田华雨
单位：中国科学院长春应用化学研究所生态环境高分子材料重点实验室
地址：吉林省长春市人民大街5625号
邮编：130022
电话：
个人主页： http://www.escience.cn/people/thy/index.html
实验室介绍：


个人简历 Personal resume


田华雨，男，研究员，国家****基金获得者。中国科学院长春应用化学研究所生态环境高分子材料重点实验室生物医用高分子课题组工作。曾在韩国KAIST、日本九州大学做客座研究，在美国犹他大学做访问****。目前主要从事高分子基因/药物载体的制备和抗肿瘤应用研究。开发了类细胞膜结构的基因载体、骨架可降解的基因载体、具有诊断治疗功能的基因载体、基因载体的靶向遮蔽体系，进行了高分子基因载体的抗肿瘤治疗研究。在Progress in Polymer Science，Journal of the American Chemical Society, Angewandte Chemie International Edition，Advanced Materials，ACS Nano，Advanced Functional Materials, Nano Letters，Biomaterials，Small等杂志发表SCI论文150余篇。获权中国发明专利25项。2019年获国家****基金资助，2007和2011年获得吉林省科技进步一等奖，入选2014年度中组部“****”青年拔尖人才，所开发的细胞用基因转染试剂实现市场销售。


研究方向 Research direction


1、生物医用高分子
2、纳米基因/药物载体
3、免疫治疗



招生信息 Enrollment information


高分子、化学、生物学、医学、药学背景的硕士生和博士生，同时接受上述领域的博士后申请。


论文专著 The monograph Researcher ID


1)A Tumor-Microenvironment-Activated Nanozyme-Mediated Theranostic Nanoreactor for Imaging-Guided Combined Tumor Therapy - ADVANCED MATERIALS - 2019 - 31, **
2)A GSH-Gated DNA Nanodevice for Tumor-Specific Signal Amplification of microRNA and MR Imaging-Guided Theranostics - SMALL - 2019 - 15, **
3)Two-dimensional nanosheets with high curcumin loading content for multimodal imaging-guided combined chemo-photothermal therapy - BIOMATERIALS - 2019 - 223, 119470
4)Porphyrin-based covalent organic framework nanoparticles for photoacoustic imaging-guided photodynamic and photothermal combination cancer therapy - BIOMATERIALS - 2019 - 223, 119459
5)Positive feedback nanoamplifier responded to tumor microenvironments for self-enhanced tumor imaging and therapy. - Biomaterials - 2019 - 216, 119255.
6)A disassembling strategy overcomes the EPR effect and renal clearance dilemma of the multifunctional theranostic nanoparticles for cancer therapy. - Biomaterials - 2019 - 197, 284-293.
7)Highly enhanced cancer immunotherapy by combining nanovaccine with hyaluronidase - Biomaterials - 2018 - 171: 198-206.
8)A glutathione-depleting chemodynamic therapy agent with photothermal and photoacoustic properties for tumor theranostics - NANOSCALE - 2019 - 12,1349-1355
9)Covalent organic nanosheets integrated heterojunction with two strategies to overcome hypoxic-tumor photodynamic therapy. - Chemistry of Materials - 2019 - 31 (9), 3313-3323.
10)Helix Self-Assembly Behavior of Amino Acid-Modified Camptothecin Prodrugs and Its Antitumor Effect. - ACS applied materials & interfaces - 2019 - 12, 7466-7476
11)A Strategy of Killing Three Birds with One Stone for Cancer Therapy through Regulating the Tumor Microenvironment by H2O2-Responsive Gene Delivery System - ACS applied materials & interfaces - 2019 - 11, 47785-47797
12)Cyanine-Assisted Exfoliation of Covalent Organic Frameworks in Nanocomposites for Highly Efficient Chemo-Photothermal Tumor Therapy - ACS applied materials & interfaces - 2019 - 11, 39503-39512
13)Molecular Strings Significantly Improved the Gene Transfection Efficiency of Polycations - Journal of the American Chemical Society - 2018 - 140 (38), 11992-12000.
14)Multifunctional Theranostic Nanoparticles Derived from Fruit-Extracted Anthocyanins with Dynamic Disassembly and Elimination Abilities - ACS Nano - 2018 - 12,8255-8265
15)BSA‐IrO2: Catalase-Like Nanoparticles with High Photothermal Conversion Efficiency and X‐Ray Absorption Coefficient for Anti-Inflammation and Tumor Theranostics - Angewandte Chemie International Edition - 2018 - 57, 10309-10313
