马宏伟
单位：中国科学院苏州纳米技术与纳米仿生研究所
地址：江苏省苏州工业园区若水路398号
邮编：215123
电话：
个人主页： http://sourcedb.sinano.cas.cn/zw/zjrck/200907/t**_**.html
实验室介绍：


个人简历 Personal resume


马宏伟，中国科学院研究员，博士生导师。1999年毕业于上海复旦大学化学系，2005年获得美国杜克大学生物医学工程系博士学位。2005年-2008年在北京大学工学院生物医学工程系任特聘研究员，博导。2008年至今在苏州纳米所工作，曾获2013年江苏省双创人才、2012年姑苏创业人才，2010年第四届苏州工业园区科技领军人才奖、2009年中国化学会青年化学奖、北京大学Exxon Mobil教学和科研奖等。研究兴趣：自身免疫疾病的纳米诊断技术。主要学术成绩：发展了表面引发聚合反应的表面修饰新技术，解决了“蛋白质非特异性吸附”（NPA）这一共性难题，构筑了一系列功能化的生物界面，开发出系列产品，初步实现产业转化。近年来，出版国际专著一部，先后在Journal of the American Chemical Society、Advaced Materials、Small等期刊发表论文78篇，被引用2000余次。拥有中国授权发明专利23项，美国授权发明专利3项，另有33项发明专利正在申请中。


