姓名　张小玲

性别　女

出生年月　1963.3

职务职称　教授，博士生导师

联系电话　68913154

传真　010-88875298

电子邮件　zhangxl000@126.com;zhangxl@bit.edu.cn

主要经历　
　　分别于1984年、1987年陕西师范大学化学系获理学学士、硕士学位，随后留校任教。2003年获西北大学分析化学专业博士学位，2005年调入北京理工大学理学院化学系任教授、博士生导师。期间2005年12月应日本筑波产业技术综合研究所（NationalInstituteofAdvancedIndustrialScienceandTechnology,AIST）邀请作为特聘研究员从事研究工作，2008-2009年美国佛罗里达大学（UniversityofFlorida）访问教授。主要从事新型光学探针试剂及功能化纳米晶的设计合成及其在分子识别与化学生物传感中的应用研究。

研究方向
1、新型光学探针分子的设计、合成

2、功能化纳米晶及纳米结构的设计、合成、组装

3、分子识别与化学生物传感

研究内容　　
　　针对目前环境污染、食品安全、疾病的早期诊断及药物靶向治疗等人类所面对的问题中所必需的高灵敏度、高特异性化学生物识别传感学方法和器件研究，利用光诱导电子转移、电荷转移、能量转移等各种光物理过程，和酶、抗体、单链DNA和核酸识体、信号肽等生物分子识别物质，设计合成性能优异的光学(包括吸光、荧光、发光)探针分子或功能化纳米晶，构建组装针对不同目标物的分子和生物纳米识别体系，实现对生命体系或环境体系中重要目标物(包括阴阳离子，中性小分子，生物大分子，病毒，细菌，肿瘤细胞，病变组织等)的光电化学识别传感，探索识别机制及其化学本质，应用于对生命、环境、食品等复杂体系中具有重要影响力目标物的特异性标记和远程、活体、原位、实时检测或显微成像分析等。

承担课题：主持或参加国家自然科学基金及其他军工项目多项:

1.信号肽介导亚细胞区域靶位近红外Ca²⁺荧光纳米传感器的研究,国家自然科学基金项目

2.高选择性硫醇探针的设计合成及分析应用,北京分子科学国家实验室开放课题基金

3.推进剂装药老化性能表征方法研究,横向

4.火炸药原材料数据库,横向

主要成果：已发表学术论文百余篇，申请国家发明专利6项，参编或主编出版教材4部，获省科技进步二等奖两项。
　　
SelectedPublications：

1.YaminLi,XiaolingZhang*,BaocunZhu,JuanXue,ZhiZhuandWeihongTan*，AsimplebuthighlysensitiveandselectivecolorimetricandfluorescentprobeforCu2+ionaqueousmedia，Analyst，2011,136,1124-1128.DOI:10.1039/C0AN00682C

2.YaminLi,XiaolingZhang*,BaocunZhu,JuanXue,JilinYAN,ADisulfide-linkedNaphthalimideDimerforHg(II)DetectioninAqueousSolution，JOURNALOFFLUORESCENCE,2011,2011,21(4)：1343-1348,DOI:10.1007/s10895-010-0820-0

3.ShutangChen,XiaolingZhang*,QiuhuaZhang,XiaomiaoHou,QiZhou,JilinYan,WeihongTan*.CdSequantumdotsdecoratedbymercaptosuccinicacidas?uorescenceprobeforCu2+,JournalofLuminescence,2011,131,947–951.

4.XiaomiaoHou,XiaolingZhang*,ShutangChen,YanFang,JilinYan,NaLi,PengxuQi.FacilesynthesisofSERSactiveAgnanoparticlesinthepresenceoftri-n-octylphosphinesulfide,AppliedSurfaceScience,2011,257,4935-4940,10.1016/j.apsusc.2010.12.154.

5.NaLi,XiaolingZhang*,ShutangChen,XiaomiaoHou,YuLiu,XiaomanZhai.SynthesisandOpticalPropertiesofCdSnanorodsandCdSenanocrystalsUsingOleylamineasbothSolventandStabilizer,MaterialsScienceandEngineeringB,2011,176(8):688-691.

6.XiaomiaoHou,XiaolingZhang*,ShutangChen,YanFang,NaLi,XiaomanZhai,YuLiu.Size-controlledsynthesisofAunanoparticlesandnanowiresandtheirapplicationasSERSsubstrates.ColloidsandSurfacesA:Physicochem.Eng.Aspects,2011,384(1-3):345-351.DOI:10.1016/j.colsurfa.2011.04.014.

7.Kang,Huaizhi;Trondoli,Anna;Zhu,Guizhi;Chen,Yan;Chang,Ya-Jen;Liu,Haipeng;Huang,Yu-Fen;Zhang,Xiaoling*;Tan,Weihong*.Near-InfraredLight-ResponsiveCore-ShellNanogelsforTargetedDrugDelivery,ACSNano,2011,5(6):5094–5099.DOI:10.1021/nn201171r.

