孙明斋 特任研究员 博士生导师
办公电话：
邮箱：mingzhai@ustc.edu.cn
主页：http://www.mbit.ustc.edu.cn


个人简介：
研究方向：
研发新型超/多光谱眼底成像系统，发展功能性眼底成像，开发糖尿病视网膜病变的早期诊断及预防手段；
眼底多模态成像系统，发展利用血氧饱和度、血流速度等功能性指标研究脑部微血管疾病（比如阿尔茨海默病、缺血性脑卒中等）的早期辅助诊断；
基于人工智能的辅助诊断系统，尤其是糖尿病、高血压等慢病防控研究；
基于多模态成像技术的皮肤癌检测系统开发；
开发光学超分辨系统，尤其是组织深度成像的超分辨系统。
学习经历：
1996 –2001 中国科学技术大学 学士 （化学物理）
2001 - 2002 中国科学技术大学 硕士 （材料物理）
2002 –2008 University of Missouri 博士 （生物物理）
工作经历：
2003 - 2005University of Missouri 研究生助教
2005 - 2008University of Missouri 助理研究员
2008 - 2012Princeton University 博士后助理研究员
2012 - 2015 Ohio State University 研究科学家，原子力测试中心主任
2016 - 至今 中国科学技术大学 特任研究员
学术任职：
Frontiers in Membrane Physiology and Membrane Biophysics (副主编)
Nature Communication （审稿）
European Biophysics Journal (审稿)
Analytical Chemistry (审稿)
Journal of Biomechanics (审稿)
Journal of Nanomaterials (审稿)
Microscopy Research and Technology (审稿)
PLos One (审稿)
中国物理快报 (审稿)
IEEE ACCESS (审稿)
IEEE Journal of Biomedical and Health Informatics (审稿)
招生信息：
发表文章：
（#：第一作者， *：通讯作者）
1、Ye, Y., Mao J., Liu L., Zhang S., Shen L., & Sun, M.* (2020). Automatic Diagnosis of Familial Exudative Vitreoretinopathy Using a Fusion Neural Network for Wide-Angle Retinal Images. IEEE Access, 8, 162-173.
2、Wang, X., Zhang, S., Liang, X., Zhou, H., Zheng, J., & Sun, M.* (2019). Accurate and Fast Blur Detection Using a Pyramid M-Shaped Deep Neural Network. IEEE Access, 7, 86611–86624.
3、Mao, J., Luo, Y., Chen, K., Lao, J., Chen, L., Shao, Y., Zhang, C., Sun, M.*, & Shen, L.*(2019). New grading criterion for retinal hemorrhages in term newborns based on deep convolutional neural networks. Clinical & Experimental Ophthalmology.
4、Mao, J., Luo, Y., Liu, L., Lao, J., Shao, Y., Zhang, M., Zhang, C., Sun, M.*, &Shen, L.* (2019). Automated diagnosis and quantitative analysis of plus disease in retinopathy of prematurity based on deep convolutional neural networks. Acta Ophthalmologica.
5、Li, Y., Zheng, R., Wu, Y., Chu, K., Xu, Q., Sun, M.*, & Smith, Z. J.* (2019). A low‐cost, automated parasite diagnostic system via a portable, robotic microscope and deep learning. Journal of Biophotonics, e.
6、Wang, X., Zhang, S., Liang, X., Zheng, C., Zheng, J., & Sun, M.* (2019). A CNN-based retinal image quality assessment system for teleophthalmology. Journal of Mechanics in Medicine and Biology, 19(05), **.
7、Chen, H., Liu, G., Zhang, S., Shen, S., Shen,S., Luo, Y., Li, J., Roberts,C.J., Sun,M.*, & Xu,R.X.*(2019). Fundus-simulating phantom for calibration of retinal vessel oximetry devices. Applied Optics, 58(14), 3877-3885.
