教师简介

1964年10月生于河南。
1995年于北京农业大学获理学博士学位。
2003年度国家杰出青年科学基金获得者。

学习与工作经历

1981.9--1985.7河南农业大学植保专业本科生
1985.7--1988.8河南农业大学植保系助教
1988.9--1991.7沈阳农业大学植物病理学专业硕士研究生
1991.9--1995.3北京农业大学植物病理学专业博士研究生
1995.12--1997.11中国科学院遗传所博士后
1997.12--2002.12中国农业大学农业生物技术国家重点实验室副教授
1999.11--2002.8美国UniversityofColoradoHealthSciencesCenter生化与分子遗传学系博士后
2002.12--今中国农业大学生物学院微生物学与免疫学系及农业生物技术国家重点实验室教授、博士生导师
2007.3--2007.9美国OregonStateUniversity的JamesCarrington教授实验室高级研究学者


研究方向

目前主要从事分子植物病毒学的基础理论及应用基础研究，研究内容包括：(1)大麦条纹花叶病毒（BSMV）对不同寄主植物致病性差异的分子机制以及抗BSMV新基因Bsr1的功能分析；建立并完善BSMV诱导的基因沉默（BSMV-basedVIGS）载体系统，为小麦、大麦、玉米、高粱和谷子等禾本科作物的基因功能分析提供高效、便捷的工具。(2)以甜菜黑色焦枯病毒（BBSV）和烟草坏死病毒A（TNV-A）等Necrovirus病毒为研究对象，分析病毒和寄主植物的相互作用以及互作过程中的一些重要蛋白质的晶体结构解析。（3）抗病毒转基因作物新品种(系)的培育。

主讲课程

本科生《病毒学》


联系方式

电话：62733326
邮件：Lidw[at]cau.edu.cn
通讯地址：北京市海淀区圆明园西路2号,中国农业大学生物学院，邮编：100193





-----------------------------------------------------------------

发表文章

GerdaSzakonyi,JoelMGuthridge,DaweiLi,YoungKendra,MichaelVHolers,XiaojiangSChen,2001,Structureofcomplementreceptor2incomplexwithitsC3dligand,Science,292:1725-1728.

DaweiLi,RuiZhao,WayneLilyestrom,DahaiGai,RongguangZhang,DeCaprioJames,EllenFanning,GerdaSzakonyi,XiaojiangSChen,2003,StructureofthereplicativehelicaseoftheoncoproteinSV40largetumourantigen,Nature,423:512-518.

DahaiGai,DaweiLi,CarlaVFinkielstein,RobertDOtt,PoonamTaneja,EllenFanning,XiaojiangSChen,2004,Insightsintotheoligomericstates,conformationalchangesandhelicaseactivitiesofSV40largetumorantigen,JournalofBiologicalChemistry,279:38952-38959.

DahaiGai,RuiZhao,DaweiLi,CarlaVFinkielstein,XiaojiangSChen,2004,MechanismsofconformationalchangeforareplicativehexamerichelicaseofSV40largeTantigen,Cell,119:47-60.

LihuaGuo,YunheCao,DaweiLi,ShengniaoNiu,ZhunanCai,ChengguiHan,YafengZhai,JialinYu,2005,AnalysisofnucleotidesequencesandmultimericformsofanovelsatelliteRNAassociatedwithBeetblackscorchvirus,JournalofVirology,79:3664-3674.

YunheCao,XuefengYuan,XiaoxingWang,LihuaGuo,ZhunanCai,ChengguiHan,DaweiLi*,JialinYu,2006,EffectonviralpathogenicityofBeetblackscorchviruscoatprotein,ProgressinBiochemistryandBiophysics,33:127-134.

ZhaohuiWang,ShuoguoFang,ZhiyanZhang,ChengguiHan,DaweiLi*,JialinYu,2006,DevelopmentofanID-ELISAforthedetectionofRiceblack-streakeddwarfvirusinplants,JournalofVirologicalMethods,134:61-65.

XuefengYuan,YunheCao,DehuiXi,LihuaGuo,ChengguiHan,DaweiLi*,YafengZhai,JialinYu,2006,AnalysisofthesubgenomicRNAsandthesmallORFsofBeetblackscorchvirusbyinvitrotranscripts,JournalofGeneralVirology,78:3077-3086.

DehuiXi,JiangLi,ChengguiHan,DaweiLi*,JialinYu,XuepingZhou,2008,CompletenucleotidesequenceofanewstrainofTobacconecrosisvirusAinfectingsoybeaninChinaandinfectivityofitsfull-lengthcDNAclone,VirusGenes,36:259-266.

MontgomeryTA,HowellM,CuperusJT,DaweiLi,AlexanderA,ChapmanEJ,FahlgrenN,AllenE,andJamesCCarrington,2008,SpecificityofARGONAUTE7-miR390InteractionandDualFunctionalityofARGONAUTE7-miR390ComplexesinTAS3Trans-ActingsiRNAFormation,Cell,133:128-141.

YongliangZhang,JiangLi,HengPu,JinJin,XiaofengZhang,MingkuanChen,BinWang,ChengguiHan,JialinYu,DaweiLi*,2010,DevelopmentofTobacconecrosisvirusAasavectorforefficientandstableexpressionofFMDVVP1peptides,PlantBiotechnologyJournal,8(4):506-523.