16)Gold Nanorods Electrostatically Binding Nucleic Acid Probe for In Vivo MicroRNA Amplified Detection and Photoacoustic Imaging‐Guided Photothermal Therapy - Advanced Functional Materials - 2018 - 28, **
17)Ultrasensitive pH Triggered Charge/size Dual-Rebound Gene Delivery System. - Nano Lett - 2016 - 2016, 16:6823-6831.
18)pH Triggered Size Increasing Gene Carrier for Efficient Tumor Accumulation and Excellent Antitumor Effect - ACS Appl Mater Inter - 2017 - 9:15297-15306.
19)Gold-Nanorods-Based Gene Carriers with the Capability of Photoacoustic Imaging and Photothermal Therapy - ACS Applied Materials & Interfaces - 2016 - 8
20)Polylysine-modified polyethylenimine (PEI-PLL) mediated VEGF gene delivery protects dopaminergic neurons in cell culture and in rat models of Parkinon's Disease (PD) - ACTA BIOMATERIALIA - 2017 - 54
21)In situ dual-crosslinked nanoparticles for tumor targeting gene delivery. - Acta biomaterialia - 2017 - 10
22)A pH-Responsive Detachable PEG Shielding Strategy for Gene Delivery System in Cancer Therapy - Biomacromolecules - 2017 - 18: 1342-1349.
23)Doxorubicin-loaded PLGA microparticles with internal pores for long-acting release in pulmonary tumor inhalation treatment - CHINESE JOURNAL OF POLYMER SCIENCE - 2015 - 33
24)Polylysine-modified polyethylenimines as siRNA carriers for effective tumor treatment - CHINESE JOURNAL OF POLYMER SCIENCE - 2015 - 33
25)N-Isopropylacrylamide Modified Polyethylenimines as Effective siRNA Carriers for Cancer Therapy - Journal of nanoscience and nanotechnology - 2015 - 16
26)Codelivery of Antitumor Drug and Gene by a pH-Sensitive Charge-Conversion System - ACS APPLIED MATERIALS & INTERFACES - 2015 - 5
27)miRNA oligonucleotide and sponge for miRNA-21 inhibition mediated by PEI-PLL in breast cancer therapy - ACTA BIOMATERIALIA - 2015 - 25
28)miRNA oligonucleotide and sponge for miRNA-21 inhibition mediated by PEI-PLL in breast cancer therapy - ACTA BIOMATERIALIA - 2015 - 25
29)Charge-conversional zwitterionic copolymer as pH-sensitive shielding system for effective tumor treatment - ACTA BIOMATERIALIA - 2015 - 26
30)Guanidinated Thiourea-Decorated Polyethylenimines for Enhanced Membrane Penetration and Efficient siRNA Delivery - ADVANCED HEALTHCARE MATERIALS - 2015 - 9
31)Pulmonary Drugs and Genes Delivery Systems for Lung Disease Treatment - Chinese Journal of Chemistry - 2014 - 32
32)PEGylated poly(aspartate-g-OEI) copolymers for effective and prolonged gene transfection - Journal of Materials Chemistry B - 2014 - 2
33)A pH sensitive co-delivery system of siRNA and doxorubicin for pulmonary administration to B16F10 metastatic lung cancer - RSC ADVANCES - 2015 - 125
34)pH-responsive zwitterionic copolypeptides as charge conversional shielding system for gene carriers - Journal of Controlled Release - 2014 - 174
35)Pulmonary Codelivery of Doxorubicin and siRNA by pH-Sensitive Nanoparticles for Therapy of Metastatic Lung Cancer - small - 2015 - 11
36)Cationic Dendron-Bearing Lipids: Investigating Structure-Activity Relationships for Small Interfering RNA Delivery - Biomacromolecules - 2013 - 14
37)Thermo-/pH-dual responsive properties of hyperbranched polyethylenimine grafted by phenylalanine - Archives of Pharmacal Research - 2014 - 37
38)Polylysine-modified polyethylenimine inducing tumor apoptosis as an efficient gene carrier - Journal of Controlled Release - 2013 - 172