8、Zhang, S., Zheng, R., Luo, Y., Wang, X., Mao, J., Roberts, C. J., & Sun, M.*(2019). Simultaneous Arteriole and Venule Segmentation of Dual-Modal Fundus Images Using a Multi-Task Cascade Network. IEEE Access, 7, 57561-57573.
9、Liu, L., Luo, Y., Shen, X., Sun, M., & Li, B. (2019). β-dropout: a Unified Dropout. IEEE Access.
10、Zheng, R., Liu, L., Zhang, S., Zheng, C., Bunyak, F., Xu, R., Li,B., & Sun, M.* (2018). Detection of exudates in fundus photographs with imbalanced learning using conditional generative adversarial network. Biomedical optics express, 9(10), 4863-4878.
11、Huang, J., Sun, M., Ma, J., & Chi, Y. (2017). Super-resolution image reconstruction for high-density three-dimensional single-molecule microscopy. IEEE Transactions on Computational Imaging, 3(4), 763-773.
12、Liu, Y., Lee, I. J., Sun, M., Lower, C. A., Runge, K. W., Ma, J., & Wu, J. Q. (2016). Roles of the novel coiled-coil protein Rng10 in septum formation during fission yeast cytokinesis. Molecular Biology of the Cell, 27(16), 2528-2541.
13、Li, H., Duann, P., Lin, P.H., Zhao, L., Fan, Z., Tan, T., Zhou, X., Sun, M., Fu, M., Orange,M.and Sermersheim, M., 2015. Modulation of Wound Healing and Scar Formation by MG53 Protein-mediated Cell Membrane Repair. Journal of Biological Chemistry, 290(40), pp.24592-24603.
14、Thutupalli, S., Sun, M., Bunyak, F., Palaniappan, K. and Shaevitz, J.W., 2015. Directional reversals enable Myxococcus xanthus cells to produce collective one-dimensional streams during fruiting-body formation. Journal of The Royal Society Interface, 12(109), p.**.
15、Huang, J., Gumpper, K., Chi, Y., Sun, M.#,* and Ma, J., 2015. Fast two-dimensional super-resolution image reconstruction algorithm for ultra-high emitter density. Optics Letters, 40(13), pp.2989-2992.
16、Huang, J., Sun, M.#,*, Gumpper, K., Chi, Y., & Ma, J. (2015). 3D multifocus astigmatism and compressed sensing (3D MACS) based superresolution reconstruction. Biomedical optics express, 6(3), 902-917.
17、Levitan, I., Shentu, T.P., Sun, M.and Forgacs, G., 2015. The Role of Cholesterol and Lipoproteins in Control of Endothelial Biomechanics. Mechanobiology of the Endothelium,
p.146.
18、Smith, S. A., Sturm, A. C., Curran, J., Kline, C. F., Little, S. C., Bonilla, I. M., Sun, M.... & Mohler, P. J. (2015). Dysfunction in the βII Spectrin–Dependent Cytoskeleton Underlies Human Arrhythmia. Circulation, 131(8), 695-708.
19、Qiu, J., He, D., Sun, M., Li, S., Wen, C., Hattrick-Simpers, J., ... & Cao, L. (2015). Effects of neutron and gamma radiation on lithium-ion batteries. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 345, 27-32.
20、Lin, P. H., Duann, P., Komazaki, S., Park, K. H., Li, H., Sun, M., ... & Ma, J. (2015). Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling. Journal of Biological Chemistry, 290(6), 3377-3389.
21、Sun, M.#,*, Huang, J., Bunyak, F., Gumpper, K., De, G., Sermersheim, M., ... & Ma, J. (2014). Superresolution microscope image reconstruction by spatiotemporal object decomposition and association: application in resolving t-tubule structure in skeletal muscle. Optics express, 22(10), 12160-12176.
