江华
教授，博士生导师，理学博士（中国科学院化学研究所），博士后（UniversityofNotreDame化学与生物化学系（美国）、InstitutEuropéendeChimieetBiologie（法国））,2008年入选中国科学院‘百人’计划,结题优秀（2012年）。国家杰出青年科学基金获得者（2011年）。曾获中国科学院优秀研究生导师（2012年）。
通信地址：北京市新街口外大街19号北京师范大学化学学院。
邮编：100875
电子邮箱：jiangh@bnu.edu.cn
教育和工作经历
2013.02–至今北京师范大学化学学院，教授，博士生导师。
2006.09–2013.06：中国科学院化学研究所，研究员，博士生导师，中国
科学院‘百人’计划，2008年获择优支持。
2004.01–2006.09：UniversityofNotreDame化学与生物化学系（美国），博士后。
2001.09–2003.12：InstitutEuropéendeChimieetBiologie（法国），博士后。
1998.09–2001.06：中国科学院化学研究所，有机化学专业，获博士学位。
1995.09–1998.07：武汉大学化学系，有机化学专业，获硕士学位。
1991.07–1995.08：湖北大学化学系，助理工程师。
1988.09–1991.06：湖北大学化学系，应用化学专业。
主持和参加的研究项目
（1）国家杰出青年科学基金：超分子有机化学（21125205）。2012-2015.。
（2）中国科学院‘百人’计划研究项目：具有螺旋结构的折叠式化合物的设计和性能研究。
（3）国家自然科学基金委面上项目：基于三唑寡聚物的螺旋纳米空腔的构筑及其性能研究（20772127），2008,1-2010,12。
（4）国家自然科学基金委重大研究计划:用于细胞信号转导过程的过渡金属离子荧光探针及其生物应用（90813002），2009.1－2011.12。
（5）国家自然科学基金委面上项目：稠环芳香类酰胺寡聚物协同组装结构及其性能研究（20972164），2010.01-2012.12。
（6）科技部973研究项目：复杂纳米体系的凝聚行为、输运过程及应用技术研究（2009CB930802）。2009,1-2013,12。
（7）科技部973研究项目：肿瘤微环境智能化纳米分子探针（2011CB935802），2011,1-2015,12。
（8）国家教委留学回国人员启动基金：N－烷基化低聚脲折叠分子：螺旋结构及分子识别行为。
（9）分子科学中心创新项目：基于氢键的低聚喹啉酰胺折叠分子：螺旋结构及分子识别，2008，3－2009，2。
（10）分子科学中心创新项目：基于螺旋的准轮烷构筑，2011，3－2012，2。
研究领域和主要学术成就
一直从事超分子有机化学研究工作，探索化学与生物学交叉学科的一些基本问题。研究方向包括自组装螺旋折叠体和生物荧光探针。主要成果：（1）与合作者利用模块设计和动态组装方法构筑了基于螺旋的准轮烷，突破了合成传统轮烷时所需要的关环反应或封端反应的制约，在此准轮烷的基础上发展了螺旋分子运动可调控的螺旋-线型分子主客体分子机器（Science,2011,331,1172）；（2）以设计新型螺旋折叠基元为切入点，发展了一系列具有结构和功能特色的芳香族折叠体系。发现芳香族酰胺低聚物利用氢键等组装形成单螺旋、双螺旋和四重螺旋等多种形式的螺旋聚集体结构；（3）发现三唑低聚物在氯离子协同下组装成为螺旋折叠体，并通过光开关实现氯离子的控制释放；（4）针对复杂的生理环境对探针分子的严重干扰等科学问题，设计了一系列基于喹啉的荧光染料，并发展一系列具有高选择性和生物相容性的锌和镉等离子比率计量荧光探针，实现了细胞原位检测和成像，特别是亚细胞器的定位成像。
发表论文目录：
67.DongjianZhu,GuopingLi,LinXue*andHuaJiang*,Developmentofratiometricnear-infraredfluorescentprobesusinganalyte-specificcleavageofcarbamate.Org.Biorg.Chem.2013,11,4577-4580.
66.WeiYao,YongliYan,LinXue,ChuangZhang,QingdongZheng,HuaJiang*,JiannianYao*,andYongShengZhao*,ControllingtheStructuresandPhotonicPropertiesofOrganicNanomaterialsviaMolecularDesign.Angew.Chem.Int.Ed.2013,inpress.