8.NaLi,XiaolingZhang*,ShutangChen,XiaomiaoHou.SynthesisandCharacterizationofCdSNanoparticlesinthePresenceofOleicAcidasSolventandStabilizer.JournalofPhysicsandChemistryofSolids，2011,72：1195-1198.DOI:10.1016/j.jpcs.2011.05.019

9.BaocunZhu,FangYuan,RongxiaLi,YaminLi,QinWei,ZhenminMa*,BinDu,*andXiaolingZhang*，Ahighlyselectivecolorimetricandratiometricfluorescentchemodosimeterforimagingfluorideioninlivingcells，Chem.Commun.,2011，47:7098-7100.DOI:10.1039/C1CC11308A

10.BaocunZhu,ChenchenGao,YunzhouZhao,CaiyunLiu,YaminLi,QinWei,ZhenminMa,BinDu*andXiaolingZhang*，A4-hydroxynaphthalimide-derivedratiometricfluorescentchemodosimeterforimagingpalladiuminlivingcells，Chem.Commun.,2011，47,8656–8658.DOI:10.1039/C1CC13215F

11.NaLi,XiaoLingZhang*,ShuTangChen,WenYang,ZhiHuiKang,WeiHongTan.One-potSelf-AssemblyofFlower-likeCu2SStructureswithNear-InfraredPhotoluminescentProperties.CrystEngComm.2011,DOI:10.1039/C1CE05603D

12.XiaodanZeng,XiaolingZhang*,BaocunZhu,HongyingJia,WenYang*,YaminLiandJuanXue,AcolorimetricandratiometricfluorescentprobeforquantitativedetectionofGSHatphysiologicallyrelevantlevels，Sensors&Actuators:B.Chemical，2011，DOI:10.1016/j.snb.2011.06.062

13.XiaodanZeng,XiaolingZhang*,BaocunZhu,HongyingJiaandYaminLi,Acolorimetricandratiometricfluorescentprobeforquantificationofbovineserumalbumin，Analyst,2011,136(19),4008-4012DOI:10.1039/C1AN15255F

14.ShutangChen，XiaolingZhang*，XiaomiaoHou，QiZhou,WeihongTan,SynthesisofCdS–Au2S–Auhybriddendriticnanostructures，MaterialsLetters，2010,64(1):489-492

15.ZhangFang,ZhangXiaoling*,OnthefluorescenceofC60atroomtemperature,SCIENCECHINA(Physics,Mechanics&Astronomy),2010,53(1):95-99

16.BaocunZhu,XiaolingZhang,HongyinJia,YaminLi,ShutangChenandSichunZhang，TheDeterminationOfThiolsBasedUsingAProbeThatUtilizesBothAnAbsorptionRed-ShiftAndFluorescenceEnhancement,DyesandPigments,2010，86：87-92.IF=2.855

17.BaocunZhu,XiaolingZhang*,HongyinJia,YaminLi,HaipengLiu，WeihongTan.Title:Ahighlyselectiveratiometricfluorescentprobefor1,4-dithiothreitol(DTT)detection,Organic&BiomolecularChemistry,2010,8（7）,1650-1654.

18.BaocunZhu,HongyinJia,XiaolingZhang*,YanChen,HaipengLiu，WeihongTan.EngineeringaSubcellularTargetable,Red-EmittingandRatiometricFluorescentProbeforCa2+andItsBioimagingApplications，AnalBioanalChem,2010,397:1245–1250

19.ShutangChen，XiaolingZhang*，XiaomiaoHou，QiZhou,WeihongTan,One-potsynthesisofPbSehollowsingle-crystallinenanoboxesbasedongasbubbleassistedOstwaldripening，CrystalGrowth&Design,2010，10（3）,1257–1262

20.ZhiZhu,CuichenWu,HaipengLiu,YuanZou,XiaolingZhang,HuaizhiKang,ChaoyongJamesYang,*andWeihongTan*,AnAptamerCross-LinkedHydrogelasaColorimetricPlatformforVisualDetection,Angew.Chem.Int.Ed.2010,49,1052–1056

21.ShutangChen，XiaolingZhang*，YanbingZhao,QiuhuaZhang,EffectsofReactionTemperatureontheSizeandOpticalPropertiesofCdSeNanocrystals，BulletinofMaterialsScience，2010,33（5）：1–6.

22.ShutangChen，XiaolingZhang*，BinkunChen,QiuhuaZhang,WeihongTan*,，Synthesis,characterizationandphotoluminescenceofCdShyperbranchednanocrystalsbyasimplesolutionchemistrymethods,JournalofNanoscienceandNanotechnology，2010,10（9）：5857-5863.

23.ShutangChen，XiaolingZhang*，QiuhuaZhang,JilinYan,WeihongTan,Synthesis,CharacterizationandOpticalPropertiesofCdSnanorodsbyaSimpleSolutionChemistryMethod,MaterialsScienceandEngineeringB,2010,166,158-162

24.陈书堂，张小玲*，侯晓淼，周琦，CdS纳米棒的制备、表征及其形成机理，物理化学学报，2010,26(02):511-514

25.ZhiZhu,RonghuaYang,MingxuYou,XiaolingZhang,YanrongWuandWeihongTan*，Single-WalledCarbonNanotubeasanEffectiveQuencher,AnalyticalandBioanalyticalChemistry，2010，396:73–83

26.LiliChen,WeiweiTan,JingboZhang,XiaowenZhou,XiaolingZhang∗,YuanLinb∗，FabricationofhighperformancePtcounterelectrodesonconductiveplasticsubstrateforflexibledye-sensitizedsolarcells,ElectrochimicaActa,2010,55(11):3721–3726

27.LiLiChen,JiaLiu,JingBoZhang,XiaoWenZhou,XiaoLingZhang*,YuanLin*,LowtemperaturefabricationofflexiblecarboncounterelectrodeonITO-PENfordye-sensitizedsolarcells,ChineseChemicalLetters,2010,21(9):1137-1140.