39)Nanoparticles for Gene Delivery - Small - 2013 - 9
40)A pH-sensitive charge-conversion system for doxorubicin delivery - Acta Biomaterialia - 2013 - 9
41)Multi-armed poly(aspartate-g-OEI) copolymers as versatile carriers of pDNA/siRNA - Acta Biomaterialia - 2013 - 9
42)A Serum-Tolerant Hydroxyl-Modified Polyethylenimine as Versatile Carriers of pDNA/siRNA - Macromolecular Bioscience - 2013 - 13
43) Robust and Flexible Free-Standing Films for Unidirectional Drug Delivery - Langmuir - 2013 - 29
44)Effective Tumor Treatment by VEGF siRNA Complexed with Hydrophobic Poly(Amino Acid)-Modified Polyethylenimine - Macromolecular Bioscience - 2013 - 13
45)Biodegradable synthetic polymers: Preparation, functionalization and biomedical application - Progress in Polymer Science - 2012 - 37
46)PEI Conjugated Gold Nanoparticles: Efficient Gene Carriers with Visible Fluorescence - Advanced Healthcare Materials - 2012 - 1
47)N-Isopropylacrylamide-Modified Polyethylenimines as Effective Gene Carriers - Macromolecular Bioscience - 2012 - 12
48)Stimuli-Sensitive Synthetic Polypeptide-Based Materials for Drug and Gene Delivery - Advanced Healthcare Materials - 2012 - 1
49)Hyperbranched PEI Grafted by Hydrophilic Amino Acid Segment Poly N-(2-hydroxyethyl)-L-glutamine as an Efficient Nonviral Gene Carrier - Journal of Applied Polymer Science - 2012 - 123
50)Hydrophobic poly (amino acid) modified PEI mediated delivery of rev-casp-3 for cancer therapy - Biomaterials - 2012 - 33
51)Hydrophobic Polyphenylalanine-Grafted Hyperbranched Polyethylenimine and its in vitro Gene Transfection - Macromolecular Bioscience - 2011 - 11
52)Oligoethylenimines Grafted to PEGylated Poly(beta-amino ester)s for Gene Delivery - Biomacromolecules - 2011 - 12
53)Chemo-Physical and Biological Evaluation of Poly( L-lysine)-Grafted Chitosan Copolymers Used for Highly Efficient Gene Delivery - Macromolecular Bioscience - 2011 - 11
54)Synthesis of oligoethylenimine grafted net-poly(amino ester) and their application in gene delivery - Journal of Controlled Release - 2011 - 152
55)A. RGD targeting hyaluronic acid coating system for PEI-PBLG polycation gene carriers - Journal of Controlled Release - 2011 - 155
56)Biodegradable mPEG-b-P(MCC-g-OEI) copolymers for efficient gene delivery - Journal of Controlled Release - 2011 - 152
57)Biodegradable mPEG-b-P(MCC-g-OEI) copolymers for efficient gene delivery - Journal of Controlled Release - 2011 - 152
58)Park T G. Preparation of novel biodegradable ternary copolymers mPEG-b-P(MCC-g-OEI) and their gene delivery - Journal of Controlled Release - 2011 - 152
59)SYNTHESIS AND CHARACTERIZATION OF GENIPIN CROSS-LINKED OLIGOETHYLENIMINE FOR GENE DELIVERY - Acta Polymerica Sinica - 2011 -
60)In vitro and in vivo gene delivery using polyethylenimine-poly (hydroxyethyl glutamine) as a non-viral carrier - Journal of Controlled Release - 2011 - 152
61)Synthesis and characterization of a pH-sensitive shielding system for polycation gene carriers - Science China-Chemistry - 2010 - 53
62)Synthesis and Characterization of the Hexachlorotriphosphaxene Cross-linked Oligo(ethyleneimine) as Gene Carrier - Chemical Journal of Chinese Universities-Chinese - 2010 - 31
63)Hydrophobic Polyphenylalanine-Grafted Hyperbranched Polyethylenimine and its in vitro Gene Transfection - Macromolecular Bioscience - 2011 - 11
