高苒 姓名：高苒
学科：比较医学
电话：
邮件：gaoran@cnilas.org
地址：北京市朝阳区潘家园南里5号



简历介绍
研究领域
社会任职
获奖及荣誉
承担科研项目情况
代表论著

高苒，女，副研究员，硕士生导师，科技发展处处长。2012年获日本筑波大学博士学位。主要从事肿瘤动物模型创制，并以动物模型为基础进行肿瘤的比较医学研究，为肿瘤预防、早期诊断和治疗提供理论和应用基础。目前课题组围绕消化道肿瘤已经构建了患者来源的肿瘤异种移植模型（PDX）资源平台，并开展了初步的药物筛选工作。同时课题组对于肿瘤发病及转移机制进行深入探讨，围绕hnrnpk对于肺癌转移及胃癌耐药等方面开展了系列工作，成果发表在Nucleic Acids Res、J BiolChem等领域经典杂志。共发表文章40余篇，其中SCI文章26篇。参编人民卫生出版社第三轮全国高等学校医学专业研究生国家级规划教材2部，英文书2部，中文科普1部。





比较医学、实验动物学、肿瘤。



中国实验动物学会理事，国际合作与交流委员会副主任委员，Animal Models and Experimental Medicine编委。


2015年荣获北京市优秀人才2016年荣获中国实验动物学会优秀青年人才，
2018年荣获中国医学科学院医学实验动物所比较医学青年英才



目前主要承担国家自然基金、重大专项、北京市优秀人才、医科院创新工程等项目。



1.Shuang Sun, Kejuan Li, Zhongfang Lei, Long Xiao, Ran Gao*, Zhenya Zhang*. Immunomodulatory activity of polysaccharide from Helicteres angustifolia L. on 4T1 tumor-bearing mice. Biomed Pharmacother. 2018(101):881-888.
2.Xudong Shi, Kai Gao, Hao Huang, and Ran Gao*. Pretargeted immuno-PET based on Bioorthogonal chemistry for imaging EGFR positive colorectal cancer. Bioconjug Chem. 2018 Feb 21;29(2):250-254.
3. Hao Huang, Yong Han, Xingjiu Yang, Mengyuan Li, Ruimin Zhu, Juanjuan Hu, Xiaowei Zhang, Rongfei Wei, Kejuan Li and Ran Gao*. HNRNPK inhibits gastric cancer cell proliferation through p53/p21/CCND1 pathway. Oncotarget. 2017 (8):103364-103374.
4.Rongfei Wei, Baolian Li, Jing Guo, Mengyuan Li, Ruimin Zhu, Xingjiu Yang, Ran Gao*. Smurf1 targets Securin for ubiquitin-dependent degradation and regulates the metaphase-to-anaphase transition. CELL SIGNAL. 2017 (38):60-66.
5.Rongfei Wei, Jing Guo, Mengyuan Li, Xingjiu Yang, Ruimin Zhu, Hao Huang, Kejuan Li, Lingqiang Zhang, Ran Gao*. (2017) Smurf1 controls S phase progression and tumorigenesis through Wee1 degradation. FEBS Lett. 2017 Apr;591(8):1150-1158.
6.Ran Gao, Navjot Shah, Jung-Sun Lee, Shashank P. Katiyar, Ling Li, Eonju Oh, Durai Sundar, Chae-Ok Yun, Renu Wadhwa, Sunil C. Kaul. (2014) Withanone-rich combination of Ashwagandha withanolides restricts metastasis and angiogenesis through hnRNP-K. Mol Cancer Ther. 13, 2930-2940.
7.Ran Gao, Rumani Singh, Zeenia Kaul, Tomoko Yaguchi, Sunil C. Kaul, Renu Wadhwa (2015) Targeting of DNA damage signaling pathway induced senescence and reduced migration of cancer cells. Journals of Gerontology: BIOLOGICAL SCIENCES, 2015, 701–713.
8.Ran Gao, Atsushi Inoue, Nashi Widodo, Tetsuro Ishii, Sunil Kaul, Renu Wadhwa (2013) hnRNP-K promotes tumor metastasis by induction of genes involved in extracellular matrix, cell movement and angiogenesis. J Biol Chem. 288, 15046-15056.
9. A-rum Yoon#, Ran Gao#, Zeenia Kaul, Il-Kyu Choi, Jihoon Ryu, Jane R. Noble, Yoshio Kato, Rumani Singh, Soichiro Saito, Takashi Hirano, Roger R. Reddel, Chae-Ok Yun, Sunil C. Kaul and Renu Wadhwa (2011) MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region. Nucleic Acids Res. 39(18), 8078-8091. (#regarded as joint First Authors)
10.Yue Yu#, Ran Gao#, Zeenia Kaul, Ling Li, Yoshio Kato, Zhenya Zhang, Joanna Groden, Sunil Kaul and Renu Wadhwa (2016) Loss-of-function screening to identity miRNAs involved in senescence: tumor suppressor activity of miRNA-335 and its new target CARF. Sci. Rep (#regarded as joint First Authors)