教师简介

赵要风，1970年生，博士，教授，博士生导师，国家杰出青年基金获得者。主要研究领域为动物分子遗传学。首次在低等脊椎动物中发现具有明确铰链区的抗体新类型并命名为IgF。在鸭嘴兽发现中发现一种新型哺乳动物免疫球蛋白并命名为IgO。首次在家养动物中发现IgD及其特殊的表达机制。分别在两栖类，爬行类动物及原始哺乳动物鸭嘴兽中发现IgD基因，为理解IgD在脊椎动物中的进化提供了重要线索。发现了猪促卵泡素b亚基（FSHβ）基因是影响猪产仔数（包括总产仔数、产活仔数）的主效基因或遗传标记。迄今为止，共在PNAS,JournalofExperimentalMedicine,JournalofImmunology,JBC等刊物上发表SCI论文近30篇。2008起任DevelopmentalandComparativeImmunology杂志编委。近年来分别为国际SCI杂志JournalofImmunology,MolecularBiologyandEvolution,EuropeanJournalofImmunology,DevelopmentalandComparativeImmunology,MucosalImmunology进行同行论文审稿，并为美国国家自然科学基金进行项目评审。



学习与工作经历

2006年三月至现在:中国农业大学生物学院,校特聘教授

1998年八月至2006年三月:KarolinskaInstitute,Stockholm,Sweden

1995年九月至1998年六月:中国农业大学动物科技学院动物遗传育种专业,获博士学位

1992年九月至1995年六月:中国农业大学生物学院动物生理生化专业,获硕士学位

1988年九月至1992年六月:河南大学生物系生物学专业,获学士学位


研究方向

主讲课程

高级分子生物学专题(研究生)


联系方式

电话：62734945
邮件：yaofengzhao
通讯地址：





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发表文章

*Correspondingauthor
2013
Acomparativeoverviewofimmunoglobulingenesandthegenerationoftheirdiversityintetrapods.SunY,WeiZ,LiN,ZhaoY*.DevCompImmunol.2013Jan;39(1-2):103-9.(*correspondingauthor)


2012
ExtensivediversificationofIgHsubclass-encodinggenesandIgMsubclassswitchingincrocodilians.GangCheng,YangGao,TaoWang,YiSun,ZhiguoWei,LingxiaoLi,LimingRen,YingGuo,XiaoxiangHu,YanLu,XuminWang,GuimingLiu,ChenglinZhang,JunYu,QiangPan-Hammarstrom,LennartHammarstrom,XiaobingWu,NingLiandYaofengZhao*.NatureCommunications,2012,inpress.(*Correspondingauthor)

EvidenceofIgYsubclassdiversificationinthereptiliansnakes:evolutionaryimplications.TaoWang,YiSun,WenweiShao,GangCheng,LingxiaoLi,ZubingCao,ZhiYang,HuiyingZou,WeiZhang,BinyueHan,YangHu,LimingRen,XiaoxiangHu,YingGuo,JingFei,LennartHammarstrom,NingLiandYaofengZhao*.JournalofImmunology.2012Oct1;189(7):3557-65.(*Correspondingauthor)

ExtensivediversificationofIgD-,IgY-andtruncatedIgY(ΔFc)-encodinggenesinthered-earedturtle(Trachemysscriptaelegans).LingxiaoLi,TaoWang,YiSun,GangCheng,HuiYang,ZhiguoWei,PingWang,XiaoxiangHu,LimingRen,QingyongMeng,RanZhang,YingGuo,LennartHammarström,NingLiandYaofengZhao*.JournalofImmunology,2012Oct15;189(8):3995-4004.(*Correspondingauthor)

ExpressionalAnalysisofImmunoglobulinDinCattle(Bostaurus),aLargeDomesticatedUngulate.BeileiXu,JingWang,MinZhang,PingWang,ZhiguoWei,YiSun,QiqingTao,LimingRen,XiaoxiangHu,YingGuo,JingFei,LeiZhang,NingLiandYaofengZhao*,Plosone.2012;7(9):e44719.(*Correspondingauthor)

ImmunoglobulinGenomicsintheGuineaPig(Caviaporcellus).GuoY,BaoY*,MengQ,HuX,MengQ,RenL,LiN,ZhaoY*.PLoSOne.2012;7(6):e39298.(*correspondingauthor)

