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姓名：夏春性别：男职务：
所在系：职称：教授导师类别：博士
政治面貌：出生年月：学位：博士
电子邮件：xiachun@cau.edu.cn办公电话：010-62733372
个人简介：夏春，中国农业大学动物医学院教授、博士生导师。1.简历1982年毕业于华中农业大学（本科）。1993年获日本爱媛大学博士学位。1995年完成于中国农业大学预防兽医学博士后研究并留校任教。1996年之后，在日本农林水产研究所免疫室、英国阿伯丁大学生命科学院、美国佐治亚医学院基因与蛋白质组研究中心进行过客座研究。2.研究领域：比较免疫学目前主要聚焦于MHC复合体精细结构与T细胞表位疫苗分子机理以及抗病机制研究；同时也进行免疫球蛋白超基因家族的起源与进化研究。主持“973”项目，国家转基因重大专项，国家自然科学基金重点项目，“863”等项目。独立指导了博士、硕士、博士后50多名。在JournalofImmunology、JournalofBiologicalChemistry、JournalofVirology、PLoSONE、Immunobiology、MolecularImmunology、Immunogenetics、Vaccine、AnimalBiotechnology等数十种刊物发表SCI论文30多篇。在国内核心刊物上发表论文60多篇。同时主编了教育部指定的“二十一世纪”本科生教材以及出版专业书籍3本。3.代表论文(*:通讯作者)1)WeihongChen,ZhenghuJia,TingZhang,NianzhiZhang,ChangyouLin,FengGao,LiWang,XiaoyingLi,YinanJiang,XinLi,GeorgefuGaoandChunXia*(2010).MHCClassIPresentationandRegulationbyIFNinBonyFishDeterminedbyMolecularAnalysisoftheClassILocusinGrassCarp.JournalofImmunology,2010;185:2209-2221.2)WeihongChen,FengGao,FuliangChu,JianhuaZhang,GeorgeFuGao,andChunXia*.Crystalstructureofabonyfishβ2-microglobulin:insightsintotheevolutionaryoriginofIgSFconstantmolecules.JournalofBiologicalChemistry,2010;285:22505-22512.3)XinLi,JunLiu,JianxunQi,FengGao,QirunLi,XiaoyingLi,NianzhiZhang,ChunXia*andGeorgeFGao*(2011).TwoDistinctConformationsofaRinderpestVirusEpitopePresentedbyCattleMHCClassIN01801(BoLA-A11):aHostStrategytoPresentFeaturedPeptides.JournalofVirology(2011,JVI00030-11).4)NianzhiZhang,LifengZhang,YinanJiang,TingZhang,ChunXia*(2009).MolecularAnalysisofSpringViraemiaofCarpVirusinChina:AFatalAquaticViralDiseasethatMightSpreadinE-astAsian.PLoSONE4(7):0006337.5)YungangLi,FulinTian,FengshanGao,XiushanTangChunXia*.ImmuneresponsesgeneratedbyLactobacillusasacarrierinDNAimmunizationagainstfoot-and-mouthdiseasevirus.Vaccine,2007,25:902-911.6)ChunXia*,C.Y.Lin,G.X.Xu,T.J.Hu,T.Y.YangcDNACloningandgenomicstructureoftheduck(Anasplatyrhynchos)MHCclassIgene,Immunogenetics,2004,56(4):304-309.7)ChunXia*,LiuJ,WuZ.G,LinC.Y,WangM.Theinterferon-agenesfromthreechickenlinesandit'seffectsonH9N2influenzaviruses,AnimalBiotechnology,2004,15(1):77-88.8)RuoQianYan,XinShengLi,TianYaoYang,ChunXia*.StructuresandhomologymodelingofchickenmajorhistocompatibilitycomplexproteinclassI,MolecularImmunology,2006,43,1040-1046.9)BeibeiWu,XiangdangDu,XingyuanCao,ChunXia*,andJianzhongShen*.InfluenceofrecombinantFloRprotein-basedantibodyandenzyme-linkedimmunosorbentassayfordetectionoftheflorfenicol-resistantE.coliisolates.JouralofClinicalMicrobiology,2006.44:378-382.10)LiWang,LeiWang,HexiaoZhang,JianhuaZhang,WeihongChen,XiaofeiRuan,ChunXia*.TheinvitroeffectsofrecombinantzebrafishIFN-alphaonspringviremiaofcarpvirusandinfectioushematopoieticnecrosisvirus.JournalofInterferonandCytokineResearch.2006(4):256-25911)Aoyagi,K.,Dijkstra,J.M.,ChunXia,Denda,I.,Ototake,M.,Hashimoto,K.,andNakanishi,T.ClassicalMHCclassIGenesComposedofHighlyDivergentSequenceLineagesShareaSingleLocusinRainbowTrout.JournalofImmunology,2002,168:260-273.12)ChunXia*,TuanjunHu,GuangxianXu,ChangyouLin,TianyaoYang,andLiWang.cDNAcloning,genomicstructure,andexpressionanalysisofthegoose(Ansercygnoides)MHCclassIgene.VeterinaryImmunology&Immunopathology,2005,107,291-302.13)RuoQianYan,TianYaoYang,XinShengLi,ChunXia*.CharacterizationofBF2andbeta2minthreeChinesechickenlines.VeterinaryImmunology&Immunopathology,2005,108,417-425.14)XinShengLi,QinMeiFang,RuoQianYan,FengShanGao,HuiFangHao,ZhenHuJia,ChangYouLin,ChunXia*.ExtensiveanalysisofdifferentallelelicstructuresofthechickenBF2andbeta2mproteins.VeterinaryImmunology&Immunopathology.2006,113:215-223.15)FengshanGao,QinMeiFang,YunGangLi,XinShengLi,HuiFangHao,ChunXia*.ReconstructionofaswineSLA-IproteincomplexanddeterminationofbindingnonamericpeptidesderivedfromtheFoot-and-MouthDiseaseVirus.VeterinaryImmunology&Immunopathology,2006,113:328-338.16)ZhangG,QiaoS,LiQ,WangX,DuanY,XiaoZ,ChunXia*.Molecualrcloningandexpressionofporcinehigh-affinityimmunoglobulinGFcreceptor.Immunogenetics.2006,58(10):845-849.17)ChunXia*,WuD,WuW.X,WanJ.Q,YangT.Y,WangL,WangQ,NingY.B.Cloningandexpressionoftheinterferon-a/-gfromadomesticporcinebreedanditseffectonclassicalswinefevervirus.VeterinaryImmunology&Immunopathology,2005,104(2):81-89.18)XiangdangDu,ChunXia,JianzhongShen,BeibeiWu,ZhangqiShen.CharacterizationofflorfenicolresistanceamongcalfpathogenicEscherichiacoli,FEMSMicrobiologyLetters,2004,236:183-189.19)ChunXia*,ZhuHongMa,HRahman,ZhiGuangWu.PCRCloningandidentificationoftheβ-hemolysingeneofAeromonashydrophilafromfreshwaterfishesinChina,Aquaculture,2004,229:45-53.20)QinmeiFang,Weisun,ChaoGeng,YingJiang,LiyanJiao,XiaohongQian,ChunXia*andFuchuHe*.ComparativePreparationandDifferentialFluorescenceLabelingEvaluationofhepatomacarcinomaCellProtein.ChineseAnalyticalchemistry.2006,1519-1523.21)ChunXia*,XuG.X.,LinC.Y.,HuT.J.,YanR.Q.,Gao,F.MolecularcloningandpolymerphismofmajorhistocompatibilitycomplexclassIgenesfromGrasscarp(Ctenophayngodonidellus),ProgressinNaturalScience,2004,14(5):403-410.22)HuifangHao,TianyaoYang,FengshanGao,ChunXia*.cDNAcloningandgenomicstructureofgrasscarpbeta2-microglobulingene.Fish&ShellfishImmunology,2006,20,118-123.23)TianyaoYang,HuifangHao,ZhenghuJia,WeihongChen,ChunXia*.Characterizationofgra-sscarp(Ctenopharyngodonidellus)MHCclassIdomainlineages.Fish&ShellfishImmunology,2006,21,583-591.24)ChunXia,Kiryu,I.,Dijkstra,J.M.,Azuma,T.,Nakanishi,T.,andOtotake,M.DifferencesinMHCclassIbetweenstrainsofRainbowTrout,Fish&ShellfishImmunology,2002,12:287-301.25)HuiFangHao,WeiHongChen,WenXueWu,ZhenHuJia,ChunXia*.Secondarystructureand3Dhomologymodelingofgrasscarp(Ctenopharyngodonidellus)majorhistocompatibilitycomplexclassImolecules.ProteinExpressionandPurification,2007,51:120-125.26)SonglinQiao,GaipingZhang,ChunXia,HongZhang,YuyangZhang,JunXi,HaitaoSong,XuewuLi.CloningandcharacterizationofporcineFcgammareceptorII(FcγRII).VeterinaryImmu-nology&Immunopathology,2006,114:178-184.27)WeihongChen,FuliangChu,HaoPeng,JianhuaZhang,JianxunQi,FanJiang,ChunXia*andFengGao*.Expression,purification,crystallizationandpreliminaryX-raydiffractionanalysisofgrasscarpB2-microglobulin.ActaCrystallographicaSectionF:StructuralBiologyandCrystallizationCommunications(2008).F64,200-202.28)Yan,R.Q.Wu,Z.M.Fang,Q.M.Zhang,Z.L.Zhang,J.Li,X.S.Hao,H.F.ChunXia*.2008.ReconstructionofachickenBF2proteincomplexandidentificationofbindingnonamerpeptidesderivedfromavianinfluenzavirushemagglutinin.VetImmunolImmunopathol.126:91-101.29)Gao,F.S*.Xu,C.B.Long,Y.H.ChunXia*(2009).Secondarystructureand3Dhomologymodelingofswineleukocyteantigenclass2(SLA-2)molecules.Immunobiology.214(6):475-482.30)JianhuaZhang,YongChen,FengGao,WeihongChen,JianxunQiandChunXia*(2010).Complexassembly,crystallizationandpreliminaryX-raycrystallographicstudiesofduckMHCclassImolecule.ActaCrystallographicaSectionF:StructuralBiologyandCrystallizationCommunicationsF66:doi:10.1107/S174430910905088X.31)XuJianming,ZhangNianzhi,JiangYinan,ZhangLifeng,XiaChun*.AbsolutequantitativeReal-timeRT-PCRassayforrapiddetectionofViralhemorrhagicsepticemiavirus(VHSV)withTaqmanMGBprobe.HighTechnologyLetters.2009.19(12).32)ChunXia*.NewOpenReadingFrameofWhiteSpotSyndromeVirusfromPenaeidShrimpsandRelatedDetectionoftheVirusbyMultiplexPolymeraseChainReaction.American.FisheriesSocietySymposium,edbyBrucePhillipsetal.(ISSN0892-2284),theAmericanFisheriesSociety.Maryland,USA.2003,38:117-179.33)YangT,DuanR,CaoH,LeeBH,ChunXia,ChangZ,KeithTanswellA,HuJ.Developmentofaninflammation-induciblegeneexpressionsystemusinghelperependentadenoviralvectors.J.GeneMed.,2010,12:832-839.34)RuiliGuan,SharadPurohit,HongjieWang,BruceBode,JohnChipReed,R.DennisSteed,StephenW.Anderson,LeighSteed,DianeHopkins,ChunXiaandJinxiongShe(2011).Chemokine(C-Cmotif)ligand2(CCL2)inseraofpatientswithtype1diabetesanddiabeticcomplications.PLoSONE6(4):e17822.35)XiaochengPan,JianxunQi,NianzhiZhang,QirunLi,RongChen,FengGaoandChunXia*(2011).Complexassembly,crystallizationandpreliminaryX-raycrystallographicanalysisoftheSLAclassImoleculecomplexedwithaPRRSV-NSP9nonapeptide.ActaCrystallographicaSectionF:StructuralBiologyandCrystallizationCommunications.(2011,PU5329).