研究所：032 兰州牧药所
专业学科：基础兽医学
研究方向：兽医药理与毒理学
导师简介：
尚若锋，男，汉族，1974年7月8日出生，甘肃省靖远县人，六级副研究员，硕士研究生导师。
自1999年以来，主要从事新兽药研究与开发科研工作。先后主持国家自然科学基金面上项目“截短侧耳素类衍生物侧链杂环结构的筛选及其构效关系研究”、中央级公益性科研院所基本科研业务费项目 “基于Azamulin结构改造的妙林类衍生物的合成及其生物活性研究”、“截短侧耳素类新兽药“羟啶妙林”的研发”等。参加国家跨越计划：“新型安全中兽药的产业化与示范”、国家“十五”攻关项目“防治高制病性禽流感生物制剂的研制应用”、国家“十五”攻关项目“新型抗菌、抗病毒新兽药 的研制”、国家“十二五”科技支撑计划安全环保型中兽药的研制与应用”、国家“十三五”科技支撑计划：“新型动物药剂创制与产业化关键技术研究”子课题等国家级项目十余项。先后获省部级科技奖励4项，院厅级奖2项，以第一完成人获得国家发明专利4项，以第一作者或通讯作者发表SCI论文28篇。
出版著作：
1.《中兽药学》，2013，主要撰稿人
2. .《生态土鸡健康养殖技术》，2016，主要撰稿人
发表文章：
1. Ruofeng Shang,Xiuying Pu, Ximing Xu, Zhijun Xin, Chao Zhang, Wenzhu Guo, Yu Liu, and Jianping Liang. Synthesis and Biological Activities of Novel Pleuromutilin Derivativeswith a Substituted Thiadiazole Moiety as Potent Drug-ResistantBacteria Inhibitors. J. Med. Chem.2014, 57, 5664?5678.
2.Ruofeng Shang, Jiatu Wang, Wenzhu Guo, and Jianping Liang. Efficient Antibacterial Agents: A Review of the Synthesis, Biological and Mechanism of Pleuromutilin Derivatives. Curr. Top. Med. Chem. 2013, 13: 3013-3025.
3. Ruofeng Shang, Zhijun Xin, Wenzhu Guo, Ximing Xu, YuLiu, Jianping Liang. Chemical synthesis, docking studies and biological activities of novel pleuromutilin derivatives with substituted amino moiety. Plos one. 2013,8: 1-10.
4.ShangRuofeng, LIU Yu, XIN Zhijun, GUO Wenzhu, GUO Zhiting, HAO Baocheng, LIANG Jianping. Synthesis and antibacterial evaluation of novel pleuromutilin derivatives. Eur. J. Med. Chem.2013, 63: 231-238.
5. Ruofeng Shang, Guanhua Wang, Ximing Xu, Sijie Liu, Yunpeng Yi, Yu Liu, Wenzhu Guo, Jianping Liang. Synthesis and Biological Evaluation of New PleuromutilinDerivatives as Antibacterial Agents. Molecules.2014, 19: 19050-19065.
6.Ruofeng Shang, Jianping Liang, Yunpeng Yi, Yu Liu and Jiatu Wang.Review of Platensimycin and Platencin: Inhibitors of β-Ketoacyl-acylCarrier Protein (ACP) Synthase III (FabH). Molecules.2015, 20: 16127-16141.
7. Ruofeng Shang, Cheng He, Jiongran Chen, Xiuying Pu, Yu Liu, Lanying Hua, Ling Wang, Jianping Liang.Hypericum perforatum extract therapy for chickens experimentally infected with infectious bursal disease virus and its influence on immunity. Can. J. Vet. Res.2012;76:180–185.
8. Ruofeng Shang, Shuijin Xu, Yunpeng Yi, Xin Ai, Jianping Liang*. Syntheses, crystal structures and antibacterial evaluation of two new pleuromutilin derivatives. Chinese J. Struct. Chem. 2016, 4, 529-536.
9. Ruo-Feng Shang, Se-jie Liu, Wen-Zhu Guo, Jian-Ping Liang, Crystal structure of 14-O-[(2-chloro-benz- amide-2-methylpropane-2-yl) thioacetate] Mutilin, C33H46ClNO5S. Z. Kristallogr. NCS. 2013, 228: 473-475.
