姓名：曾辉 性别：男 职称：研究员、教授 招生院所：地坛医院 招生类型：科学学位(博) 科学学位(硕) 招生专业：免疫学(博) 免疫学(硕) 研究方向名称：感染免疫 电子信箱：zenghui@ccmu.edu.cn


社会任职
1. 北京市新发突发传染病重点实验室副主任
2. 国家中管局三级实验室（感染免疫）负责人
3. 中国医师协会体外生命支持专业委员第一届委员会常务委员兼总干事
个人简历
1. 198809-199307:首都医科大学 临床医学本科
2. 199309-199607:首都医科大学 临床医学硕士
3. 199608-199804:首都医科大学附属北京同仁医院 血液科住院医师、主治医师
4. 199804-200002:美国华盛顿大学医学院 血液内科访问
5. 200005-200405:德国杜伊斯堡-埃森大学医学院 生物学博士、医学博士
6. 200405-200606:德国杜伊斯堡-埃森大学医学院 博士后
7. 200606-:首都医科大学附属北京地坛医院 研究所所长，教授，研究员
重要学术论文
1. Fan L#, Han J#, Xiao J, Dai G, Hao Y, Yang D, Liang H, Wu L, Song C, Li G, Li B, Wang D, Zeng Y, Pang X, Zhang F, Zeng H*, Zhao H*.The stage-specific impairment of granulopoiesis in people living with HIV/AIDS (PLWHA) with neutropenia. J Leukoc Biol. 2020,107(4):635-647.SCI
2. Han J, Mu W, Zhao H, Hao Y, Song C, Zhou H, Sun X, Li G, Dai G, Zhang Y, Zhang F*, Zeng H*.HIV-1 low-level viremia affects T-cell activation rather than T-cell development in school-age children, adolescents, and young adults during antiretroviral therapy. International Journal of Infectious Diseases. 2020,91:210-217.SCI
3. Du P, Liu D, Song H, Zhang P, Li R, Fu Y, Liu X, Jia J, Li X, Fanning S, Wang Y, Bai L*, Zeng H*.Novel IS26-mediated hybrid plasmid harboring tet(X4) in Escherichia coli. J Glob Antimicrob Resist. 2020,pii: S2213-7165(20):30082-5.SCI
4. Chen C#, Gao G#, Xu Y#, Pu L#, Wang Q#, Wang L#, Wang W#, Song Y1, Chen M, Wang L, Yu F, Yang S, Tang Y, Zhao L, Wang H, Wang Y, Zeng H*, Zhang F*.SARS-CoV-2-Positive Sputum and Feces After Conversion of Pharyngeal Samples in Patients With COVID-19. Ann Intern Med. 2020,暂无:doi: 10.7326/M20-0991.SCI
5. Kong Y#, Tian Y#, Hao Y#, Chong X, Xiao J, Yang D, Song C, Han J, Dai G, Zhang F, Zheng H, Zhao H*, Zeng H*.Two Types of Immunological Poor Responders Showed Distinct Responses to Long-Term HAART. Int J Infect Dis. 2019,86:178-187.SCI
6. Jiang D#, Wang J#, Zhao X, Li Y, Zhang Q, Song C, Zeng H*, Wang X*.Entecavir resistance mutations rtL180M/T184L/M204V combined with rtA200V lead to tenofovir resistance. Liver Int. 2019,40(1):83-91.SCI
7. Li M, Wang B, Li L, Wong G, Liu Y, Ma J, Li J, Lu H, Liang M, Li A, Zhang X, Bi Y*,Zeng H*.Rift Valley Fever Virus and Yellow Fever Virus in Urine: A Potential Source of Infection. Virol Sin. 2019,34(3):342-345.SCI
8. Zhao C, Jia B, Wang M, Schell TD, Claxton DF, Ehmann WC, Rybka WB, Mineishi S, Naik S, Songdej N, Sivik JM, Hohl RJ, Zeng H*, Zheng H*.Multi-dimensional analysis identifies an immune signature predicting response to decitabine treatment in elderly patients with AML. Br J Haematol. 2019,188(5):674-684.SCI
9. Song Y, Wang B, Song R, Hao Y, Wang D, Li Y, Jiang Y, Xu L, Ma Y, Zheng H, Kong Y*, Zeng H*. T-cell Immunoglobulin and ITIM Domain Contributes to CD8+ T-cell Immunosenescence. Aging Cell. 2018,17(2):e12716.SCI
10. Chen C#*, Jiang D#, Ni M#, Li J#, Chen Z, Liu J, Ye H, Wong G, Li W, Zhang Y, Wang B, Bi Y, Chen D, Zhang P, Zhao X, Kong Y, Shi W, Du P, Xiao G, Ma J, Gao GF, Cui J, Zhang F, Liu W, Bo X, Li A*, Zeng H*, Liu D*.Phylogenomic analysis unravels evolution of yellow fever virus within hosts. PLoS Negl Trop Dis. 2018,12(9):e**.SCI
11. Zhu L, Liu L, Zhang Y, Pu L, Liu J, Li X, Chen Z, Hao Y, Wang B, Han J, Li G, Liang S, Xiong H, Zheng H, Li A, Xu J, Zeng H*.High level of neutrophil extracellular traps correlates with poor prognosis of severe influenza A infection. J Infect Dis. 2018,217(3):428-437.SCI