65.QuanGan,YingWangandHuaJiang*,TwistedHelicalMicrofibersbyHierarchicalSelf-AssemblyofanAromaticOligoamideFoldamer,Chin.J.Chem.2013,31,651-656.
64.QingLiu,GuopingLi,DongjianZhu,LinXue*,HuaJiang*,DesignofQuinoline-basedFluorescentProbeforRatiometricDetectionofCadmiuminAqueousMedia,Chin.Chem.Lett.2013,24,479-482.
63.Li,Guoping;Zhu,Dongjian;Liu,Qing;Xue,Lin*;Jiang,Hua*,AStrategyforHighlySelectiveDetectingandImagingHypochloriteUsingSelenoxideElimination,Org.Lett.2013,15(8),2002-2005.
62.EdwardJ.O’Neil,HuaJiang,BradleyD.Smith*,Effectofbridginganionsonthestructureandstabilityofphenoxidebridgedzincdipicolylaminecoordinationcomplexes,SupramolecularChemistry,2013,inpress.
61.GuopingLi,DongjianZhu,QingLiu,LinXue,*HuaJiang*,RapidDetectionofHydrogenPeroxideBasedonAggregationInducedRatiometricFluorescenceChange,Org.Lett.2013,15(4),924–927.
60.LinXue，GuopingLi,DongjianZhu,QingLiu,andHuaJiang*，RationalDesignofRatiometricandTargetableFluorescentProbeforImagingLysosomalZincIons.Inorg.Chem.2012,51,10842-10849.DOI:10.1021/ic301307v.
59.TaoPang,JieShang,Qin-WanYang,YuSun,An-XinWu,*andHuaJiang*,AnUnprecedentedTripleHelix:BasedonATetramericAssemblyofMacrocycledrivenbyweakC–H···πandC–H···OInteraction,CrystEngComm,2012,14,5170–5173.DOI:10.1039/C2CE25549A.
58.Quinoline-basedfluorescentprobeforratiometricdetectionofhydrogenperoxideinaqueoussolution,Yuan-YuQian,*,LinXue,Guo-PingLi,HuaJiang,*DyesandPigments,2012,95,373-376.doi:10.1016/j.dyepig.2012.05.013.
57.LisaLogie,JeanHarthill,KashyapPatel,SandraBacon,D.LeeHamilton,KatherineMacrae,GordonMcDougall,Huan-HuanWang,LinXue,HuaJiang,KeiSakamoto,AlanR.Prescott,andGrahamRena*,CellularResponsestotheMetal-BindingPropertiesofMetformin,Diabetes,2012,61,1423-1433.DOI:10.2337/db11-0961.
56.QuanGan,JieShang,BriceKauffmann,YingWang,FushengBieandHuaJiang*,Ahighlystabledoublehelixofaromaticoligoamidecomprisedoffusedringaromaticunits,Tetrahedron,2012,68，4479-4484.
55.LinXue,GuopingLi,CailanYu,andHuaJiang*,ARatiometricandTargetableFluorescentSensorforQuantificationofMitochondrialZincIons,Chem.-AEur.J.2012,18,1050-1054.
54.FeiSun,GuanxinZhang,DeqingZhang,*LinXue,andHuaJiang,AqueousFluorescenceTurn-onSensorforZn2+withaTetraphenylethyleneCompound,Org.Lett.2011,13(24),6378-6381(DOI:10.1021/ol2026735).
53.王颖，甘泉，江华*，阴离子协同组装折叠体，高等学校化学学报，2011,32(9),1928-1938（邀请综述）。
52.HuanhuanWang,LinXueandHuaJiang*,RatiometricFluorescentSensorforSilverIonandItsResultantComplexforIodideAnioninAqueousSolution,Org.Lett.2011,13(15),3844-3847.(DOI:10.1021/ol2013632).
51.YannFerrand,QuanGan,BriceKauffmann,HuaJiang*andIvanHuc*,Templateinducedscrewmotionswithinanaromaticamidefoldamerdoublehelix,Angew.Chem.Int.Ed.2011,50,7572-7575.(DOI:10.1002/anie.201101697).
50.Huan-HuanWang,LinXue,Cai-LanYu,Yuan-YuQian*andHuaJiang*,Rhodamine-basedfluorescentsensorformercuryinbuffersolutionandlivingcells.DyesandPigments,2011,91,350-355.
