教师简介

<pclass="MsoNormal"style="line-height:150%;text-indent:21pt"><fontface="Verdana">教授、博士生导师。实施了世界第一例DNA免疫法治疗艾滋病的临床试验。1992年以来，先后在国际上发表了80多篇SCI论文，同时获得了9项美国和3项中国发明专利。</font><fontface="Verdana">现就任于中国农业大学生物学院微生物与免疫学系和农业生物技术国家重点实验室教授。担任美国DNAandCellBiology杂志编委。<br/>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2003年5月在中国农业大学生物学院建立了分子免疫学实验室，目前<spanstyle="font-family:宋体;mso-ascii-font-family:Arial;mso-bidi-font-family:Arial;mso-hansi-font-family:''''TimesNewRoman''''">实验室现有</span><spanstyle="font-family:宋体;mso-ascii-font-family:Arial;mso-bidi-font-family:Arial;mso-hansi-font-family:''''TimesNewRoman''''">助教</span><spanlang="EN-US"style="font-family:Arial">1</span><spanstyle="font-family:宋体;mso-ascii-font-family:Arial;mso-bidi-font-family:Arial;mso-hansi-font-family:''''TimesNewRoman''''">名、博士后1名、博士生</span><spanlang="EN-US"style="font-family:Arial">6</span><spanstyle="font-family:宋体;mso-ascii-font-family:Arial;mso-bidi-font-family:Arial;mso-hansi-font-family:''''TimesNewRoman''''">名、硕博生</span><spanlang="EN-US"style="font-family:Arial">10</span><spanstyle="font-family:宋体;mso-ascii-font-family:Arial;mso-bidi-font-family:Arial;mso-hansi-font-family:''''TimesNewRoman''''">名、硕士生</span><spanlang="EN-US"style="font-family:Arial">2</span><spanstyle="font-family:宋体;mso-ascii-font-family:Arial;mso-bidi-font-family:Arial;mso-hansi-font-family:''''TimesNewRoman''''">名。拥有分子免疫学、分子生物学和病毒学研究所需的各种仪器和设备。<br/></span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;实验室同时与国外<spanlang="EN-US"style="font-family:Arial">UniversityofPennsylvania,UniversityofIllinois,TexasTechUniversity,LeibnizInstituteforAgeResearch</span><spanstyle="font-family:宋体;mso-ascii-font-family:Arial;mso-bidi-font-family:Arial;mso-hansi-font-family:''''TimesNewRoman''''">著名大学，研究所及</span><spanlang="EN-US"style="font-family:Arial">Wyeth</span><spanstyle="font-family:宋体;mso-ascii-font-family:Arial;mso-bidi-font-family:Arial;mso-hansi-font-family:''''TimesNewRoman''''">公司在科研方面进行合作。</span></font></p>


学习与工作经历

<p>1978年入学山东大学生物系，1982年毕业后服务于中科院北京动物所。1984年赴美国辛辛那提大学医学院攻读发育生物学博士学位；1990年在美国Wistar研究所做博士后研究；1992年至1998年在美国宾夕法尼亚大学医学院任instructor、assistantprofessor；2000年新疆大学生物学院特聘教授；2003年中国农业大学特聘教授。</p>


