Individual Resume I am an associate professor at theNational Center for Mathematics and Interdisciplinary Sciencesand theKey Laboratory of Systems and Controlof theAcademy of Mathematics and Systems Science,Chinese Academy of Sciences.Between 2009 and 2012, I was a postdoctoral researcher at Prof.Fengzhu Sun's lab atUniversity of Southern California.I obtained my PhD inProbability and Mathmetical StatisticsfromPeking Universityin 2009, under the supervision of Prof.Minping Qianand Prof.Minghua Deng. I obtained my BS inPhysicsfromNanjing Universityin 2003.My current research focuses on:


1. Computational Biology and Systems Biology
2. Data Science
3. Stochastic Systems
4. System Identification


Education

·Peking University
Ph.D. inProbability and Mathematical Statistics(2009)


·Nanjing University
B.Sc. inPhysics(2003)
Research Experience·Academy of Mathematics and Systems Science
Associate Professor (2014.3-)
Assistant Professor (2011.8-2014.2)


·Mathematical Biosciences Institute,The Ohio State University

Visiting Professor (2016.9-2016.12)


·Center of Excellence in Genomic Science,Molecular and Computational Biology Program,
University of Southern California
Postdoctoral Research Associate (2009-2012)

·Key Laboratory of Systems and Control,Institute of Systmes Science,Academy ofMathematics
and Systems Science
Postdoctoral Research Fellow (2009-2011)


·Department of Epidemiology,Michigan State University
Visiting Research Assistant (2007.2-2007.6)


·Center for Quantitative Biology,Peking University
Research Assistant (2003-2009)
Grants ·Modeling, Computation, and Synthesis of Biological/Biomedical Spatial-Temporal Data National Natural Science Foundation of China (No. **), PI, 2016-2019


·The Mathematical Models and Methods of Gene Regulatory Networks for Next Generation
Sequencing Data
National Natural Science Foundation of China (No. **), PI, 2013-2015

·Complex Disease Gene Regulatory Network Analysis
China Postdoctoral Science Foundation (No. ), PI, 2010-2011
Honors and Awards·Early Career Award (2016)
Mathematical Biosciences Institute (MBI)


·Member of the Youth Innovation Promotion Association (2016)
Chinese Academy of Sciences


·Guan Zhao-Zhi Young Scholar Award (2014)
Institute of Systems Science, Chinese Academy of Sciences


·Exemplary Teaching Award (2014)

Academy of Mathematics and Systems Science, Chinese Academy of Sciences


·Best Poster Award (2008)

The Third National Conference on Bioinformatics and System Biology of China


·Award for Science and Technology Progress in Chinese Medical Sciences (2007)

China Academy of Chinese Medical Sciences


·People's Scholarship (2001)

Nanjing University
Courses·Probability and Statistics (B13004Y)
University of Chinese Academy of Sciences (2016 Spring)
(Teaching Assistant)


·System Estimation (210036H)
University of Chinese Academy of Sciences (2015 Spring)


·System Estimation (213030H)

University of Chinese Academy of Sciences (2013 Winter - 2014 Spring)


Short Courses



·Introduction to Computational and System Biology
National Summer School of Modern Mathematical Biology
Fudan University (2015 Summer)


·Introduction to Computational and System Biology

National Summer School of Modern Mathematical Biology
Fudan University (2014 Summer)


·System Biology
National Summer School of Complex Systems
Institute of Systems Science, Chinese Academy of Sciences (2013 Summer)

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Research Computational Biology and Systems Biology

Data Science

Stochastic Systems

System Identification

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Academic Paper Open Access Individual differences in schizophrenia Rolls ET, Lu W, Wan L, Yan H, Wang C, Yang F, Tan Y, Li L, Chinese Schizophrenia Collaboration Group, Yu H, Liddle PF, Palaniyappan L, Zhang D, Yue W and Feng J (2017) British Journal of Psychiatry Open, 3(6):265-273; doi: 10.1192/bjpo.bp.117.005058.

