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微流控芯片加工工艺及生物相容性探究

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微流控芯片加工工艺及生物相容性探究
Process of Microfluidic Fabrication and Biocompatibility Exploration
投稿时间:2018-10-20
DOI:10.15918/j.tbit1001-0645.2019.s1.022
中文关键词:微流控芯片加工工艺细胞培养包被
English Keywords:microfluidic chipfabrication progresscell culturecoating
基金项目:JCKY(JCKY2016602C009)
作者单位E-mail
周迪北京理工大学 生命学院, 北京 100081
李瑞北京理工大学 生命学院, 北京 100081
北京东方传感技术有限公司, 北京 100176
邓玉林北京理工大学 生命学院, 北京 100081deng@bit.edu.cn
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中文摘要:
本文就实验室微流控玻璃芯片湿法刻蚀加工工艺进行了研究,并对加工后芯片表面的生物相容性进行了评估.结果该工艺展宽100 μm,H2SO4处理后的基质生物相容性更好.所以在涉及具体的操作前,有必要进行相应的清洗以及包被处理,以便后续实验顺利开展.对于微流控芯片相关实验具有借鉴与指导意义.
English Summary:
The study of Microfluidic chip has been a popular research area for its low reagent consumption, integration and high throughput. Researchers prefer glass chip as their experimental platform for its favourable optical properties and mature process. In this paper, the progress of wet-etchingin glass microfluidic chip was analyzed and the biocompatibilities of the substrate after etching technique were explored. The results show that, the broadening can reach 100 μm and biocompability is more reliable after H2SO4 disposed. As a result, it is necessary to provide appropriate cleaning and coating which might ensure follow-up operation. It provides a reference and guidance for microfluidic chip experiments.
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