10. Ruo-Feng Shang, Jian-Ping Liang, Wen-Zhu Guo, Crystal structure of 14-O-[(3-chloro-benz-amide-2- methylpropane-2-yl) thioacetate] Mutilin, C33H46ClNO5S. Z. Kristallogr. NCS. 2013, 228: 135-137.
11. Ruo-Feng Shang,Yunpeng Yi and Jianping Liang. Crystal structure of 14-((1-(benzyloxycarbonylamino)-2-methylpropan-2-yl)sulfanyl)acetateMutilin, C34H49NO6S. Z. Kristallogr. NCS.2016,231: 465-467.
12. Yi Yunpeng, Xu Ximing, Liu Yu, Xu Shuijin, Huang Xin, Liang Jianping, Shang Ruofeng*. Synthesis and antibacterial activities of novel pleuromutilin derivatives with a Substituted Pyrimidine Moiety. Eur. J. Med. Chem. 2017,126: 687-695.
13. Xin Ai, Xiuying Pu, Yunpeng Yi, Yu Liu, Shuijin Xu, Jianping Liang and Ruofeng Shang*, Synthesis and Pharmacological Evaluation ofNovel Pleuromutilin Derivatives withSubstituted Benzimidazole Moieties. Molecules.2016, 21: 1488-1499.
14.Sijie Liu, Ruofeng Shang*, David Chi-Cheong Wan, Huangquan Lin, lanxiang shi. Synthesis and biological evaluation of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives as dual binding site acetylcholinesterase inhibitors. Eur. J. Med. Chem.2014, 81, 237-244.
15.Yunpeng Yi, Guanzhou Yang, Chao Zhang, Jiongran Chen, Jianping Liang*, Ruofeng Shang*. Synthesis and evaluation of novel pleuromutilin derivatives with a substituted pyrimidine moiety. Eur. J. Med. Chem. 2015, 101, 179-184.
16. Chao Zhang, Yunpeng Yi, Jiongran Chen, Rensheng Xin, Zhen Yang, Zhiting Guo, Jianping Liang* and Ruofeng Shang*. In Vivo Efficacy and Toxicity Studies of a Novel Antibacterial Agent: 14-O-[(2-Amino-1,3,4-thiadiazol-5-yl)Thioacetyl] Mutilin. Molecules, 2015, 20, 5299-5312.
17. Sijie Liu, Ruofeng Shang*, David Chi-Cheong Wan, Huang quan Lin. Design, synthesis, and evaluation of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives as dual binding site acetylcholinesterase inhibitors. Chem. Bio.Dru.Des. 2014, 84: 169–174.
18. Yunpeng Yi, Yunxing Fu, Pengcheng Dong, Wenwen Qin, Yu Liu, Jiangping Liang andRuofeng Shang. Synthesis and Biological Activity Evaluation of NovelHeterocyclic Pleuromutilin Derivatives. Molecules, 2017, 22, 996.
19. YiYunPeng,XuWenJun HuangXin, Jiangping Liang and Ruofeng Shang*. An Efficient Novel Synthesis of 14-O-[(4-Amino-6-hydroxy-pyrimidine-2-yl)thioacetyl] Mutilin and the Antibacterial Evaluation.Chinese J. Struct. Chem.2017, 36, 1433─1438.
20. Yunpeng Yi, Yunxing Fu, Keli Wang, Yongzhen Shui, Jing Cai, Zhong Jia, Biao Niu, Jiangping Liang and Ruofeng Shang*. Synthesis and antibacterial activities of novel pleuromutilin derivatives. Arch. Pharm. Chem. 2018, 7, e**.
21. RuofengShang, Chao Zhang, Yunpeng Yi, Yu Liu, Wanxia Pu*. Determination of a New PleuromutilinDerivative in Broiler Chicken Plasma byRP-HPLC-UV and Its Application to aPharmacokinetic Study.Journal of Chromatographic Science, 2018, 56, 604-610
22. Yunpeng Yi, Guanzhou Yang, Zhiting Guo, Xin Ai, Ruofeng Shang*, Jianping Liang*. A new pleuromutilin derivative: Synthesis, crystal structure and antibacterial evaluation. Chinese J. Struct. Chem. 2015, 34, 1434-1439.
