姓名：张钠
地址：科学岛
类型：博导
所在科研单元：强磁场中心


导师介绍



.1985/09-1989/07，南开大学化学系，化学，学士1996/08-1998/08，美国杨百翰大学，有机化学，硕士1998/09-2005/09，美国康奈尔大学，生化与结构生物学，博士2005/10-2007/09，美国哈佛大学医学院生化与分子药理系，博士后2007/10-2012/01，美国哈佛大学医学院麻州总医院，资深博士后研究助理2012/02-2013/03，中科院强磁场科学中心，副研究员2013/04-至今， 中科院强磁场科学中心，研究员

Introduction



Na Zhang received his B.S. degree in chemistry from Chemistry Department of Nankai University in 1989, his M.S. degree in organic synthesis from Chemistry Department of Brigham Young University in 1999, and his Ph.D. degree in biochemistry & structural biology from Cornell University Graduate School of Medical Sciences in 2005. Subsequently he pursued a two-year postdoc as a research fellow at BCMP Department, Harvard Medical School and then a four-year HHMI postdoc as a research associate at Massachusetts General Hospital/Harvard Medical School. Following his postdoctoral work, in February 2012, Na joined High Magnetic Field Laboratory, Chinese Academy of Sciences in Hefei, as an associate professor and was promoted to a full professor a year later. During his Ph.D. study and postdoctoral work, Na has been applying NMR to identify the interactions between carcinogenic small molecules binding with DNA/RNA; to solve 3D structures of DNA-drug complex and the higher order DNA architectures of G-quadruplex formed by guanine-rich sequences, including the fragment of human telomeric DNA repeats; and to characterize the self-chemical replication of nucleic acid systems which function as a key component of a primitive cell in origin of life.Currently in Na Zhang's group, structural biology of nucleic acid is the main scheme. In particular, the solution NMR will be used as a primary tool to understand the structure, dynamics and function of biologically significant RNAs and DNAs, as well as their corresponding complexes interacted with protein or small molecule ligand.

研究领域



.应用液体核磁共振(NMR)技术研究核酸结构生物学，包括生物大分子核酸DNA、RNA自身；以及核酸与相关蛋白或小分子配体（天然产物/药物/代谢产物）形成的复合物三维结构并表征其动态特性，以此解释静态/动态结构与生物功能的内在相关联系；应用NMR研究分子间的相互作用；DNA/RNA化学生物学领域。

招生专业



博士招生计划：          1、专业：生物物理学招生方向：核磁共振技术与应用学术硕士招生计划：          1、专业：生物物理学（硕士）招生方向：核磁共振技术与应用专业学位硕士招生计划：          1、专业：生物与医药（专硕）招生方向：核磁共振技术与应用博士招生计划：          1、专业：生物物理学招生方向：核磁共振技术与应用          2、专业：生物物理学招生方向：环境化学与毒理学学术硕士招生计划：          1、专业：生物物理学（硕士）招生方向：核磁共振技术与应用          2、专业：生物物理学（硕士）招生方向：物理生物与技术博士招生计划：          1、专业：生物物理学招生方向：核磁共振技术与应用          2、专业：生物物理学招生方向：环境化学与毒理学

研究成果



Wan CJ, Fu WQ, Jing HT, Zhang N. NMR Solution Structure of an Asymmetric Intermolecular Leaped V-Shape G-Quadruplex: Selective Recognition of the d(G2NG3NG4) Sequence Motif by a Short Linear G-Rich DNA Probe. Nucleic Acids Research, (2019) 47, p1544–1556.Zhang N, Phan A, Patel D. (3+1) assembly of three human telomeric DNA repeats into an asymmetrical dimeric G-quadruplex. J Am Chem Soc. (2005) 127, p17277-17285.Zhang N, Zhang SL, Szostak JW. Activated ribonucleotides undergo a sugar pucker switch upon binding to a single-stranded RNA template. J Am Chem Soc. (2012) 134, p3691-3694.Zhang S, Zhang N, Blain JC, Szostak JW. Synthesis of N3´-P5´-linked Phosphoramidate DNA by Nonenzymatic Template-Directed Primer Extension. J Am Chem Soc. (2013), 135, p924-932.Trevino S, Zhang N, Elenko M, Lupták A, Szostak JW. Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity. Proc Natl Acad Sci USA (2011) 108, p13492-13497.Zhang N, Ding S, Kolbanovskiy A, Shastry A, Kuzmin VA, Bolton JL, Patel DJ, Broyde S, Geacintov NE. NMR and computational studies of stereoisomeric equine estrogen-derived DNA cytidine adducts in oligonucleotide duplexes: opposite orientations of diastereomeric forms. Biochemistry (2009) 48, p7098-7109.Zhang N, Lin Y, Xiao Z, Jones GB, Goldberg IH. Solution structure of a designed spirocyclic helical ligand binding at a two-base bulge site in DNA. Biochemistry (2007) 46, p4793-4803.