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王波
专业技术职务： 副教授行政职务：
主要研究方向： 农学
学位： 博士
联系电话： 18519892836
电子邮箱： wangbo123@cau.edu.cn
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部门： 动物科学技术学院
性别： 男
民族： 汉族
--> 专业技术职务： 副教授
行政职务：
主要研究方向： 农学
毕业院校： 华盛顿州立大学
学位： 博士
--> 政治面貌： 中国共产党党员
联系电话： 18519892836
电子邮箱： wangbo123@cau.edu.cn
办公地址： 动科楼355
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个人简介
本科(2010)、硕士(2012)毕业于中国农业大学动物科技学院，师从袁建敏教授。博士(2017)毕业于华盛顿州立大学杜敏教授实验室，获动物科学专业哲学博士学位。2017年7月-2019年4月在麦克马斯特大学医学院Dr. Greg Steinberg实验室从事博士后研究工作。2018年9月引进到中国农业大学动物科技学院工作。长期研究脂肪细胞分化机理、胎儿程序化、营养水平对脂肪及肌肉发育的影响。近年来，系统阐明了维生素A在脂肪发育过程中的作用和机制，为防治肥胖及其相关的代谢疾病提供了理论依据。通过研究维生素A在怀孕期和哺乳期对后代脂肪的沉积的程序化作用，揭示了早期营养因素对抗肥胖能力的长远影响。同时，揭示了血管调控脂肪细胞发育并提供脂肪前体细胞的作用机理，为防治肥胖相关代谢疾病以及改善动物肉品质提供了新的靶点。在畜牧学领域，通过研究维生素A对肉牛肌间脂肪和肌肉发育的影响，提出了在动物生长早期增加肌内脂肪前体细胞库以增加肌内脂肪细胞数目，从而针对性地增加肌内脂肪的沉积潜力。此外，构建了诱导反刍动物细胞体外3D培养和诱导脂肪分化的方法，为反刍动物脂肪发育研究提供了急需的实验手段。
相关研究获得了社会广泛关注，多次在国际会议做口头报告，有一些新闻报道和评论：
https://www.healthcanal.com/metabolic-problems/obesity/237286-prenatal-vitamin-boosts-good-fat-prevent-obesity.html
https://news.wsu.edu/2017/04/27/vitamin-affects-good-fat-obesity/
https://www.biotechniques.com/news/Happy-Hour-Hit-or-Miss/biotechniques-366396.html
在社交媒体如Facebook和Twitter上也引起了广泛关注。
欢迎有科研热情的学生参与我的研究，也欢迎社会各界的科研合作。请联系18519892836或wangbo123@cau.edu.cn, wangb80@mcmaster.ca，Wechat ID：hellowangbo。
部分科研内容：
Maternal supplementation of vitamin A promotes angiogenesis and beige adipogenesis, which protects offspring from high fat-induced obesity.
Retinoic acid inhibits white adipogenesis by disrupting GADD45A mediated Zfp423 DNA demethylation
Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+ adipose progenitors
论文：
1. Wang B, Fu X, Liang XW, Wang ZX, Zhao L, Tian QY, Zhao JX, Gomez NA, Trombetta SC, Avila JM, Zhu MJ, and Du M. Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+ adipose progenitors. Cell discovery, 2017, 3:17036.
2. Wang B, Wang ZX, Avila JM, Zhu MJ, Zhang FY, Gomez NA, Zhao L, Tian QY, Zhao JX, Maricelli J, Zhang H, Rodgers BD and Du M. Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling. FASEB J, 2017 Vol.31.
3. Wang B, Fu X, Zhu MJ, Du M. Retinoic acid inhibits white adipogenesis by disrupting GADD45A mediated Zfp423 DNA demethylation. Journal of molecular cell biology, 2017, 9(4):338-349.
4. Wang B, Fu X, Liang XW, Wang ZX, Yang QY, Zou TD, Nie W, Zhao JX, Gao PF, Zhu MJ, Avila JM, Maricelli J, Rodgers BM, and Du M. Maternal Retinoids Increase PDGFRα+ Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development. EbioMedicine, 2017, 18: 288-299.
