李春燕

大数据精准医疗高精尖创新中心副研究员

Email：lichunyan@buaa.edu.cn

教育经历:

09/2003—07/2009  中国科学院遗传与发育生物学研究所 博士 发育生物学

09/1999—07/2003 山东师范大学 生命科学学院 学士 生物科学

工作经历:

06/2019 北京航空航天大学 特聘副研究员

06/2016—12/2017 美国德州大学MD安德森癌症中心 生物信息和计算生物学系 访问助理教授

07/2009—06/2019 中国科学院北京基因组研究所 助理研究员、副研究员

研究领域:

利用多维基因组学数据的整合分析，研究人类重大疾病（肿瘤、老年疾病和遗传疾病等）的个体化诊疗策略，并进一步利用细胞系和模式生物解析增强子等调控元件的作用机制。

1.从进化生物学的角度研究肿瘤内的异质性和肿瘤细胞的进化过程，探索新的癌症治疗模式。   

2.利用泛基因组数据，通过多维基因组学数据整合分析，在全基因组水平筛选与癌症发生发展紧密相关的增强子。以此为基础，结合CRISPRi-cas9技术，在多种癌细胞系中筛选与某种表型（增殖、迁移和抗药性等）紧密相关的增强子，进一步解析这些增强子的调控机制。以此为基础，探索新的癌症诊断和治疗策略。   

3. 利用家族谱系的外显子组（和全基因组）测序数据，解析罕见遗传疾病的新的致病基因，探索个体化诊疗模式。

发表文章:

1. X. Bai*, Z. Liu*, X. Shao, D. Wang, E. Dong, Y. Wang, C. Wu, Y. Yuan, X. Lu#, C. Li#, The heterogeneity of plasma miRNA profiles in hepatocellular carcinoma patients and the exploration of diagnostic circulating miRNAs for hepatocellular carcinoma, PLoS ONE 14, e0211581 (2019).

2. H. Chen*, C. Li*, X. Peng, Z. Zhou, The Cancer Genome Atlas Research Network, J. N. Weinstein, H. Liang, A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples. Cell 173, 386-399 (2018).

3. H. Chen*, C. Li*, Z. Zhou, H. Liang, Fast-evolving human-specific neural enhancers are associated with aging-related diseases. Cell Systems 6, 604-611 (2018).

4. C. Li*, Y. Hou*, J. Xu*, A. Zhang, Z. Liu, F. Qi, Z. Yang, K. Chen, S. Liu, H. Huang, Q. Wang, J. Dong, C. Wu, X. Lu, A direct test of selection in cell populations using the diversity in gene expression within tumors. Molecular Biology and Evolution 34, 1730-1742 (2017).

5. C. Li*, Z. Liu*, F. Yang*, W. Liu, D. Wang, E. Dong, Y. Wang, C. Wu, X. Lu, siRNAs with decreased off-target effect facilitate the identification of essential genes in cancer cells. Oncotarget 6, 21603-21613 (2015).

6. S. Liu*, Z. Yang*, G. Li*, C. Li, Y. Luo, Q. Gong, X. Wu, T. Li, Z. Zhang, B. Xing, X. Xu#, X. Lu#, Multi-omics Analysis in Primary Cell Culture Models Reveals the Genetic and Epigenetic Basis of Phenotypic Diversity within Tumors, Genomics, Proteomics & Bioinformatics, accepted (2019)

7. Y. Tao*, Z. Hu*, S. Ling*, S. Yeh, W. Zhai, K. Chen, C. Li, Y. Wang, K. Wang, H. Wang, E. A. Hungate, K. Onel, J. Liu, C. Zeng, R. R. Hudson, P. Chen, X Lu#, C. Wu#, Further genetic diversification in multiple tumors and an evolutionary perspective on therapeutics, bioRxiv 2015:025429

8. Z. Chong*, W. Zhai*, C. Li, M. Gao, Q. Gong, J. Ruan, J. Li, L. Jiang, X. Lv, E. Hungate, and C. I. Wu, The evolution of small insertions and deletions in the coding genes of Drosophila melanogaster. Molecular Biology and Evolution 30, 2699-2708 (2013).

9. J. Ruan*, L. Jiang*, Z. Chong*, Q. Gong*, H. Li, C. Li, Y. Tao, C. Zheng, W. Zhai, D. Turissini, C. H. Cannon, X. Lu#, C. I. Wu#, Pseudo-Sanger sequencing: massively parallel production of long and near error-free reads using NGS technology. BMC Genomics 14, 711 (2013).

10. Y. Tao*, J. Ruan*, S. H. Yeh*, X. Lu*, Y. Wang*, W. Zhai*, J. Cai*, S. Ling, Q. Gong, Z. Chong, Z. Qu, Q. Li, J. Liu, J. Yang, C. Zheng, C. Zeng, H. Y. Wang, J. Zhang, S. H. Wang, L. Hao, L. Dong, W. Li, M. Sun, W. Zou, C. Yu, C. Li, G. Liu, L. Jiang, J. Xu, H. Huang, C. Li, S. Mi, B. Zhang, B. Chen, W. Zhao, S. Hu, S. M. Zhuang, Y. Shen, S. Shi, C. Brown, K. P. White, D. S. Chen#, P. J. Chen, C. I. Wu#, Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. Proceedings of the National Academy of Sciences of the United States of America 108, 12042-12047 (2011).

11. X. Lu*, J. A. Shapiro*, C. T. Ting, Y. Li, C. Li, J. Xu, H. Huang, Y. J. Cheng, A. J. Greenberg, S. H. Li, M. L. Wu, Y. Shen, C. I. Wu, Genome-wide misexpression of X-linked versus autosomal genes associated with hybrid male sterility. Genome Research 20, 1097-1102 (2010).

12. C. Li, Z. Guo, Z. Wang, TGFß receptor saxophone non-autonomously regulates germline proliferation in a Smox/dSmad2-dependent manner in Drosophila testis. Developmental Biology 309, 70-77 (2007).