方志友
单位：合肥物质科学研究院健康与医学技术研究所
地址：安徽省合肥市蜀山湖路350号
邮编：230031
电话：
个人主页：
实验室介绍：


个人简历 Personal resume


中国科学院合肥物质科学研究院，健康与医学技术研究所副所长，研究员，博士研究生导师。1998年本科毕业于安徽农业大学，2006获中国科学技术大学细胞生物学博士学位。2007-2013年留学美国马萨诸塞州大学医学院。2013年12月入职中科院合肥物质科学院。已在Cancer Res.,Theranostics, Circulation，J Bio Chem., J Pineal Res., J Exp Clin Cancer Res., Mol. Cell Proteomics, Traffic, Front Oncol.,Cancer Lett.,J Cell Sci.,Mol Biol Cell 等国际SCI杂志上发表论文二十多篇。


研究方向 Research direction


1、细胞生物学/细胞运动与转移
2、肿瘤生物学/肿瘤发生、复发
3、肿瘤药物学/肿瘤耐药性



招生信息 Enrollment information


欢迎具有肿瘤学、生物学、医学、生物信息学等相关专业背景的同学报考博士/硕士研究生，加入我们研究团队！联系方式：中国科学院合肥物质科学研究院，健康与医学技术研究所联系地址：安徽合肥蜀山湖路350号，邮编：230031 联系电话：电子邮箱：z.fang@cmpt.ac.cn


论文专著 The monograph


1)Melatonin attenuates hypoxia-induced epithelial-mesenchymal transition and cell aggressive via Smad7/ CCL20 in glioma - Oncotarget - 2017 - 8(55):93580-93592
2)EZH2 palmitoylation mediated by ZDHHC5 in p53 mutant glioma drives malignant development and progression. Cancer Res - Cancer Res. - 2017 - 77(18):4998-5010
3)A novel splice variant of supervillin, SV5, promotes carcinoma cell proliferation and cell migration - Biochem Biophys Res Commun. - 2017 - 482(1):43-49
4)Melatonin inhibits tumorigenicity of glioblastoma stem-like cells via the AKT-EZH2-STAT3 signaling axis - J Pineal Res. - 2016 - 61(2):208~217
5)Supervillin-mediated suppression of p53 protein enhances cell survival - Journal of Biological Chemistry - 2013 - 288 (11):7918~7929
6)The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility - Traffic - 2010 - 11(6) : 782~799
7)Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4 - Molecular & Cellular Proteomics - 2006 - 5(8):1437~1449
8)Preparation and Affinity-Purification of Supervillin Isoform 4 (SV4) Specific Polyclonal Antibodies - Protein J. - 2016 - 35(2):107~114
9)Supervillin couples myosin-dependent contractility to podosomes and enables their turnover - Journal of Cell Science - 2012 - 125(Pt 9): 2300~2314
10)Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress - Circulation - 2012 - 125(22):2762~2771
11)Novel interactors and a role for supervillin in early cytokinesis - Cytoskeleton (Hoboken) - 2010 - 67(6): 346~364
12)Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency - Molecular Biology of the Cell - 2009 - 20(3):948~962