5. Wang B, Zhang FY, Wang ZX, Zhang H, Du M. Alcohol aggravate cancer induced cachexia via inducing adipose browning and skeletal muscle atrophy. Oncotarget, 2017.
6. Wang B, Min Z, Yuan JM, Zhang BK, Guo YM. Effects of dietary tryptophan and stocking density on the performance, meat quality, and metabolic status of broilers. Journal of Animal Science and Biotechnology 2014, 5(1): 44.
7. Wang B, Yang G, Liang XW, Zhu MJ, and Du M. Grape seed extract prevents skeletal muscle wasting in interleukin 10 knockout mice. BMC-Complementary and Alternative Medicine, 2014, (14): 162.
8. Wang B., Q. Yang, C. L. Harris, M. L. Nelson, J. R. Busboom, M. J. Zhu, and Du M. Nutrigenomic regulation of aidpose tissue development – role of retinoic acid. Meat Science, 2016, 120: 100-106.
9. Wang B, Nie W, Fu X, de Avila JM, Ma Y, Zhu MJ, Maquivar M, Parish SM, Busboom JR, Nelson ML, Du M: Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers. Journal of Animal Science and Biotechnology 2018, 9:82.
10. C. L. Harris, B. Wang, J. M. Deavila, J. R. Busboom, M. Maquivar, S. M. Parish, B. McCann, M. L. Nelson, M. Du, Vitamin A administration at birth promotes calf growth and marbling fat development in Angus beef cattle. Journal of animal science and biotechnology, in press.
11. Ma YN, Wang B, Wang ZX, Zhu MJ, Du M. Adipogenic differentiation of bovine stromal vascular cells in organoid culture. Animal, 2018.
12. Wang B, Min Z, Yuan JM. Apparent ileal digestible tryptophan requirements of 22-to 42-day-old broiler chicks. The Journal of Applied Poultry Research, 2015: pfv061.
13. Maricelli JA, Bishaw YM, Wang B, Du M and Rodgers BD. Systemic smad7 gene therapy increases striated muscle mass and enhances exercise capacity in a dose-dependent manner. Human gene therapy, 2017.
14. Fu X, Yang QY, Wang B, Zhao JX, Zhu MJ, Parish SM, Du M. Reduced satellite cell density and myogenesis in Wagyu compared with Angus cattle as a possible explanation of its high marbling. Animal, 2017.
15. Yang Q, Liang X, Sun X, Zhang L, Fu X, Rogers CJ, Berim A, Zhang S, Wang S, Wang B, Foretz M, Viollet B, Gang DR, Rodgers BD, Zhu MJ, Du M. AMPK/α-ketoglutarate axis dynamically mediates DNA demethylation in the Prdm16 promoter and brown adipogenesis. Cell metabolism. 2016.
16. Zou T, Chen D, Yang Q, Wang B, Zhu MJ, Nathanielsz PW, Du M: Resveratrol supplementation to high fat diet‐fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring. The Journal of physiology. 2017.
17. Liang, X., Yang Y, Fu X, Rogers CJ, Wang B, Pan H, Zhu MJ, Nathanielsz PW, and Du M. Maternal obesity epigenetically alters visceral fat progenitor cell properties in male offspring mice. The Journal of Physiology, 2016, 594 (15): 4453-4466.
18. Du M, Wang B, Fu X, Yang Q, Zhu MJ. Fetal programming in meat production. Meat science, 2015 (109): 40-47.
19. Huang C, Wang B, Min Z, Yuan JM. Dietary inclusion level and time effects of taurine on broiler performance, meat quality, oxidative status and muscle taurine content. British poultry science, 2014, 55 (5), 598-604.
20. Yuan JM, Wang B, Huang Z, Fan Y, Huang C, Hou Z. Comparisons of egg quality traits, egg weight loss and hatchability between striped and normal duck eggs. British Poultry Science 54.2 (2013): 265-269.
