马兰青
n 理学博士，教授，硕士生导师
n 生物科学与工程学院，院长
n 农业农村部华北都市农业重点实验室，主任





个人简介
1971年7月出生，1989年–1996年，在内蒙古农业大学获农学学士和硕士学位，2002年–2005年，在吉林大学获理学博士学位。2005-2008年，于中国科学院植物研究所分子与发育生物学研究中心从事博士后研究；2008-2009年，于美国波士顿大学化学系从事博士后研究。2009年至今，受聘于北京农学院，生物科学与工程学院教授，吉林省植物学会常务理事，吉林大学客座教授，《生物技术进展》杂志编委。
现担任农业农村部都市农业学科群重点实验室学术委员会委员，北京农学院林木分子设计育种高精尖创新中心重要树种个性化分子设计与育种体系研究方向研究员。多年来，围绕对经济林木和药用植物重要性状形成具有关键作用和具有重要生物学活性的次生代谢产物的生物活性、及其生成途径中关键基因功能和分子调控机制开展研究工作。以第一作者或通讯作者在Oncogenesis、Am J Cancer Res、Sci Rep 、Future Med Chem、Nutrients、Planta、Phytochemistry等刊物上发表SCI研究论文20余篇，授权国家发明专利15项，国际PCT专利2项。

主要论文：
1. Yang MF, Lu HS, Xue FY, Ma LQ*. Identifying High Confidence microRNAs in the Developing Seeds of Jatropha curcas. Sci. Rep. 2019 (Accepted) (SCI IF= 4.12)
2. Liu C, Dai LH , Liu Y, Dou DQ*, Sun YX, Ma LQ*. Pharmacological activities of mogrosides. Future Med Chem, 2018, 2017, 845-850. (SCI IF=3.969).
3. Guo HL, Yang YD, Xue FY, Zhang H, Huang TR, Liu WB, Liu H, Zhang FQ, Yang MF, Liu CM, Lu HS, Zhang YS, Ma LQ. Effect of flexible linker length on the activity of fusion protein 4-coumaroyl-CoA ligase::stilbene synthase. Mol Biosyst, 2017, 13(3): 598~606 (SCI IF=2.759).
4. Guo HL, Yang YD, Ma YD, Liu WB, Feng J, Luo ZQ, Lu HS, Liu CM, Yang MF, Wang YN, Ma LQ*. A bifunctional type III polyketide synthase from raspberry (Rubus idaeus L.) with both chalcone synthase and benzalacetone synthase activity, J Plant Biochem Biot 2017, 26(1): 80~90 (SCI IF=1.352).
5. Liu C, Dai LH, Liu YP, Rong L, Dou DQ , Sun YX, Ma LQ*. Antiproliferative Activity of Triterpene Glycoside Nutrient from Monk Fruit in Colorectal Cancer and Throat Cancer, Nutrients, 2016, 304: 282~288 (SCI IF= 4.196)
6. Liu C, Dai LH, Dou DQ, Ma LQ*, Sun YX. A natural food sweetener with anti-pancreatic atic cancer properties. Oncogenesis 5, e217(2016) (SCI IF=5.02).
7. Xue FY , Guo HL, Hu YY, Liu R, Huang LN, Lv HS, Liu CM, Yang MF, Ma LQ*. Expression of Codon-Optimized Plant Glycosyltransferase UGT72B14 in Escherichia coli Enhances Salidroside, Biomed Res Int 2016, 2016(**):1~8(SCI IF=2.583).
8. Liu C, Zeng Y, Dai LH, Cai TY, Zhu YM, Dou DQ, Ma LQ*, Sun YX. Mogrol represents a novel leukemia therapeutic, via ERK and STAT3 inhibition. Am J Cancer Res 2015 5(4): 1308-1318 (SCI IF= 4.17).
9. Zhang H, Guo YW, Yang YD, Ma YJ, Liu BY, Ye HC, Wang H, Ma LQ*. Cloning of a novel type III polyketide synthase encoded by a three-intron gene from Polygonum cuspidatum. J Plant Biochem Biot 2014 23(1): 104–111 (SCI IF=1.352).
10. Guo YW, Guo HL, Li X, Huang LL, Zhang BN, Pang XB, Liu BY, Ma LQ*. Two Type III Polyketide Synthases from Polygonum Cuspidatum: Gene Structure, Evolutionary Route and Metabolites, Plant Biotechnol Rep , 2013, 7: 371~381 (SCI IF=1.49)
11. Lu HS, Yang MF, Liu CM, Lu P, Cang HX, Ma LQ*. Protein preparation, crystallization and preliminary X-ray analysis of Polygonum cuspidatum bifunctional chalcone synthase/benzalacetone synthase. Acta Crys, 2013 69: 871-875 (SCI IF=0.989).
12. Yu HS, Ma LQ (Co-first-author), Zhang JX, Shi GL, Hu YH*. Characterization of glycosyltransferases responsible for salidroside biosynthesis in Rhodiola sachalinensis. Phytochemistry 2011 72 (9), 862-870 (SCI IF=3.37).
13. Zhang JX, Ma LQ (Co-first-author), Yu HS, Zhang H, Wang HT, Qin YF, Shi GL*. A tyrosine decarboxylase catalyzes the initial reaction of the salidroside biosynthesis pathway in Rhodiola sachalinensis. Plant Cell Rep 2011 30(8), 1443-1453 (SCI IF=3.07).
14. Guo YW , Ma LQ (Co-first-author), Ji YP, Pu GB, Liu BY, Du ZG, Li GF, Ye HC, Wang H*. Isolation of the 5'-End of plant genes from genomic DNA by TATA-Box-based degenerate primers. Mol Biotechnol 2011 47, 152-156 (SCI IF=2.47).
15. Ma LQ, Guo YW, Gao DY, Ma DM, Li GF, Liu BY, Wang H*, Ye HC*. Identification of a Polygonum cuspidatum three-intron gene encoding a type III polyketide synthase producing both naringenin and p-hydroxybenzalacetone. Planta 2009 229 (4), 1077-1086 (SCI IF=3.26).
16. Ma LQ, Pang XB, Shen HY, Pu GB, Wang HH, Lei CY, Wang H, Li GF, Liu BY*, Ye HC* A novel type III polyketide synthase encoded by a three-intron gene from Polygonum cuspidatum Sieb. et Zucc. Planta 2009 229 (3), 457-469 (SCI IF=3.26).
17. Ma LQ, Gao DY, Wang YN, Wang HH, Zhang JX, Pang XB, Hu TS, Lv SY , Li GF, Ye HC*, Li YF*, Wang H. Effects of overexpression of endogenous phenylalanine ammonia-lyase (PALrs1) on accumulation of salidroside in Rhodiola sachalinensis. Plant Biology 2008 (10), 323-333 (SCI IF=2.63).
18. Ma LQ, Liu BY, Gao DY, Pang XB, Lv SY, Yu HS, Wang H, Yan F, Li ZQ, Li YF*, Ye HC*. Molecular cloning and overexpression of a novel UDP-glucosyltransferase elevating salidroside levels in Rhodiola sachalinensis. Plant Cell Rep 2007 (26), 989-999 (SCI IF=3.07).
19. 马兰青,柳春梅, 于寒松, 张继星, 高东尧, 李彦舫*, 王有年*. 红景天甙生物合成途径：酪醇合成的起始反应及其糖基化. 生物工程学报 2012, 28(3): 282-294.
20. 吕鹤书, 柳春梅, 路平, 师光禄, 马兰青*. 植物类型III聚酮合酶超家族晶体结构与功能. 生物工程学报 2012, 28(1), 2-15.
21. 马兰青, 师光禄, 叶和春, 刘本叶*, 王有年*. 植物类型III聚酮合酶超家族基因结构、功能及代谢产物. 生物工程学报 2010, 26(11), 1482-1492.
22. 于寒松, 张继星, 李彦舫, 马兰青*. 高山红景天中糖基转移酶家族cDNA全长基因的克隆. 食品科学 2010 31(21), 244-247.