49.LinXue,ZhangjianFang,GuopingLi,andHuaJiang*,Highlysensitivefluorescentsensorsfordetectionofzincioninaqueoussolutionandtwo-photonbioimaging,Sensors&Actuators:B.Chemical.2011,156,410-415.
48.LinXue,GuopingLi,QingLiu,HuanhuanWang,ChunLiu,XunleiDing,ShengguiHe*andHuaJiang*,ARatiometricFluorescentSensorBasedonInhibitionofResonanceforDetectingCadmiumandItsCellularImaging,Inorg.Chem.2011,50,3680-3690.
47.IvanHuc*andHuaJiang*,OrganicFoldamersandHelices,chapterinSupramolecularChemistry:FromMoleculestoNanomaterials,EditedbyPhilipA.GaleandJonathanW.Steed,Wiley.Inpress.
46.Q.Gan,Y.Wang,andH.Jiang*,Aromaticamidefoldamers:Aparadigmforstructure-propertyrelationships,Curr.Org.Chem.2011,15,1293-1301.
45.QuanGan,YannFerrand,ChunyanBao,BriceKauffmann,AxelleGrélard,HuaJiang*andIvanHuc*,Helix-RodHost-GuestComplexeswithShuttlingRatesMuchFasterthanDisassembly,Science,2011,331,1172-1175.(HighlightedbyScience,2011,331,ThisweekinScience;NatureChemistry,2011,3(5),338;Chemical&EngineeringNews,March7,2011,89(10),42.)
44.YingWang,JunfengXiang,andHuaJiang*,Halide-GuidedOligo(aryl-triazole-amide)sFoldamers:ReceptorsforMultipleHalideIons,Chem.-AEur.J.2011,17(2),613-619.
43.WenpengZhang,YueWu,YingChen,HuaJiang,ZilinChen*，SimultaneousSeparationofFourMetalIonsbyCEUsingBis(2-Pyridylmethyl)(8-Pyridylmethyloxy-Quinoline-2-Methyl)AmineasChelatingAgent，Chromatographia,2010,72,1201–1205。
42.YingWang,FushengBie,andHuaJiang*,ControllingBindingAffinitiesforAnionsbyaPhotoswitchableFoldamer,Org.Lett.2010,12(16),3630-3633.
41.Huan-HuanWang,LinXue,Zhang-JianFang,Guo-PingLi,HuaJiang*,Acolorimetricandfluorescentchemosensorforcopperionsinaqueousmediaanditsapplicationinlivingcells,NewJ.Chem.2010,34,1239-1242.HighlightsinChemicalSciences,2010,Volume6,3.Top10mostaccessedarticlesinNewJ.ChemfromJulytoOctber,2010.
40.H.Wang,L.Xue,Y.Qian*,andH.Jiang*,Anovelratiometricfluorescentsensorforsilverions,Org.Lett.2010,12(2),292-295.
39.QuanGan,FeiLi,GuopingLi,BriceKauffmann,JunfengXiang,IvanHuc*andHuaJiang*,Heteromericdoublehelixformationbycross-hybridizationofchloro–andfluoro–substitutedquinolineoligoamides,ChemComm.2010,46(2),297-299.
38.BaohuaZhang,TianhuYuan,HuaJiang*,MingLei*,Moleculardynamicssimulationsonthestabilityandassemblymechanismsofquadrupleanddoublehelicalaromaticamidefoldamers,J.Phys.Chem.B,2009,113(31),10934-10941.
37.LinXue,QingLiuandHuaJiang*,RatiometricZn2+FluorescentSensorandNewApproachforSensingCd2+byRatiometricDisplacement,Org.Lett.2009,11(15),3454-3457.
36.YingWeng;FangWang;LinXue;ZilinChen,HuaJiang,HighSensitiveDeterminationofZincwithNovelWater-solubleSmallMolecularFluorescentSensor,AnalyticaChimicaActa,2009,647(2),215-218.
35.ChunyanBao,QuanGan,BriceKauffmann,HuaJiang,*andIvanHuc*，Aself-assembledfoldamercapsule:combiningsingleanddoublehelicalsegmentsinonearomaticamidesequence,Chem.-AEur.J.2009,15(43),11530-11536.
34.YingWang,FeiLi,YumiaoHan,FuyiWang,andHuaJiang*,FoldingandAggregationofCationicOligo(aryl-triazole)sinAqueousSolution,Chem.-AEur.J.2009,15(37),9424-9433.
