苑玉和
苑玉和女，副研究员，硕士生导师，1971年6月出生。2005年于医科院基础所生物化学与分子生物学系毕业后在医科院药物所药理室工作。
联系方式：
电话：01063165182邮箱：yuanyuhe@imm.ac.cn
研究领域：
主要从事抗帕金森病创新药物的研制及相关机制的研究。主要方向：以与帕金森病发病相关基因?-synuclein为靶点，针对其过表达、突变、异常剪接及聚集等因素，从分子、细胞及动物水平建立抗帕金森病创新药物筛选及评价模型，并对活性化合物的作用机制进行深入研究。到目前为止，发表相关论文30余篇，其中SCI收录的文章19篇；参与申请的专利2项；主持的课题共4项，其中国家级课题2项。
主要代表性论文：
1.YuheYuan,JiandongSun,MingZhao,JinfengHu,XiaoliangWang,GuohuaDu,Nai-HongChen,Overexpressionofa-synucleindown-regulatesBDNFexpression,CellMolNeurobiol2010，30：939-946
2.YuheYuan,JinJin,YangBo,Zhangyun,HuJinfeng,Nai-HongChen,OverexpressedAlpha-synucleinRegulatedtheNuclearFactor-kappaBSignalPathway.CellMolNeurobiol,2008,28:21-33
3.YuheYuan,ChengboFu,HongChen,XinWang,WeiweiDengandBing-RenHuang.TheRanbindingproteinRanBPMinteractswithTrkAreceptor.NeurosciLett.2006.407:26-31
4.SunJD,LiuY,YuanYH,LiJ,ChenNH.GapJunctionDysfunctioninthePrefrontalCortexInducesDepressive-LikeBehaviorsinRats.Neuropsychopharmacology.2012;37:1305-20
5.SunF,SunJD,HanN,LiCJ,YuanYH,ZhangDM,ChenNH.PolygalasaponinFinduceslong-termpotentiationinadultrathippocampusviaNMDAreceptoractivation.ActaPharmacolSin.2012.（online）
6.Kai-LiMa,Yu-HeYuan,Lian-KunSong,NingHan,NaihongChen*.Over-expressionofα-synuclein98triggersintracellularoxidativestressandenhancessusceptibilitytorotenone.NeurosciLett.2011,491:148-152.
7.Bo-YuLi,YunZhang,Yu-heYuan,NaihongChen*.AnewperspectiveinParkinson’sDisease,chaperone-mediatedautophagy.PharkinsonismandRelatD.2011,17:231-235.
8.LiBY,YuanYH,HuJF,ZhaoQ,ZhangDM,ChenNH.ProtectiveeffectofBu-7,aflavonoidextractedfromClausenalansium,againstrotenoneinjuryinPC12cells,ActaPharmacolSin.2011,32:1321-6.
9.Ling-LeiKong,Jin-FengHu,WeiZhang,Yu-HeYuan,NingHan,Nai-HongChen.C19,aC-terminalpeptideofchemokine-likefactor1,protectsthebrainagainstfocalbrainischemiainrats.NeuroscienceLetters.2012,508:13–16.
10.NaNING,Jin-fengHU,Yu-heYUAN,Xin-yuanZHANG,Jun-guiDAI,Nai-hongCHEN*.Hsp70involvedinhuperzine-AderivativeM3protectingPC12cellsfromapoptosisinducedbysodiumnitroprusside.ActaPharmacologicaSinica,2011:1-7
11.HuJF,NiuF,NingN,DuanWZ,ChuSF,XueW,YuanYH,ChenNH,ZhangJT.ActivationofERK1/2-CREBpathwayduringpotentiatingsynaptictransmissionof(-)clausenamideinratdentategyrus.JAsianNatProdRes.2012,14:256-62.
12.Jin-FengHu,Xiu-YunSong,Shi-FengChu,JiChen,XiaoyuChen,HaijieJi,YuheYuan,NaihongChen*.InhibitoryeffectofginsenosideRg1onlipopolysaccharide-inducedmicroglialactivationinmice.BrainRes.2011,1374:8-14.
13.Ling-LeiKong,Jin-FengHu,WeiZhang,Yu-HeYuan,Kai-LiMa,NingHan,Nai-HongChen.Expressionofchemokine-likefactor1afterfocalcerebralischemiaintherat.NeuroscienceLetters.2011,505:14-18.
14.LIChuang-Jun,YANGJing-Zhi,YUShi-Shan,ZHANGDong-Ming*,XUEWei,YUANYu-He,CHENNai-Hong.TriterpenoidSaponinsandOligosaccharidesfromtheRootsofPolygalatenuifoliaWilld.ChineseJournalofNaturalMedicines.2011,9:321-328.
15.Jin-FengHu,Shi-FengChu,NaNing,Yu-heYuan,NaihongChen*,Jun-TianZhang.Protectiveeffectof(-)clausenamideagainstAβ-inducedneurotoxicityindifferentiatedPC12cells.NeurosciLett,.2010,483:78-82.
16.GangLi,DongmeiWang,MingnaSun,GuangyanLi,JinfengHu,YunZhang,YuheYuan,HaijieJi,NaihongChen,*GangLiu*.DiscoveryandOptimizationofNovel3-PiperazinylCoumarinAntagonistofChemokine-likefactor1withoralAnti-asthmaactivityinmice.JMedChem.2010,53:1741–1754.
17.Zhen-ZhenWang,GangLi,Xiao-YuChen,MingZhao,Yu-HeYuan,Xiao-LiangWang,NaihongChen*.Chemokine-likefactor1,anovelcytokine,inducesnervecellmigrationthroughthenon-extracellularCa2+-dependenttyrosinekinasespathway.BrainRes.2010,1308:24-34.
18.WeiXue,Jin-fengHu,Yu-HeYuan,Jian-dongSun,Bo-YuLi,Dong-MingZhang,Chuang-JunLi,NaihongChen*.PolygalasaponinXXXIIfrompolygalatenuifoliarootimproveshippconpal-dependentlearningandmemory.ActaPharmacolSin.2009,30:1211-1219.
19.Jin-fengHu,WeiXue,NaNing,YuheYuan，NaihongChen*.GinsenosideRg1activatedCaMKIIαmediatedextracellularsignal-regulatedkinase/mitogenactivatedproteinkinasesignalingpathway.ActaPharmacolSin.2008,29:1119-1126.
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