宇，郑梅琴，王彬，赵伟杰，李芃，初乃惠，梁博文.氯法齐明抗结核分枝杆菌的体内外活性研究. 中华结核和呼吸杂志. 2008,31（10）:752-755.核心期刊
70. 陆宇，高孟秋，赵伟杰，王彬，马丽萍，朱莉贞.结核分枝杆菌持留状态体内外模型的建立和检测. 中华结核和呼吸杂志. 2007,30(3):211-215.核心期刊
71. 陆宇，王彬，郑梅琴，赵伟杰，李芃.应用Alamar Blue 和MTT对抗结核药物进行最低抑菌浓度测定的研究. 中国防痨杂志. 2007,29（6）:499-501.核心期刊
72. 陆宇，高孟秋，初乃惠，马丽萍，朱莉贞.Ag85BmRNA定量检测作为化疗监测指标的初步研究. 中国防痨杂志. 2005,27（5）:281-284.核心期刊
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