BoZhou,YongliangZhang,XianbingWang,JiangliDong,BinWang,ChengguiHan,JialinYu,DaweiLi*,2010,Oraladministrationofplant-basedrotavirusVP6inducesantigen-specificIgAs,IgGsandpassiveprotectioninmice,Vaccine,28(37):6021-6027.

YanhongHan,HaiyingXiang,QianWang,YuanyuanLi,WenqiWu,ChengguiHan,DaweiLi,JialinYu,2010,RingstructureaminoacidsaffectthesuppressoractivityofMelonaphid-borneyellowsvirusP0protein.Virology,406(1):21-27.

YanjingZhang,XiaofengZhang,ShaofangNiu,ChengguiHan,JialinYu,DaweiLi*,2011,NuclearlocalizationofBeetblackscorchviruscapsidproteinanditsinteractionwithimportinα,VirusResearch,155(1):307-315.

ChengYuan,CuiLi,LijieYan,AndrewOJackson,ZhiyongLiu,ChengguiHan,JialinYu,DaweiLi^*,2011,AhighthroughputBarleystripemosaicvirusvectorforvirusinducedgenesilencinginmonocotsanddicots,PLoSONE,6:e26468.

YuCui,MiYeonLee,NaxinHuo,JenniferBragg,LijieYan,ChengYuan,CuiLi,SaraJ.Holditch,JingzhongXie,Ming-ChengLuo,DaweiLi,JialinYu,JoelMartin,WendySchackwitz,Yong-QiangGu,JohnP.Vogel,AndrewO.Jackson,ZhiyongLiu1,andDavidF.Garvin,2012,FinemappingoftheBarleystripemosaicvirusresistancegeneBsr1inthemodelgrassBrachypodiumdistachyon,PLoSONE,7(6):e38333.

XiuchunZhang,XiaofengZhang,JasleenSingh,DaweiLi,andFengQu,2012,Temperature-dependentsurvivalofTurnipcrinklevirus-infectedArabidopsisplantsreliesonanRNAsilencing-baseddefensethatrequiresDCL2,AGO2,andHEN1,JournalofVirology,86:6847-6854.

XiaohuiWang,YanjingZhang,JinXu,LindanShi,HuiyanFan,DaiweiLi,ChengguiHan,JialinYu,2012,TheR-richmotifofBeetblackscorchvirusP7amovementproteinisimportantforthenuclearlocalization,nucleolartargetingandviralinfectivity,VirusResearch,167(2):207-218.

DeshuiLiu,LindanShi,ChengguiHan,JialinYu,DaweiLi,YongliangZhang2012,Validationofreferencegenesforgeneexpressionstudiesinvirus-infectedNicotianabenthamianausingquantitativeReal-TimePCR.PLoSONE,7:e46451.

JinXu,XianbingWang,LindanShi,YuanZhou,DaweiLi,ChengguiHan,ZidingZhang,JialinYu,2012,TwodistinctsitesareessentialforvirulentinfectionandsupportofvariantsatelliteRNAreplicationinspontaneousBeetblackscorchvirusvariants.JournalofGeneralVirology,93(12):2718-2728.

MiYeonLee⁺,LijieYan⁺,FlorienA.Gorter,BrianY.T.Kim,YuCui,YueHu,ChengYuan,JessicaGrindheim,UmaGanesan,ZhiyongLiu,ChengguiHan,JialinYu,DaweiLi*andAndrewO.Jackson*,2012,BrachypodiumdistachyonBd3-1resistanceiselicitedbytheBarleystripemosaicvirusTripleGeneBlock1movementprotein.JournalofGeneralVirology,93(12):2729-2739.(Coverstory)

Thi-SauDinh,CuijiZhou,XiulingCao,ChengguiHan,JialinYu,DaweiLi,YongliangZhang,2012.ThecompletegenomesequenceofSouthernriceblack-streakeddwarfvirusisolatedfromVietnam.ThePlantPathologyJournal,28(4):428-432.

XiulingCao,YinguiLu,DianpingDi,ZhiyanZhang,HeLiu,LanzhiTian,AihongZhang,YanjingZhang,LindanShi,BihongGuo,JinXu,XifeiDuan,XianbingWang,ChengguiHan,HongqinMiao*,JialinYu*,DaweiLi*,2013,EnhancedvirusresistanceintransgenicmaizeexpressingadsRNA-specificendoribonucleasegenefromE.coli.PLoSONE,8(4):e60829.

XiaofengZhang,XiaofeiZhao,YanjingZhang,ShaofangNiu,FengQu,YongliangZhang,ChengguiHan,JialinYu,DaweiLi*,2013,N-terminalbasicaminoacidresiduesofBeetblackscorchviruscapsidproteinplayacriticalroleinvirionassemblyandsystemicmovement,VirologyJournal,10(1):200

（*Correspondingauthor）



-----------------------------------------------------------------

获奖情况

获国家教委科技进步一等奖（1997）、北京市科学技术二等奖（2002）、教育部二等奖（自然科学类）（2003）和河南省科学技术进步二等奖（2008）各一项。




-----------------------------------------------------------------

承担项目及课题




-----------------------------------------------------------------

专利情况

授权专利：“甜菜黑色焦枯病毒作为外源基因的表达载体”（ZL02155378.5）




-----------------------------------------------------------------

社会兼职

2006.5-今中国农业生物技术学会常务理事
2005.4-今中国农业生物技术学会微生物技术分会副会长
2004.4-2009.12ChineseJournalofAgriculturalBiotechnology(英国CABI集团出版)特邀编辑