研究方向 Research direction


1、生物芯片与疫病诊疗
2、免疫
3、生物界面



招生信息 Enrollment information


知识背景：需要物理化学或是细胞生物学方面的学习经历。考试科目与学生待遇参照研究所统一标准。


论文专著 The monograph


1)Subcellular and Dynamic Coordination between Src Activity and Cell Protrusion in Microenvironment - Scientific Reports - 201508 - 5:12963
2)An ultralow background substrate for protein microarray technology - Analyst - 201506 - 140（16）
3)A quartz crystal microbalance as a tool for biomolecular interaction studies - RSC Adv. - 201507 - 5（79）
4)Chimeric peptide constructs comprising linear B-cell epitopes: application to the serodiagnosis of infectious diseases - Scientific Reports - 201508 - 5:13364
5)Autoantibodies to chromogranin A are potential diagnostic biomarkers for non-small cell lung cancer - Tumor Biol. - 201507 - 36（12）
6)iPDMS based microarray reveals relationship between non-specific interaction and irreproducibility - Anal Chem. - 201506 - 87（14）
7)Robust anti-reflective silica nanocoatings: abrasion resistance enhanced via capillary condensation of APTES - J. Mater. Chem. C - 201503 - 3（17）
8)Surface confined retro Diels-Alder reaction driven by the swelling of weak polyelectrolytes - ACS Appl. Mater. Inter. - 201503 - 7（11）
9)In Vitro Hemocompatibility and Toxic Mechanism of Graphene Oxide on Human Peripheral Blood T Lymphocytes and Serum Albumin - ACS Appl. Mater. Inter. - 201411 - 6（22）
10)Trend of telomerase activity change during human iPSC self-renewal and differentiation revealed by a quartz crystal microbalance based assay - Scientific Reports - 201411 - 4:6978
11)Interaction of graphene oxide with human serum albumin and its mechanism - RSC Adv. - 201410 - 4（98）
12)Molecular Composition, Grafting Density and Film Area Affect the Swelling-Induced Au-S Bond Breakage - ACS Appl. Mater. Inter. - 201406 - 6（11）
13)Long-term self-renewal of human pluripotent stem cells on peptide-decorated poly(OEGMA-co-HEMA) brushes under fully defined conditions - Acta Biomater. - 201307 - 9（11）
14)FRET imaging of calcium signaling in live cells in the microenvironment - Integr.Biol. - 201211 - 5（2）
15)Single-Step Rapid Assembly of DNA Origami Nanostructures for Addressable Nanoscale Bioreactors - J. Am. Chem. Soc. - 201212 - 135（2）
16)Label-Free Real-Time Detection of DNA Methylation Based on Quartz Crystal Microbalance Measurement - Anal. Chem. - 201301 - 85（4）
17)Simultaneous and rapid detection of multiple pesticide and veterinary drug residues by suspension array technology - Biosens.Bioelectron. - 201210 - 41（5）
18)A proton shelter inspired by the sugar coating of acidophilic archaea - Scientific Reports - 201211 - 2（48）
19)Single-chain polymers achieved from radical polymerization under single initiator conditions - Langmuir - 201210 - 28（42）
20)Poly(ionic liquid)-wrapped single-walled carbon nanotubes for sub-ppb detection of CO2 - Chem. Commun. - 201206 - 48（66）
21)Surface initiated polymerization from integrated poly(dimethylsiloxane) enables crack-free large area wrinkle formation - Polym.Adv. Technol. - 201108 - 23（9）
22)old nanoparticles-based nanoconjugates for enhanced enzyme cascade and glucose sensing - Analyst - 201208 - 137（19）
23)Solidified liquid layer model expands the application fields of quartz crystal microbalance - Macro. Rapid Commun. - 201205 - 33（9）
24)Unexpected Temperature-dependent Single Chain Mechanics of Poly(N-isopropyl-acrylamide) in Water - Langmuir - 201202 - 28（11）
25)Tunning the surface chemistry of iPDMS for improved protein microarray performance - J. Mater.Chem. - 201202 - 22（13）
26)The change in thickness of the solidified liquid layer rather than the immobilized mass determines the frequency response of a quartz crystal microbalance - SCI CHINA CHEM. - 201101 - 55（1）
27)Fibronectin and Bone Morphogenetic Protein-2-Decorated Poly(OEGMA-r-HEMA) Brushes Promote Osseointegration of Titanium Surfaces - Langmuir - 201109 - 27（19）
28)Predicting Au-S bonds breakage from the swelling behavior of surface tethered polyelectrolytes - Soft Matter - 201110 - 7（24）
29)Swelling induced Au-S bond breakage is determined by the molecular composition of surface tethered copolymers-carboxylated poly(OEGMA-r-HEMA) - Chem. Commun. - 201107 - 47（47）
30) Solidified liquid layer model makes quartz crystal microbalance a convenient molecular ruler - Colloid Surface B. - 201106 - 85（1）
31)The use of micropatterning to control smooth muscle myosin heavy chain expression and limit the response to transforming growth factor β1 in vascular smooth muscle cells - Biomaterials - 201009 - 32（2）
32)Directly observed Au-S bond breakage due to swelling of the anchored polyelectrolyte - Chem. Commun. - 201011 - 47（4）