Estimating Phred scores of Illumina base calls by logistic regression and sparse modeling Zhang S, Wang B, Wan L and Li LM (2017) BMC Bioinformatics, 18:335; doi: 10.1186/s12859-017-1743-4.

An adaptive decorrelation method removes Illumina DNA base-calling errors caused by crosstalk between adjacent clusters Wang B, Wan L, Wang AQ and Li LM (2017) Scientific Reports, 7:41348; doi: 10.1038/srep41348.

Functional connectivity decreases in autism in emotion, self, and face circuits identified by Knowledge-based Enrichment Analysis Cheng W, Rolls ET, Zhang J, Sheng W, Ma L, Wan L, Luo Q and Feng J (2017) NeuroImage, 148:169-178; doi: 10.1016/j.neuroimage.2016.12.068.

Achieving Accurate and Fast Base-calling by a Block Model of the Illumina Sequencing Datas Wang B, Wan L and Li LM (2015) IFAC-PapersOnLine, 48(28):1462-1465; doi: 10.1016/j.ifacol.2015.12.339.

Tracking the Evolving Spatial-Temporal Gene Networks Gong WK and Wan L (2015) IFAC-PapersOnLine, 48(28):1365-1368; doi: 10.1016/j.ifacol.2015.12.322.

Modeling RNA degradation for RNA-Seq with applications Wan L,Yan XT, Chen T and and Sun FZ (2012) Biostatistics, 13(4):734-747; doi: 10.1093/biostatistics/kxs001.

CEDER: Accurate detection of differentially expressed genes by combining significance of exons using RNA-Seq Wan L and Sun FZ (2012) IEEE/ACM Transactions on Computational Biology and Bioinformatics, 9(5): 1281-1292; doi: 10.1109/TCBB.2012.83.

Hybridization and amplification rate correction for affymetrix SNP arrays Wang Q, Peng PC, Qian MP, Wan L* and Deng MH* (2012) BMC Medical Genomics, 5:24; doi: 10.1186/1755-8794-5-24. (*Corresponding author)

A study of biases of DNA copy number estimation based on PICR model Wang Q, Qu JH, Cheng XX, Kang YJ, Wan L, Qian MP, and Deng MH (2011) Frontiers of Mathematics in China, 6(6) 1203-1216; doi: 10.1007/s11464-011-0125-x.

RseqFlow: Workflows for RNA-Seq data analysis Wang Y, Mehta G, Mayani R, Lu J, Souaiaia T, Chen Y, Clark A, Yoon HJ, Wan L, Evgrafov OV, Knowles JA, Deelman E,and Chen T (2011) Bioinformatics, 27(18): 2598-2600; doi: 10.1093/bioinformatics/btr441.

New powerful statistics for alignment-free sequence comparison under a pattern transfer model Liu XM*, Wan L* Li J, Reinert G, Waterman MS, and Sun FZ (2011) Journal of Theoretical Biology, 284(1): 106-116; doi: 10.1016/j.jtbi.2011.06.020. (*Co-first author)

Alignment-free sequence comparison (II): Theoretical power of comparison statistics Wan L, Reinert G, Sun FZ, and Waterman MS (2010) Journal of Computational Biology, 17(11): 1467-1490; doi: 10.1089/cmb.2010.0056.

The biases of copy numbers from Affymetrix SNP arrays and their corrections Wan L, Xiao Y, Deng MH and Qian MP (2010) Communications in Information and Systems, 10(2):83-98.

Hybridization modeling of oligonucleotide SNP arrays for accurate DNA copy number estimation Wan L, Sun KL, Ding Q, Cui YH, Li M, Wen YL, Elston R, Qian MP and Fu WJ (2009) Nucleic Acids Research, 37(17):e117; doi: 10.1093/nar/gkp559.

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联系方式 +86-10-8254-1620
Academy of Mathematics and Systems Science Chinese Academy of Sciences No 55, Zhongguancun East Road Haidian District, Beijing 100190, China
lwan@amss.ac.cn

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