陈晓光
陈晓光，女，博士，研究员，1958年7月5日出生，现任中国医学科学院药物研究所副所长、药理学研究室主任、博士生导师。
教育情况：
1978.4-1982.7佳木斯医学院医疗系医学专业学士
1985.8-1988.7黑龙江中医学院基础药理学专业硕士
1992.8-1994.12中国医学科学院/北京协和医学院药物研究所博士
工作经历：
1982.08-1985.07佳木斯医学院基础部药理学教研室助教
1988.08-1992.07佳木斯医学院基础部药理学教研室讲师
1995.01-1996.02中国医学科学院/北京协和医学院药物研究所助研
1996.03-1996.11日本大阪市立大学医学部第二生化学教室客员助教授
1996.12-1997.04中国医学科学院/北京协和医学院药物研究所副研究员
1997.05-1997.08瑞士Vaudois州立大学附属医院癌研究中心访问学者
1997.09-1999.09中国医学科学院/北京协和医学院药物研究所副研究员
1999.10-2000.11中国医学科学院/北京协和医学院药物研究所研究员
2000.12-2001.08美国亨利福特医学中心福特医院神经科学访问学者
2001.09～中国医学科学院/北京协和医学院药物研究所研究员
专业研究领域：
主要从事抗肿瘤药物的分子药理学研究及新药创制与开发，主要研究领域为抗肿瘤药物研究新靶点-法尼基蛋白转移酶、TGF-b、MEKK1、EGFR、VEGFR、c-Raf酪氨酸激酶抑制剂以及Aurora激酶抑制剂等方面的研究。目前正在主持1个1.1类（有自主知识产权）新药进行I期临床开发研究，尚有几个新药侯选物正在临床前研究和验证的不同阶段。到目前为止，在国内外学术刊物上已发表学术论文100余篇；申请国内、国际化学发明专利24项；承担或完成国家级项目10余项，其中包括"973"子课题、"863"、国家科技部肿瘤药效学"技术平台"、多项国家自然科学基金以及国家“十一五”“十二五”新药重大专项等。目前主要学术任职为；中国抗癌协会、抗癌药物专业委员会委员，中国药理学会分子与生化药理专业委员会委员，中国药学会海洋药物专业委员会委员、国家科技部重大新药创制专项“十一五”“十二五”评审专家，SFDA新药评审专家库成员，SFDA保健品评审专家，北京生物技术和新医药产业促进中心新药项目评审专家。中国医学科学院/北京协和医学院学位评定委员会委员、学术委员会委员，中国医学科学院药物研究所学位评定分委会委员，中国医学科学院药物研究所学术委员会委员。中华肿瘤学杂志等编委。2004年被国家人事部等七部委授予首批新世纪百千万人才工程国家级人选；2005年获得国家政府特殊津贴。
近年发表论文:(2006～)
1.ZhenjiaLiu,HainingLv,HongyanLi,YiZhang,HaijingZhang,FuqinSu,YikangSi,ShishanYu,XiaoguangChen.(2011)AnticancereffectandneurotoxicityofS-(+)-deoxytylophorinidine,anewphenanthroindolizidinealkaloidthatinteractswithnucleicacids.JournalofAsianNaturalProductsResearch.5(13),400-408
2.XiangyanLi,YanLi,YiZhang,KeWang,XiaYuan,JingJin,YanZhang,ZhanzhuLiu,XiaoguangChen.(2011)Anovelbisindolymaleimidederivative(WK234)inhibitsproliferationandinducesapoptosisthroughtheproteinkinaseCbpathway,inchronicmyelogenousleukemiaK562cells.Leukemia&Lymphoma.OnlineonMay3,2011
3.XiaYuan,YiZhang,HaijingZhang,JingJin,XiangyanLi,HeLiu,ZhiqiangFeng,XiaoguangChen.(2011)ActivityofthepotentdualAbl/SrctyrosinekinaseinhibitorFB2againstBcr-Ablpositivecelllinesinvitroandinvivo.LeukemiaResearch.;35(2):237-42
4.MengHuang,XinZhao,MengZhang,JunGu,XiaoguangChen,DaliYin.(2010)Synthesisandstructure-activityrelationshipsofsinenxanAderivativesasmultidrugresistancereversalagents.Bioorganic&MedicinalChemistryLetters,20:5418-5421
5.SujuanWang,ShengLin,ChenggenZhu,YonghunYang,ShuaiLi,JianjunZhang,XiaoguangChenandJiangongShi.(2010)Highlyacylatedditerpenoidswithanew3,4-secograyananeskeletonfromtheflowerbudsofrhododendronmolle.OrganicLetters,12(7):1560-1563
6.KeWang,Xiang-YanLi,Xiao-GuangChen,Zhan-zhuliu.(2010)Synthesisandantitumoractivityofbisindolymaleimideandaminoacidesterconjugates.J.ofAsianNaturalProductsResearch,12(1):36-42
7.JingLi,YanLi,ZhiqiangFeng,XiaoguangChen.(2010)F84,aquinazolinederivative,exhibitshighpotentantitumoractivityagainsthumangynecologicmalignancies.InvestigationalNewDrugs,28(2):132
8.Zhang,Yi;Li,Hongyan;Wang,Hongbo;Su,Fuqin;Qu,Runjiang;Yin,Dali;Dai,Jungui;Li,Yan;Chen,Xiaoguang.（2010）Syl611,anovelsemisynthetictaxanederivative,reversesmultidrugresistancebyp-glycoproteininhibitionandfacilitatinginwardtransmembraneaction.CancerChemotherapyandPharmacology.66:851-859
9.LiHongyan,ZhengXuguang,WangHongbo,ZhangYi,XinHongqiandChenXiaoguang.XLF-III-43,anovelcoumarin-aspirincompound,preventsdiabeticnephropathyinratsviainhibitingadvancedglycationendproducts.EuropeanJ.Pharmacology,2009;627:340-347
10.FuqinSu,HongyanLi,ChaoqiYan,BaoqingJia,YiZhangandXiaoguangChen.(2009)DepletingMEKK1expressioninhibitstheabilityofinvasionandmigrationofhumanpancreaticcancercells.JCancerResClinOncol,135:1655-1663
11.HeLiu,HongyanLi,ZhiqiangFeng,JunTai,YangMeng,HongboWang,HongqiXin,SenZhang,MingxinZuo,YanZhangandXiaoguangChen.(2009)ActivityofFB2,anoveldualAbl/Srctyrosinekinaseinhibitor,againstimatinib-resistantchronicmyeloidleukemiainvivoandinvitro.Leukemia&Lymphoma,50(3):437-446.