28.XiaomiaoHou,XiaolingZhang*,YanFang,ShutangChen,QiZhou,Surface-enhancedRamanscatteringofC60onco-modifiedsubstrateofFe3O4andAunanoparticles,ChemicalPhysics,2010,372:1-5.doi：10.1016/j.chemphys.2010.04.036，封面文章

29.XiaomiaoHou,XiaolingZhang*,YanFang,ShutangChen,NaLi,QiZhou,1-HexadecylamineasbothReducingAgentandStabilizertoSynthesizeAu,AgNanoparticlesandTheirSERSApplication,JournalofNanoparticleResearch，2010,13(5):1929-1936,DOI:10.1007/s11051-010-9945-y.

30.XiaomiaoHou,XiaolingZhang*,YanFang,ShutangChen,NaLi,QiZhou,SynthesisofSERSActiveAuNanowiresinDifferentNoncoordinatingSolvents,JournalofNanoparticleResearch.2010，13(6):2625-2632,DOI:10.1007/s11051-010-0155-4

31.BaocunZhu,XiaolingZhang*,YaminLi,PengfeiWang,*HongyanZhang,andXiaoqingZhuang,Acolorimetricandratiometricfluorescentprobeforthiolsanditsbioimagingapplications,Chem.Commun.,2010,46,5710-5712.

32.ZHENGHaiRong1*,XULiangMin1,ZHANGZhengLong1,DONGJun1,CHENShuTang2&ZHANGXiaoLing2*,FluorescenceenhancementofacridineorangeinawatersolutionbyAunanoparticles.SCIENCECHINAPhysics,Mechanics&Astronomy,2010,53(10):1799–1804,doi:10.1007/s11433-010-4103-1

33.YaminLi,XiaolingZhang*,BaocunZhu,JilinYAN,andWeipingXU,AHighlySelectiveColorimetricand“off-on-off”FluorescentProbeforFluorideIon,AnalyticalSciences,2010,26,1077-1080.

34.FangZhangandXiaolingZhang*,Solvent-inducedOpticalPropertiesofC60,JournalofLuminescence,2010,130,787-791.

35.HuaizhiKang,HaipengLiu,XiaolingZhang*,JilinYan,ZhiZhu,LuPeng,HuanghaoYang,YoungmiKimandWeihongTan*,PhotoresponsiveDNA-CrosslinkedHydrogelsforControllableReleaseandCancerTherapy,Langmuir,2010,27,399-408.DOI:10.1021/la1037553((ThisworkhasbeenhighlightedbyNATURE,2011,470:9,3FEBRUARY,2011)

36.ShutangChen,XiaolingZhang*,YanbingZhao,JilinYanandWeihongTan.PreparationandCharacterizationofCdSeNanoparticlesinthePresenceofTriocytlphosphineasSolventandCappingAgent.MaterialsLetters，2009,63(8):712-714

37.Liu,Weimin;Xu,Liwei;Zhang,Hongyan;You,Juanjuan;Zhang,Xiaoling*;Sheng,Ruilong;Li,Huaping;Wu,Shikang;Wang,Pengfei.DithiolanelinkedthiorhodaminedimerforHg2+recognitioninlivingcells.Organic&BiomolecularChemistry,2009,7(4),660-664.

38.Yu-FenHuang,DihuaShangguan,HaipengLiu,JosephA.Phillips,XiaolingZhang,YanChen,andWeihongTan.Molecularassemblyofanaptamer-drugconjugatefortargeteddrugdeliverytotumorcells.ChemBioChem，2009,10（5）,862-868.

39.ShutangChen,XiaolingZhang*,QiuhuaZhang,WeihongTan*，TrioctylphosphineasbothsolventandstabilizertosynthesizeCdSnanorods，NanoscaleResearchLetters，2009，4:1159–1165。

40.张芳，张小玲*，C60室温荧光发射现象研究，中国科学（G辑），2009，39（12）：1710-1715

41.XiaolingZhang,HaipengLiu,WeihongTan.DNA-CrosslinkedHydrogelsforStimuli-ReactiveandTargetedDrugDelivery.60thPittsburghConferenceonanalyticalchemistryandappliedspectroscopy,2009，March8-13.Chicago,IL,USA.

42.XianwuZou,TefuQin,LuohuaHuang,XiaolingZhang,ZhiYang,andYongWang，MechanismsandMainRegularitiesofBiomassLiquefactionwithAlcoholicSolvents，EnergyFuels，2009,23,5213–5218