23. Shang, R.F. Yi, Y.P. Zhang, C. Fu, Y.X. Liang, J.P. Pu, W.X. Antibacterial activity and pharmacokinetic profile of a promising antibacterial agent: 14-O-[(4-Amino-6-hydroxy-pyrimidine-2-yl)thioacetyl] mutilin. Pharmacolog. Res. 2018, 129: 424-431.
24. Wen-Zhu Guo, Ruo-Feng Shang*, Jian-Ping Liang and Yu Liu.Crys tal struc ture of 14-O-[(2- methylbenzamide-2-methyl pro pane-2-yl) thioacetate]Mutilin, C38H61NO7S. 2013, 228:488-490.
25. Si-Jie Liu, Ruo-Feng Shang*, Jing-Yu He, Hong-Kun Yue, Ran Zhou. Crystal structure of 6-benzyl-3-(2-(2-morpholinoethoxy)phenyl)-7Hthiazolo[3,2-b]-1,2,4-triazin-7-one, C24H24N4O3S. Z. Kristallogr. NCS. 2013, 228 :349-350.
26. Shang Ruofeng, Liang Jianping, Na Zhongyuan. In vivo inhibitiong of NAS preparation on H9N2 subtype AIV. Virologica Sinence, 2010, 4: 145-150.
27. Si-Jie Liu, Ruo-Feng Shang*, PengFei Jia, Xin Wang and Yu-Pin Song. Crystal structure of N,N-diethyl-2-(2-(6-(4-methoxybenzyl)-7-oxo-7H-thiazolo[3,3-b][1,2,4]triazin-3-yl)phenoxy)acetamide,C25H26N4O4S. Z. Kristallogr. NCS,2016, 231,499–501.
28. Yunxing Fua, Lijun Ma, Yunpeng Yi, Yuan Fan, Jianping Lianga, Ruofeng Shang*. A new pleuromutilin candidate with potent antibacterial activity againstPasteurella multocida. Microbial Pathogenesis2019, 127: 202-207.
29.尚若锋，刘 宇，陈炅然，郭文柱，郭志廷，梁剑平.金丝桃素粉剂对人工感染传染性囊病病毒鸡的治疗效果研究.中国兽医杂志，2012, 48（1）：12-15.
30.尚若锋, 那中元, 杨红军, 祝艳华, 梁建平. NAS制剂对H5N1亚型禽流感病毒感染鸡的保护实验. 黑龙江畜牧兽医, 2008, 9: 61-63.
31.尚若锋, 梁剑平, 何成, 刘宇, 郭志厅, 郭文柱, 华兰英, 王学红. 金丝桃素粉剂对雏鸡人工感染法氏囊病毒的预防试验. 湖北农业科学, 2010, 2485-2488.
32.尚若锋, 那中元, 杨红军, 梁建平, 王学红, 华玉英, 刘宇, 郭文柱. NAS制剂在体外对H5N1亚型和H9N2亚型禽流感病毒的杀灭效果研究. 中兽医医药杂志, 2008, 6: 5-8.
33.尚若锋, 梁建平, 何成, 郭志厅, 郭文柱, 王学红, 华玉英. 金丝桃素粉剂对雏鸡人工感染法氏囊病毒的预防试验. 湖北农业科学, 2010, 10: 2485-2488.
34.尚若锋, 胡正英, 张新国, 罗永江, 史彦彬, 罗超应. 富铜酵母的研制. 中兽医医药杂志, 2005, 5: 29-32.
35.尚若锋, 梁剑平. 防治禽流感及其他RNA病毒的新兽药---金丝桃素. 兽药市场指南, 2005, 10: 42.
36.尚若锋, 梁剑平, 刘宇, 崔颖, 王玲. 截短侧耳类抗生素研究进展. 中兽医医药杂志, 2010, 3: 29-32.
37.杨冠洲，尚若锋*. 截短侧耳素类化合物的研究进展.南方农业学报，2015：1527-1532.
联系地址：甘肃省兰州市七里河区硷沟沿335号
电子邮箱：shangrf1974@163.com
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