12. Zhu L, Kong Y, Zhang J, Claxton DF, Ehmann WC, Rybka WB, Palmisiano ND, Wang M, Jia B, Bayerl M, Schell TD, Hohl RJ, Zeng H*, Zheng H.Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia. J Hematol Oncol. 2017,10:124.SCI
13. Zhang H, He G, Kong Y, Chen Y, Wang B, Sun X, Jia B, Xie X, Wang X, Chen D, Wei L, Zhang M, Zeng H*, Chen H*.Tumor-activated liver stromal cells regulate myeloid-derived suppressor cells accumulation in the liver. Clin Exp Immunol. 2017,188(1):96-108:96-108.SCI
14. Hou Z, Ye Q*, Qiu M, Hao Y, Han J, Zeng H*.Increased activated regulatory T cells proportion correlate with the severity of idiopathic pulmonary fibrosis. Respir Res. 2017,18(1):170.SCI
15. Xing Z, Han J, Hao X, Wang J, Jiang C, Hao Y, Wang H, Shen L, Dong X, Li T, Li G, Zhang J, Hou, X*, Zeng H*.Immature monocytes contribute to cardiopulmonary bypass-induced acute lung injury by generating inflammatory descendants. Thorax. 2017,72(3):245-255.SCI
16. Jia B, Zhao C, Li G, Kong Y, Ma Y, Wang Q, Wang B*, Zeng H*.A Novel CD48-Based Analysis of Sepsis-Induced Mouse Myeloid-Derived Suppressor Cell Compartments. Mediators Inflamm. 2017,2017:**.SCI
17. Yu F, Hao Y, Zhao H, Xiao J, Han N, Zhang Y, Dai G, Chong X, Zeng H*, Zhang F* .Distinct Mitochondrial Disturbance in CD4+T and CD8+T Cells from HIV-infected Patients. J Acquir Immune Defic Syndr. 2017,74(2):206-212.SCI
18. Ni M, Chen C, Qian J, Xiao HX, Shi WF, Luo Y, Wang HY, Li Z, Wu J, Xu PS, Chen SH, Wong G, Bi Y, Xia ZP, Li W, Lu HJ, Ma J, Tong YG, Zeng H, Wang SQ, Gao GF, Bo XC, Liu D.Intra-host dynamics of Ebola virus during 2014. Nat Microbiol. 2016,1(11):16151.SCI
19. Kong Y, Li Y, Zhang W, Yuan S, Winkler R, Kr??hnert U, Han J, Lin T, Zhou Y, Miao P, Wang B, Zhang J, Yu Z, Zhang Y, Kosan C*, Zeng H*.Sepsis-induced thymic atrophy is associated with defects in early lymphopoiesis. Stem Cells. 2016,34(12):2902-2915.SCI
20. Sun Y, Liu N, Guan X, Wu H, Sun Z*, Zeng H*.Immunosuppression Induced by Chronic Inflammation and the Progression to Oral Squamous Cell Carcinoma. Mediators Inflamm. 2016,2016:2016:**.SCI
21. Kong Y, Zhu L, Schell TD, Zhang J, Claxton DF, Ehmann WC, Rybka WB, George MR, Zeng H*, Zheng H*.T-cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8+ T cell Exhaustion and Poor Clinical Outcome in AML Patients. Clin Cancer Res. 2016,22(12):3057-66.SCI
22. He Y, Bei J, Zeng H, Pan Z.The roles of sepsis-induced myeloid derived suppressor cells in mice corneal, skin and combined transplantation. Transpl Immunol. 2016,34:8-13.SCI
23. He Y, Wang B, Jia B, Guan J, Zeng H*, Pan Z*.Effects of Adoptive Transferring Different Sources of Myeloid-Derived Suppressor Cells in Mice Corneal Transplant Survival. Transplantation. 2015,99:2102-8.SCI
24. Zeng H, Liu H, Wan G, Wang X.Answer to 'Misdiagnosis of patients may be derived from the interfering factors and used cut-offs in indexes'. J Viral Hepat. Zeng H. 2015,22:513-4.SCI
25. Ju L, Zeng H, Chen Y, Wu Y, Wang B, Xu Q.Dual polarization of microglia isolated from mixed glial cell cultures: Dual Polarized Activation of Microglia. Journal of Neuroscience Research. 2015,93:1345–1352:1345–1352.SCI