21. Xing, T., Y. Kang, X. Xu, B. Wang, M. Du, and M. J. Zhu*. Raspberry supplementation improves insulin signaling and promotes brown-like adipocyte development in white adipose tissue of obese mice. Molecular Nutrition and Food Research, 2018.
22. Zou T, Wang B, Yang Q, de Avila JM, Zhu MJ, You J, Chen D, Du M. Raspberry promotes brown and beige adipocyte development in mice fed high-fat diet through activation of AMP-activated protein kinase (AMPK) α1. The Journal of Nutritional Biochemistry. 2018.
23. Zhao L, Zou TD, Gomez N, Wang B, Zhu MJ, and Min D. Raspberry alleviates obesity-induced inflammation and insulin resistance in skeletal muscle through activation of AMP-activated protein kinase (AMPK) α1. Nutrition & Diabetes, 2018. 。
24. Wang B, Qu Y, Wang Y, Ma Y, Xu C, Li F, Liu C, Lu X, Wang B, Xiu P: Triplet Male Lambs Are More Susceptible than Twins to Dietary Soybean Oil–Induced Fatty Liver. The Journal of nutrition 2019, 149(6):989-995.
25. Zhao L, Wang B, Gomez NA, de Avila JM, Zhu M-J, Du M: Even a low dose of tamoxifen profoundly induces adipose tissue browning in female mice. International Journal of Obesity (Lond) 2019.
26. 王波,闵芝智,呙于明,袁建敏. 1-21日龄雄性肉鸡表观回肠可消化色氨酸需要量研究.中国畜牧杂志，2015,11:27-33. 27. 王璐，易路，王波，尹晓楠，闵芝智，梁恒之，袁建敏.家禽不同料重比测定方法的比较研究. 中国家禽，2015,37（17）：31-34.
28. 王波，闵芝智，李晓明，李庆云，袁建敏，呙于明.1-21日龄肉鸡色氨酸适宜水平研究.中国家禽，2014,36（11）：31-34.
29. 梁恒之，王 波，尹达菲，侯卓成，袁建敏.不同饲料转化率的北京鸭和枫叶鸭消化器官发育及盲肠微生物菌群的比较研究. 中国畜牧杂志,2013,49(19):42-46.
30. 王波，何龙，黄春喜,袁建敏.螺纹蛋发生特点及产螺纹蛋母鸭生理指标比较研究，水禽世界，2011，增刊：214-219. 31. 黄春喜,袁建敏，周淑亮，王波.牛磺酸对肉仔鸡生长性能、消化器官和免疫器官的影响，动物营养学报，2011，23（5）：854-861
32. 王波，袁建敏.鸭饮水习性及饮水用具研究进展. 水禽世界，2010,2:41-43.
33. 王波， 秦春华，周佳，蒋纪才，初芹，史远刚，王雅春.宁夏几个肉牛杂交群体与秦川牛的BPI比较研究.中国牛业科学,2010，36(004):9-11.
34. 宗宁远，徐威，周伟华，王波，袁建敏.产螺纹蛋鸭与正常鸭消化器官及输卵管形态和组织学比较. 水禽世界，2009，增刊，162-165.
35. 黄志敏，范彧，王波，袁建敏.螺纹蛋蛋白特性的研究. 水禽世界，2009，增刊，181-183. 34. 王波，袁建敏，阎磊，陈瑶.螺纹蛋对孵化性能的影响，中国家禽，2009，31（8）：46-47.
Abstract:
1. Wang, B., X. Fu, S. M. Zhang, X. W. Liang, M. J. Zhu, and M. Du. Maternal Vitamin A Supplementation Expands Adipose Progenitor Population through Promoting Vascular Development. Experimental Biology Meeting, San Diego, California, April 1-5, 2016.
2. Wang, B., M. J. Zhu, and M. Du. All-trans-Retinoic Acid Inhibits Adipogenesis by Interrupting Gadd45α Induced Zfp423 Demethylation. Experimental Biology Meeting, San Diego, California, April 1-5, 2016.
