郭淑元 副教授 

1、姓名：郭淑元  学位：博士   职称：副教授

2、联系方式

地址：北京理工大学生命学院
邮编：100081
电话：68914495-803
传真：(010)-68915956
电子邮件：guosy @bit.edu.cn

3、个人简历

1988年9月－1995年7月，东北农业大学生物工程系获学士和硕士学位；
1995年7月－2001年8月，哈尔滨医科大学基础医学学院微生物学教研室教师；
2001年9月－2004年7月，清华大学生物科学与技术系，获博士学位；
2004年7月至今为北京理工大学生命学院教师，生物化学与分子生物学课群组组长；
2008年6-12月，法国农业科学院，客作研究；
2010年9-11月，法国农业科学院，访问学者。

4、研究领域/方向

研究方向为生物活性蛋白的结构与功能。
主要从事苏云金芽胞杆菌杀虫蛋白的结构功能以及杀虫活性机理研究。
参加国家科技部的973、863等相关项目，并主持国家自然基金面上项目一项。

5、招生专业

生物学专业硕士生

6、代表性文章：

1. Wenhui Yang, Kanglai He, Jie Zhang, Shuyuan Guo*，(2012) pH-Controlled Bacillus thuringiensis Cry1Ac Protoxin Loading and Release from Polyelectrolyte Microcapsules，PLOS ONE, 7(9), e45233.
2. Shuyuan Guo, Sheng Ye, Yanfeng Liu, Lei Wei, Jing Xue, Hongfu Wu, Fuping Song, Jie Zhang, Xiaoai Wu, Dafang Huang, Zihe Rao. (2009) Crystal Structure of Bacillus thuringiensis Cry8Ea1: An Insecticidal Toxin Toxic to Underground Pests, the Larvae of Holotrichia parallela, Journal of Structure Biology, 168: 259-266.
3. Xiaoai Wu, Sheng Ye, Shuyuan Guo, Wupeng Yan, Mark Bartlam, Zihe Rao. (2010) Structural basis for a reciprocating mechanism of negative cooperativity in dimeric phosphagen kinase activity. Federation of American Societies for Experimental Biology Journal (FASEB J.) 24(1): 242-252.
4. Guo, S. Y., Li, J., Liu, Y. F., Song, F. P., Zhang, J. (2011) The role of DNA binding with the Cry8Ea1 toxin of Bacillus thuringiensis. FEMS Microbiology Letters, 317: 203-210.
5. Guo, S. Y., Zhang, C. L., Lin, X. Y., Zhang, Y. R., He, K. L., Song, F. P., Zhang, J. (2011) Purification of an active fragment of Cry1Ie toxin from Bacillus thuringiensis, Protein Expression & Purification, 78: 204-208.
6. Guo Shu-Yuan, Wang Zheng, Ni Shao-Wei, Wang Xi-Cheng. (2003) Consequences of a six residual deletion from the N-terminal of rabbit muscle creatine kinase, Biochimie, 29 (10): 999-1005.
7. Guo Shu-Yuan,, Guo Zhi, Guo Qin, Chen Bao-Yu, Wang Xi-Cheng. (2003) Expression, purification and characterization of arginine kinase from the sea cucumber Stichopus japonicus, Protein Express. Purif. 29: 230-234.
8. Shuyuan Guo, Yancai Zhang, Fuping Song, Jie Zhang, Dafang Huang. (2009) Protease-resistant core form of Bacillus thuringiensis Cry1Ie: monomer and oligomer formed in solution. Biotechnology Letter, 31: 1769-1774.
9. Huicong Shen, Chunlu Zhang, Shuyuan Guo＊, Jie Zhang, Fuping Song. (2009) Effect of N-terminal and C-terminal Deletion of Cry1Ie of Bacillus thuringiensis on its Expression and Purification，3rd International Conference on Bioinformatics and Biomedical Engineering (ICBBE), ＊通讯作者. (EI)
10. Guo Shu-Yuan, Guo Zhi, Chen Bao-Yu, Guo Qin, Ni Shao-Wei, Wang Xi-Cheng. (2003) Urea induced inactivation and unfolding of arginine kinase from the sea cucumber stichopus japonicus. Biochemistry (Moscow), 68 (11): 1575-1580.
11. Zheng Yan-Bin, Guo Shu-Yuan, Guo Zhi, Wang Xi-Cheng. (2003) Effects of N-terminal Deletion Mutations on Rabbit Muscle Lactate Dehydrogenase. Biochemistry (Moscow), 69 (4): 401-406.
12. Guo Qin, Zhao Feng, Guo Shu-yuan, Wang Xi-Cheng. (2004) The tryptophan residues of dimeric arginine kinase: Roles of Trp-208 and Trp-218 in active site and conformation stability. Biochimie, 86：379-386.