26. He G, Zhang H, Zhou J, Wang B, Chen Y, Kong Y, Xie X, Wang X, Fei R, Wei L, Chen H*, Zeng H*.Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma. J Exp Clin Cancer Res. 2015,34:141.SCI
27. Kong Y, Zhang J, Claxton DF, Ehmann WC, Rybka WB, Zhu L, Zeng H, Schell TD, Zheng H.PD-1(hi)TIM-3(+) T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation. Blood Cancer J. 2015,5:e330.SCI
28. Hou X*, Yang X, Du Z, Xing J, Li H, Jiang C, Wang J, Xing Z, Li S, Li X, Yang F, Wang H and Zeng H (曾辉)*.Superior vena cava drainage improves upper body oxygenation during veno-arterial extracorporeal membrane oxygenation in sheep. Crit Care. 2015,19:68.SCI
29. Liu Y, Zhu L, Liang S, Yao S, Li R, Liu S, Ma Y, Zhou X, Zhang J, Zeng H(曾辉)*, Wang X*.Galactose protects hepatocytes against TNF-α-induced apoptosis by promoting activation of the NF-κB signaling pathway in acute liver failure. Lab Invest. 2015,95:504-14 .SCI
30. Liu H#, Zhang H#, Wan G, Sang Y, Chang Y, Wang X*, Zeng H (曾辉)* .Neutrophil- lymphocyte ratio: a novel predictor for short-term prognosis in acute-on-chronic hepatitis B liver failure. J Viral Hepat. 2014,21(7):499-507.SCI
31. Song R, Pang X, Yang P, Shu Y, Zhang Y, Wang Q, Chen Z, Liu J, Cheng J, Jiao Y, Jiang R, Lu L, Chen L, Ma J, Li C, Zeng H (曾辉), Peng X, Huang L, Zheng Y, Deng Y, Li X*.Surveillance of the first case of human avian influenza A (H7N9) virus in Beijing, China. Infection. 2014,42:127-133.SCI
32. Hou J, Sun Y*, Zeng H（曾辉）*.Answer to ‘COPD and IPF: it’s all about regulation and balance’. Thorax. 2014,69:490-491.SCI
33. Shi G, Han J, Liu G, Hao Y, Ma Y, Li T, Wu X, Liu Y, Wang B, Kong Y, Zhou J, Zeng H（曾辉）*.Expansion of activated regulatory T cells by myeloid-specific chemokines via an alternative way in CSF of bacterial meningitis patients. Eur J Immunol. 2014,44:420-430.SCI
34. Zhu L#, Meng Q#, Liang S, Ma Y, Li R, Li G, Zeng H (曾辉)*.The transcription factor GFI1 negatively regulates NLRP3 inflammasome activation in macrophages. FEBS Lett. 2014,588(23) :4513-4519.SCI
35. Miao P, Kong Y, Ma Y, Zeng H*(曾辉), Yu Z*.Hypothermia predicts the prognosis in colon ascendens stent peritonitis mice. J Surg Res. 2013,181(1):1061-7.SCI
36. Dong X, Gong Y, Zeng H（曾辉）, Hao Y, Wang X, Hou J, Wang J, Li J, Zhu Y, Liu H, J Han J, Zhou H, Shen L, Gao T, Zhou T, Yang S, Li S, Chen Y, Meng Q, Li H*.Imbalance between circulating CD4+ regulatory T and conventional T lymphocytes in patients with HBV-related acute-on-chronic liver failure. Liver Int. 2013,33:1517-26.SCI
37. Hou J, Sun Y*, Hao Y, Zhuo J, Liu X, Bai P, Han J, Zheng X, Zeng H（曾辉）*.Imbalance between subpopulations of regulatory T cells in COPD. Thorax. 2013,68:1131-1139.SCI
38. Phelan JD, Saba I, Zeng H（曾辉）, Kosan C, Messer MS, Olsson HA, Fraszczak J, Hildeman DA, Aronow BJ, Moroy T, Grimes HL.Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors. PLOS Genet. 2013,9:e**.SCI
39. Zhou H, Zhao H, Hao Y, Song C, Han J, Zhang J, Gao G, Han N, Yang D, Li Y, Zhang F, Zeng H(曾辉)*.Excessive conversion and impaired thymic output contribute to disturbed regulatory T-cell homeostasis in AIDS patients with low CD4 cell counts. AIDS. 2013,27(7):1059–1069.SCI
40. Vassen L, Dührsen U, Kosan C, Zeng H*(曾辉), Moroy T*.Growth factor independence 1 (Gfi1) regulates cell-fate decision of a bipotential granulocytic-monocytic precursor defined by expression of Gfi1 and CD48. Am J Blood Res. 2012,2:228-42.