主要专利：
1. LIU Can; DOU Dequan; MA Lanqing; RONG Long; ZHAO Xiaomeng; WANG Yan; LI Juntao; SUN Yuanxia. Mogrosides and the salts thereof, the preparing method and the use of the same and pharmaceutical compositions comprising the mogrosides and the salts thereof, 2017.12.18-2037.12.18, WIPO,
2. Liu Can; Ma Lanqing; Dou Dequan; Rong Long; Zhao Xiaomeng Liu Xu;Chang Mingming; Zhang Jing; Liu Xuhang; Sun Yuanxia. Use of mogrosides or the pharmaceutically acceptable salts thereof in the manufacture of a tumorradiation sensitizing agent, 2017.11.1-2037.11.1, 欧洲, GB**
3. 郭辉力；马兰青等. 融合蛋白Nt4CL3aPcSTS及其制备方法与应用.7.3
4. 马兰青；郭辉力等. 融合蛋白Nt4CL7aPcSTS的相关生物材料及其应用.6.8
5. 郭辉力；马兰青等. 融合蛋白Nt4CL3aPcSTS的相关生物材料及其应用.2.3
6. 郭辉力；马兰青等. 融合蛋白Nt4CL5aPcSTS及其制备方法与应用. 1.9
7. 王有年；马兰青等. 融合蛋白Nt4CL7aPcSTS及其制备方法与应用.2.5
8. 郭辉力；马兰青等. 融合蛋白Nt4CL5aPcSTS的相关生物材料及其应用. 9.3