33.F.Li,Q.Gan,L.Xue,Z.-M.Wang,andHuaJiang*,H-bondingdirectedone-stepsynthesisofnovelmacrocyclicpeptidesfromε-aminoquinolinecarboxylicacid,Tetra.Lett.,2009,50(20),2367-2369.
32.X.Lin,C.LiuandH.Jiang*,Ahighlysensitiveandselectivefluorescentsensorfordistinguishingcadmiumfromzincionsinaqueousmedia,Org.Lett.2009,11(7),1655-1658.
31.X.Lin,C.LiuandH.Jiang*,AratiometricfluorescentsensorwithalargeStokesshiftforimagingzincioninlivingcell,Chem.Commun.2009,1061-1063.
30.C.Bao,B.Kauffmann,Q.Gan,K.Srinivas,HuaJiang,andI.Huc,“Convertingsequencesofaromaticaminoacidmonomersintofunction:secondgenerationhelicalcapsules”,Angew.Chem.Int.Ed.2008,47,4153-4156.Hotpaper.HightlightedbyNatureChemistry,DOI:10.1038/nchem.9.
29.L.Xue,H.Wang,X.Wang,andHuaJiang*,“ModulatingaffinitiesofDPA-substitutedquinolinesensorsforzincionsbyvaryingpendantligands”,Inorg.Chem.2008,47,4310-4318.
28.Johnson,J.R.;Jiang,H.;Smith,B.D.“Zinc(II)-CoordinatedOligotyrosine:ANewClassofCellPenetratingPeptide”Bioconj.Chem.2008,19,1033-1039.Coverpaper.
27.W.M.Leevy,S.T.Gammon,J.R.Johnson,A.J.Lampkins,HuaJiang,M.Marquez,D.Piwnica-Worms,M.A.Suckow,andB.D.Smith,“NoninvasiveOpticalImagingofStaphylococcusaureusBacterialInfectioninLivingMiceUsingaBis-Dipicolylamine-Zinc(II)AffinityGroupConjugatedtoaNear-InfraredFluorophore”Bioconj.Chem.2008,686-692.
26.Q.Gan,C.Bao,B.Kauffmann,A.Grélard,J.Xiang,S.Liu,I.Huc*,andHuaJiang*“Quadrupleanddoublehelicesof8-fluoroquinolineoligoamides”Angew.Chem.Int.Ed.2008,47,1715-1718.Hotpaper.
25.H.Wang,Q.Gan,X.Wang,L.Xue,S.LiuandHuaJiang*“AWater-soluble,SmallMolecularFluorescentSensorwithFemtomolarSensitivityforZincIon.”Org.Lett.2007,9,4995-4998.
24.D.Haldar,HuaJiang,J.-M.Léger,I.Huc.“Doubleversussinglehelicalstructuresofoligopyridine-dicarboxamidestrands.Part2:theroleofside-chains”Tetrahedron,2007,63,6322-6330.
23.W.M.Leevy,S.T.Gammon,Hua.Jiang,J.R.Johnson,D.J.Maxwell,E.N.Jackson,M.Marquez,D.Piwnica-Worms,B.D.Smith.“OpticalImagingofBacterialInfectioninLivingMiceUsingaFluorescentNear-InfraredMolecularProbe”J.Am.Chem.Soc.2006,128,16476-16477.
22．D.Haldar,HuaJiang,J.-M.Léger,andI.Huc.Interstrandsidechain–sidechaininteractionsinadoublehelicalfoldamer.Angew.Chem.Int.Ed.2006,5483-5486.
21.HuaJiang,B.D.Smith.“Dynamicmolecularrecognitiononthesurfaceofvesiclemembrane.”Chem.Comm.2006,1407-1409.
20.C.Dolain,HuaJiang,J.Léger,P.Guionneau,andI.Huc.“ChiralInductioninQuinoline-DerivedOligoamideFoldamers:AssignmentofHelicalHandednessandRoleofStericEffects.”J.Am.Chem.Soc.2005,127,12943-12951.
19.C.Dolain,A.Grélard,M.Laguerre,HuaJiang,V.Maurizot,I.Huc.SolutionStructureofQuinoline-andPyridine-DerivedOligoamideFoldamers.Chem.Eur.J.2005,11,6135-6144.