12.JingLi,YanLi,Zhi-qiangFeng,Xiao-guangChen.(2009)Anti-tumoractivityofnovelEGFRtyrosinekinaseinhibitoragainsthumanNSCLCinvitroandinvivo.CancerLetters,279：213-220
13.HaixingWang,FuqinSu,LiangZhuo,XiaoguangChen,PingshengLei.(2009)Synthesisandcytotoxicitiesoficogeninanalogueswithdisaccharideresidues.Bioorganic&MedicinalChemistryLetters,10:1016
14.HongboWang,HongyanLi,MinxinZuo,YiZhang,HeLiu,WeishuoFang,XiaoguangChen.(2008)Lx2-32c,anoveltaxaneanditsantitumoractivitiesinvitroandinvivo.CancerLetters,268（1）：89-97
15.ZuoMingxin,LiYan,WangHongbo,ZhuoJianhua,LiHongyan,LiuHe,XinHongqi,ZhangSen,ChenXiaoguang.(2008)ActivityofmeisoindigoagainsthumancolorectalcancercellsHT-29invitroandinvivo.J.Chemotherapy,20(4):8-15
16.JungguiDai,RunjiangQu,JianhuaZou,XiaoguangChen.(2008)Structuraldiversificationoftaxanesbywhole-cellbiotransformation.Tetrahedron,64:8102-8116
17.JianhuaLi,JunguiDai,XiaoguangChen,andPingZhu.(2007)Microbialtransformationofcephalomanninebyluteibactersp.J.Nat.Prod.70:1846-1849
18.YangMeng,YanLi,JingLi,HongyanLi,JianjiangFu,YueLiu,HeLiuandXiaoguangChen.(2007)(-)Gossypolanditscombinationwithimatinibinduceapoptosisinhumanchronicmyeloidleukemiccells.Leukemia&Lymphoma,48(11)2204-2212
19.LiYu-yan,YouQi-dong,WangLei,ChenSheng,ChenXiao-guang,LiYanandLiHong-yan.(2007)20(S)-20-O-camptothecinb-aminopropionate:novelsynthesisandtumoractivityinvitro.Chem.Res.ChineseU.22(6):727-731
20.LinYang,RunjiangQu,JunguiDai,XiaoguangChen.(2007)SpecificmethylationandepoxidationofsinenxanAbyMucorgenevensisandthemulti-drugresistanttumorreversalactivitiesofthemetabolites.J.ofMolecularCatalysisB:Enzymatic,46:8-13
21.QuR,LiY,ChenJ,GaoQ,ShengLH,ZhangJ,LiuZ,ChenXG,ChoppM.(2007)Neurotrophicandgrowthfactorgeneexpressionprofilingofmousebonemarrowstromalcellsinducedbyischemicbrainextracts.Neuropathology,27:355-365.
22.JiangjiangFu,YanDing,DanHuang,HongyanLi,xiaoguangChen.(2007)TheretinoidXreceptor-selectiveligand,LGD1069,inhibitstumor-inducedangiogensisviasuppressionofVEGFinhumannon-smallcelllungcancer.CancerLettesr248(1):153-163
23.YanLi,YangMeng,HongyanLi,JingLi,JiangjiangFu,YueLiu,andXiaoguangChen.(2006)GrowthinhibitionanddifferentiationinducedbyperoxisomeproliferatoractivatedreceptorgammaligandrosiglitazoneinhumanmelanomacelllineA375.MedicalOncology,23(3):393-402
24.Jian-HuaZou,JunguiDai,XiaoguangChenandJing-QuanYuan.(2006)Pentacyclictriterpenoidsfromleavesofexcoecariaagallocha.Chem.Pharm.Bull.54(6):920-921
25.HongqinXin,YiLi,XiaoguangChenandMichaelChopp.(2006)BonemarrowstromalcellsinduceBMP2/4productioninoxygen-glucose-deprivedastrocytes,whichpromotesanastrocyticphenotypeinadultsubventricularprogenitorcells.J.NeuroscienceRes,83:1485-1493
26.Zhan-ZhuLiu,Yewang,Ye-FengTang,Shi-ZhiChen,Xiao-GuangChenandHong-YanLi.(2006)Synthesisandantitumoractivityofsimplifiedecteinascidin-saframycinanalogs.Bioorganic&MedicinalChemistryLetters.16:1282-1285
27.DanHuang,YanDing,YanLi,WenmingZhang,WeishuoFang,XiaoguangChen.(2006)Anti-tumoractivityofa3-oxoderivativeofoleanolicacid.CancerLetters233:289-296
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