AnalysisofimmunoglobulintranscriptsintheostrichStruthiocamelus,aprimitiveavianspecies.HuangT,ZhangM,WeiZ,WangP,SunY,HuX,RenL,MengQ,ZhangR,GuoY,HammarstromL,LiN,ZhaoY*.PLoSOne.2012;7(3):e34346.(*correspondingauthor)
2011

CharacterizationoftheMHCclassIIα-chaingeneinducks.RenL,YangZ,WangT,SunY,GuoY,ZhangZ,FeiJ,BaoY,QinT,WangJ,HuangY,HuX,ZhaoY*,LiN*.Immunogenetics.2011Oct;63(10):667-78.(*correspondingauthor)

ApreliminaryanalysisoftheimmunoglobulingenesintheAfricanelephant(Loxodontaafricana).GuoY,BaoY*,WangH,HuX,ZhaoZ,LiN,ZhaoY*.PLoSOne.2011Feb25;6(2):e16889.(*correspondingauthor)

Theimmunoglobulinδgeneinjawedvertebrates:acomparativeoverview.SunY,WeiZ,HammarstromL,ZhaoY*.DevCompImmunol.2011Sep;35(9):975-81.Epub2010Dec21.Review.(*correspondingauthor)
2010

Acomprehensiveanalysisofgermlineandexpressedimmunoglobulinrepertoireinthehorse.SunY,WangC,WangY,ZhangT,RenL,HuX,ZhangR,MengQ,GuoY,FeiJ,LiN,ZhaoY*.DevCompImmunol.2010Sep;34(9):1009-1020.(*correspondingauthor)

Phylogeny,genomicorganizationandexpressionoflambdaandkappaimmunoglobulinlightchaingenesinareptile,Anoliscarolinensis.WuQ,WeiZ,YangZ,WangT,RenL,HuX,MengQ,GuoY,ZhuQ,RobertJ,HammarstromL,LiN*,ZhaoY*.DevCompImmunol.2010May;34(5):579-89.(*correspondingauthor)

TheimmunoglobulingenelociintheteleostGasterosteusaculeatus.BaoY*,WangT,GuoY,ZhaoZ,LiN,ZhaoY*.FishShellfishImmunol.2010Jan;28(1):40-8.(*correspondingauthor)


2009
ZhiguoWei,QianWu,LimingRen,XiaoxiangHu,YingGuo,GregoryW.Warr,LennartHammarstrom,NingLi*andYaofengZhao*.ExpressionofIgM,IgDandIgYinareptile,Anoliscarolinensis.JImmunol.2009183(6):3858-3864.(*correspondingauthor)

ZhaoY*,CuiH,WhittingtonCM,WeiZ,ZhangX,ZhangZ,YuL,RenL,HuX,ZhangY,HellmanL,BelovK,LiN*,HammarströmL*.Ornithorhynchusanatinus(platypus)linkstheevolutionofimmunoglobulingenesineutherianmammalsandnonmammaliantetrapods.JImmunol.2009183(5):3285-93.(*correspondingauthor)(Firsttwoauthorscontributedtothework)

2008

QinT,RenL,HuX,GuoY,FeiJ,ZhuQ,ButlerJE,WuC,LiN,HammarstromL,ZhaoY*.(2008)GenomicorganizationoftheimmunoglobulinlightchaingenelociinXenopustropicalis:Evolutionaryimplications.DevCompImmunol.32(2):156-65(*correspondingauthor)

2007

QiangPan-Hammarstrom,YaofengZhao,LennartHammarstrom.(2007)Classswitchrecombination,acomparisonbetweenmouseandhuman.AdvancesinImmunology.93:1-61

ZhihuiZhao#,YaofengZhao#,QiangPan-Hammarström,WeiLiu,ZhaoliangLiu,YonghuiZhao,NingLiandLennartHammarström.(2007)Physicalmappingofthegiantpandaimmunoglobulinheavychainconstantregiongenes.DevelopmentalandComparativeImmunology.31(10):1034(#contributedequally).


2006
NehaPant,AnnaHultberg,YaofengZhao,LennartSvensson,etal.,(2006)Lactobacilliexpressingvariabledomainofllamaheavy-chainantibodyfragments(Lactobodies)conferprotectionagainstrotavirus-induceddiarrhea.JournalofInfectiousDisease.194(11):1580-8.