33)Poly(dimethylsiloxane) elastomers with tethered peptide ligands for cell adhesion studies - Acta Biomater. - 201002 - 6（8）
34)A quartz crystal microbalance-based molecular ruler for biopolymers - Chem. Commun. - 200912 - 46（6）
35)Optimization of evanescent wave imaging for the visualization of protein adsorption layers - SCI CHINA PHYS MECH. - 201008 - 53（10）
36)Surface initiated polymerization from substrates of low initiator density and its applications in biosensors - ACS Appl. Mater. Inter. - 201010 - 2（11）
37)A DNA-origami chip platform for label-free SNP genotyping using toehold-mediated strand displacement - Small - 201009 - 6（17）
38)A nanofibrous membrane with tunable surface chemistry: preparation and application in protein microarrays - J. Mater. Chem. - 201009 - 20（45）
39)Arranging junctions for nanofibers - Nanoscale - 200911 - 2（2）
40)Integrated poly(dimethysiloxane) with an intrinsic nonfouling property approaching “Absolute” zero background in immunoassays - Anal. Chem. - 201007 - 82（15）
41)Controlled wrinkle formation via bubble inflation strain engineering - Soft Matter - 201008 - 6（18）
42) One-step fabrication of porous polymeric microcage via electrified jetting - Nanoscale - 201005 - 2（6）
43)Electrospinning of poly (dimethylsiloxane) nanofibrous membrane: fabrication and application in protein microarrays - Biomacromolecules - 200911 - 10（12）
44)Substrate induced controllable wrinkling for facile nanofabrication - Macromol. Rapid Commun. - 200907 - 30（18）
45) Real-time measurement of the mass of water expelled by poly(N-isopropylacrylamide) brushes upon thermo-induced collapse - Chem. Commun. - 200904 - issue 23
46) Convergence of dissipation and impedance analysis of quartz crystal microbalance studies - Anal. Chem. - 200812 - 81（2）
47)Photoelectric conversion switch based on quantum dots with i-motif DNA scaffolds - Chem. Commun. - 200903 - 17（17）
48)Quartz crystal microbalance study of the kinetics of surface initiated polymerization - Sci. China, Ser. B Chem. - 200912 - 52（12）
49)Surface-imprinted nanostructured layer-by-layer film for molecular recognition of theophylline derivatives - Langmuir - 200809 - 24（20）
50)Study viscoelasticity of ultra-thin poly(oligo(ethylene glycol) methacrylate) brushes by a quartz crystal microbalance with dissipation - Langmuir - 200805 - 24（12）
51)Investigation of the interactions between silver nanoparticles and hela cells by scanning electrochemicalmicroscopy - Analyst - 200807 - 133（9）
52)Superhydrophobic poly(dimethylsiloxane) via surface- initiated polymerization with ultralow initiator density - Macromolecules - 200808 - 41（18）
53)A facile method for permanent and functional surface modification of poly(dimethylsiloxane) - J. Am. Chem. Soc. - 200705 - 129（23）
54)Study and application of a linear frequency-thickness relation for surface initiated atom transfer radical polymerization in quartz crystal microbalance - Macromolecules - 200704 - 40（9）
55)Protein resistant polymer coatings on silicon oxide by surface initiated atom transfer radical polymerization - Langmuir - 200603 - 22（8）
56)Surface-initiated atom transfer radical polymerization of oligo(ethylene glycol) methyl methacrylatefrom mixed self-assembled monolayer on gold - Adv. Funct. Mater. - 200701 - 8（2）
57)Analysis of long range correlations due to coherent light scattering due from in vitro cell arrays using angle-resolved low coherence interferometry - J. Biomed. Opt. - 200606 - 11（3）
58)Monitoring kinetics of surface-initiated atom transfer radical polymerization by quartz crystal microbalance with dissipation - Biointerphases - 200603 - 1（1）
59)Pretreatment of amphiphilic comb polymer surfaces dramatically affects protein adsorption - Biomacromolecules - 200509 - 6（6）
60)Fabrication of biofunctionalized quasi-three-dimensional microstructures of a nonfouling comb polymer using soft lithography - Adv. Funct.Mater. - 200503 - 15（4）
61)Stimulus-responsive poly(N-isopropylacrylamide) brushes and nanopatterns prepared by Surface- Initiated Polymerization - Chem. Mater. - 200408 - 16（19）
62)“Non-fouling” oligo(ethylene glycol)-functionalized polymerbrushessynthesized by surface-initiated atom transfer radical polymerization - Adv. Mater. - 200402 - 16（4）
63)Surface engineering strategies for control of protein and cell interactions - Surf. Sci. - 200410 - 570（1-2）
64)Universal route to cell micropatterning using an amphiphilic comb polymer - Adv. Mater. - 200304 - 15（7-8）
65)Micropatterns of a cell-adhesive peptide on an amphiphilic comb polymer film - Langmuir - 200203 - 18（8）
66)Radical-mediated diastereoselective construction of a chiral synthon for synthesis of dolabellanes - Org. Lett. - 199908 - 1（5）