41. Guo X, Jie Y, Ren D, Zeng H(曾辉), Zhang Y, He Y, Pan Z*.In vitro-expanded CD4+CD25high Foxp3+ regulatory T cells controls corneal allograft rejection. Hum Immunol. 2012,73:1061-7.SCI
42. Khandanpour C, Kosan C, Gaudreau MC, Dührsen U, Hébert J, Zeng H(曾辉)*, Moroy T*.Growth Factor Independence 1 (Gfi1) Protects Hematopoietic Stem Cells Against Apoptosis But Also Prevents the Development of a Myeloproliferative-Like Diseaseflammatory response by antagonizing NF-kappaB p65. Stem Cells. 2011,29:376-385.SCI
43. Sharif-Askari E, Vassen L, Kosan C, Khandanpour C, Gaudreau MC, Heyd F, Okayama T, Jin J, Rojas ME, Grimes HL, Zeng H(曾辉)*, Moroy T*.Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65. Mol Cell Biol. 2010,30(16):3929-3934.SCI
44. He Y, Jie Y, Wang B, Zeng H（曾辉）, Zhang Y, Pan Z*.Adoptive Transfer of donor corneal antigen-specific regulatory T cells can prolong mice corneal grafts survival. Cornea. 2010,29 (suppl. 1):S25-S31.SCI
45. Han J, Wang B, Han N, Zhao Y, Song C, Feng X, Mao Y, Zhang F, Zhao H*，Zeng H(曾辉)*.CD14highCD16+ monocytes correlate with disease progression in chronic HIV-infected patients and normalize after HAART. J Acquired Immune Deficiency Syndrome. 2009,52(5):553–559.SCI
46. Moroy T*, Zeng H (曾辉), Jin J, Schmid KW, Carpinteiro A，Gulbins E* .The zinc finger protein and transcriptional repressor Gfi1as a regulator of the innate immune response. Immunobiology. 2008,213(3-4):341-52.SCI
47. Jin J, Zeng H (曾辉), Schmid KW, Toetsch M, Uhlig S. and Moroy T*.The zinc finger protein Gfi1 acts upstream of TNF to attenuate endotoxin-mediated inflammatory responses in the lung. Eur. J. Immunol. 2006,36(2):421-430.SCI
48. Zeng H (曾辉), Yucel R, Kosan C, Klein-Hitpass L, Moroy T*.Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J. 2004,23（20）:4116-25.SCI
49. Karsunky H, Zeng H (曾辉), Schmidt T, Zevnic B, Kluge R, Schimid KW, Duhrsen U, Moroy T*.Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1. Nat Genet. 2002,30(3):295-300.SCI
50. Zeng H (曾辉), Masuko M, Jin L, Neff T, Otto KG, Blau CA*.Receptor specificity in the self-renewal and differentiation of primary multipotential hemopoietic cells. Blood. 2001,98(2): 328-334.SCI
51. Jin L, Zeng H (曾辉), Chien S, Otto KG, Richard RE, Emery DW, Blau CA*.In vivo selection using a cell growth switch. Nat Genet. 2000,26(1):64-6.SCI
52. Richard, RE, Wood B, Zeng H (曾辉), Jin L, Papayannopoulou T, Blau CA*.Expansion of genetically modified primary human hemopoietic cells using chemical inducers of dimerization. Blood. 2000,95(2):430-6.SCI
主编或副主编的著作/译著
重要奖项
1. 北京市科学技术进步奖 体外膜氧合生命支持关键技术创新及临床推广应用 二等奖 201912
2. 解毒凉血健脾法提高慢加急肝衰竭疗效的创新技术建立及推广应用 中华医学科技奖 二等奖 2018
3. 北京市科学技术奖 解毒凉血健脾法提高慢加急肝衰竭疗效的创新技术建立及推广应用 三等奖 2016