YaofengZhao*,QiangPan-Hammarstrom,ShuyangYu,WertzNancy,XiaofengZhang,NingLi,JohnButler,LennartHammarstrom*.(2006)IdentificationofIgF,ahinge-region-containingIgclass,andIgDinXenopustropicalis.ProcNatlAcadSciUSA.103(32):12087-92.(*correspondingauthor)

QiangPan-Hammarström,AleksiLähdesmäki,YaofengZhao,LikunDu,ZhihuiZhao,SichengWen,VictorL.Ruiz-Perez,DeborahK.Dunn-Walters,JudithA.Goodship,LennartHammarström.(2006).DisparaterolesofATRandATMinimmunoglobulinclassswitchrecombinationandsomatichypermutation.JournalofExperimentalMedicine,203(1):99-210

YaofengZhao,StephenM.JacksonandRobertAitken,(2006)Thebovineantibodyrepertoire.Developmentalandcomparativeimmunology.30(1-2):175-186

2005
VascoM.Barreto,QiangPan-Hammarstrom,YaofengZhao,LennartHammarstrom,ZivaMisulovin,MichelC.Nussenzweig.(2005)AIDfrombonyfishcatalyzesclassswitchrecombination:implicationsforevolutionoftheimmunoglobulinswitchreaction.JournalofExperimentalMedicine.202(6):733-738

YaofengZhao*,QiangPan-Hammarström,ZhihuiZhao,SichengWen,LennartHammarström,(2005)SelectiveIgG2deficiencyduetoapointmutationcausingabnormalsplicingoftheCg2gene.InternationalImmunology.17(1):95-101(*correspondingauthor)

YaofengZhao*,QiangPan-Hammarström,ZhihuiZhao,LennartHammarström.(2005)Identificationofactivation-inducedcytidinedeaminasefromfish:anevolutionaryanalysis.DevelopmentalandComparativeImmunology.29:61-71(*correspondingauthor)


2004
QiangPan-Hammarström,YaofengZhao,andLennartHammarström(2004)LackofassociationbetweenhumanswitchrecombinationbreakpointsandthesecondarystructureofthetargetedDNAregions.JournalofImmunology172:2727

2003
YaofengZhao,ImreKacskovics,ZhihuiZhao,LennartHammarström,(2003)Presenceofthedi-leucinemotifinthecytoplasmictailofthepigFcRnachain.VeterinaryImmunologyandImmunopathology96:229-233.

YaofengZhao,ImreKacskovics,HodjattallahRabbani,LennartHammarström.(2003)Physicalmappingoftheimmunoglobulinheavychainconstantregiongenelocus.TheJournalofBiologicalChemistry,278(37):35024-32

YaofengZhao*,QiangPan-Hammarström.ImreKacskovicsandLennartHammarström.(2003)TheporcineIgdeltagene:uniquechimericsplicingofthefirstconstantregiondomaininitsheavychaintranscripts.TheJournalofImmunology,171(3):1312-8(*correspondingauthor)

QiangPan-Hammarström,ShujingDai,YaofengZhao,IrisF.VanDijkHärd,RichardGatti,Anne-LiseBorrensen-DaleandLennartHammarström,(2003)ATMisnotrequiredinsomatichypermutationofVH,butisinvolvedintheintroductionofmutationsintheswitchmuregion.TheJournalofImmunology,170:3707-3716

YaofengZhao,LennartHammarström,(2003)Cloningofthecompleteratimmunoglobulindgene:evolutionaryimplications.Immunology,108:288-295.


2002
YaofengZhao*,ImreKacskovics,QiangPan,DavidA.Liberles,JanosGeli,ScottK,Davis,HodjattallahRabbani,andLennartHammarström,(2002)ArtiodactylIgD:themissinglink.TheJournalofImmunology,169(8):4408-16(*correspondingauthor)


2000
Y.Zhao,H.Rabbani,A.Shimizu,LHammarström,(2000)Mappingofthechickenimmunoglobulinheavy-chainconstantregiongenerevealsaninvertedageneupstreamofacondensedugene.Immunology,101:348-353.





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获奖情况

曾获2002度教育部自然科学一等奖及2003度国家技术发明二等奖




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承担项目及课题

1.中国农业大学人才引进项目(2006-2008)。
2.863高科技计划(2006-2010)。
3.自然科学基金(2007-2009)。
4.教育部新世纪优秀人才支持计划(2007-2010)。
5.国家杰出青年基金(2008-2011)。





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专利情况

现有美国专利一项。




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社会兼职

暂无