64)Bioreducible crosslinked low molecular weight branched PEI-PBLG as an efficient gene carrier - Science China-Chemistry - 2010 - 53
65)Multi-armed poly(L-glutamic acid)-graft-oligoethylenimine copolymers as efficient nonviral gene delivery vectors - Journal of Gene Medicine - 2010 - 12
66)Multi-armed poly(L-glutamic acid)-graft-oligoethylenimine copolymers as efficient nonviral gene delivery vectors - Journal of Gene Medicine - 2010 - 12
67)PROGRESS IN THE DEVELOPMENT OF BIOMEDICAL POLYMER MATERIALS FABRICATED BY 3-DIMENSIONAL PRINTING TECHNOLOGY - Acta Polymerica Sinica - 2013 -
68)Synergistic treatment of cancer stem cells by combinations of antioncogenes and doxorubicin - JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY - 2015 - 30
69)Maruyama A. RGD targeting hyaluronic acid coating system for PEI-PBLG polycation gene carriers - Journal of Controlled Release - 2011 - 55
70)Biodegradable mPEG-b-P(MCC-g-OEI) copolymers for efficient gene delivery - Journal of Controlled Release - 2011 - 154
71)SYNTHESIS AND CHARACTERIZATION OF GENIPIN CROSS-LINKED OLIGOETHYLENIMINE FOR GENE DELIVERY - Acta Polymerica Sinica - 2011 - 10
72)SYNTHESIS AND CHARACTERIZATION OF GENIPIN CROSS-LINKED OLIGOETHYLENIMINE FOR GENE DELIVERY - Acta Polymerica Sinica - 2011 - 10
73)SYNTHESIS AND CHARACTERIZATION OF GENIPIN CROSS-LINKED OLIGOETHYLENIMINE FOR GENE DELIVERY - Acta Polymerica Sinica - 2011 - 10
74)Preparation of novel biodegradable ternary copolymers mPEG-b-P(MCC-g-OEI) and their gene delivery - Journal of Controlled Release - 2011 - 52
75)In vitro and in vivo gene delivery using polyethylenimine-poly (hydroxyethyl glutamine) as a non-viral carrier - Journal of Controlled Release - 2011 - 52
76)Synthesis and characterization of a pH-sensitive shielding system for polycation gene carriers - Science China-Chemistry - 2010 - 53
77)Bioreducible crosslinked low molecular weight branched PEI-PBLG as an efficient gene carrier - Science China-Chemistry - 2010 - 52
78)Synthesis and Characterization of the Hexachlorotriphosphaxene Cross-linked Oligo(ethyleneimine) as Gene Carrier - Chemical Journal of Chinese Universities-Chinese - 2010 - 31
79)Multi-armed poly(L-glutamic acid)-graft-oligoethylenimine copolymers as efficient nonviral gene delivery vectors - Journal of Gene Medicine - 2010 - 12
80)Recent developments in intelligent biomedical polymers - Science in China Series B-Chemistry - 2009 - 52
81)Poly(alpha,L-glutamic acid) Microspheres for Oral Insulin Delivery - Chemical Journal of Chinese Universities-Chinese - 2009 - 30
82)Prostate cancer cell-specific VEGF siRNA delivery system using cell targeting peptide conjugated polyplexes - Journal of Drug Targeting - 2009 - 17
83)Insulin nanoparticle preparation and encapsulation into poly(lactic-co-glycolic acid) microspheres by using an anhydrous system - International Journal of Pharmaceutics - 2009 - 378
84)SYNTHESIS AND CHARACTERIZATION OF A CROSSLINKING POLYETHYLENIMINE AS SMART GENE CARRIER AND EFFECTS OF PEGYLATION DEGREE - Acta Polymerica Sinica - 2009 - 2
85)A Highly Efficient siRNA Carrier of PBLG Modified Hyperbranched PEI - Macromolecular Bioscience - 2009 - 9
86)Thiourea modified polyethylenimine for efficient gene delivery mediated by the combination of electrostatic interactions and hydrogen bonds[J] - Polymer Chemistry - 2014 - 05