3. Wang B., M. Du. Maternal obesity sets offspring adipose development. Center for Reproductive Biology Annual Retreat, Moscow, ID, August 7, 2015.
4. Wang, B., G. Yang, X. Wei, M. J. Zhu, and M. Du. Grape seed extract prevents skeletal muscle wasting in interleukin 10 knockout mice [M]. The Annual Meeting of Institute for Food Technologists, New Orleans, LA, June 21-24, 2014.
5. Yuan J, D Liu, Wang B, Z Huang, Y Fan, C Huang. Comparative of egg quality, minerals content, albumen characteristics and weight loss between luowen egg and normal egg of duck. World’s Poultry Science Journal, Egg Meat Symposia 2011, b-044, (67):40-41.
6. Yuan J, C Huang, Wang B, S Zhou. Effects of Cage Versus Floor Litter Environments on Blood Parameters and Meat Quality in Broilers. Poult Sci. 2011, Vol 89, E-Suppl.1.
7. Huang C, Yuan JM, Zhou SL, Wu J, Wang B. Effect of Dietary Taurine on Growth Performance and Development of Structure and Function of Digestive Organs in Broiler Chicken. Proceedings of the 6th National Symposium on Feed Nutrition, 2010.
8. Yuan J, Liu D, Wang B, Huang Z, Fan Y, Huang C. Comparative of egg quality, minerals content, albumen characteristics and weight loss between luowen egg and normal egg of duck. World’s Poultry Science Journal, Egg Meat Symposia 2011, b-044, (67):40-41.
9. 王波，袁建敏，闵芝智，黄春喜. 色氨酸对不同饲养密度下肉鸡生产性能、肉品质和抗氧化能力的影响. 畜牧兽医年会. 2011.
教学科研概况
社会职务
活动动态
研究领域
脂肪、肌肉生物学
肥胖与糖尿病
肉品质
动物营养学
开授课程
1、家畜生态学，2019-2020，第二学期，星期三，西校区
2、家畜生态学，2018-2019，第二学期，星期三，西校区
科研项目
纵向项目
横向项目1、2019.05.09-2020.05.08，企事业单位委托科技项目，植物提取物减肥机理研究以及其在宠物食品中的应用，主持
论文
Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance Nature Communications SCI 2020 JM Yabut McMaster University 6
Dietary apple polyphenols promote fat browning in high‐fat diet‐induced obese mice through activation of AMP‐activated protein kinase (AMPK) α Journal of the Science of Food and Agriculture SCI 2020 T Zou Jiangxi Agricultural University 2
Even a low dose of tamoxifen profoundly induces adipose tissue browning in female mice International Journal of Obesity SCI 2019 L Zhao Wahington State University 2
Triplet male lambs are more su Journal of Nutrition SCI 2019 Bo Wang China Agricultural University 1/并列
Raspberry supplementation reduces lipid accumulation and improves insulin sensitivity in skeletal muscle of mice fed a high-fat diet Journal of Functional Foods SCI 2019 T Zou Washington State University 3
Dietary alpha‐ketoglutarate promotes beige adipogenesis and prevents obesity in middle‐aged mice Aging cell SCI 2019 Q Tian Washington State University 4
Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers Journal of Animal Science and Biotechnology SCI 2018 B Wang China Agricultural University 1
Adipogenic differentiation of bovine stromal vascular cells in organoid culture Animal SCI 2018 YN Ma/ B Wang Wahington State University 1/并列
Raspberry supplementation improves insulin signaling and promotes brown-like adipocyte development in white adipose tissue of obese mice Molecular Nutrition and Food Research SCI 2018 T Xing Wahington State University 4
Raspberry promotes brown and beige adipocyte development in mice fed high-fat diet through activation of AMP-activated protein kinase (AMPK) α1 The Journal of Nutritional Biochemistry SCI 2018 T Zou Wahington State University 2
Raspberry alleviates obesity-induced inflammation and insulin resistance in skeletal muscle through activation of AMP-activated protein kinase (AMPK) α1 Nutrition & Diabetes SCI 2018 L Zhao Wahington State University 4
