阮　科，1999 和2002年分别获北京大学化学与分子工程学院本科和硕士学位。2002年起就读于约翰霍普金斯大学，研究核磁残留偶极耦合的理论与应用，2008年获化学博士学位。2008-2010进入辉瑞（美国）的研发部门，研究全自动高精确高通量核磁药物结构解析以及细胞内药物片段筛选与设计。2010年初任英国Beatson癌症研究所资深研究员。2011年1月作为“海外人才引进”受聘于中国科学技术大学生命科学学院任职副教授，在J. Am. Chem. Soc., Chemical Reviews, Analytical Chemistry, J. Biom. NMR等期刊发表论文近20篇，并多次在实验核磁年会(ENC)等国际会议作会议报告。

主要研究兴趣：
1）基于片段的活性小分子的筛选优化与抗肿瘤增殖/迁移的功能研究；
2）现代核磁技术例如残留偶极耦合、顺磁标记、CEST等在超大分子复合物，例如核小体及其调控蛋白中的应用。

代表性论文：
1. Ruan, K.; Tolman, J. R. Composite Alignment Media for the Measurement of Independent Sets of NMR Residual Dipolar Couplings. J. Am. Chem.Soc.2005, 127:15032-15033.
2. Gebel, E. B.; Ruan, K.; Tolman, J. R.; Shortle, D. Multiple Alignment Tensors from a Denatured Protein. J. Am. Chem. Soc.2006, 128:9310-9311.
3. Tolman, J. R.; Ruan, K. NMR Residual Dipolar Couplings as Probes of Biomolecular Dynamics. Chemical Reviews2006, 106:1720-1736.
4. Ruan, K.; Wang B.-H., Xiao J.-X., et al. Interfacial tension of aqueous three-phase systems formed by triton X-100/PEG/dextran. J. Disp. Sci. & Tech. 2006, 27:927-930.
5. Ruan, K.; Briggman, K. B.; Tolman,J. R. De novo determination of internuclear vector orientations from residual dipolar couplings measured in three independent alignment media.Journal of BiomoleculearNMR2008, 41:61-76.
6. Ruan, K.; Yang, S.; Van Sant K. A.; Likos, J. J. “Application of Hadamard Spectroscopy to Automated Combined Verification in High-throughput NMR”.Magnetic Resonance in Chemistry2009, 47:693-700.
7. Norcross,J. A.; Milling C. T.; Olson, D. L.; Xu, D.; Audrieth, A.; Albrecht, R.; Ruan, K.; Likos, J.; Jones, C.; Peck, T. L.; “Multiplexed NMR: An Automated CapNMR Dual-Sample Probe”.Analytical Chemistry2010, 82:7227–7236.
8. He, C; Pillai, S; Taglini, F; Li, FD; Ruan, K; Zhang, JH; Wu, JH; *Shi, YY; Bayne, EH. “Structural analysis of Stc1 provides insights into the coupling of RNAi and chromatin modification”, PNAS, 2013, 110: 1879-1888.
9. Dai, YN; Chi, CB; Zhou, K; Cheng, W; Jiang, YL; Ren, YM; Ruan, K; Chen, YX; *Zhou, CZ. “Structure and catalytic mechanism of yeast 4-amino-4-deoxychorismate lyase”, Journal of Biological Chemistry, 288, 22985-22992, 2013.
10. Gao, J; Ma, RS; Wang, W; Wang, N; Sasaki, R; Snyderman, D; Wu, JH; Ruan, K^*. “Automated NMR Fragment Based Screening Identified a Novel Interface Blocker to the LARG/RhoA Complex”, Plos One, 2014, 9:88098.
11. Liu, ZH; Li, FD; Ruan, K; Zhang, JH; Mei, YD; Wu, JH^*; Shi, YY^*. “Structural and Functional Insights into the Human Borjeson-Forssman-Lehmann Syndrome- associated Protein PHF6”, Journal of Biological Chemistry, 2014, 289:10069-10083.
12. Ma, RS; Li, QF; Wang, AD; Zhang, JH; Liu, ZJ; Wu, JH; Su, XC^*; Ruan, K^*; “Determination of pseudocontact shifts of low-populated excited states by NMR chemical exchange saturation transfer”, Physical Chemistry Physical Chemistry, 2016, 18:13794-13798.
13. Ma, RS; Wang, PC; Wu, JH; Ruan, K^*. “Process of Fragment-Based Lead Discovery—A Perspective from NMR”, Molecules,2016, 21:854 [Review].
14. Wei, QT; Chen, JJ; Mi, J; Zhang, JH; Ruan, K^*; Wu, JH^*; “NMR Backbone Assignment of Large Proteins by Using ¹³Cα -Only Triple-Resonance Experiments”, Chemistry-A European Journal, 2016, 22:9556-9564.
15. Wang, N; Li, FD; Bao, HY; Li, J; Wu, JH^*; Ruan, K^*. “NMR Fragment Screening Hit Induces Plasticity of BRD7/9 Bromodomains”, ChemBioChem, 2016, 17:1456-1463.
16. Liu, JY; Li, FD; Bao, HY; Jiang, YY; Zhang, SY; Ma, RS; Gao, J; Wu, JH; Ruan, K^*. “The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water‐mediated interaction network”, FEBS Journal, 2017, 284:1082-1095.
17. Liu, JY; Gao, J; Li, FD; Ma, RS; Wei, QT; Wang, AD; Wu, JH; Ruan, K^*. “NMR characterization of weak interactions between RhoGDI2 and fragment screening hits”, BBA-General Subjects, 2017, 1861:3061-3070.
18. Xu, L; Cheng, AM; Huang, M; Zhang, JH; Jiang, YY; Wang, CY; Li, FD; Bao, HY; Gao, J; Wang, N; Liu, JY; Wu, JH; Wong, CCL; Ruan, K^*.“Structural insight into the recognition of acetylated histone H3K56ac mediated by the bromodomain of CREB-binding protein”, FEBS Journal, 2017, 284:3422-3436.
19. Cheng, XX; Liu, JY; Zhang, H; Li, FD; Zhang, SY; Xu, M; Ruan, K^*; Wang, YH^*; Fu, AG^*. “Crystal structure of Psb27 from Arabidopsis thaliana determined at a resolution of 1.85 ?”, Photosynth. Res.2017, doi: 10.1007/s11120-017-0450-3.
20. Bao, XL; Liu, H; Liu, X; Ruan, K; Zhang, YH; Zhang, ZY; Hu, Q; Liu, Y; Akram, S; Zhang, JH; Gong, QG; Wang, WW; Yuan, X; Li, J; Zhao, LL; Dou, Z; Tian, RJ; Yao, XB^*; Wu, JH^*; Shi, YY^*. “Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation”, J. Mol. Cell Biol.2017, doi: 10.1093/jmcb/mjx045.
21. Gao, J; Liang, E; Ma, RS; Li, FD; Liu, YX; Liu, JY; Jiang, L;, Li, CG; Dai, HM; Wu, JH; Su, XC; He, W; Ruan, K^*. “Fluorine Pseudocontact Shifts Used for Characterizing the Protein-Ligand Interaction Mode in the Limit of NMR Intermediate Exchange”, Angew. Chem. Int. Ed.2017, 56:12982-12986.
联系方式：kruan@ustc.edu.cn
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