张笑天
博士
电话：
E-mail：xiaotianzhang@bnu.edu.cn


个人简历
2011年毕业于北京大学医学部生物化学与分子生物学专业，获得理学博士学位；2011至2014年北京大学博士后；2014年9月至今，在北京师范大学生命科学学院任职。主要研究方向为mRNA修饰介导的基因转录后调控。主持国家自然科学基金、北京市自然科学基金和北京师范大学青年教师基金等科研项目。承担本科生《生物化学A》、《生物技术概论》和《生物技术大实验》等课程。目前担任2016级和2017级励耘班辅导员。


主要研究内容
RNA修饰是表观转录调控的重要方面。人们发现真核生物的mRNA和ncRNA中都存在大量的m6A和m5C修饰，这些修饰方式在转录后调控过程（如mRNA前体剪切、mRNA降解和翻译等）中发挥重要作用。我们主要利用生物化学、分子生物学、细胞生物学和基因组学等研究手段， 通过体外细胞实验和动物模型探讨介导mRNA分子m5C修饰的RNA甲基转移酶NSun2以及其他RNA结合蛋白（如HuR, TTP和AUF1等）参与转录后调控的分子机制和生物学功能。



代表性论著
1.Kelei Li＊, Xiaotian Zhang＊, Gong Chen, Lijun Pei, Hailong Xiao,Jiajing Jiang, Jiaomei Li, Xiaoying Zheng, and Duo Li. Association of fatty acids and lipids metabolism in placenta with early spontaneous pregnancy loss in Chinese women. Food & Function, 2018, 9: 1179-1186.
2.Kelei, Li＊, Xiaotian Zhang＊, Lijun Pei, Gong, Chen, Jianmeng Liu, Mark L. Wahlqvist, Xiaoying Zheng, and Duo Li. High ratios of C20:4n-6/C20:5n-3 and thromboxane B2/6-Keto-Prostaglandin F1a in placenta are potential risk contributors for Neural Tube Defects: a case-control study in Shanxi Province, China. Birth defects research Part A, 2017, 109(8): 550-563.
3.Pengfei Xu, Jiao Li, Jin Liu, Jing Wang, Zekai Wu, Xiaotian Zhang＃, and Yonggong Zhai＃. Mature adipocytes observed to undergo reproliferation and polyploidy. FEBS Open Bio, 2017, 7(5):652-658.
4.Shuhong Sun＊, Xiaotian Zhang＊＃, Lin Lyu, Xixi Li, Siliang Yao, and Junjie Zhang＃. Autotaxin expression is regulated at the post-transcriptional level by the RNA-binding proteins HuR and AUF1. Journal of Biological Chemistry, 2016，219(50): 25823-36.
5.Xiaotian Zhang＊, Zhenyun Liu＊, Jie Yi, Hao Tang, Junyue Xing, Mingwei Yu, Tanjun Tong, Yongfeng Shang, Myriam Gorspe, and Wengong wang. The tRNA methyltransferase NSun2 stabilizes p16INK4 mRNA by methylating the 3’-untranslated region of p16. Nature Communication, 2012, 3: 712. doi:10.1038/ncomms1692.
6.Fang Xu＊, Xiaotian Zhang＊, Yutao Lei, ect. Loss of repression of HuR translation by miR-16 may be responsible for the elevation of HuR in human breast carcinoma. Journal of Biological Chemistry. 2010, 11(3): 727-34.
7.Hao Tang, Hu Wang, Xiaolei Cheng, Xiuqin Fan, Fan Yang, Mengmeng Zhang, Yanlian Chen, Yuyang Tian, Cihang Liu, Dongxing Shao, Bin jiang, Yali Dou, Yusheng Cong, Junyue Xing, Xiaotian Zhang, Xia Yi, ect. HuR regulates telomerase activity through TERC methylation. Nature Comunication, 2018, 9(1):2213. doi: 10.1038/s41467-018-04617-7
8.Shuhong Sun, Ran Wang, Jianwen Song, Ming Guan, Na Li, Xiaotian Zhang, Zhanwen Zhao, Junjie Zhang. Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity. Journal of Lipid Research, 2017, 58(11): 2102-2113.
9.Junwei Ni, Mingyang jiang, Xiaotian Zhang, Hao Tang, Hengwei Jin and ect. Post- transcriptional regulation of Nkx2.5 by RHAU in heart development. Cell Report, 2015, 13(4): 723-32.