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驻极体外静电场对不同参数环孢菌素A贴剂极化特性的影响

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驻极体外静电场对不同参数环孢菌素A贴剂极化特性的影响
Influence of External Electric Field of Electret on Polarization Properties of Cyclosporine A Patch
投稿时间：2014-10-15
DOI：10.15918/j.tbit1001-0645.2017.02.015
中文关键词:驻极体环孢菌素A静电场极化d33
English Keywords:electretcyclosporine Aelectrostatics fieldpolarizationd33
基金项目:第二军医大学学校军事医学专项课题资助项目（2013JSD2）；国家自然科学基金资助项目（50977089，51477175）
作者单位E-mail
郭鑫第二军医大学 基础部数理教研室, 上海 200433
王桃上海市第二军医大学附属长海医院血液内科, 上海 200433
石岩第二军医大学 基础部数理教研室, 上海 200433
黄平第二军医大学 基础部数理教研室, 上海 200433
梁媛媛第二军医大学 基础部数理教研室, 上海 200433
王春晓第二军医大学 基础部数理教研室, 上海 200433
江键第二军医大学 基础部数理教研室, 上海 200433jjiang@smmu.edu.cn
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中文摘要:
以环孢菌素A为模型药物，以不同浓度促渗剂、不同含量模型药物的环孢菌素A贴剂为研究对象，将不同表面电位正极性驻极体产生的外静电场作为电场源，系统研究驻极体引起各类环孢菌素A贴剂的极化规律及其与贴剂参数间的关系.结果显示：驻极体产生的外静电场能引起环孢菌素A贴剂的极化，驻极体的等效表面电位越高，贴剂的极化程度越强；驻极体引起环孢菌素A贴剂的极化与模型药物的含量及促渗剂的浓度密切相关.在特定电场下贴剂的极化强度随模型药物含量和促渗剂浓度的增加而下降；驻极体引起环孢菌素A贴剂的极化程度呈现出：促渗剂的极化 > 模型药物的极化 > 含促渗剂模型药物的极化.结果表明：驻极体外静电场能引起环孢菌素A和促渗剂的极化，极化的环孢菌素A在电场的作用下有望实现可控迁移和释放的目的.
English Summary:
In this paper, the cyclosporine A and ethyl oleate were selected as model drug and enhancer respectively. A series of patches with different content of drug and/or enhancers were prepared. The positive electrets with different surface potentials were applied to the patches to study the relationships between polarization rules and patch parameters. The results show that the external electric field produced by electret can result in the polarization of the cyclosporine A patches. The polarization degree of the patch is proportional to the surface potential of the electret, but inversely proportional to the content of the drug as well as enhancer. The polarization degree caused by electret for different patches is in the following order:enhancer patches > drug patches > enhancer containing drug patches. Therefore, the external electric field of the electret can cause the polarization of the drug and enhancer which is favorable for the controllable transport and release of the drug.
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