李宁
类别：博士研究生导师
单位：07中医基础理论研究所
出生年月：1979年01月
专业技术职务：副研究员
学位：医学博士
毕业学校：瑞士日内瓦大学
所在一级学科：中西医结合
所在二级学科：中西医结合基础
研究方向：纳米中药在代谢疾病中的靶向递送及应用研究
联系电话：**@163.com
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lili.li.ning@gmail.com
Email：**@163.com
通信地址：北京市东城区东直门内南小街16号
邮编：100700
个人简介:
李宁，女，研究员。2009年毕业于瑞士日内瓦大医学院细胞生理与代谢系，获得医学博士学位，其后在瑞士日内瓦大医学院进行博士后研究工作，主要研究方向是线粒体在代谢性疾病中的病理生理学基础。2013年至2017年于中国医学科学院基础医学研究所生物化学与分子生物学系任副研究员，从事病毒致病机制与干预研究，同期获得英国伦敦大学clinical trials第二硕士学位。2017年调入中国中医科学院中医基础理论研究所，主要从事纳米中药在代谢疾病中的靶向递送及应用研究。曾两次获得欧洲糖尿病研究基金（EFSD）资助，归国后主持或参与国家自然科学基金、“973”计划等国家及省部级课题6项。作为主要完成者在Diabetes，Trends Endocrinal Metab., Redox Biology等杂志发表SCI论文17篇，参与撰写论著2部。?
代表性论文:
1. Tauroursodeoxycholic Acid (TUDCA) Inhibits Influenza A Viral Infection by Disrupting Viral Proton Channel M2. Science Bulletin 2019-01
2. MicroRNAs from plants to animals, do they define a new messenger for communication? Nutrition and Metabolism (Lond) 2018-10
3.Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity. Redox Biology 2017-10
4. FAT10 is critical in influenza A virus replication by inhibiting type I IFN. J Immunol. 2016-06
5.Diabetogenic millieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets. Hum Mol Genet. 2015-04
6. Neuraminidase of influenza A virus binds lysosome-associated membrane proteins directly and induces lysosome rupture. J Virol. 2015-04
7. Angiotensin II receptor blocker as a novel therapy in acute lung injury induced by avian influenza A H5N1 virus infection in mouse. Sci China Life Sci. 2015-03
8. 牛磺熊去氧胆酸减轻TGF-β1诱导的MRC-5纤维化表型 基础医学与临床 2015-05
9. Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections. Nat Commun. 2014-05
10. Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids. PloS One. 2014-08
11. Mitochondrial hormesis in pancreatic β-cells: does uncoupling protein 2 play a role? Oxid Med Cell Longev. 2012-11
12. NAD(P)H oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion. Diabetes. 2012-06
13. Mitochondrial dysfunction in pancreatic β-cells. Trends Endocrinol Metab. 2012-06
14. Glucose metabolism in breast cancer and its implication in cancer therapy. Int J Clin Med. 2011-02
15. Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction. J Biol Chem. 2009-05
16. The sensitivity of pancreatic beta-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress. Biochem Soc Trans. 2008-04
17. Saikosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury. Biochem Cell Biol. 2007-07
18. Mechanism of saikosaponin-d in the regulation of rat mesangial cell proliferation and synthesis of extracellular matrix proteins. Biochem Cell Biol. 2007-07

代表性专著:
The Islet of Langerhans Adv Exp Med Biol. 2010
Stem cell-based modalities: from basic biology to integration and regeneration. Frontiers in Biomaterials 2017

获奖:
中医药防治糖尿病胰岛素抵抗技术平台建立与应用 2018 其他 二等奖