孙宝林 导师介绍
姓名
孙宝林



工作单位
中国科学技术大学先进技术研究院/中国科学技术大学生命科学学院

学位/职称
博士/教授

办公室电话


Email
sunb@ustc.edu.cn

教育背景
美国Michigan State University微生物学博士

研究方向
细菌病原体的耐药与致病性发生的分子机制研究

任职经历
2004年至今，中国科学技术大大学生命科学学院，教授。

获得荣誉、奖项
1.王宽诚育才奖（一等奖）（2008）
2.研究生导师招生先锋奖（2011）

主持、参与项目
1.结核病靶标研究（2008年科技部重大传染病防治专项）
2.金黄色葡萄球菌临床菌株III-A CRISPR-Cas 系统的功能与机制研究（2017年面上项目）
3.金黄色葡萄球菌群体感应信号分子AI-2的受体鉴定及调控致病性的分子机制（2019年面上项目）
4.金黄色葡萄球菌耐药发生的分子机制研究（2019中科院先导专项）

论文、著作
1.Jiang Q, Jin Z, Sun B (2018). MgrA negatively regulates biofilm formation and detachment by repressing the expression of psmoperons in Staphylococcus aureus. Appl Environ Microbiol 84:e01008-18.
2.Wen W, Liu B, Xue L, Zhu Z, Niu L, Sun B (2018). Autoregulation and virulence control by the toxin-antitoxin system SavRS in Staphylococcus aureus. Infect Immun 86:e00032-18.
3.Guan J, Wang W, Sun B (2017). Chromosomal targeting by the type III-A CRISPR-Cas system can reshape genomes in Staphylococcus aureus. mSphere 2:e00403-17.
4.Zhao C, Shu X, Sun B (2017). Construction of a gene knockdown system based on catalytically inactive ("dead") Cas9 (dCas9) in Staphylococcus aureus. Appl Environ Microbiol 83:e00291-17.
5.Liu X, Zhang S, Sun B (2016). SpoVG regulates cell wall metabolism and oxacillin resistance in methicillin-resistant Staphylococcus aureusstrain N315. Antimicrob Agents Chemother 60:3455–3461.
6.Zhang S, Ma R, Liu X, Zhang X, Sun B (2015). Modulation of ccrABexpression and SCCmecexcision by an inverted repeat element and SarS in methicillin-resistant Staphylococcus aureus.Antimicrob Agents Chemother 59:6223-6232.
7.Chen C, Zhang X, Shang F, Sun H, Sun B, Xue T (2015). The Staphylococcus aureusprotein-coding gene gdpSmodulates sarSexpression via mRNA-mRNA interaction. Infect Immun 83:3302-3310.
8.Hu J, Zhang X, Liu X, Chen C, Sun B (2015). Mechanism of reduced vancomycin susceptibility conferred by walKmutation in community-acquired methicillin-resistant Staphylococcus aureusstrain MW2. Antimicrob Agents Chemother 59:1352-1355.
9.Xue T, You Y, Hong D, Sun H, Sun B (2011). The Staphylococcus aureusKdpDE two-component system couples extracellular K+sensing and Agr signaling to infection programming. Infect Immun 79:2154-2167.
10.Zhao L, Xue T, Shang F, Sun H, Sun B (2010). Staphylococcus aureusAI-2 quorum sensing associates with the KdpDE two-component system to regulate capsular polysaccharide synthesis and virulence. Infect Immun 78:3506-3515.
11.Tao L, Wu X, Sun B (2010). Alternative sigma factor σHmodulates prophage integration and excision in Staphylococcus aureus. PLoS Pathog 6:e**.
12.Shang F, Xue T, Sun H, Xing L, Zhang S, Yang Z, Zhang L, Sun B (2009). The Staphylococcus aureusGGDEF domain-containing protein, GdpS, influences protein A gene expression in a cyclic diguanylic acid-independent manner. Infect Immun 77:2849-2856.