Effects of dietary phosphorous supplementation on laying performance, egg quality, bone health and immune responses of laying hens challenged with Escherichia coli lipopolysaccharide Journal of animal science and biotechnology SCI 2018 N Wei China Agricultural University 2
Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+ adipose progenitors Cell discovery SCI 2017 B Wang Wahington State University 1
Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling FASEB J SCI 2017 B Wang China Agricultural University 1
Retinoic acid inhibits white adipogenesis by disrupting GADD45A mediated Zfp423 DNA demethylation Journal of molecular cell biology SCI 2017 B Wang China Agricultural University 1
Maternal Retinoids Increase PDGFRα+ Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development EbioMedicine SCI 2017 B Wang China Agricultural University 1
Alcohol aggravate cancer induced cachexia via inducing adipose browning and skeletal muscle atrophy . Oncotarget SCI 2017 B Wang China Agricultural University 1
Effects of dietary tryptophan and stocking density on the performance, meat quality, and metabolic status of broilers Journal of Animal Science and Biotechnology SCI 2017 B Wang China Agricultural University 1
Vitamin A administration at birth promotes calf growth and marbling fat development in Angus beef cattle Journal of animal science and biotechnology SCI 2017 C. L. Harris/B Wang Wahington State University 1/并列
Systemic smad7 gene therapy increases striated muscle mass and enhances exercise capacity in a dose-dependent manner Human gene therapy SCI 2017 Maricelli JA Wahington State University 3
Reduced satellite cell density and myogenesis in Wagyu compared with Angus cattle as a possible explanation of its high marbling Animal SCI 2017 X Fu Wahington State University 3
Resveratrol supplementation to high fat diet‐fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring The Journal of physiology SCI 2017 T Zou Wahington State University 4
Nutrigenomic regulation of aidpose tissue development – role of retinoic acid Meat Science SCI 2016 B Wang Wahington State University 1
AMPK/α-ketoglutarate axis dynamically mediates DNA demethylation in the Prdm16 promoter and brown adipogenesis Cell metabolism SCI 2016 QY yang Wahington State University 10
Maternal obesity epigenetically alters visceral fat progenitor cell properties in male offspring mice The Journal of Physiology SCI 2016 Liang X Wahington State University 5
Apparent ileal digestible tryptophan requirements of 22-to 42-day-old broiler chicks The Journal of Applied Poultry Research SCI 2015 B Wang China Agricultural University 1
Fetal programming in meat production Meat Science SCI 2015 M Du Wahington State University 2
1-21日龄雄性肉鸡表观回肠可消化色氨酸需要量研究 中国畜牧杂志 中文核心 2015 王波 中国农业大学 1
Grape seed extract prevents skeletal muscle wasting in interleukin 10 knockout mice BMC-Complementary and Alternative Medicine SCI 2014 B Wang Wahington State University 1
Dietary inclusion level and time effects of taurine on broiler performance, meat quality, oxidative status and muscle taurine content British poultry science SCI 2014 C Huang China Agricultural University 2
1-21日龄肉鸡色氨酸适宜水平研究 中国家禽 中文核心 2014 王波 中国农业大学 1
Comparisons of egg quality traits, egg weight loss and hatchability between striped and normal duck eggs British Poultry Science SCI 2013 JM Yuan China Agricultural University 2
螺纹蛋发生特点及产螺纹蛋母鸭生理指标比较研究 水禽世界 2011 王波 中国农业大学 1
鸭饮水习性及饮水用具研究进展 水禽世界 2010 王波 中国农业大学 1
宁夏几个肉牛杂交群体与秦川牛的BPI比较研究 中国牛业科学 中文核心 2010 王波 中国农业大学 1
陈瑶.螺纹蛋对孵化性能的影响 中国家禽 中文核心 2009 王波 中国农业大学 1
科技成果
软件著作
专利