研究方向

主讲课程

<p>研究生：分子免疫学专题</p>


联系方式

电话：62733055
邮件：bwang3
通讯地址：北京市海淀区圆明园西路2号，中国农业大学农业生物技术国家重点实验室





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发表文章

近年来发表的SCI论文：
2007
Xi-JuSHI,CanZHANG,BinWANG&MingWANG.ImmuneEnhancingEffectsofRecombinantBovineIL-18onFoot-andMouthDiseaseVaccinationinMiceModel.Vaccine2007,25:1257-1264.
YangYu,HualiJin,ZeChen,QinglingYu,YijieMa,ChongXiao,XiaolinSunandBinWang.Childrenvaccinesdonotinducethecross-reactivityagainstSARS-CoV.J.Clin.Pathol.2007,60:208-211.
YouminKang,HualiJin,GuoxingZheng,XiaogangDu,ChongXiao,XiaoyingZhang,ShuangGeng,Xiaolin,Li,AoshuangChenandBinWang.Co-InoculationofDNAandProteinVaccinesInducesAntigenSpecificTCellSuppression.BBRC2007,353:1034-1039.
KaichunZhu,HualiJin,ChongXiao,ZhonghuaiHe,QinghongZhuandBinWang.Acontinuousthermallysisforthelarge-scalepreparationofplasmidDNA.Nat.Protocl,2007,1:3088-3093.
XiaogangDu,GuoxingZheng,HualiJin,YouminKang,JunpengWang,ChongXiao,ShuoZhang,MingyuLiu,LinZhao,AoshuangChenandBinWang.EffectoftheCo-stimulatorymolecules,4-1BBL,OX40LandCD70,asadjuvantsonthecellularandmemoryresponsesonHBsAgDNAvaccination.J.GeneMedicine,2007;9:136–146.
JiangmeiYin,HualiJin,FuYang,ZenDing,ChangHuang,QinghongZhuandBinWang.SynergisticeffectsoftheadjuvantsIFN-gammaandlevamisoleonDNAvaccinationagainsttheinfectionofNewcastlediseasevirus.ViralImmunol.2007,20:288-299.
XiaolinLi,HualiJin,ZhifangWu,SimonRayner,JiangmeiYin,YangYu,WenjuanZhang,ZhonghuaiHe,ChenWangandBinWang.AnautomatedprocessextractsplasmidDNAbyalkalinelysis.ApplMicrolandBiotech2007,75:1217-1223.
ChongXiao,HualiJin,YanxinHu,JunpengWang,XiaogangDu,YouminKang,YuYang,RuipingSheandBinWang.Enhancedprotectiveefficacyandreducedviralloadoffoot-and-mouthdiseaseDNAvaccinewithco-stimulatorymoleculesasthemolecularadjuvants.AntiviralResearch2007,76:11-22.
XiangLi,BinWang,HualiJin,JiangWei,TianJiesheng,GuanFengandYinLi.BacterialMagneticParticles(BMPs)-PEIasanovelnon-viralvectorforefficientgenedeliveryinvitroandinvivo.JGeneMedicine20079:679–690.
YanxinHu,HualiJin,XiaogangDu,ChongXiao,DongmeiLuo,BinWang,andRuipingShe.EffectsofChronicHeatStressonImmuneResponsesoftheFoot-and-mouthDisease(FMD)DNAVaccination.DNA&CellBiology,2007,26(8):619-626.
HualiJin,ChongXiao,GanZhao,XiaogangDu,YangYu,YouminKangandBinWang.InductionofImmatureDendriticCellApoptosisbyFootandMouthDiseaseVirusIsanIntegrinReceptorMediatedEventbeforeViralInfection.J.Cell.Biochem.2007,102:980-991.
JinyaoLi,HualiJin,AilianZhang,YijieLi,BinWangandFuchunZhang.Enhancedcontraceptiveresponsebyco-immunizationofDNAandproteinvaccinesencodingthemousezonapellucida3withminimaloophoritisinmouseovary.JGeneMed.2007,9:1095-1103.
HualiJin,XiaoWang,ChongXiao,YangYu,YouminKang,XiaogangDu,XuefengWei,andBinWang.EnhancementofFMDV-specifichumoralandcellularimmuneresponsesbyvaccinationwithDNAexpressingviral-like-particle.ViralImmunol.2007,20,429-440.
2008
PingTai,JunpengWang,HualiJin,XiaomingSong,JunYan,YouminKang,LinZhao,XiaojinAn,XiaogangDu,XiufenChen,GuoliangXiaandBinWang.EstrogenisapotentialmediatortoconvertactivatedCD4+CD25-TcellsintoCD4+CD25+regulatoryTcells.J.Cell.Physol.2008,214:456-464.
XiaoWang,HualiJin,XiaogangDu,ChunCai,YangYu,GanZhao,BaoweiSu,ShanHuang,YanxinHu,DongmeiLuo,RuipingShe,XinsongLuo,XianfangZeng,XinyuanYiandBinWang.TheprotectiveefficacyaganistSchistosomajaponicuminfectionbyimmunizationwithDNAvaccineandlevamisoleasadjuvantinmice.Vaccine2008,26:1832-1845.
XiaolinSun,YingzhuLi,WeidongYu,BinWang,YunxiaTao,andZonghanDai.Mt1-mmpasadownstreamtargetofbcr-abl/abi1signaling:polarizeddistributionandinvolvementinenhancedleukemiccellmigration.Leukemia2007doi:10.1038/sj.leu.2404990.
XiaolinLi,HualiJin,ZhifangWu,SimonRayner&BinWang.AcontinuousprocesstoextractplasmidDNAbasedonalkalinelysis.Nat.Protocl,2008,3:176-180.
HualiJin,YouminKang,LinZhao,ChongXiao,XiaogangDu,Xiaolin,Sun,TerryNg,SteveChuandBinWang.PreventionofFleaAllergyDermatitisviaInductionofAntigenSpecificAdaptiveTRCellsbyCo-InoculationofDNAplusProteinRegimens.J.Immunol.2008,180:5360–5372.
YouminKang,XuLipeng,BinWang,AoshuangChenandGuoxingZheng.Immunosuppressantasadjuvantfortolerogenicimmunization.J.Immunol.2008,180:5172–5176.



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获奖情况



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承担项目及课题

目前实验室已承担了国家自然科学基金课题、国家863重大、“863”、国家十五科技攻关、十一五支撑、世界卫生组织(WHO)、FortDodgeAnimalHealthResearchOptionFund和中国农业大学优秀人才引进等项目。




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专利情况



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社会兼职

2007年－现在美国《DNAandCellBiology》杂志编委
2004年－现在美国富道动物保健公司科学顾问
2005年－现在中国生物工程学会理事
2005年－现在科学中国人专家委员会“生命科学与医药卫生”专业委员
2005年－现在中国病毒学编委会委员
2006年－现在中国农业大学微生物资源与应用农业部重点实验室主任
2006年－现在中国微生物学会理事