22、Balagam R, Litwin DB, Czerwinski F, Sun M,Kaplan HB, Shaevitz JW, et al. Myxococcus xanthus gliding motors are elastically coupled to the substrate as predicted by the focal adhesion model of gliding motility. Whitworth DE, editor. PLoS Comput Biol. 2014 May;10(5):e**.
23、Deng Y, Sun M,Lin P-H, Ma J, Shaevitz JW. Spatial covariance reconstructive (SCORE) super-resolution fluorescence microscopy. PLoS ONE. 2014;9(4):e94807.
24、Deng Y, Coen P, Sun M,Shaevitz JW. Efficient multiple object tracking using mutually repulsive active membranes. PLoS ONE. 2013;8(6):e65769.
25、Nishi M, Aoyama F, Kisa F, Zhu H, Sun M,Lin P, et al. TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells. J Biol Chem. 2012 Sep 28;287(40):33523–32.
26、Hong Z., Ersoy I., Sun M.,Bunyak F., Hampel P. Jin M., and Palaniappan K. Influence of membrane cholesterol and substrate elasticity on endothelial cell spreading behavior. Journal of Biomedical Materials Research Part A, 2012:00A
27、Levitan, I., Shentu, T. P., Sun, M.,& Forgacs, G. (2015). The Role of Cholesterol and Lipoproteins in Control of Endothelial Biomechanics.Mechanobiology of the Endothelium,
146.(book chapter, )
28、Deng Y, Sun M,Shaevitz JW. Direct measurement of cell wall stress stiffening and turgor pressure in live bacterial cells. Phys Rev Lett. 2011 Oct 7;107(15):158101.
29、Sun M,Wartel M, Cascales E, Shaevitz JW, Mignot T. From the Cover: Motor-driven intracellular transport powers bacterial gliding motility. P Natl Acad Sci USA. 2011 May 3;108(18):7559–64.
30、Ersoy, I., Bunyak, F., Palaniappan, K.,Sun, M.,& Forgacs, G. (2008). Cell spreading analysis with directed edge profile-guided level set active contours. InMedical Image Computing and Computer-Assisted Intervention–MICCAI 2008(pp. 376-383).
31、Sun M,Northup N, Marga F, Huber T, Byfield FJ, Levitan I, et al. The effect of cellular cholesterol on membrane-cytoskeleton adhesion. J Cell Sci. 2007 ed. 2007 Jul 1;120(Pt 13):2223–31.
32、Hosu BG, Sun M,Marga F, Grandbois M, Forgacs G. Eukaryotic membrane tethers revisited using magnetic tweezers. Phys Biol. 2007 Jun;4(2):67–78.
33、Sun M, Graham JS, Hegedus B, Marga F, Zhang Y, Forgacs G, et al. Multiple membrane tethers probed by atomic force microscopy. Biophys J. 2005 ed. 2005 Dec; 89(6):4320–9.
34、Fan, HY. andSun, M.(2002). Bipartite Entangled State and its Applications in Quantum Communication. J. Opt. B-Quantum S O. 4 (3):228-234.
35、Fan, HY. and Sun, M.(2002). Entanglement of the Common Eigenvector of Two Particles Center-of-Mass Coordinate and Mass-Weighted Relative Momentum. Commun. Theor. Phys. 37 (5):535-538.
36、Liang, XT. and Sun, M.(2002). Resonance Fluorescence in Two-Photon JC Models Analyzed by Supersymmetric Transformation. Commun. Theor. Phys. 37 (4):405-408.
37、Fan, HY., Fan, Y., and Sun, M.(2001). Density Matrix and Partition Function for a Generalized Nondegenerate Parametric Amplifier Gained Via aType of Two-Mode Special Squeezed Coherent State Representation. Mod. Phys. Lett B. 15 (11):351-357.
38、Fan, HY. andSun, M.(2001). Angular Velocity and Coriolis Effect In Time-Dependent Quantum Mechanical SU2 Rotation. Chinese Phys. 10 (5):380-383.