18.HuaJiang,E.O’Neil,K.DiVittorio,B.Smith.“Anion-MediatedPhaseTransferofZinc(II)-CoordinatedTyrosineDerivatives.”Org.Lett.2005,3013-3016.
17.J.Mahoney,K.Stucker,HuaJiang,I.Carmichael,N.R.Brinkmann,A.M.Beatty,B.C.Noll,B.D.Smith,“MolecularRecognitionofTrigonalOxyanionsUsingaDitopicSaltReceptor:EvidenceforAnisotropicShieldingSurfacearoundNitrateAnion.”J.Am.Chem.Soc.2005,127,2922-2928.
16.R.Hanshaw,S.Hilkert,HuaJiang,andB.D.Smith.“AnIndicatorDisplacementSystemforFluorescentDetectionofPhosphateOxyanionsunderPhysiologicalConditions”Tetra.Lett.2004,45(47),8721-8724.
15.HuaJiang,J-MLéger,P.Guionneau,andI.Huc.“StrainedAromaticOligoamideMacrocyclesasNewMolecularClips.”Org.Lett.2004,6,2985.
14.HuaJiang,V.MaurizotandI.Huc.“Doubleversussinglehelicalstructuresofoligopyridine-dicarboxamidestrands.Part1:EffectofOligomerLength.”Tetrahedron.2004,60,10029-10038.
13.HuaJiang,C.Dolain,J.Léger,H.Gornitzka,I.Huc,“SwitchingofChiralInductioninHelicalAromaticOligoamidesUsingSolidState-SolutionStateEquilibrium.”J.Am.Chem.Soc.2004,126,1034-1035.
12.HuaJiang,J.Léger,C.Dolain,P.Guionneau,andI.Huc.“Aromaticd-peptides:design,synthesisandstructuralstudiesofhelicalquinoline-derivedoligoamidefoldamers.”Tetrahedron,2003,59,8365-8374.
11.HuaJiang,J.Léger,I.Huc,“AromaticdPeptides.”J.Am.Chem.Soc.2003,125,3448-3449.
10.江华，许慧君，用能量转移探测萘－蒽二元体系的构象变化，物理化学学报，2001,17(2),1092-1096.
9.HuaJiangandH.Xu.“Intramolecularexciplexandcation-mediatedcharge-transferfluorescenceinapodandcarryingterminalelectrondonorandacceptorgroups.”J.Chem.Soc.PerkinTrans.2.2001,8.1274-1279.
8.HuaJiang,C.NiuandL.Chen.“SynthesisandCrystalStructureof13-Phenyl-1,10-dithia-4,7-dioxa-13-aza-15-Crown-5”ChineseJ.StructuralChemistry.2001,20(2),83-87.
7.HuaJiang,H.XuandJ.Ye,“Synthesisandcation-mediatedelectrontransferinintramolecularfluorescencequenchingofdonor–acceptorpodands:observationofMarcusinvertedregioninforwardelectrontransferreactions.”J.Chem.Soc.PerkinTrans.2.2000,5,925-930.
6.HuaJiangandH.Xu,“Synthesisandcation-mediatedelectrontransferinfluorescencequenchingofdonor-acceptorpodands”,ChineseChemicalLetters,2000,11(9),767-770.
5.江华，许慧君，沈淑引，周庆复，蒽醌冠醚铕离子络合物分子内能量转移，感光科学与光化学,2000,18(3),223-228.
4.H.Xu,X.LI,HuaJiangandQ.Zhou,“EffectofHost-guestinteractionsonthephotophysicalpropertiesofamonocrownethersubstitutedphthalocyanine”,MaterialsScienceandEngineering(C),1999,10,71-74.
3.HuaJiangandH.Xu,P.Xia,Q.Zhou,“Synthesisandeffectofcationbindingonphotophysicalpropertiesof1,8-anthraceno-18-crown-5”,ChineseChemicalLetters,1999,10(12),1015-1018.
2.C.Niu,HuaJiangandC.Wu,“Synthesisandcrystalstructureof10-phenyl-1,7-dithia-4-oxa-10-aza-12-crown-4”,ChemicalResearchinChineseUniversities,1998,14(4),375-378.
1.C.Niu,HuaJiangandC.Wu.“SynthesisofTwoNewTypesofN-PhenylandN,N’-DiphenylAzathiacrownEtherAnalogs”,ChineseChemicalLetters,1998,9(1),17-20.
